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PE20000435A1 - Compuestos azapoliciclicos condensados con arilo - Google Patents

Compuestos azapoliciclicos condensados con arilo

Info

Publication number
PE20000435A1
PE20000435A1 PE1999000340A PE00034099A PE20000435A1 PE 20000435 A1 PE20000435 A1 PE 20000435A1 PE 1999000340 A PE1999000340 A PE 1999000340A PE 00034099 A PE00034099 A PE 00034099A PE 20000435 A1 PE20000435 A1 PE 20000435A1
Authority
PE
Peru
Prior art keywords
alkyl
azapolicyclic
fluor
piperazine
bound
Prior art date
Application number
PE1999000340A
Other languages
English (en)
Inventor
Jotham Wadsworth Coe
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20000435A1 publication Critical patent/PE20000435A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22Bridged ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS AZAPOLICICLICOS CONDENSADOS CON ARILO DE FORMULA I, DONDE Z ES CH2, C=O, CF2; R1 ES H, ALQUILO C1-C6, ALQUENILO C3-C6, BENCILO, XC(=O)R13, -CH2CH2-O-(ALQUILO C1-C4); R2 Y R3 SON H, ALQUENILO C2-C6, ALQUINILO C2-C6, OH, -SOq-(ALQUILO C1-C6), ENTRE OTROS; q ES 0-2, CO2R4, CONR5R6, SO2NR7R8, C(=O)R13, X(C=O)R13; O R2 Y R3 FORMAN UN ANILLO CARBOCICLICO MONOCICLICO DE 4-7 MIEMBROS O BICICLICO DE 10-14 MIEMBROS DE PREFERENCIA DE FORMULA a, b, ENTRE OTROS; R10 Y R17 SON H Y ALQUILO C1-C6; R4, R5, R6, R7, R8, R13 SON H, ALQUILO C1-C6; O R5 Y R6 O R7 Y R8 JUNTO CON N FORMAN PIRROLIDINA, PIPERIDINA, MORFOLINA, AZETIDINA, PIPERAZINA, -N-(ALQUIL C1-C6)PIPERAZINA, TIOMORFOLINA; X ES ALQUILENO C1-C6; a)UNO DE R1, R2 Y R3 NO ES H; b)CUANDO R2 Y R3 SON H; R1 NO ES METILO o H; c)NINGUN FLUOR DE ALQUILO O ALCOXI SUSTITUIDO CON FLUOR DE R2 Y R3 ESTA UNIDO AL CARBONO QUE ESTA UNIDO A UN HETEROATOMO. EL COMPUESTO I SE UNE A SITIOS ESPECIFICOS DE RECEPTORES NICOTINICOS DE ACETILCOLINA PRESENTES EN LAS NEURONAS Y SON UTILES PARA MODULAR LA FUNCION COLINERGICA Y PUEDE SER UTIL PARA LA REDUCCION DE LA ADICCION A LA NICOTINA, REDUCIR EL USO DE TABACO, TRATAMIENTO DE LA ENFERMEDAD INFLAMATORIA DEL INTESTINO, SINDROME DEL INTESTINO IRRITABLE, DISTONIA ESPASTICA
PE1999000340A 1998-04-29 1999-04-23 Compuestos azapoliciclicos condensados con arilo PE20000435A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8355698P 1998-04-29 1998-04-29

Publications (1)

Publication Number Publication Date
PE20000435A1 true PE20000435A1 (es) 2000-05-26

Family

ID=22179102

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000340A PE20000435A1 (es) 1998-04-29 1999-04-23 Compuestos azapoliciclicos condensados con arilo

Country Status (41)

