PE20000021A1 - Eteres ciclicos de piperidinilaminometil trifluorometilo como antagonista de la sustancia p - Google Patents
Eteres ciclicos de piperidinilaminometil trifluorometilo como antagonista de la sustancia pInfo
- Publication number
- PE20000021A1 PE20000021A1 PE1998001112A PE00111298A PE20000021A1 PE 20000021 A1 PE20000021 A1 PE 20000021A1 PE 1998001112 A PE1998001112 A PE 1998001112A PE 00111298 A PE00111298 A PE 00111298A PE 20000021 A1 PE20000021 A1 PE 20000021A1
- Authority
- PE
- Peru
- Prior art keywords
- disorders
- alkyl
- haloalkyl
- compound
- emergency
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/76—Benzo[c]pyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 ES ALQUILO C1-C6; R2 ES H, ALQUILO C1-C6, HALOALQUILO C1-C6 o FENILO; R3 ES H o HALOGENO; R4 Y R5 SON H, ALQUILO C1-C6 o HALOALQUILO C1-C6; n ES 1-3. SON COMPUESTOS PREFERIDOS (2S,3S)-3-[(1R)-(6-METOXI-1-METIL-1-TRIFLUOROMETILISOCROMAN-7-IL]METILAMINO-2-FENILPIPERIDINA; (2S,3S)-3-[(3R)-(6-METOXI)-3-METIL-3-TRIFLUOROMETIL-1,3-DIHIDROBENZOFURAN-5-IL)METILAMINO-2-FENILPIPERIDINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN COMPUESTO DE FORMULA III, DONDE W ES H o Q(O=)C-; Q ES H, ALQUILO C1-C6, HALOALQUILO C1-C6. EL COMPUESTO I ES UN ANTAGONISTA DE LA SUSTANCIA P (PEPTIDO DE LA TAQUICININA) Y PUEDE SER UTIL PARA EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES, TRASTORNOS ALERGICOS, ANGIOGENESIS, TRASTORNOS GASTROINTESTINALES, TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL, ENFERMEDADES INFLAMATORIAS, EMESIS, INCONTINENCIA URINARIA, DOLOR, MIGRANA, TRASTORNOS DE ANSIEDAD SEVERA, TRASTORNOS DE ESTRES, QUEMADURAS SOLARES, TRASTORNOS PROVOCADOS POR HELICOBACTER PILORI, DISFUNCION SEXUAL
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB9701466 | 1997-11-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000021A1 true PE20000021A1 (es) | 2000-02-25 |
Family
ID=11004634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1998001112A PE20000021A1 (es) | 1997-11-19 | 1998-11-16 | Eteres ciclicos de piperidinilaminometil trifluorometilo como antagonista de la sustancia p |
Country Status (39)
| Country | Link |
|---|---|
| US (2) | US20030208079A1 (es) |
| EP (1) | EP1032571B1 (es) |
| JP (2) | JP3394239B2 (es) |
| KR (1) | KR100366902B1 (es) |
| CN (1) | CN1173974C (es) |
| AP (1) | AP909A (es) |
| AR (1) | AR016422A1 (es) |
| AT (1) | ATE219078T1 (es) |
| AU (1) | AU734218B2 (es) |
| BG (1) | BG63969B1 (es) |
| CA (1) | CA2310627C (es) |
| CO (1) | CO4771153A1 (es) |
| CZ (1) | CZ297315B6 (es) |
| DE (1) | DE69806045T2 (es) |
| DK (1) | DK1032571T3 (es) |
| DZ (1) | DZ2655A1 (es) |
| EA (1) | EA002621B1 (es) |
| ES (1) | ES2177058T3 (es) |
| HR (1) | HRP20000313B1 (es) |
| HU (1) | HUP0101112A3 (es) |
| ID (1) | ID24240A (es) |
| IL (1) | IL135631A0 (es) |
| IS (1) | IS2202B (es) |
| MA (1) | MA26567A1 (es) |
| MY (1) | MY120558A (es) |
| NO (2) | NO20002544L (es) |
| NZ (1) | NZ503912A (es) |
| OA (1) | OA11380A (es) |
| PA (1) | PA8463001A1 (es) |
| PE (1) | PE20000021A1 (es) |
| PL (1) | PL193484B1 (es) |
| PT (1) | PT1032571E (es) |
| RS (1) | RS49792B (es) |
| SK (1) | SK283460B6 (es) |
| TN (1) | TNSN98210A1 (es) |
| TR (1) | TR200001463T2 (es) |
| TW (1) | TW426667B (es) |
| UA (1) | UA59417C2 (es) |
| WO (1) | WO1999025714A1 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9812617D0 (en) * | 1998-06-11 | 1998-08-12 | Merck Sharp & Dohme | Therapeutic use |
| GB9812662D0 (en) * | 1998-06-11 | 1998-08-12 | Merck Sharp & Dohme | Therapeutic use |
