EE200100298A - Arüül- ja heterotsüklüülasendatud pürimidiini derivaadid kui hüübimisvastased ained - Google Patents

Arüül- ja heterotsüklüülasendatud pürimidiini derivaadid kui hüübimisvastased ained

Info

Publication number: EE200100298A
Authority: EE; Estonia
Prior art keywords: anticoagulants; heterocyclyl; aryl; pyrimidine derivatives; substituted pyrimidine
Prior art date: 1998-12-04

Application number

EEP200100298A

Other languages

English (en)

Estonian (et)

Inventor

D. Davey David

B. Phillips Gary

Original Assignee

Berlex Laboratories, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-04

Filing date

1999-12-03

Publication date

2002-12-16

1999-12-03 Application filed by Berlex Laboratories, Inc. filed Critical Berlex Laboratories, Inc.

2002-12-16 Publication of EE200100298A publication Critical patent/EE200100298A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Oncology (AREA)
Emergency Medicine (AREA)
Communicable Diseases (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Separation Of Suspended Particles By Flocculating Agents (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

EEP200100298A 1998-12-04 1999-12-03 Arüül- ja heterotsüklüülasendatud pürimidiini derivaadid kui hüübimisvastased ained EE200100298A (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/205,498 US6127376A (en)	1998-12-04	1998-12-04	Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants
PCT/US1999/028537 WO2000033844A1 (en)	1998-12-04	1999-12-03	Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants

Publications (1)

Publication Number	Publication Date
EE200100298A true EE200100298A (et)	2002-12-16

Family

ID=22762435

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200100298A EE200100298A (et)	1998-12-04	1999-12-03	Arüül- ja heterotsüklüülasendatud pürimidiini derivaadid kui hüübimisvastased ained

Country Status (26)

Country	Link
US (2)	US6127376A (xx)
EP (1)	EP1135131A4 (xx)
JP (1)	JP2002531506A (xx)
KR (1)	KR20010093799A (xx)
CN (1)	CN1329491A (xx)
AU (1)	AU760370B2 (xx)
BG (1)	BG105557A (xx)
BR (1)	BR9915938A (xx)
CA (1)	CA2354040A1 (xx)
CZ (1)	CZ20011932A3 (xx)
EE (1)	EE200100298A (xx)
HR (1)	HRP20010499A2 (xx)
HU (1)	HUP0104508A3 (xx)
IL (2)	IL143347A0 (xx)
LT (1)	LT4912B (xx)
LV (1)	LV12783B (xx)
MX (1)	MXPA01005656A (xx)
NO (1)	NO20012701L (xx)
NZ (1)	NZ512104A (xx)
PL (1)	PL348034A1 (xx)
RO (1)	RO120971B1 (xx)
RU (1)	RU2001118466A (xx)
SI (1)	SI20637A (xx)
SK (1)	SK7632001A3 (xx)
WO (1)	WO2000033844A1 (xx)
ZA (1)	ZA200104235B (xx)

