LV12783B - Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants - Google Patents

Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants

Info

Publication number: LV12783B
Authority: LV; Latvia
Prior art keywords: coagulants; aryl; pyrimidine derivatives; heterocyclyl substituted; substituted pyrimidine
Prior art date: 1998-12-04

Application number

LVP-01-100A

Other languages

English (en)

Latvian (lv)

Other versions

LV12783A (en

Inventor

David D. Davey

Gary B. Phillips

Original Assignee

Berlex Laboratories, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-04

Filing date

2001-07-04

Publication date

2002-10-20

2001-07-04 Application filed by Berlex Laboratories, Inc. filed Critical Berlex Laboratories, Inc.

2002-01-20 Publication of LV12783A publication Critical patent/LV12783A/en

2002-10-20 Publication of LV12783B publication Critical patent/LV12783B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Oncology (AREA)
Emergency Medicine (AREA)
Communicable Diseases (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Separation Of Suspended Particles By Flocculating Agents (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

LVP-01-100A 1998-12-04 2001-07-04 Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants LV12783B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/205,498 US6127376A (en)	1998-12-04	1998-12-04	Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants
PCT/US1999/028537 WO2000033844A1 (en)	1998-12-04	1999-12-03	Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants

Publications (2)

Publication Number	Publication Date
LV12783A LV12783A (en)	2002-01-20
LV12783B true LV12783B (en)	2002-10-20

Family

ID=22762435

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LVP-01-100A LV12783B (en)	1998-12-04	2001-07-04	Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants

Country Status (26)