| EP1175417B1 (en) * | 1999-05-06 | 2004-01-07 | Pfizer Products Inc. | Substituted benzolactam compounds |
| RS49964B (sr) | 1999-05-17 | 2008-09-29 | Pfizer Products Inc., | Postupak za dobijanje 2-fenil-3-aminopiridina,njegovih supstituisanih fenil derivata, i njegovih soli |
| IL145949A0 (en) * | 1999-05-21 | 2002-07-25 | Pfizer Prod Inc | 1-trifluoromethyl-4-hydroxy-7-piperidinyl-aminomethylchroman derivatives |
| DE60012953T2 (de) * | 1999-10-07 | 2005-08-18 | Hisamitsu Pharmaceutical Co., Inc., Tosu | 3-amino-2-phenylpiperidinderivate als substanz p antagonisten |
| ATE257477T1 (de) * | 1999-10-18 | 2004-01-15 | Pfizer Prod Inc | Verfahren zur herstellung von zyklischen piperidinylaminomethyl-trifluoromethyl- etherderivaten |
| JP2001172178A (ja) * | 1999-10-25 | 2001-06-26 | Pfizer Prod Inc | 偏頭痛治療用のｎｋ−１レセプターアンタゴニスト及びエレトリプタン |
| IL142810A0 (en) * | 2000-05-03 | 2002-03-10 | Pfizer Prod Inc | Pharmaceutical uses for fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles |
| US20020049211A1 (en) * | 2000-09-06 | 2002-04-25 | Sobolov-Jaynes Susan Beth | Combination treatment for depression and anxiety |
| EP1192952A3 (en) * | 2000-09-28 | 2003-03-26 | Pfizer Products Inc. | Combination, for treating depression and anxiety, containing an NK-3 receptor antagonist and a CNS penetrant NK-1 receptor antagonist |
| US6555581B1 (en) | 2001-02-15 | 2003-04-29 | Jones Pharma, Inc. | Levothyroxine compositions and methods |
| MXPA03007337A (es) | 2001-02-15 | 2005-03-07 | King Pharmaceuticals Inc | Composicion farmaceutica y de hormona tiroidea estabilizada y metodo de preparacion de la misma. |
| US7101569B2 (en) | 2001-08-14 | 2006-09-05 | Franz G Andrew | Methods of administering levothyroxine pharmaceutical compositions |
| ATE332897T1 (de) | 2001-08-30 | 2006-08-15 | Pfizer Prod Inc | Verfahren zur herstellung von 2-(4-alkyl-1- piperazinyl)-benzaldehyd und -benzylidenyl- derivaten durch nucleophile substitution von 2- fluorobenzaldehyd mit 4-alkyl-1-piperazinen in wasser als lösungsmittel |
| US20040001895A1 (en) * | 2002-06-17 | 2004-01-01 | Pfizer Inc. | Combination treatment for depression and anxiety |
| JP2005537322A (ja) * | 2002-08-27 | 2005-12-08 | マーク エル． ウィッテン | タバコの煙の影響の改善 |
| US6911544B2 (en) * | 2002-10-23 | 2005-06-28 | Pfizer Inc. | Process for the preparation of (S,S)-cis-2-phenyl-3-aminopiperidine |
| US7122700B2 (en) | 2004-07-30 | 2006-10-17 | Xerox Corporation | Arylamine processes |
| DE102008000891A1 (de) | 2008-03-31 | 2009-10-01 | Robert Bosch Gmbh | Schutzsystem für Werkzeugmaschinen |
| US9782397B2 (en) | 2011-07-04 | 2017-10-10 | Irbm Science Park S.P.A. | Treatment of corneal neovascularization |
| RU2020131446A (ru) | 2018-02-26 | 2022-03-28 | Оспедале Сан Раффаэле С.Р.Л. | Антагонисты nk-1 для применения в лечении глазной боли |
| EP4117673A1 (en) | 2020-03-11 | 2023-01-18 | Ospedale San Raffaele S.r.l. | Treatment of stem cell deficiency |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9317987D0 (en) * | 1993-08-26 | 1993-10-13 | Glaxo Group Ltd | Chemical compounds |
| KR19980703354A (ko) * | 1995-03-27 | 1998-10-15 | 나카토미히로타카 | 피페리딘 유도체 |
| TW475930B (en) * | 1995-04-24 | 2002-02-11 | Novartis Ag | Novel compound, its use and pharmaceutical composition comprising it |
| JP3042894B2 (ja) * | 1995-07-07 | 2000-05-22 | ファイザー製薬株式会社 | サブスタンスｐアンタゴニストとしての置換ベンゾラクタム化合物 |
| TW340842B (en) * | 1995-08-24 | 1998-09-21 | Pfizer | Substituted benzylaminopiperidine compounds |