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EP1569912B1 (en)	2002-12-03	2015-04-29	Pharmacyclics, Inc.	2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
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GB0206215D0 (en)	2002-03-15	2002-05-01	Novartis Ag	Organic compounds
CN103169708B (zh)	2002-07-29	2018-02-02	里格尔药品股份有限公司	用2,4‑嘧啶二胺化合物治疗或者预防自体免疫性疾病的方法
JP4555082B2 (ja) *	2002-08-08	2010-09-29	アムジエン・インコーポレーテツド	バニロイド受容体リガンドおよびそれの治療での使用
US7122542B2 (en)	2003-07-30	2006-10-17	Rigel Pharmaceuticals, Inc.	Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
WO2005047268A2 (en) *	2003-11-10	2005-05-26	X-Ceptor Therapeutics, Inc.	Substituted pyrimidine compositions and methods of use
ATE540035T1 (de) *	2004-11-24	2012-01-15	Rigel Pharmaceuticals Inc	Spiro-2,4-pyrimidindiamin-verbindungen und ihre verwendungen
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CA2657745C (en) *	2006-07-21	2015-02-17	Novartis Ag	Pyrimidine derivatives and their use as pesticides
PT2323993E (pt)	2008-04-16	2015-10-12	Portola Pharm Inc	2,6-diamino-pirimidina-5-il-carboxamidas como inibidores de quinasses syk ou jak
US8138339B2 (en)	2008-04-16	2012-03-20	Portola Pharmaceuticals, Inc.	Inhibitors of protein kinases
US9273077B2 (en)	2008-05-21	2016-03-01	Ariad Pharmaceuticals, Inc.	Phosphorus derivatives as kinase inhibitors
PT2300013T (pt)	2008-05-21	2017-10-31	Ariad Pharma Inc	Derivados de fósforo como inibidores de cinases
US8338439B2 (en)	2008-06-27	2012-12-25	Celgene Avilomics Research, Inc.	2,4-disubstituted pyrimidines useful as kinase inhibitors
US11351168B1 (en)	2008-06-27	2022-06-07	Celgene Car Llc	2,4-disubstituted pyrimidines useful as kinase inhibitors
EP2361248B1 (en)	2008-06-27	2018-09-19	Celgene CAR LLC	Heteroaryl compounds and uses thereof
US8278084B2 (en)	2009-02-11	2012-10-02	Northwestern University	Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition
US8932842B2 (en)	2009-02-11	2015-01-13	Northwestern University	Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition
JP5918693B2 (ja)	2009-05-05	2016-05-18	ダナファーバーキャンサーインスティテュートインコーポレイテッド	Ｅｇｆｒ阻害剤及び疾患の治療方法
NZ607845A (en)	2010-08-10	2015-03-27	Celgene Avilomics Res Inc	Besylate salt of a btk inhibitor
WO2012061299A1 (en)	2010-11-01	2012-05-10	Avila Therapeutics, Inc.	Heterocyclic compounds and uses thereof
EP2635285B1 (en)	2010-11-01	2017-05-03	Celgene Avilomics Research, Inc.	Heteroaryl compounds and uses thereof
US8796255B2 (en)	2010-11-10	2014-08-05	Celgene Avilomics Research, Inc	Mutant-selective EGFR inhibitors and uses thereof
EP2704572B1 (en)	2011-05-04	2015-12-30	Ariad Pharmaceuticals, Inc.	Compounds for inhibiting cell proliferation in egfr-driven cancers
EP2770830A4 (en)	2011-10-28	2015-05-27	Celgene Avilomics Res Inc	METHODS OF TREATING A DISEASE OR DISEASE ASSOCIATED WITH TYROSINE KINASE BTK (BRUTON'S TYROSINE KINASE)
US8877760B2 (en)	2011-11-23	2014-11-04	Portola Pharmaceuticals, Inc.	Substituted pyrazine-2-carboxamide kinase inhibitors
MX356753B (es)	2012-03-15	2018-06-12	Celgene Avilomics Res Inc	Formas solidas de un inhibidor de cinasa del receptor del factor de crecimiento epidermico.
PT2825042T (pt)	2012-03-15	2018-11-16	Celgene Car Llc	Sais de um inibidor de cinases do recetor do fator de crescimento epidérmico
AU2013204563B2 (en)	2012-05-05	2016-05-19	Takeda Pharmaceutical Company Limited	Compounds for inhibiting cell proliferation in EGFR-driven cancers
US9126950B2 (en)	2012-12-21	2015-09-08	Celgene Avilomics Research, Inc.	Heteroaryl compounds and uses thereof
WO2014124230A2 (en)	2013-02-08	2014-08-14	Celgene Avilomics Research, Inc.	Erk inhibitors and uses thereof
US9611283B1 (en)	2013-04-10	2017-04-04	Ariad Pharmaceuticals, Inc.	Methods for inhibiting cell proliferation in ALK-driven cancers
US9492471B2 (en)	2013-08-27	2016-11-15	Celgene Avilomics Research, Inc.	Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
US9415049B2 (en)	2013-12-20	2016-08-16	Celgene Avilomics Research, Inc.	Heteroaryl compounds and uses thereof
ES2741785T3 (es)	2014-08-13	2020-02-12	Celgene Car Llc	Formas y composiciones de un inhibidor de ERK
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1998
- 1998-12-04 US US09/205,498 patent/US6127376A/en not_active Expired - Fee Related
1999
- 1999-12-03 HU HU0104508A patent/HUP0104508A3/hu unknown
- 1999-12-03 HR HR20010499A patent/HRP20010499A2/hr not_active Application Discontinuation
- 1999-12-03 CZ CZ20011932A patent/CZ20011932A3/cs unknown
- 1999-12-03 JP JP2000586336A patent/JP2002531506A/ja active Pending
- 1999-12-03 RU RU2001118466/14A patent/RU2001118466A/ru not_active Application Discontinuation
- 1999-12-03 MX MXPA01005656A patent/MXPA01005656A/es not_active IP Right Cessation
- 1999-12-03 BR BR9915938-4A patent/BR9915938A/pt not_active IP Right Cessation
- 1999-12-03 EP EP99965087A patent/EP1135131A4/en not_active Withdrawn
- 1999-12-03 EE EEP200100298A patent/EE200100298A/xx unknown
- 1999-12-03 CN CN99814024A patent/CN1329491A/zh active Pending
- 1999-12-03 AU AU31075/00A patent/AU760370B2/en not_active Ceased
- 1999-12-03 SK SK763-2001A patent/SK7632001A3/sk unknown
- 1999-12-03 KR KR1020017006934A patent/KR20010093799A/ko not_active Withdrawn
- 1999-12-03 WO PCT/US1999/028537 patent/WO2000033844A1/en not_active Ceased
- 1999-12-03 PL PL99348034A patent/PL348034A1/xx not_active Application Discontinuation
- 1999-12-03 RO ROA200100606A patent/RO120971B1/ro unknown
- 1999-12-03 CA CA002354040A patent/CA2354040A1/en not_active Abandoned
- 1999-12-03 NZ NZ512104A patent/NZ512104A/en unknown
- 1999-12-03 IL IL14334799A patent/IL143347A0/xx active IP Right Grant
- 1999-12-03 SI SI9920090A patent/SI20637A/sl not_active IP Right Cessation
2000
- 2000-03-30 US US09/539,812 patent/US6372751B1/en not_active Expired - Fee Related
2001
- 2001-05-23 ZA ZA200104235A patent/ZA200104235B/en unknown
- 2001-05-24 IL IL143347A patent/IL143347A/en not_active IP Right Cessation
- 2001-06-01 NO NO20012701A patent/NO20012701L/no not_active Application Discontinuation
- 2001-06-01 BG BG105557A patent/BG105557A/xx unknown
- 2001-06-12 LT LT2001061A patent/LT4912B/lt not_active IP Right Cessation
- 2001-07-04 LV LVP-01-100A patent/LV12783B/xx unknown

