ES2159943T3 - Neuvos derivados de piridina y composiciones farmaceuticas que los contienen. - Google Patents
Neuvos derivados de piridina y composiciones farmaceuticas que los contienen.Info
- Publication number
- ES2159943T3 ES2159943T3 ES98914202T ES98914202T ES2159943T3 ES 2159943 T3 ES2159943 T3 ES 2159943T3 ES 98914202 T ES98914202 T ES 98914202T ES 98914202 T ES98914202 T ES 98914202T ES 2159943 T3 ES2159943 T3 ES 2159943T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- optionally substituted
- co2r
- group
- so2nr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006590 (C2-C6) alkenylene group Chemical group 0.000 abstract 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 239000012453 solvate Chemical group 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Un compuesto de fórmula I: en la cual: X esO,SoCH2; R 1 y R 2 son independientemente hidrógeno, alquilo C1-6 o cicloalquilo C3-6, oR 1 y R 2 junto con el átomo de carbono al que están unidos forman un grupo cicloalquilo C3-6; Ar 1 es un sistema bicíclico de anillos condensados que contiene uno o más heteroátomos, un sistema tricíclico de anillos condensados que contiene opcionalmente un átomo de oxígeno, o Ar 1 es un grupo R 3 -R 4 en el cual uno de R 3 /R 4 es un anillo de fenilo y el otro es un anillo heterocíclico de 5 ó 6 miembros que contiene uno o más heteroátomos, estando cada grupo Ar 1 sustituido opcionalmente con halo, nitro, alquilo C1-6 (sustituido opcionalmente con uno o más átomos de úor) CN, -Y-NR 6 C(O)NR 7 R 8 , -O-Y-C(O) NR 7 R 8 , -O-Y-C(S)NR 7 R 8 , -Y-C(O)NR 7 R 8 , -Y-C(S)NR 7 R 8 , -Y-SO2NR 7 R 8 , -Y-NR 7 R 8 , SO2NR 7 R 8 , C(O)NR 7 ,R 8 , C(S)NR 7 R 8 , C(O)R 9 , -OC(O)R 9 , -Y-OR 9 , -Y-CO2R 9 , -Y-NR 10 C(O)NR 11 -ZR 12 , SO2NR 10 C(O)NR 7 R 8 , -Y-SOsNHR 7 R 8 ,-Y-C(O)NR 11 -Z-R 12 , -Y-C(S)NR 11 -Z-R 12 , N(R 10 )SO2R 11 , N(R 10 )C(O)R 11 o N(R 10 )CO2R 11 donde: Y es un enlace, alquileno C1-6 o alquenileno C2-6; R 7 y R 8 son independientemente hidrógeno o alquilo C1-6 o, junto con el átomo de nitrógeno al cual están unidos, forman un anillo heterocíclico de 5 a 7 miembros opcionalmente sustituido que contiene opcionalmente un heteroátomo adicional seleccionado de nitrógeno, oxígeno o azufre; R 5 , R 6 , R 9 , R 10 y R 11 son independientemente hidrógeno o alquilo C1-10 (sustituido opcionalmente con uno o más átomos de fluor); Z es alquileno C1-6; y R 12 es un grupo NR 10 C(O)R 11 , NR 10 CO2R 11 , OR 5 , NR 7 R 8 o CO2R 13 donde R 5 , R 7 , R 8 , R 10 y R 11 son como se define anteriormente y R 13 es hidrógeno, alquilo C1-6, alquilC1-6-arilo o arilo sustituido opcionalmente con hidroxi, o una sal o solvato de aquél.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9701194A SE9701194D0 (sv) | 1997-04-01 | 1997-04-01 | Novel compounds |
| SE9702200A SE9702200D0 (sv) | 1997-06-09 | 1997-06-09 | Novel compounds |
| SE9704402A SE9704402D0 (sv) | 1997-11-28 | 1997-11-28 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2159943T3 true ES2159943T3 (es) | 2001-10-16 |
Family
ID=27355867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98914202T Expired - Lifetime ES2159943T3 (es) | 1997-04-01 | 1998-03-27 | Neuvos derivados de piridina y composiciones farmaceuticas que los contienen. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6143751A (es) |
| EP (1) | EP0984961B1 (es) |
| JP (1) | JP2001517228A (es) |
| KR (1) | KR20010005840A (es) |
| CN (1) | CN1258296A (es) |
| AR (1) | AR012216A1 (es) |
| AT (1) | ATE202351T1 (es) |
| AU (1) | AU6861198A (es) |
| BR (1) | BR9808447A (es) |
| CA (1) | CA2284597A1 (es) |
| DE (1) | DE69800970T2 (es) |
| DK (1) | DK0984961T3 (es) |
| EE (1) | EE9900435A (es) |
| ES (1) | ES2159943T3 (es) |
| GR (1) | GR3036638T3 (es) |
| ID (1) | ID23163A (es) |
| IL (1) | IL131854A0 (es) |
| NO (1) | NO994764L (es) |
| PL (1) | PL335884A1 (es) |
| PT (1) | PT984961E (es) |
| SK (1) | SK133399A3 (es) |
| TR (1) | TR199902433T2 (es) |