Country	Link
US (2)	US6127376A (no)
EP (1)	EP1135131A4 (no)
JP (1)	JP2002531506A (no)
KR (1)	KR20010093799A (no)
CN (1)	CN1329491A (no)
AU (1)	AU760370B2 (no)
BG (1)	BG105557A (no)
BR (1)	BR9915938A (no)
CA (1)	CA2354040A1 (no)
CZ (1)	CZ20011932A3 (no)
EE (1)	EE200100298A (no)
HR (1)	HRP20010499A2 (no)
HU (1)	HUP0104508A3 (no)
IL (2)	IL143347A0 (no)
LT (1)	LT4912B (no)
LV (1)	LV12783B (no)
MX (1)	MXPA01005656A (no)
NO (1)	NO20012701L (no)
NZ (1)	NZ512104A (no)
PL (1)	PL348034A1 (no)
RO (1)	RO120971B1 (no)
RU (1)	RU2001118466A (no)
SI (1)	SI20637A (no)
SK (1)	SK7632001A3 (no)
WO (1)	WO2000033844A1 (no)
ZA (1)	ZA200104235B (no)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0813525T3 (da)	1995-03-10	2004-02-16	Berlex Lab	Benzamidinderivater, deres fremstilling og anvendelse som antikoagulanter
US6686364B2 (en)	1997-12-08	2004-02-03	Berlex Laboratories, Inc.	Benzamidine derivatives and their use as anti-coagulants
US6262088B1 (en) *	1998-11-19	2001-07-17	Berlex Laboratories, Inc.	Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
US6350761B1 (en)	1999-07-30	2002-02-26	Berlex Laboratories, Inc.	Benzenamine derivatives as anti-coagulants
US7129242B2 (en)	2000-12-06	2006-10-31	Signal Pharmaceuticals, Llc	Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto
US7122544B2 (en)	2000-12-06	2006-10-17	Signal Pharmaceuticals, Llc	Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
EP1569912B1 (en)	2002-12-03	2015-04-29	Pharmacyclics, Inc.	2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
TWI329105B (en)	2002-02-01	2010-08-21	Rigel Pharmaceuticals Inc	2,4-pyrimidinediamine compounds and their uses
US7351729B2 (en)	2002-03-08	2008-04-01	Signal Pharmaceuticals, Llc	JNK inhibitors for use in combination therapy for treating or managing proliferative disorders and cancers
GB0206215D0 (en)	2002-03-15	2002-05-01	Novartis Ag	Organic compounds
CN103169708B (zh)	2002-07-29	2018-02-02	里格尔药品股份有限公司	用2,4‑嘧啶二胺化合物治疗或者预防自体免疫性疾病的方法
JP4555082B2 (ja) *	2002-08-08	2010-09-29	アムジエン・インコーポレーテツド	バニロイド受容体リガンドおよびそれの治療での使用
US7122542B2 (en)	2003-07-30	2006-10-17	Rigel Pharmaceuticals, Inc.	Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
WO2005047268A2 (en) *	2003-11-10	2005-05-26	X-Ceptor Therapeutics, Inc.	Substituted pyrimidine compositions and methods of use
ATE540035T1 (de) *	2004-11-24	2012-01-15	Rigel Pharmaceuticals Inc	Spiro-2,4-pyrimidindiamin-verbindungen und ihre verwendungen
US7449458B2 (en)	2005-01-19	2008-11-11	Rigel Pharmaceuticals, Inc.	Prodrugs of 2,4-pyrimidinediamine compounds and their uses
US20060270694A1 (en) *	2005-05-03	2006-11-30	Rigel Pharmaceuticals, Inc.	JAK kinase inhibitors and their uses
CA2657745C (en) *	2006-07-21	2015-02-17	Novartis Ag	Pyrimidine derivatives and their use as pesticides
PT2323993E (pt)	2008-04-16	2015-10-12	Portola Pharm Inc	2,6-diamino-pirimidina-5-il-carboxamidas como inibidores de quinasses syk ou jak
US8138339B2 (en)	2008-04-16	2012-03-20	Portola Pharmaceuticals, Inc.	Inhibitors of protein kinases
US9273077B2 (en)	2008-05-21	2016-03-01	Ariad Pharmaceuticals, Inc.	Phosphorus derivatives as kinase inhibitors
PT2300013T (pt)	2008-05-21	2017-10-31	Ariad Pharma Inc	Derivados de fósforo como inibidores de cinases
US8338439B2 (en)	2008-06-27	2012-12-25	Celgene Avilomics Research, Inc.	2,4-disubstituted pyrimidines useful as kinase inhibitors
US11351168B1 (en)	2008-06-27	2022-06-07	Celgene Car Llc	2,4-disubstituted pyrimidines useful as kinase inhibitors
EP2361248B1 (en)	2008-06-27	2018-09-19	Celgene CAR LLC	Heteroaryl compounds and uses thereof
US8278084B2 (en)	2009-02-11	2012-10-02	Northwestern University	Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition
US8932842B2 (en)	2009-02-11	2015-01-13	Northwestern University	Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition
JP5918693B2 (ja)	2009-05-05	2016-05-18	ダナファーバーキャンサーインスティテュートインコーポレイテッド	Ｅｇｆｒ阻害剤及び疾患の治療方法
NZ607845A (en)	2010-08-10	2015-03-27	Celgene Avilomics Res Inc	Besylate salt of a btk inhibitor
WO2012061299A1 (en)	2010-11-01	2012-05-10	Avila Therapeutics, Inc.	Heterocyclic compounds and uses thereof
EP2635285B1 (en)	2010-11-01	2017-05-03	Celgene Avilomics Research, Inc.	Heteroaryl compounds and uses thereof
US8796255B2 (en)	2010-11-10	2014-08-05	Celgene Avilomics Research, Inc	Mutant-selective EGFR inhibitors and uses thereof
EP2704572B1 (en)	2011-05-04	2015-12-30	Ariad Pharmaceuticals, Inc.	Compounds for inhibiting cell proliferation in egfr-driven cancers
EP2770830A4 (en)	2011-10-28	2015-05-27	Celgene Avilomics Res Inc	METHODS OF TREATING A DISEASE OR DISEASE ASSOCIATED WITH TYROSINE KINASE BTK (BRUTON'S TYROSINE KINASE)
US8877760B2 (en)	2011-11-23	2014-11-04	Portola Pharmaceuticals, Inc.	Substituted pyrazine-2-carboxamide kinase inhibitors
MX356753B (es)	2012-03-15	2018-06-12	Celgene Avilomics Res Inc	Formas solidas de un inhibidor de cinasa del receptor del factor de crecimiento epidermico.
PT2825042T (pt)	2012-03-15	2018-11-16	Celgene Car Llc	Sais de um inibidor de cinases do recetor do fator de crescimento epidérmico
AU2013204563B2 (en)	2012-05-05	2016-05-19	Takeda Pharmaceutical Company Limited	Compounds for inhibiting cell proliferation in EGFR-driven cancers
US9126950B2 (en)	2012-12-21	2015-09-08	Celgene Avilomics Research, Inc.	Heteroaryl compounds and uses thereof
WO2014124230A2 (en)	2013-02-08	2014-08-14	Celgene Avilomics Research, Inc.	Erk inhibitors and uses thereof
US9611283B1 (en)	2013-04-10	2017-04-04	Ariad Pharmaceuticals, Inc.	Methods for inhibiting cell proliferation in ALK-driven cancers
US9492471B2 (en)	2013-08-27	2016-11-15	Celgene Avilomics Research, Inc.	Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
US9415049B2 (en)	2013-12-20	2016-08-16	Celgene Avilomics Research, Inc.	Heteroaryl compounds and uses thereof
ES2741785T3 (es)	2014-08-13	2020-02-12	Celgene Car Llc	Formas y composiciones de un inhibidor de ERK
CN109897005B (zh) *	2019-04-12	2022-07-22	湖南省农业生物技术研究所	含取代苯氧基的苯基嘧啶类似物及其制备方法和应用

