AU2003262794A1 - Total synthesis of heparin - Google Patents
Total synthesis of heparinInfo
- Publication number
- AU2003262794A1 AU2003262794A1 AU2003262794A AU2003262794A AU2003262794A1 AU 2003262794 A1 AU2003262794 A1 AU 2003262794A1 AU 2003262794 A AU2003262794 A AU 2003262794A AU 2003262794 A AU2003262794 A AU 2003262794A AU 2003262794 A1 AU2003262794 A1 AU 2003262794A1
- Authority
- AU
- Australia
- Prior art keywords
- heparin
- total synthesis
- synthesis
- total
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title 1
- 229960002897 heparin Drugs 0.000 title 1
- 229920000669 heparin Polymers 0.000 title 1
- 238000006257 total synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40563402P | 2002-08-23 | 2002-08-23 | |
| US60/405,634 | 2002-08-23 | ||
| PCT/US2003/026349 WO2004017910A2 (en) | 2002-08-23 | 2003-08-22 | Total synthesis of heparin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2003262794A8 AU2003262794A8 (en) | 2004-03-11 |
| AU2003262794A1 true AU2003262794A1 (en) | 2004-03-11 |
Family
ID=31946908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003262794A Abandoned AU2003262794A1 (en) | 2002-08-23 | 2003-08-22 | Total synthesis of heparin |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU2003262794A1 (en) |
| WO (1) | WO2004017910A2 (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040171819A1 (en) | 2002-10-10 | 2004-09-02 | Aventis Pharma S.A. | Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them |
| US20090197308A1 (en) * | 2005-05-12 | 2009-08-06 | Jian Liu | Enzymatic synthesis of sulfated polysaccharides |
| WO2007058592A1 (en) * | 2005-11-21 | 2007-05-24 | Ge Healthcare Bio-Sciences Ab | A method of chromatography using semi-synthetic heparin ligands |
| US7745584B2 (en) * | 2006-05-22 | 2010-06-29 | California Institute Of Technology | Antibodies to sulfated carbohydrates |
| US8912149B1 (en) | 2007-11-28 | 2014-12-16 | California Institute Of Technology | Glycosaminoglycan mimetics |
| US11203772B2 (en) | 2010-12-23 | 2021-12-21 | The University Of North Carolina At Chapel Hill | Chemoenzymatic synthesis of structurally homogeneous ultra-low molecular weight heparins |
| EP3011043B1 (en) * | 2013-06-17 | 2022-05-11 | The University of North Carolina At Chapel Hill | Reversible heparin molecules |
| US10227370B2 (en) | 2013-08-02 | 2019-03-12 | California Institute Of Technology | Heparan sulfate/heparin mimetics with anti-chemokine and anti-inflammatory activity |
| US9770461B2 (en) | 2013-08-02 | 2017-09-26 | California Institute Of Technology | Tailored glycopolymers as anticoagulant heparin mimetics |
| WO2018135027A1 (en) * | 2017-01-19 | 2018-07-26 | 味の素株式会社 | Method for producing heparosan compound having isomerized hexulonic acid residue |
| CN110446511B (en) | 2017-03-10 | 2024-04-02 | 北卡罗来纳大学查珀尔希尔分校 | Short-acting heparin-based anticoagulant compounds and methods |
| US11993627B2 (en) | 2017-07-03 | 2024-05-28 | The University Of North Carolina At Chapel Hill | Enzymatic synthesis of homogeneous chondroitin sulfate oligosaccharides |
| EP3691653B1 (en) | 2017-11-03 | 2025-03-12 | The University Of North Carolina At Chapel Hill | Sulfated oligosaccharides having anti-inflammatory activity |
| EP3810152A4 (en) | 2018-06-20 | 2022-04-27 | The University of North Carolina at Chapel Hill | CELLULAR PROTECTION METHODS AND COMPOSITIONS |
| ES2962132T3 (en) * | 2018-07-11 | 2024-03-15 | Ajinomoto Kk | Method for the enzymatic sulfurylation of alcohols and amines that uses a bacterium of the Enterobacteriaceae family |
| CA3144968A1 (en) * | 2019-07-09 | 2021-01-14 | Optimvia Llc | Methods for synthesizing anticoagulant polysaccharides |
| CN114763518B (en) * | 2021-09-10 | 2023-04-28 | 江南大学 | Construction and application of yeast engineering bacteria for fermentative production of heparin |
| CN117384812B (en) * | 2023-10-12 | 2025-06-10 | 江南大学 | A recombinant Escherichia coli for producing heparin precursor and its construction and application |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6030807A (en) * | 1996-09-10 | 2000-02-29 | The Rockefeller University | Highly regulable promoter for heterologous gene expression |
-
2003
- 2003-08-22 WO PCT/US2003/026349 patent/WO2004017910A2/en not_active Ceased
- 2003-08-22 AU AU2003262794A patent/AU2003262794A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004017910A3 (en) | 2004-09-30 |
| AU2003262794A8 (en) | 2004-03-11 |
| WO2004017910A2 (en) | 2004-03-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |