IN2014DN02837A - - Google Patents
Info
- Publication number
- IN2014DN02837A IN2014DN02837A IN2837DEN2014A IN2014DN02837A IN 2014DN02837 A IN2014DN02837 A IN 2014DN02837A IN 2837DEN2014 A IN2837DEN2014 A IN 2837DEN2014A IN 2014DN02837 A IN2014DN02837 A IN 2014DN02837A
- Authority
- IN
- India
- Prior art keywords
- polysaccharide
- pap
- paps
- ost
- enzyme
- Prior art date
Links
- 150000004676 glycans Chemical class 0.000 abstract 5
- 229920001282 polysaccharide Polymers 0.000 abstract 5
- 239000005017 polysaccharide Substances 0.000 abstract 5
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000011541 reaction mixture Substances 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- GACDQMDRPRGCTN-KQYNXXCUSA-N 3'-phospho-5'-adenylyl sulfate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OS(O)(=O)=O)[C@@H](OP(O)(O)=O)[C@H]1O GACDQMDRPRGCTN-KQYNXXCUSA-N 0.000 abstract 1
- AEOBEOJCBAYXBA-UHFFFAOYSA-N A2P5P Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(O)=O)C(O)C1OP(O)(O)=O AEOBEOJCBAYXBA-UHFFFAOYSA-N 0.000 abstract 1
- WHTCPDAXWFLDIH-KQYNXXCUSA-N adenosine 3',5'-bismonophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H]1O WHTCPDAXWFLDIH-KQYNXXCUSA-N 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001180 sulfating effect Effects 0.000 abstract 1
- 230000019635 sulfation Effects 0.000 abstract 1
- 238000005670 sulfation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/64—Preparation of S-glycosides, e.g. lincomycin
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
A method of sulfating a polysaccharide is provided. The method can include providing a reaction mixture comprising at least one 0-sulfotransferase (OST) enzyme and 3'- phosphoadenosine 5'-phosphosulfate (PAPS); incubating a polysaccharide substrate with the reaction mixture, wherein production of the sulfated polysaccharide from the polysaccharide substrate is catalyzed by the OST enzyme with a conversion of the PAPS to adenosine 3',5'-diphosphate (PAP); and providing a reaction condition which modifies PAP to reduce an inhibitory effect of PAP on the polysaccharide sulfation.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68039205P | 2005-05-12 | 2005-05-12 | |
| PCT/US2006/018778 WO2006124801A2 (en) | 2005-05-12 | 2006-05-12 | Enzymatic synthesis of sulfated polysaccharides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN02837A true IN2014DN02837A (en) | 2015-07-10 |
Family
ID=37431995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2837DEN2014 IN2014DN02837A (en) | 2005-05-12 | 2006-05-12 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20090197308A1 (en) |
| EP (1) | EP1885865A4 (en) |
| IN (1) | IN2014DN02837A (en) |
| WO (1) | WO2006124801A2 (en) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009014715A2 (en) * | 2007-07-23 | 2009-01-29 | The University Of North Carolina At Chapel Hill | Enzymatic synthesis of sulfated polysaccharides without iduronic acid residues |
| CN101591401A (en) * | 2009-02-27 | 2009-12-02 | 江南大学 | A method for preparing high activity low molecular weight heparin |
| JP2013521300A (en) * | 2010-03-03 | 2013-06-10 | ネオキュティス エスアー | Compositions and methods for the treatment of skin diseases and disorders using antimicrobial peptide sequestering compounds |
| WO2012088416A2 (en) | 2010-12-23 | 2012-06-28 | The University Of North Carolina At Chapel Hill | Chemoenzymatic synthesis of structurally homogeneous ultra-low molecular weight heparins |
| WO2013149161A1 (en) * | 2012-03-30 | 2013-10-03 | Deangelis Paul L | High molecular weight heparosan polymers and methods of production and use thereof |
| CA3012383C (en) | 2013-02-28 | 2021-03-02 | Teewinot Technologies Limited | Biosynthesis of cannabinoids |
| ES2924830T3 (en) | 2013-06-17 | 2022-10-11 | Univ North Carolina Chapel Hill | reversible heparin molecules |
| JP6622793B2 (en) | 2014-08-25 | 2019-12-18 | ティーウィノット テクノロジーズ リミテッド | Apparatus and method for simultaneously producing cannabinoid compounds |
| CN105483187A (en) * | 2015-12-09 | 2016-04-13 | 中国药科大学 | Anti-tumor effect of sulfated polysaccharide |
| HRP20230820T1 (en) | 2015-12-28 | 2023-11-10 | Ajinomoto Co., Inc. | Heparan sulfate having high 3-o-sulfation rate of glucosamine residues |
| TWI769176B (en) * | 2016-09-07 | 2022-07-01 | 瑞瑟勒綜合技術協會 | Biosynthetic heparin |
| CN106755205A (en) * | 2016-11-14 | 2017-05-31 | 江南大学 | A kind of method that enzyme process prepares chondroitin sulfate |