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB824908A (en) *	1958-06-03	1959-12-09	May & Baker Ltd	Improvements in or relating to triazine derivatives
JPS5922697B2 (ja) *	1976-01-13	1984-05-28	エーザイ株式会社	ビス−（メタ−アミジノフエノキシ）−化合物
US5451700A (en) *	1991-06-11	1995-09-19	Ciba-Geigy Corporation	Amidino compounds, their manufacture and methods of treatment
EP0518818A3 (en) *	1991-06-11	1993-04-28	Ciba-Geigy Ag	Arylethers, their manufacture and use as medicament
ZA928276B (en) *	1991-10-31	1993-05-06	Daiichi Seiyaku Co	Aromatic amidine derivates and salts thereof.
WO1993015756A1 (en) *	1992-02-14	1993-08-19	Corvas International, Inc.	Inhibitors of thrombosis
US5492895A (en) *	1992-02-14	1996-02-20	Corvas International, Inc.	Inhibitors of thrombosis
DE4213919A1 (de) *	1992-04-28	1993-11-04	Thomae Gmbh Dr K	Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
IL106324A (en) *	1992-07-17	1998-09-24	Shell Int Research	Transformed pyrimidine compounds, their preparation and use as pesticides
AU675981B2 (en) *	1992-12-02	1997-02-27	Bristol-Myers Squibb Company	Guanidinyl-substituted heterocyclic thrombin inhibitors
ATE177752T1 (de) *	1992-12-15	1999-04-15	Corvas Int Inc	Neue inhibitoren von faktor xa
US5332822A (en) *	1992-12-24	1994-07-26	Bristol-Myers Squibb Company	Heteroaromatic and thioheteroaromatic substituted sulfonamide thrombin inhibitors
US5633381A (en) *	1994-07-05	1997-05-27	Berlex Laboratories, Inc.	(Z,Z), (Z,E) and (E,Z) isomers of substituted bis(phenylmethylene)cycloketones
IL115420A0 (en) *	1994-09-26	1995-12-31	Zeneca Ltd	Aminoheterocyclic derivatives
US5691364A (en) *	1995-03-10	1997-11-25	Berlex Laboratories, Inc.	Benzamidine derivatives and their use as anti-coagulants
DK0813525T3 (da) *	1995-03-10	2004-02-16	Berlex Lab	Benzamidinderivater, deres fremstilling og anvendelse som antikoagulanter
US5612363A (en) *	1995-06-02	1997-03-18	Berlex Laboratories, Inc.	N,N-di(aryl) cyclic urea derivatives as anti-coagulants
US5849759A (en)	1995-12-08	1998-12-15	Berlex Laboratories, Inc.	Naphthyl-substituted benzimidazole derivatives as anti-coagulants
US5994375A (en) *	1996-02-12	1999-11-30	Berlex Laboratories, Inc.	Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants
US5753635A (en) *	1996-08-16	1998-05-19	Berlex Laboratories, Inc.	Purine derivatives and their use as anti-coagulants
US5693641A (en) *	1996-08-16	1997-12-02	Berlex Laboratories Inc.	Bicyclic pyrimidine derivatives and their use as anti-coagulants
US6008234A (en)	1996-09-12	1999-12-28	Berlex Laboratories, Inc.	Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants
EP0929547B1 (en) *	1996-09-12	2002-11-27	Schering Aktiengesellschaft	Benzamidine derivatives substituted by cyclic amino acid or cycl ic hydroxy acid derivatives and their use as anti-coagulants
US6004985A (en)	1996-10-09	1999-12-21	Berlex Laboratories, Inc.	Thio acid derived monocylic N-heterocyclics as anticoagulants
AU7976998A (en) *	1997-06-19	1999-01-04	Du Pont Merck Pharmaceutical Company, The	(amidino)6-membered aromatics as factor xa inhibitors
CN1143855C (zh)	1997-12-19	2004-03-31	舍林公开股份有限公司	作为抗凝剂的邻氨基苯甲酰胺衍生物