Country Link
US (3) US6462035B1 (es)
EP (1) EP1076650B1 (es)
JP (1) JP2002513007A (es)
KR (1) KR100420423B1 (es)
CN (1) CN1144787C (es)
AP (1) AP1154A (es)
AR (1) AR018596A1 (es)
AT (1) ATE258921T1 (es)
AU (1) AU749831B2 (es)
BG (1) BG64556B1 (es)
BR (1) BR9910058A (es)
CA (1) CA2330576A1 (es)
CO (1) CO5021124A1 (es)
DE (1) DE69914594T2 (es)
DK (1) DK1076650T3 (es)
DZ (1) DZ2778A1 (es)
EA (1) EA003669B1 (es)
ES (1) ES2213354T3 (es)
GT (1) GT199900059A (es)
HR (1) HRP20000731A2 (es)
HU (1) HUP0103340A3 (es)
ID (1) ID26700A (es)
IL (1) IL138917A0 (es)
IS (1) IS5649A (es)
MA (1) MA26623A1 (es)
MY (1) MY133474A (es)
NO (1) NO317300B1 (es)
NZ (1) NZ507035A (es)
OA (1) OA11506A (es)
PA (1) PA8471301A1 (es)
PE (1) PE20000435A1 (es)
PL (1) PL344010A1 (es)
PT (1) PT1076650E (es)
SK (1) SK15952000A3 (es)
TN (1) TNSN99080A1 (es)
TR (1) TR200003122T2 (es)
UA (1) UA61991C2 (es)
UY (1) UY25636A1 (es)
WO (1) WO1999055680A1 (es)
YU (1) YU64400A (es)
ZA (1) ZA992971B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20050506A2 (en) * 1997-12-31 2006-03-31 Pfizer Products Inc. Aryl fused azapolycyclic compounds
US6605610B1 (en) 1997-12-31 2003-08-12 Pfizer Inc Aryl fused azapolycyclic compounds
US20010036943A1 (en) * 2000-04-07 2001-11-01 Coe Jotham W. Pharmaceutical composition for treatment of acute, chronic pain and/or neuropathic pain and migraines
RU2282619C9 (ru) * 2001-04-20 2006-12-20 Пфайзер Продактс Инк. Способы получения замещенных арилконденсированных азаполициклических соединений, промежуточные продукты и способы их получения
SK1912004A3 (en) * 2001-10-31 2004-09-08 Pfizer Prod Inc Nicotinic acetylcholine receptor agonists in the treatment of restless legs syndrome
BR0214578A (pt) 2001-11-30 2004-11-03 Pfizer Prod Inc Compostos azopolicìclicos fundidos com arila
AU2003233228A1 (en) * 2002-05-03 2003-11-17 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Novel spiro ketone and carboxylic acid derivatives as specific inhibitors for (po3h2) ser/(po3h2)thr-pro-specific peptidyl-prolyl-cis/trans-isomerases
US20040224963A1 (en) * 2003-05-09 2004-11-11 Pfizer Inc Pharmaceutical composition for the prevention and treatment of nicotine addiction in a mammal
US20040224962A1 (en) * 2003-05-09 2004-11-11 Pfizer Inc Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss
CA2533100A1 (en) * 2003-07-21 2005-01-27 Pfizer Products Inc. Aryl fused azapolycyclic compounds
WO2005007655A1 (en) 2003-07-21 2005-01-27 Pfizer Products Inc. Nicotine addiction reducing heteroaryl fused azapolycyclic compounds
US20050043407A1 (en) * 2003-08-22 2005-02-24 Pfizer Inc Pharmaceutical composition for the prevention and treatment of addiction in a mammal
ES2306250T3 (es) * 2004-12-07 2008-11-01 Pfizer Products Incorporated Derivados de 1,2,3,3a,8,8a-hexahidro-2,7a-diaza-ciclopenta(a)indan-7-ona que se unen a sitios receptores nicotinicos neuronales especificos de acetilcolina y son utiles para modular la funcion colinergica.
US20060210498A1 (en) 2005-03-18 2006-09-21 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Novel resorcinol derivatives for skin
US20060210497A1 (en) * 2005-03-18 2006-09-21 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Novel resorcinol derivatives
DE102005061426A1 (de) * 2005-12-22 2007-07-05 Grünenthal GmbH Substituierte tricyclische Piperidon-Derivate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3687937A (en) * 1970-06-23 1972-08-29 Us Of America The 1,5-methano-3-benzazocine derivatives
JPS4914473A (es) * 1972-06-09 1974-02-07
JPS4924968A (es) * 1972-07-01 1974-03-05

Also Published As

Publication number Publication date
JP2002513007A (ja) 2002-05-08
TNSN99080A1 (fr) 2005-11-10
NZ507035A (en) 2003-05-30
US6462035B1 (en) 2002-10-08
AP9901524A0 (en) 1999-06-30
KR20010043143A (ko) 2001-05-25
US6706702B2 (en) 2004-03-16
AP1154A (en) 2003-03-27
CA2330576A1 (en) 1999-11-04
HUP0103340A3 (en) 2002-10-28
DE69914594D1 (de) 2004-03-11
HRP20000731A2 (en) 2001-06-30
EP1076650A1 (en) 2001-02-21
AU749831B2 (en) 2002-07-04
MY133474A (en) 2007-11-30
DE69914594T2 (de) 2004-12-09
ID26700A (id) 2001-02-01
NO20005397L (no) 2000-10-26
BG104983A (en) 2001-09-28
SK15952000A3 (sk) 2002-06-04
DK1076650T3 (da) 2004-05-24
ES2213354T3 (es) 2004-08-16
DZ2778A1 (fr) 2005-04-23
NO317300B1 (no) 2004-10-04
MA26623A1 (fr) 2004-12-20
NO20005397D0 (no) 2000-10-26
US7122534B2 (en) 2006-10-17
ATE258921T1 (de) 2004-02-15
EA003669B1 (ru) 2003-08-28
UY25636A1 (es) 2000-02-23
OA11506A (en) 2004-05-14
IL138917A0 (en) 2001-11-25
AR018596A1 (es) 2001-11-28
YU64400A (sh) 2003-01-31
TR200003122T2 (tr) 2001-03-21
GT199900059A (es) 2000-10-11
HK1036453A1 (en) 2002-01-04
CN1144787C (zh) 2004-04-07
BR9910058A (pt) 2000-12-26
WO1999055680A1 (en) 1999-11-04
CN1298394A (zh) 2001-06-06
UA61991C2 (en) 2003-12-15
EA200000996A1 (ru) 2001-06-25
PA8471301A1 (es) 2000-09-29
HUP0103340A2 (hu) 2002-02-28
ZA992971B (en) 2000-10-30
IS5649A (is) 2000-09-29
US20030008890A1 (en) 2003-01-09
PL344010A1 (en) 2001-09-24
CO5021124A1 (es) 2001-03-27
KR100420423B1 (ko) 2004-03-04
AU2951699A (en) 1999-11-16
BG64556B1 (bg) 2005-07-29
PT1076650E (pt) 2004-05-31
EP1076650B1 (en) 2004-02-04
US20040167149A1 (en) 2004-08-26

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