| EP3572522A4 (en) | 2017-01-19 | 2020-10-28 | Ajinomoto Co., Inc. | PROCESS FOR PRODUCING A HEPAROSAN COMPOUND WITH ISOMERIZED HEXULONIC ACID |
| JP7330893B2 (en) * | 2017-03-10 | 2023-08-22 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | Short-acting heparin-based antiaggregant compounds and methods |
| US11993627B2 (en) | 2017-07-03 | 2024-05-28 | The University Of North Carolina At Chapel Hill | Enzymatic synthesis of homogeneous chondroitin sulfate oligosaccharides |
| JP7200948B2 (en) | 2017-09-05 | 2023-01-10 | 味の素株式会社 | 2-O-Sulfase Mutants and 3-O-Sulfase Mutants and Methods of Using Them |
| WO2019090203A1 (en) | 2017-11-03 | 2019-05-09 | The University Of North Carolina At Chapel Hill | Sulfated oligosaccharides having anti-inflammatory activity |
| WO2019246264A1 (en) | 2018-06-20 | 2019-12-26 | The University Of North Carolina At Chapel Hill | Cell protective methods and compositions |
| TWI851587B (en) * | 2018-07-11 | 2024-08-11 | 日商味之素股份有限公司 | Method for enzymatic sulfurylation of alcohols and amines using bacterium of the family enterobacteriaceae |
| WO2022015794A1 (en) | 2020-07-14 | 2022-01-20 | Optimvia, Llc | Methods for synthesizing non-anticoagulant heparan sulfate |
| AU2020209822A1 (en) * | 2019-01-15 | 2021-09-09 | Optimvia, Llc | Engineered aryl sulfate-dependent enzymes |
| CA3130763A1 (en) | 2019-02-25 | 2020-09-03 | Ginkgo Bioworks, Inc. | Biosynthesis of cannabinoids and cannabinoid precursors |
| BR112022000255A8 (en) | 2019-07-09 | 2022-03-22 | Optimvia Llc | Methods for synthesizing anticoagulant polysaccharides |
| JP7420377B2 (en) | 2020-01-31 | 2024-01-23 | 真一 原 | How to create a tennis technique improvement support database and a tennis technique improvement support system |
| JP6684976B1 (en) | 2020-01-31 | 2020-04-22 | 三井Ｅ＆Ｓ環境エンジニアリング株式会社 | Contaminant image analysis system used for pretreatment facility of organic waste treatment and operation system of pretreatment facility using contaminant image analysis system |
| WO2021199445A1 (en) * | 2020-04-03 | 2021-10-07 | Rensselaer Polytechnic Institute | Method for producing sulfated polysaccharide and method for producing paps |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3818676B2 (en) * | 1994-07-22 | 2006-09-06 | 生化学工業株式会社 | Heparan sulfate 6-O-sulfotransferase |
| JP3672359B2 (en) * | 1995-07-24 | 2005-07-20 | 生化学工業株式会社 | Heparan sulfate 2-O-sulfotransferase |
| US5935824A (en) * | 1996-01-31 | 1999-08-10 | Technologene, Inc. | Protein expression system |
| US6861254B1 (en) * | 1997-10-24 | 2005-03-01 | Massachusetts Institute Of Technology | Heparan sulfate D-glucosaminyl 3-O-sulfotransferases, and uses therefor |
| US6255088B1 (en) * | 1999-05-11 | 2001-07-03 | The Scripps Research Institute | Enzymatic sulfation of biomolecules |
| CA2441984A1 (en) * | 2001-03-28 | 2002-10-10 | Massachusetts Institute Of Technology | Methods of 6-o-sulfating polysaccharides and 6-o-sulfated polysaccharide preparations |
| WO2004005475A2 (en) * | 2002-07-05 | 2004-01-15 | University Of North Carolina At Chapel Hill | Purified and isolated heparan sulfate 3-o-sulfotransferase isoform 5 nucleic acids and polypeptides and therapeutic and screening methods using same |
| AU2003262794A1 (en) * | 2002-08-23 | 2004-03-11 | Neose Technologies, Inc. | Total synthesis of heparin |
| US7655445B2 (en) * | 2003-11-12 | 2010-02-02 | Massachusetts Institute Of Technology | Methods for synthesis of sulfated saccharides |
| US7619637B2 (en) * | 2004-04-09 | 2009-11-17 | Samsung Electronics Co., Ltd. | Systems and methods for improved gamut mapping from one image data set to another |
-
2006
- 2006-05-12 US US11/920,319 patent/US20090197308A1/en not_active Abandoned
- 2006-05-12 WO PCT/US2006/018778 patent/WO2006124801A2/en not_active Ceased
- 2006-05-12 IN IN2837DEN2014 patent/IN2014DN02837A/en unknown
- 2006-05-12 EP EP06770377A patent/EP1885865A4/en not_active Withdrawn
-
2012
- 2012-03-12 US US13/417,641 patent/US8771995B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20090197308A1 (en) | 2009-08-06 |
| WO2006124801A2 (en) | 2006-11-23 |
| EP1885865A2 (en) | 2008-02-13 |
| US8771995B2 (en) | 2014-07-08 |
| WO2006124801A3 (en) | 2007-04-12 |
| EP1885865A4 (en) | 2010-12-22 |
| US20120322114A1 (en) | 2012-12-20 |
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