[go: up one dir, main page]

PE20020905A1 - Derivados de alcoxicarbonilaminotetrazolil fenilo o acido alcoxicarbonilamino benzoico como antagonistas ip - Google Patents

Derivados de alcoxicarbonilaminotetrazolil fenilo o acido alcoxicarbonilamino benzoico como antagonistas ip

Info

Publication number
PE20020905A1
PE20020905A1 PE2002000168A PE2002000168A PE20020905A1 PE 20020905 A1 PE20020905 A1 PE 20020905A1 PE 2002000168 A PE2002000168 A PE 2002000168A PE 2002000168 A PE2002000168 A PE 2002000168A PE 20020905 A1 PE20020905 A1 PE 20020905A1
Authority
PE
Peru
Prior art keywords
phenyl
benzoic acid
alcoxycarbonylamine
alcoxicarbonylaminotetrazolil
antagonists
Prior art date
Application number
PE2002000168A
Other languages
English (en)
Inventor
Francisco Javier Lopez-Tapia
Dov Nitzan
Yang Counde O'
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20020905A1 publication Critical patent/PE20020905A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A DERIVADOS DE ALCOXICARBONILAMINOTETRAZOLIL FENILO O ACIDO ALCOXICARBONILAMINO BENZOICO DE FORMULA I DONDE G1 ES a, b1, ENTRE OTROS; A ES FENILO, PIRIDINILO, PIRIMIDINILO, PIRIDAZINILO, ENTRE OTROS; R' Y R'' SON H, ALQUILO; G2 ES c, d, ENTRE OTROS; R1 Y R2 SON H, ALQUILO, HALOGENO, HALOGENOALQUILO, ENTRE OTROS; R1 Y R2 JUNTO A LOS CARBONOS AL QUE ESTAN UNIDOS PUEDEN FORMAR UN ANILLO AROMATICO; n ES 0-3. SON COMPUESTOS PREFERIDOS ACIDO 2-[5-(4-FLUORO-FENIL)-BENZOFURAN-2-ILMETOXICARBONIL-AMINO]-5-ISOPROPOXI-BENZOICO, ACIDO 2-[5-(4-FLUORO-FENIL)-BENZOFURAN-2-ILMETOXICARBONIL-AMINO]-6-METIL-BENZOICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y UN PROCESO PARA LA PREPARACION. LOS COMPUESTOS MENCIONADOS SON ANTAGONISTAS IP DE PROSTAGLANDINAS Y SON UTILES PARA EL TRATAMIENTO INCONTINENCIA URINARIA, HIPERTROFIA PROTATICA BENIGNA
PE2002000168A 2001-03-02 2002-02-28 Derivados de alcoxicarbonilaminotetrazolil fenilo o acido alcoxicarbonilamino benzoico como antagonistas ip PE20020905A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27287201P 2001-03-02 2001-03-02
US31255901P 2001-08-15 2001-08-15

Publications (1)

Publication Number Publication Date
PE20020905A1 true PE20020905A1 (es) 2002-10-19

Family

ID=26955795

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000168A PE20020905A1 (es) 2001-03-02 2002-02-28 Derivados de alcoxicarbonilaminotetrazolil fenilo o acido alcoxicarbonilamino benzoico como antagonistas ip

Country Status (16)

Country Link
US (1) US6903086B2 (es)
EP (1) EP1379516B1 (es)
JP (1) JP4018985B2 (es)
KR (1) KR100559015B1 (es)
CN (1) CN1256334C (es)
AR (1) AR033430A1 (es)
AT (1) ATE309994T1 (es)
AU (1) AU2002253061B2 (es)
BR (1) BR0207795A (es)
CA (1) CA2438737A1 (es)
DE (1) DE60207399T2 (es)
ES (1) ES2252443T3 (es)
MX (1) MXPA03007865A (es)
PA (1) PA8540601A1 (es)
PE (1) PE20020905A1 (es)
WO (1) WO2002070500A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0218876D0 (en) * 2002-08-13 2002-09-25 Merck Sharp & Dohme Therapeutic agents
WO2004071508A1 (en) * 2003-02-14 2004-08-26 Medical Research Council Ip receptor antagonists for the treatment of pathological uterine conditions
GB0503056D0 (en) * 2005-02-14 2005-03-23 Smithkline Beecham Corp Chemical compounds
NZ583350A (en) * 2007-08-21 2012-03-30 Senomyx Inc Heteroaryl-hydantoin derivatives as bitter taste inhibitors
US8076491B2 (en) * 2007-08-21 2011-12-13 Senomyx, Inc. Compounds that inhibit (block) bitter taste in composition and use thereof
GB0907551D0 (en) * 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
WO2014143592A1 (en) 2013-03-12 2014-09-18 Allergan, Inc. Inhibition of neovascularization by inhibition of prostanoid ip receptors
US9295665B2 (en) 2013-03-12 2016-03-29 Allergan, Inc. Inhibition of neovascularization by simultaneous inhibition of prostanoid IP and EP4 receptors
CN106496036A (zh) * 2016-09-29 2017-03-15 福建天富生物科技发展有限公司 一种抗凝血药物中间体5‑甲氧基‑2‑硝基苯甲酸的制备方法
EP3680232B1 (en) 2017-08-07 2024-12-11 Amenis Biosciences, Inc. Novel anthranilic acid-based compound, and pin1 inhibitor, therapeutic agent for inflammatory diseases and therapeutic agent for cancer that use the same
WO2019152955A1 (en) 2018-02-02 2019-08-08 Steven Albert Everett Small molecule drug conjugates of gemcitabine monophosphate
CN108774183A (zh) * 2018-08-03 2018-11-09 成都苑东生物制药股份有限公司 一种乙二醇类化合物的制备方法
EP4119138A1 (en) * 2021-07-12 2023-01-18 Universität Hamburg Dhodh inhibitors and their use as antiviral agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6174905B1 (en) 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer
US5998424A (en) 1997-06-19 1999-12-07 Dupont Pharmaceuticals Company Inhibitors of factor Xa with a neutral P1 specificity group
US6184242B1 (en) 1997-09-04 2001-02-06 Syntex Usa (Llc) 2-(substituted-phenyl)amino-imidazoline derivatives
US6320078B1 (en) 1998-07-24 2001-11-20 Mitsui Chemicals, Inc. Method of producing benzamide derivatives
WO2000006550A1 (en) 1998-07-31 2000-02-10 Nippon Soda Co., Ltd. Phenylazole compounds, process for producing the same and drugs for hyperlipemia
AU5216801A (en) * 2000-03-16 2001-09-24 Hoffmann La Roche Carboxylic acid derivatives as ip antagonists

