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JO3813B1 - أحماض دهنية جديدة واستخدامها بالاقتران مع جزيئات حيوية - Google Patents

أحماض دهنية جديدة واستخدامها بالاقتران مع جزيئات حيوية

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Publication number
JO3813B1
JO3813B1 JOP/2015/0150A JOP20150150A JO3813B1 JO 3813 B1 JO3813 B1 JO 3813B1 JO P20150150 A JOP20150150 A JO P20150150A JO 3813 B1 JO3813 B1 JO 3813B1
Authority
JO
Jordan
Prior art keywords
disease
conjugate
fatty acid
diabetes
alcoholic
Prior art date
Application number
JOP/2015/0150A
Other languages
English (en)
Inventor
Richardson Usera Aimee
Marshall Bruce Alexandra
Yamada Ken
Clare Kirman Louise
Duttaroy Alokesh
Ibebunjo Chikwendu
Weninger Barnes David
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53491695&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3813(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of JO3813B1 publication Critical patent/JO3813B1/ar

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Abstract

يوفر الاختراع متقارن يشتمل على جزئ حيوي مرتبط بحمض دهني من خلال رابط حيث يكون للحمض الدهني الصيغ التالية A1، A2 أو A3: A1 A2 أو A3 1) حيث تكون R1, R2, R3, R4, Ak, n, m وp معرفة هنا. يتعلق الاختراع أيضاً بطريقة لتصنيع متقارن الاختراع مثل متقارن GDF15، واستخداماته العلاجية مثل علاج أو الوقاية من اضطرابات أو أمراض أيضية، النوع الثاني من داء السكري، السمنة، التهاب البنكرياس، عسر شحميات الدم، مرض الكبد الدهني الكحولي وغير الكحولي/التهاب الكبد الدهني وغيرها من أمراض الكبد التقدمية، مقاومة الأنسولين، فرط الانسولينية، الحساسية المفرطة تجاه الجلوكوز، ارتفاع السكر في الدم، المتلازمة الأيضية، ارتفاع ضغط الدم، أمراض القلب والأوعية الدموية، تصلب الشرايين، أمراض الشرايين الطرفية، السكتة الدماغية، هبوط القلب، مرض القلب التاجي، مضاعفات السكري (تتضمن لكنها لا تقتصر على مرض الكلى المزمن)، اعتلال الأعصاب، خزل المعدة واضطرابات أيضية أخرى. يوفر الاختراع الحالي كذلك توليفة من عوامل نشطة صيدلية وتركيبة صيدلية.
JOP/2015/0150A 2014-06-23 2015-06-21 أحماض دهنية جديدة واستخدامها بالاقتران مع جزيئات حيوية JO3813B1 (ar)

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US201462015862P 2014-06-23 2014-06-23
US201462082327P 2014-11-20 2014-11-20
US201562107016P 2015-01-23 2015-01-23

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JO3813B1 true JO3813B1 (ar) 2021-01-31

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EP (2) EP3988170A1 (ar)
JP (5) JP6636959B2 (ar)
KR (2) KR20230056796A (ar)
CN (3) CN114099693A (ar)
AP (1) AP2016009585A0 (ar)
AU (1) AU2015280351C1 (ar)
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Families Citing this family (68)

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Publication number Priority date Publication date Assignee Title
TW200936156A (en) 2008-01-28 2009-09-01 Novartis Ag Methods and compositions using Klotho-FGF fusion polypeptides
US8420088B2 (en) 2008-01-28 2013-04-16 Novartis Ag Methods and compositions using FGF23 fusion polypeptides
EP2694092B1 (en) 2011-04-08 2017-01-04 Amgen Inc. Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15)
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