1998
- 1998-12-04 US US09/205,498 patent/US6127376A/en not_active Expired - Fee Related
1999
- 1999-12-03 HU HU0104508A patent/HUP0104508A3/hu unknown
- 1999-12-03 HR HR20010499A patent/HRP20010499A2/hr not_active Application Discontinuation
- 1999-12-03 CZ CZ20011932A patent/CZ20011932A3/cs unknown
- 1999-12-03 JP JP2000586336A patent/JP2002531506A/ja active Pending
- 1999-12-03 RU RU2001118466/14A patent/RU2001118466A/ru not_active Application Discontinuation
- 1999-12-03 MX MXPA01005656A patent/MXPA01005656A/es not_active IP Right Cessation
- 1999-12-03 BR BR9915938-4A patent/BR9915938A/pt not_active IP Right Cessation
- 1999-12-03 EP EP99965087A patent/EP1135131A4/en not_active Withdrawn
- 1999-12-03 EE EEP200100298A patent/EE200100298A/xx unknown
- 1999-12-03 CN CN99814024A patent/CN1329491A/zh active Pending
- 1999-12-03 AU AU31075/00A patent/AU760370B2/en not_active Ceased
- 1999-12-03 SK SK763-2001A patent/SK7632001A3/sk unknown
- 1999-12-03 KR KR1020017006934A patent/KR20010093799A/ko not_active Withdrawn
- 1999-12-03 WO PCT/US1999/028537 patent/WO2000033844A1/en not_active Ceased
- 1999-12-03 PL PL99348034A patent/PL348034A1/xx not_active Application Discontinuation
- 1999-12-03 RO ROA200100606A patent/RO120971B1/ro unknown
- 1999-12-03 CA CA002354040A patent/CA2354040A1/en not_active Abandoned
- 1999-12-03 NZ NZ512104A patent/NZ512104A/en unknown
- 1999-12-03 IL IL14334799A patent/IL143347A0/xx active IP Right Grant
- 1999-12-03 SI SI9920090A patent/SI20637A/sl not_active IP Right Cessation
2000
- 2000-03-30 US US09/539,812 patent/US6372751B1/en not_active Expired - Fee Related
2001
- 2001-05-23 ZA ZA200104235A patent/ZA200104235B/en unknown
- 2001-05-24 IL IL143347A patent/IL143347A/en not_active IP Right Cessation
- 2001-06-01 NO NO20012701A patent/NO20012701L/no not_active Application Discontinuation
- 2001-06-01 BG BG105557A patent/BG105557A/xx unknown
- 2001-06-12 LT LT2001061A patent/LT4912B/lt not_active IP Right Cessation
- 2001-07-04 LV LVP-01-100A patent/LV12783B/xx unknown

