PA8582201A1 - Indoles 2,7-sustituidos - Google Patents
Indoles 2,7-sustituidosInfo
- Publication number
- PA8582201A1 PA8582201A1 PA20038582201A PA8582201A PA8582201A1 PA 8582201 A1 PA8582201 A1 PA 8582201A1 PA 20038582201 A PA20038582201 A PA 20038582201A PA 8582201 A PA8582201 A PA 8582201A PA 8582201 A1 PA8582201 A1 PA 8582201A1
- Authority
- PA
- Panama
- Prior art keywords
- indoles
- replaced
- methods
- compound
- formula
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical compound C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA PRESENTE INVENCION PROPORCIONA UN COMPUESTO DE FORMULA 1: UNA SAL O UN PROFARMACO FARMACEUTICAMENTE ACEPTABLES DEL MISMO, DONDE R1, R2, R3, R4, Y N SON TAL COMO SE HAN DEFINIDO AQUI. LA PRESENTE INVENCION TAMBIEN PROPORCIONA COMPOSICIONES QUE COMPRENDEN, METODOS DE USO, Y METODOS PARA LA PREPARACION DE UN COMPUESTO DE FORMULA 1.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41123902P | 2002-09-17 | 2002-09-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PA8582201A1 true PA8582201A1 (es) | 2004-04-23 |
Family
ID=32030655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PA20038582201A PA8582201A1 (es) | 2002-09-17 | 2003-09-12 | Indoles 2,7-sustituidos |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US7247651B2 (es) |
| EP (1) | EP1587788B9 (es) |
| JP (1) | JP4327091B2 (es) |
| KR (1) | KR100686758B1 (es) |
| CN (1) | CN1314669C (es) |
| AR (1) | AR041255A1 (es) |
| AT (1) | ATE362469T1 (es) |
| AU (1) | AU2003273855B2 (es) |
| BR (1) | BR0314352A (es) |
| CA (1) | CA2496765A1 (es) |
| DE (1) | DE60313895T2 (es) |
| DK (1) | DK1587788T3 (es) |
| ES (1) | ES2287518T3 (es) |
| GT (1) | GT200300199A (es) |
| HR (1) | HRP20050229A2 (es) |
| MX (1) | MXPA05002696A (es) |
| MY (1) | MY138826A (es) |
| NO (1) | NO20050666L (es) |
| NZ (1) | NZ537982A (es) |
| PA (1) | PA8582201A1 (es) |
| PE (1) | PE20050054A1 (es) |
| PL (1) | PL376020A1 (es) |
| PT (1) | PT1587788E (es) |
| RU (1) | RU2327685C2 (es) |
| TW (1) | TWI249402B (es) |
| UY (1) | UY27980A1 (es) |
| WO (1) | WO2004026830A1 (es) |
| ZA (1) | ZA200501306B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR039127A1 (es) | 2002-03-27 | 2005-02-09 | Glaxo Group Ltd | Compuesto de quinolina, procedimiento para su preparacion, composicion farmaceutica que lo comprende y uso del mismo para la fabricacion de un medicamento |
| RS20060035A (sr) | 2003-07-22 | 2008-08-07 | Arena Pharmaceuticals Inc., | Derivati diaril i arilheteroaril uree kao modulatori receptora 5-ht2a serotonina korisni u profilaksi i lečenju poremećaja u vezi sa njima |
| JP4090491B2 (ja) * | 2003-12-23 | 2008-05-28 | ハー・ルンドベック・アクチエゼルスカベット | ２−（１ｈ−インドリルスルファニル）−ベンジルアミン誘導体 |
| AR052308A1 (es) * | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
| US7713954B2 (en) * | 2004-09-30 | 2010-05-11 | Roche Palo Alto Llc | Compositions and methods for treating cognitive disorders |
| ES2348467T3 (es) | 2004-09-30 | 2010-12-07 | F. Hoffmann-La Roche Ag | Derivados y usos de la benzoxazina y la quinoxalina. |
| WO2006062481A1 (en) * | 2004-12-09 | 2006-06-15 | Biovitrum Ab | New benzofuran derivatives and their use in the treatment of obesity, type ii diabetes and cns disorders . |
| AR054393A1 (es) * | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos. |
| US7629473B2 (en) * | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
| CA2668959A1 (en) * | 2006-11-09 | 2008-05-15 | F. Hoffmann-La Roche Ag | Indole and benzofuran 2-carboxamide derivatives |
| EP2508177A1 (en) | 2007-12-12 | 2012-10-10 | Glaxo Group Limited | Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline |
| WO2009123714A2 (en) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
| CN103288707B (zh) * | 2013-05-28 | 2015-12-23 | 浙江大学 | 一种3-苯巯基吲哚衍生物的制备方法 |
| JP6454346B2 (ja) | 2013-12-20 | 2019-01-16 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． | 芳香族複素環式化合物及び医薬におけるその応用 |
| CA2953004C (en) | 2014-07-08 | 2023-02-21 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