Also Published As

Publication number Publication date
JP2004529899A (ja) 2004-09-30
US6903086B2 (en) 2005-06-07
AR033430A1 (es) 2003-12-17
PA8540601A1 (es) 2002-09-30
MXPA03007865A (es) 2003-12-04
JP4018985B2 (ja) 2007-12-05
AU2002253061B2 (en) 2005-04-07
WO2002070500A1 (en) 2002-09-12
US20020165235A1 (en) 2002-11-07
DE60207399T2 (de) 2006-08-03
CA2438737A1 (en) 2002-09-12
KR20040023591A (ko) 2004-03-18
DE60207399D1 (de) 2005-12-22
ATE309994T1 (de) 2005-12-15
EP1379516B1 (en) 2005-11-16
BR0207795A (pt) 2004-03-23
CN1256334C (zh) 2006-05-17
ES2252443T3 (es) 2006-05-16
KR100559015B1 (ko) 2006-03-10
EP1379516A1 (en) 2004-01-14
CN1527824A (zh) 2004-09-08

Similar Documents

Publication Publication Date Title
PE20020905A1 (es) Derivados de alcoxicarbonilaminotetrazolil fenilo o acido alcoxicarbonilamino benzoico como antagonistas ip
PE20001305A1 (es) Derivados de pirazolopiridina
PE20040832A1 (es) Derivados de indolil pirazinona
AR037901A1 (es) Beta-amino-alfa-cianoacrilatos
PE20030086A1 (es) Derivados de acidos tiofen dicarboxilicos como inhibidores de histona desacilasa (hdca)
AR014948A1 (es) Compuestos macrolidos, composiciones, su uso para la manufactura de medicamentos y metodo para prepararlos.
NO20033385L (no) Fuserte heterocykliske forbindelser
EP1065204A4 (en) Bicyclic carbonyl indole compounds as anti-inflammatory / analgesic agents and as COX-2 inhibitors
HRP20090162T1 (en) Quinolinone-carboxamide compounds as 5-ht4 receptor agonists
EA200300619A1 (ru) Серотонинергические средства
ECSP045078A (es) Tiofen- y tiazolsulfonamidas como agentes antineoplásicos
PE20040698A1 (es) Derivados de isoindolina
PE20010962A1 (es) Derivados de heterociclo-alquilsulfonil-pirazol como agentes anti-inflamatorios/analgesicos
ES2054304T3 (es) Feniletanolaminometiltetralinas, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
DK0902018T3 (da) 2-(arylpheny)amino-imidazolinderivater
AR071486A1 (es) 2-( fenil sustituido ) -6- hidroxi o alcoxi -5- substituido -4- pirimidin carboxilatos y su uso como herbicidas
DK1204658T3 (da) Benzofurylpiperazin-serotoninagonister
AR023111A1 (es) Derivados de sulfonamida utiles como antagonistas del receptor 5-ht7, un procedimiento para su preparacion y composicion farmaceutica que los comprenden
DE50101861D1 (de) Tocotrienolchinon- zyklisierungsprodukte mit antihypercholesterin wirkung
NO20050612L (no) Pyrrolidinderivater som oksytocinantagonister
PE20040658A1 (es) Derivados de 3-guanidinocarbonil-1-heteroaril-pirrol, procedimiento de preparacion e intermediarios de este procedimiento y composiciones farmaceuticas que los comprenden
AR035247A1 (es) Derivados de piperidinacarboxamida, un procedimiento para su preparacion y las composiciones farmaceuticas que los contienen
AR033429A1 (es) Derivados del acido alcoxicarbonilamino-heteroarilcarboxilico, su uso, un procedimiento para prepararlos y composiciones farmaceuticas que los comprenden
ATE486060T1 (de) Halogenierte chinolinderivate und mittel zur bekämpfung von ectoparasiten
ATE256466T1 (de) Verwendung von manzaminen als entzündungshemmende mittel

Legal Events

Date Code Title Description
FA Abandonment or withdrawal