| WO (1) | WO1998043971A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000040557A1 (en) * | 1999-01-08 | 2000-07-13 | Vertex Pharmaceuticals Incorporated | Process for the formation of intermediates useful for the preparation of pharmaceuticals |
| CA2314458A1 (en) * | 1999-08-02 | 2001-02-02 | Kazumi Okuro | Process for production of 3-(3-pyridyl)-1-propanol derivatives |
| US6376524B1 (en) | 2000-06-21 | 2002-04-23 | Sunesis Pharmaceuticals, Inc. | Triphenyl compounds as interleukin-4 antagonists |
| JO3598B1 (ar) | 2006-10-10 | 2020-07-05 | Infinity Discovery Inc | الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني |
| KR101888026B1 (ko) | 2010-02-03 | 2018-08-13 | 인피니티 파마슈티컬스, 인코포레이티드 | 지방산 아미드 하이드롤라제 저해제 |
| WO2013097052A1 (en) | 2011-12-30 | 2013-07-04 | Abbott Laboratories | Bromodomain inhibitors |
| WO2013185284A1 (en) | 2012-06-12 | 2013-12-19 | Abbott Laboratories | Pyridinone and pyridazinone derivatives |
| EP3693369A3 (en) | 2016-04-15 | 2020-09-09 | AbbVie Inc. | Bromodomain inhibitors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7955287A (en) * | 1986-10-14 | 1988-04-21 | G.D. Searle & Co. | Pyridine derivatives |
| EP0264114A1 (en) * | 1986-10-16 | 1988-04-20 | G.D. Searle & Co. | Alpha-[(phenylmethoxy)methyl]pyridine-alkanol derivatives |
| TR199801000T2 (xx) * | 1995-12-06 | 1998-08-21 | Astra Pharmaceuticals Ltd. | Bile�ikler |
-
1998
- 1998-03-27 KR KR1019997008914A patent/KR20010005840A/ko not_active Withdrawn
- 1998-03-27 IL IL13185498A patent/IL131854A0/xx unknown
- 1998-03-27 JP JP54155998A patent/JP2001517228A/ja active Pending
- 1998-03-27 AU AU68611/98A patent/AU6861198A/en not_active Abandoned
- 1998-03-27 SK SK1333-99A patent/SK133399A3/sk unknown
- 1998-03-27 BR BR9808447-0A patent/BR9808447A/pt not_active IP Right Cessation
- 1998-03-27 ID IDW991125D patent/ID23163A/id unknown
- 1998-03-27 ES ES98914202T patent/ES2159943T3/es not_active Expired - Lifetime
- 1998-03-27 CA CA002284597A patent/CA2284597A1/en not_active Abandoned
- 1998-03-27 US US09/068,521 patent/US6143751A/en not_active Expired - Fee Related
- 1998-03-27 PT PT98914202T patent/PT984961E/pt unknown
- 1998-03-27 EP EP98914202A patent/EP0984961B1/en not_active Expired - Lifetime
- 1998-03-27 DK DK98914202T patent/DK0984961T3/da active
- 1998-03-27 EE EEP199900435A patent/EE9900435A/xx unknown
- 1998-03-27 PL PL98335884A patent/PL335884A1/xx unknown
- 1998-03-27 TR TR1999/02433T patent/TR199902433T2/xx unknown
- 1998-03-27 CN CN98805505A patent/CN1258296A/zh active Pending
- 1998-03-27 WO PCT/SE1998/000575 patent/WO1998043971A1/en not_active Ceased
- 1998-03-27 AT AT98914202T patent/ATE202351T1/de not_active IP Right Cessation
- 1998-03-27 DE DE69800970T patent/DE69800970T2/de not_active Expired - Fee Related
- 1998-03-31 AR ARP980101459A patent/AR012216A1/es unknown
-
1999
- 1999-09-30 NO NO994764A patent/NO994764L/no not_active Application Discontinuation
-
2001
- 2001-09-18 GR GR20010401496T patent/GR3036638T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE202351T1 (de) | 2001-07-15 |
| SK133399A3 (en) | 2000-05-16 |
| EP0984961A1 (en) | 2000-03-15 |
| IL131854A0 (en) | 2001-03-19 |
| ID23163A (id) | 2000-03-23 |
| DK0984961T3 (da) | 2001-09-17 |
| AU6861198A (en) | 1998-10-22 |
| CN1258296A (zh) | 2000-06-28 |
| BR9808447A (pt) | 2000-05-23 |
| PT984961E (pt) | 2001-11-30 |
| WO1998043971A1 (en) | 1998-10-08 |
| US6143751A (en) | 2000-11-07 |
| AR012216A1 (es) | 2000-09-27 |
| EP0984961B1 (en) | 2001-06-20 |
| JP2001517228A (ja) | 2001-10-02 |
| NO994764D0 (no) | 1999-09-30 |
| DE69800970T2 (de) | 2002-04-04 |
| DE69800970D1 (de) | 2001-07-26 |
| CA2284597A1 (en) | 1998-10-08 |
| EE9900435A (et) | 2000-04-17 |
| GR3036638T3 (en) | 2001-12-31 |
| TR199902433T2 (xx) | 2000-04-21 |
| KR20010005840A (ko) | 2001-01-15 |
| PL335884A1 (en) | 2000-05-22 |
| NO994764L (no) | 1999-09-30 |
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