| AU2016276966A1 (en) | 2015-06-12 | 2018-01-18 | Axovant Sciences Gmbh | Diaryl and arylheteroaryl urea derivatives useful for the prophylaxis and treatment of REM sleep behavior disorder |
| EP3322415A4 (en) | 2015-07-15 | 2019-03-13 | Axovant Sciences GmbH | DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR FOR PROPHYLAXIS AND TREATMENT OF HALLUCINATIONS RELATED TO A NEUROGENERATIVE DISEASE |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2679903B1 (fr) * | 1991-08-02 | 1993-12-03 | Elf Sanofi | Derives de la n-sulfonyl indoline portant une fonction amidique, leur preparation, les compositions pharmaceutiques en contenant. |
| CA2194984C (en) | 1994-07-26 | 2002-07-02 | John Eugene Macor | 4-indole derivatives as serotonin agonists and antagonists |
| US6114532A (en) * | 1998-02-03 | 2000-09-05 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals |
| AU4726699A (en) | 1998-06-30 | 2000-01-17 | Eli Lilly And Company | Piperidine derivatives having effects on serotonin related systems |
| FR2788772B1 (fr) * | 1999-01-26 | 2001-03-02 | Adir | Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| GB9912413D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| EP1335722B1 (en) * | 2000-11-24 | 2006-08-30 | Smithkline Beecham Plc | Indolyl-sulfonyl- compounds useful in the treatment of cns disorders |
| PL367305A1 (en) * | 2001-06-07 | 2005-02-21 | F.Hoffmann-La Roche Ag | New indole derivatives with 5-ht6 receptor affinity |
| JP2005501019A (ja) * | 2001-06-15 | 2005-01-13 | エフ．ホフマン−ラ ロシュ アーゲー | ５−ｈｔ６レセプター親和性を有する４−ピペラジニルインドール誘導体 |
| EP1414442A1 (en) * | 2001-08-07 | 2004-05-06 | Smithkline Beecham Plc | 3-arylsulfonyl-7-piperazinyl- indoles, -benzofurans and -benzothiophenes with 5-ht6 receptor affinity for treating cns disorders |
| US7943639B2 (en) | 2002-06-20 | 2011-05-17 | Proximagen Limited | Compounds |
-
2003
- 2003-09-11 WO PCT/EP2003/010101 patent/WO2004026830A1/en not_active Ceased
- 2003-09-11 ES ES03757820T patent/ES2287518T3/es not_active Expired - Lifetime
- 2003-09-11 KR KR1020057004480A patent/KR100686758B1/ko not_active Expired - Fee Related
- 2003-09-11 AT AT03757820T patent/ATE362469T1/de not_active IP Right Cessation
- 2003-09-11 EP EP03757820A patent/EP1587788B9/en not_active Expired - Lifetime
- 2003-09-11 CN CNB03821590XA patent/CN1314669C/zh not_active Expired - Fee Related
- 2003-09-11 JP JP2004537044A patent/JP4327091B2/ja not_active Expired - Fee Related
- 2003-09-11 CA CA002496765A patent/CA2496765A1/en not_active Abandoned
- 2003-09-11 HR HR20050229A patent/HRP20050229A2/hr not_active Application Discontinuation
- 2003-09-11 DE DE60313895T patent/DE60313895T2/de not_active Expired - Lifetime
- 2003-09-11 AU AU2003273855A patent/AU2003273855B2/en not_active Ceased
- 2003-09-11 NZ NZ537982A patent/NZ537982A/en unknown
- 2003-09-11 PL PL03376020A patent/PL376020A1/xx not_active Application Discontinuation
- 2003-09-11 PT PT03757820T patent/PT1587788E/pt unknown
- 2003-09-11 DK DK03757820T patent/DK1587788T3/da active
- 2003-09-11 BR BR0314352-0A patent/BR0314352A/pt not_active IP Right Cessation
- 2003-09-11 RU RU2005111587/04A patent/RU2327685C2/ru not_active IP Right Cessation
- 2003-09-11 MX MXPA05002696A patent/MXPA05002696A/es active IP Right Grant
- 2003-09-12 TW TW092125197A patent/TWI249402B/zh not_active IP Right Cessation
- 2003-09-12 PA PA20038582201A patent/PA8582201A1/es unknown
- 2003-09-12 PE PE2003000929A patent/PE20050054A1/es not_active Application Discontinuation
- 2003-09-15 AR ARP030103331A patent/AR041255A1/es unknown
- 2003-09-15 UY UY27980A patent/UY27980A1/es not_active Application Discontinuation
- 2003-09-16 MY MYPI20033528A patent/MY138826A/en unknown
- 2003-09-16 GT GT200300199A patent/GT200300199A/es unknown
- 2003-09-16 US US10/663,314 patent/US7247651B2/en not_active Expired - Fee Related
-
2005
- 2005-02-08 NO NO20050666A patent/NO20050666L/no not_active Application Discontinuation
- 2005-02-14 ZA ZA200501306A patent/ZA200501306B/xx unknown
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