| US6329396B1 (en) * | 1996-06-10 | 2001-12-11 | Pfizer Inc. | Substituted benzylaminopiperidine compounds |
| IL145949A0 (en) * | 1999-05-21 | 2002-07-25 | Pfizer Prod Inc | 1-trifluoromethyl-4-hydroxy-7-piperidinyl-aminomethylchroman derivatives |
| ATE257477T1 (de) * | 1999-10-18 | 2004-01-15 | Pfizer Prod Inc | Verfahren zur herstellung von zyklischen piperidinylaminomethyl-trifluoromethyl- etherderivaten |
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1998
- 1998-10-21 TW TW087117444A patent/TW426667B/zh not_active IP Right Cessation
- 1998-10-26 NZ NZ503912A patent/NZ503912A/xx unknown
- 1998-10-26 HU HU0101112A patent/HUP0101112A3/hu unknown
- 1998-10-26 CN CNB988112930A patent/CN1173974C/zh not_active Expired - Fee Related
- 1998-10-26 WO PCT/IB1998/001704 patent/WO1999025714A1/en not_active Ceased
- 1998-10-26 EA EA200000432A patent/EA002621B1/ru not_active IP Right Cessation
- 1998-10-26 UA UA2000042374A patent/UA59417C2/uk unknown
- 1998-10-26 CZ CZ20001834A patent/CZ297315B6/cs not_active IP Right Cessation
- 1998-10-26 ID IDW20000926A patent/ID24240A/id unknown
- 1998-10-26 DK DK98947726T patent/DK1032571T3/da active
- 1998-10-26 TR TR2000/01463T patent/TR200001463T2/xx unknown
- 1998-10-26 AU AU94549/98A patent/AU734218B2/en not_active Ceased
- 1998-10-26 CA CA002310627A patent/CA2310627C/en not_active Expired - Fee Related
- 1998-10-26 IL IL13563198A patent/IL135631A0/xx not_active IP Right Cessation
- 1998-10-26 RS YUP-294/00A patent/RS49792B/sr unknown
- 1998-10-26 DE DE69806045T patent/DE69806045T2/de not_active Expired - Fee Related
- 1998-10-26 ES ES98947726T patent/ES2177058T3/es not_active Expired - Lifetime
- 1998-10-26 HR HR960576A patent/HRP20000313B1/xx not_active IP Right Cessation
- 1998-10-26 SK SK723-2000A patent/SK283460B6/sk unknown
- 1998-10-26 AT AT98947726T patent/ATE219078T1/de not_active IP Right Cessation
- 1998-10-26 EP EP98947726A patent/EP1032571B1/en not_active Expired - Lifetime
- 1998-10-26 JP JP2000521096A patent/JP3394239B2/ja not_active Expired - Fee Related
- 1998-10-26 PT PT98947726T patent/PT1032571E/pt unknown
- 1998-11-11 PA PA19988463001A patent/PA8463001A1/es unknown
- 1998-11-16 PE PE1998001112A patent/PE20000021A1/es not_active Application Discontinuation
- 1998-11-17 AR ARP980105829A patent/AR016422A1/es unknown
- 1998-11-17 MA MA25354A patent/MA26567A1/fr unknown
- 1998-11-17 MY MYPI98005209A patent/MY120558A/en unknown
- 1998-11-18 TN TNTNSN98210A patent/TNSN98210A1/fr unknown
- 1998-11-18 DZ DZ980265A patent/DZ2655A1/xx active
- 1998-11-18 CO CO98067902A patent/CO4771153A1/es unknown
- 1998-11-19 AP APAP/P/1998/001402A patent/AP909A/en active
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2000
- 2000-04-26 IS IS5470A patent/IS2202B/is unknown
- 2000-05-12 OA OA1200000138A patent/OA11380A/en unknown
- 2000-05-15 BG BG104437A patent/BG63969B1/bg unknown
- 2000-05-18 PL PL98340642A patent/PL193484B1/pl unknown
- 2000-05-18 NO NO20002544A patent/NO20002544L/no not_active Application Discontinuation
- 2000-05-18 KR KR10-2000-7005431A patent/KR100366902B1/ko not_active Expired - Fee Related
-
2002
- 2002-06-18 JP JP2002177452A patent/JP2003040777A/ja active Pending
-
2003
- 2003-04-21 US US10/419,425 patent/US20030208079A1/en not_active Abandoned
-
2004
- 2004-07-07 NO NO20042879A patent/NO20042879L/no not_active Application Discontinuation
- 2004-11-18 US US10/991,977 patent/US20050171354A1/en not_active Abandoned
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