Also Published As

Publication number	Publication date
PL348034A1 (en)	2002-05-06
EP1135131A1 (en)	2001-09-26
AU760370B2 (en)	2003-05-15
AU3107500A (en)	2000-06-26
NZ512104A (en)	2003-10-31
CN1329491A (zh)	2002-01-02
SK7632001A3 (en)	2001-12-03
SI20637A (sl)	2002-02-28
MXPA01005656A (es)	2002-04-24
RU2001118466A (ru)	2003-04-20
IL143347A (en)	2006-12-10
EE200100298A (et)	2002-12-16
HRP20010499A2 (en)	2003-04-30
NO20012701D0 (no)	2001-06-01
LT4912B (lt)	2002-04-25
ZA200104235B (en)	2002-08-23
LV12783A (en)	2002-01-20
BG105557A (en)	2001-12-29
HUP0104508A2 (hu)	2002-05-29
EP1135131A4 (en)	2002-01-02
HUP0104508A3 (en)	2002-07-29
RO120971B1 (ro)	2006-10-30
US6127376A (en)	2000-10-03
CA2354040A1 (en)	2000-06-15
JP2002531506A (ja)	2002-09-24
CZ20011932A3 (cs)	2001-10-17
BR9915938A (pt)	2001-08-21
US6372751B1 (en)	2002-04-16
WO2000033844A1 (en)	2000-06-15
IL143347A0 (en)	2002-04-21
KR20010093799A (ko)	2001-10-29
LT2001061A (en)	2001-12-27
NO20012701L (no)	2001-07-25

Publication	Publication Date	Title
LV12783B (en)	2002-10-20	Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants
AU1676200A (en)	2000-06-13	Polyhydroxylated heterocyclic derivatives as anti-coagulants
DE69821985D1 (de)	2004-04-01	Ortho-anthranilamide derivate als antikoagulantien
DE69918422D1 (de)	2004-08-05	Phthalazinone pde iii/iv hemmer
IL128062A0 (en)	1999-11-30	Bicyclic pyrimidine derivatives and pharmaceutical compositions containing the same
AP2001002103A0 (en)	2001-03-31	Substituted phenyl derivatives, their preparation and use.
TR200000065T2 (tr)	2000-11-21	Epotilon türevleri.
ATE248175T1 (de)	2003-09-15	Epothilonderivate und ihre verwendung als antitumormittel
TR200200820T2 (tr)	2002-09-23	Benzodiazepin türevleri,bunların üretimi ve kullanımları
BG105028A (en)	2001-07-31	Bridged indenopyrrolocarbazoles
IT1315267B1 (it)	2003-02-03	Derivati di 2-(1h-indol-3-il)-2-oxo-acetammidi ad attivita'antitumorale
LT2002009A (en)	2002-07-25	Benzenamine derivatives as anti-coagulants
CA2273303A1 (en)	1998-06-11	Thienylsulfonylamino(thio)carbonyl compounds
DK1140933T3 (da)	2004-12-20	Fremgangsmåde til fremstilling af N6-substituerede deaza-adenosinderivater
WO2000043375A3 (de)	2002-09-26	Substituierte arylheterocyclen
DE69703115D1 (de)	2000-10-19	Zwischenprodukte um 2-imidazolin-5onederivate herzustellen.
NZ505406A (en)	2003-01-31	Processes and intermediates useful to make antifolates
DK1140932T3 (da)	2004-07-05	Derivater af benzo-1,8-naphtyridin
GB9911556D0 (en)	1999-07-21	Immunosuppressant tricyclic compounds
MX9703899A (es)	1998-06-30	Derivado de arilacrilamida.
MY127539A (en)	2006-12-29	Bridged indenopyrrolocarbazoles