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IT1189353B - Procedimento per la preparazione di insulina umana e suoi esteri - Google Patents

Procedimento per la preparazione di insulina umana e suoi esteri

Info

Publication number
IT1189353B
IT1189353B IT8249114A IT4911482A IT1189353B IT 1189353 B IT1189353 B IT 1189353B IT 8249114 A IT8249114 A IT 8249114A IT 4911482 A IT4911482 A IT 4911482A IT 1189353 B IT1189353 B IT 1189353B
Authority
IT
Italy
Prior art keywords
esters
procedure
preparation
human insulin
insulin
Prior art date
Application number
IT8249114A
Other languages
English (en)
Other versions
IT8249114A0 (it
IT8249114A1 (it
Inventor
Finn Hede Andresen
Per Balschmidt
Kim Ry Hejnaes
Hans Kofod
Original Assignee
Nordisk Insulinlab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nordisk Insulinlab filed Critical Nordisk Insulinlab
Publication of IT8249114A0 publication Critical patent/IT8249114A0/it
Publication of IT8249114A1 publication Critical patent/IT8249114A1/it
Application granted granted Critical
Publication of IT1189353B publication Critical patent/IT1189353B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
IT8249114A 1982-06-07 1982-09-14 Procedimento per la preparazione di insulina umana e suoi esteri IT1189353B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK254582 1982-06-07
DK254682 1982-06-07

Publications (3)

Publication Number Publication Date
IT8249114A0 IT8249114A0 (it) 1982-09-14
IT8249114A1 IT8249114A1 (it) 1984-03-14
IT1189353B true IT1189353B (it) 1988-02-04

Family

ID=26066590

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8249114A IT1189353B (it) 1982-06-07 1982-09-14 Procedimento per la preparazione di insulina umana e suoi esteri

Country Status (11)

Country Link
US (1) US4601979A (it)
EP (1) EP0088117B1 (it)
JP (1) JPS58501455A (it)
AU (1) AU551174B2 (it)
CA (1) CA1174623A (it)
DK (1) DK149457C (it)
ES (1) ES8400772A1 (it)
FI (1) FI78119C (it)
IT (1) IT1189353B (it)
NO (1) NO156052C (it)
WO (1) WO1983001074A1 (it)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0092829B1 (en) * 1982-04-23 1990-11-07 Wako Pure Chemical Industries, Ltd. Process for semi-synthesis of human insulin and alkaline protease for use therein
EP0294851A3 (de) * 1987-06-12 1990-05-09 Berlin-Chemie Ag Verfahren zur Herstellung von Humaninsulin und seinen Derivaten
US5130236A (en) * 1989-12-07 1992-07-14 Eli Lilly And Company Process for producing des(64,65)-proinsulin
BR9813111A (pt) 1997-10-24 2000-08-15 Lilly Co Eli Composições de insulina insolúveis
CO4970787A1 (es) * 1997-12-23 2000-11-07 Lilly Co Eli Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea
US6323311B1 (en) 1999-09-22 2001-11-27 University Of Utah Research Foundation Synthesis of insulin derivatives
US7396903B2 (en) * 2001-11-19 2008-07-08 Novo Nordisk A/S Process for preparing insulin compounds
CA2464616C (en) 2001-11-19 2012-07-24 Are Bogsnes Process for preparing insulin compounds
US8173840B2 (en) * 2003-07-29 2012-05-08 Signature R&D Holdings, Llc Compounds with high therapeutic index
US7589233B2 (en) * 2003-07-29 2009-09-15 Signature R&D Holdings, Llc L-Threonine derivatives of high therapeutic index
CN105849273B (zh) * 2013-12-23 2020-01-14 拜康研究有限公司 人胰岛素甲酯的生产方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3276961A (en) * 1963-04-08 1966-10-04 Squibb & Sons Inc Process for preparing human insulin
US3903068A (en) * 1972-12-26 1975-09-02 Us Health Education & Welfare Facile synthesis of human insulin by modification of porcine insulin
AU545416B2 (en) * 1979-04-06 1985-07-11 Carlsberg Biotechnology Ltd. A/S A process for enzymatic production of peptides
JPS55138393A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd Semisynthesis of insulin
EP0017938B1 (en) * 1979-04-13 1983-08-03 Shionogi & Co., Ltd. Process for preparing a b30-threonine insulin
JPS55138392A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd Semisynthesis of insulin
JPS55138391A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd New synthetic method of peptide derivative
IE50892B1 (en) * 1980-02-11 1986-08-06 Novo Industri As Process for preparing insulin esters
DK147437A (en) * 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
DK319780A (da) * 1980-07-24 1982-01-25 Forenede Bryggerier As Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
DE3101382A1 (de) * 1981-01-17 1982-09-02 Hoechst Ag, 6000 Frankfurt "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"

Also Published As

Publication number Publication date
DK213983A (da) 1983-05-13
NO156052C (no) 1987-07-15
DK213983D0 (da) 1983-05-13
NO831730L (no) 1983-05-13
AU8953982A (en) 1983-04-08
FI831157A0 (fi) 1983-04-06
FI831157L (fi) 1983-04-06
JPH0526469B2 (it) 1993-04-16
JPS58501455A (ja) 1983-09-01
FI78119C (fi) 1989-06-12
EP0088117B1 (en) 1986-09-24
US4601979A (en) 1986-07-22
CA1174623A (en) 1984-09-18
EP0088117A1 (en) 1983-09-14
AU551174B2 (en) 1986-04-17
DK149457B (da) 1986-06-16
IT8249114A0 (it) 1982-09-14
FI78119B (fi) 1989-02-28
ES515713A0 (es) 1983-11-01
ES8400772A1 (es) 1983-11-01
IT8249114A1 (it) 1984-03-14
DK149457C (da) 1991-11-25
WO1983001074A1 (en) 1983-03-31
NO156052B (no) 1987-04-06

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19960925