Also Published As

Publication number	Publication date
PL348034A1 (en)	2002-05-06
EP1135131A1 (en)	2001-09-26
AU760370B2 (en)	2003-05-15
AU3107500A (en)	2000-06-26
NZ512104A (en)	2003-10-31
CN1329491A (zh)	2002-01-02
SK7632001A3 (en)	2001-12-03
SI20637A (sl)	2002-02-28
MXPA01005656A (es)	2002-04-24
RU2001118466A (ru)	2003-04-20
IL143347A (en)	2006-12-10
HRP20010499A2 (en)	2003-04-30
NO20012701D0 (no)	2001-06-01
LT4912B (lt)	2002-04-25
ZA200104235B (en)	2002-08-23
LV12783A (en)	2002-01-20
BG105557A (en)	2001-12-29
HUP0104508A2 (hu)	2002-05-29
EP1135131A4 (en)	2002-01-02
HUP0104508A3 (en)	2002-07-29
RO120971B1 (ro)	2006-10-30
US6127376A (en)	2000-10-03
CA2354040A1 (en)	2000-06-15
JP2002531506A (ja)	2002-09-24
LV12783B (en)	2002-10-20
CZ20011932A3 (cs)	2001-10-17
BR9915938A (pt)	2001-08-21
US6372751B1 (en)	2002-04-16
WO2000033844A1 (en)	2000-06-15
IL143347A0 (en)	2002-04-21
KR20010093799A (ko)	2001-10-29
LT2001061A (en)	2001-12-27
NO20012701L (no)	2001-07-25

Publication	Publication Date	Title
EE200100298A (et)	2002-12-16	Arüül- ja heterotsüklüülasendatud pürimidiini derivaadid kui hüübimisvastased ained
DE50004955D1 (de)	2004-02-12	Senkkopfschraube
DE60026861D1 (de)	2006-05-11	Purin-derivate
ATE238336T1 (de)	2003-05-15	Purin-derivate
NO20016109L (no)	2002-02-15	Purinderivater
DK1104422T3 (da)	2004-06-14	Phenylxanthinderivater
DK1117669T3 (da)	2003-05-26	Antiviruspurinderivater
DE60019164D1 (de)	2005-05-04	N6 heterocyclische 8-modifizierte adenosinderivate
DE60029856D1 (de)	2006-09-21	Falle
DE10084610T1 (de)	2002-05-02	Feststoffelektrolytkondensator
ATE233746T1 (de)	2003-03-15	Thiazole derivate
DE50010134D1 (de)	2005-06-02	Senkkopfschraube
DE60026102D1 (de)	2006-04-27	Kassettenbehälter
DE69915564D1 (de)	2004-04-22	Nahe-Infrarot-Absorbtionszusammensetzung
DE60007475D1 (de)	2004-02-05	Filter
ATE266012T1 (de)	2004-05-15	Thiazole derivate
DE59910200D1 (de)	2004-09-16	Kühlbares Bauteil
NO20022682L (no)	2002-07-17	Heterosykliske derivater
FI19992604A7 (fi)	2001-06-04	Aseen lukitusmenetelmä ja -järjestely
ATE266631T1 (de)	2004-05-15	Imidamid-derivate
LU90463B1 (de)	2001-04-26	Etagenofen
DE59909479D1 (de)	2004-06-17	Imidamid-derivate
DE10085196T1 (de)	2002-11-21	Sicherheitstasche
DE60035659D1 (de)	2007-09-06	Kassettenbehälter
ATA70499A (de)	2000-06-15	Plattenförmiger sicherheitsbauteil