IL87608A0 - Recombinant dna-derived bordetella toxin subunit analogs - Google Patents

Recombinant dna-derived bordetella toxin subunit analogs

Info

Publication number: IL87608A0
Authority: IL; Israel
Prior art keywords: recombinant dna; derived; subunit analogs; toxin subunit; bordetella
Prior art date: 1987-09-04

Application number

IL87608A

Other languages

English (en)

Original Assignee

Amgen Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-04

Filing date

1988-08-30

Publication date

1989-01-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26788722&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL87608(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1988-08-30 Application filed by Amgen Inc filed Critical Amgen Inc

1988-08-30 Priority to IL10312188A priority Critical patent/IL103121A/en

1989-01-31 Publication of IL87608A0 publication Critical patent/IL87608A0/xx

1992-09-09 Priority to IL103121A priority patent/IL103121A0/xx

Links

241000588807 Bordetella Species 0.000 title abstract 2
108020004511 Recombinant DNA Proteins 0.000 title abstract 2
239000003053 toxin Substances 0.000 title abstract 2
231100000765 toxin Toxicity 0.000 title abstract 2
OTLLEIBWKHEHGU-UHFFFAOYSA-N 2-[5-[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-4-phosphonooxyhexanedioic acid Chemical compound C1=NC=2C(N)=NC=NC=2N1C(C(C1O)O)OC1COC1C(CO)OC(OC(C(O)C(OP(O)(O)=O)C(O)C(O)=O)C(O)=O)C(O)C1O OTLLEIBWKHEHGU-UHFFFAOYSA-N 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
231100000776 exotoxin Toxicity 0.000 abstract 1
239000002095 exotoxin Substances 0.000 abstract 1
230000002163 immunogen Effects 0.000 abstract 1
230000005847 immunogenicity Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000012986 modification Methods 0.000 abstract 1
230000004048 modification Effects 0.000 abstract 1
229960005486 vaccine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K2039/10—Brucella; Bordetella, e.g. Bordetella pertussis; Not used, see subgroups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Virology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)

IL87608A 1987-09-04 1988-08-30 Recombinant dna-derived bordetella toxin subunit analogs IL87608A0 (en)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
IL10312188A IL103121A (en)	1987-09-04	1988-08-30	Recombinant dna-derived bordetella toxin subunit analogs
IL103121A IL103121A0 (en)	1987-09-04	1992-09-09	Recombinant dna-derived bordetella toxin subunit analogs

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US9430787A	1987-09-04	1987-09-04
US23248288A	1988-08-17	1988-08-17

Publications (1)

Publication Number	Publication Date
IL87608A0 true IL87608A0 (en)	1989-01-31

Family

ID=26788722

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
IL87608A IL87608A0 (en)	1987-09-04	1988-08-30	Recombinant dna-derived bordetella toxin subunit analogs
IL10312188A IL103121A (en)	1987-09-04	1988-08-30	Recombinant dna-derived bordetella toxin subunit analogs
IL103121A IL103121A0 (en)	1987-09-04	1992-09-09	Recombinant dna-derived bordetella toxin subunit analogs

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
IL10312188A IL103121A (en)	1987-09-04	1988-08-30	Recombinant dna-derived bordetella toxin subunit analogs
IL103121A IL103121A0 (en)	1987-09-04	1992-09-09	Recombinant dna-derived bordetella toxin subunit analogs

Country Status (16)

Country	Link
US (1)	US5773600A (xx)
EP (2)	EP0629696A1 (xx)
JP (1)	JP2918895B2 (xx)
KR (1)	KR0168039B1 (xx)
CN (1)	CN1033866C (xx)
AT (1)	ATE125568T1 (xx)
CA (1)	CA1341560C (xx)
DE (1)	DE3854213T3 (xx)
DK (1)	DK175821B1 (xx)
ES (1)	ES2076160T5 (xx)
FI (1)	FI101632B1 (xx)
GR (1)	GR3017497T3 (xx)
IE (1)	IE69753B1 (xx)
IL (3)	IL87608A0 (xx)
NO (2)	NO301844B1 (xx)
WO (1)	WO1989001976A1 (xx)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5925546A (en) *	1987-11-02	1999-07-20	Chiron S.P.A.	Immunologically active polypeptides with altered toxicity useful for the preparation of an antipertussis vaccine
US6713072B1 (en) *	1987-11-02	2004-03-30	Chiron S.R.L.	Immunologically active polypeptides with altered toxicity useful for the preparation of an antipertussis vaccine
IT1223334B (it) *	1987-11-02	1990-09-19	Sclavo Spa	Polipeptidi immunologicamente attivi con una tossicita' alterata utili per la preparazione di un vaccino antipertosse
US5332583A (en) *	1987-11-24	1994-07-26	Connaught Laboratories Limited	Vaccine containing genetically-detoxified pertussis holotoxin
GB8727489D0 (en) *	1987-11-24	1987-12-23	Connaught Lab	Detoxification of pertussis toxin
US5358868A (en) *	1987-11-24	1994-10-25	Connaught Laboratories Limited	Genetic detoxification of pertussis toxin
CA2009991A1 (en) *	1989-02-15	1990-08-15	Witold Cieplak	Pertussis toxin gene: cloning and expression of protective antigen
US7232671B2 (en) *	1989-02-15	2007-06-19	The United States Of America As Represented By The Secretary, Department Of Health And Human Services	Pertussis toxin gene: cloning and expression of protective antigen
EP0396964B1 (en) *	1989-04-28	1995-09-06	SCLAVO S.p.A.	Pertussis toxin mutants, bordetella strains capable of producing such mutants and their use in the development of antipertussis vaccines
US5786189A (en) *	1989-11-29	1998-07-28	Smithkline Beecham Biologicals (S.A.)	Vaccine
GB9326174D0 (en) *	1993-12-22	1994-02-23	Biocine Sclavo	Mucosal adjuvant
US20030072774A1 (en) *	1994-06-10	2003-04-17	Diane M. Gajewczyk	Proteinaceous adjuvants
ES2180758T3 (es) *	1995-05-04	2003-02-16	Aventis Pasteur	Vacunas de pertussis acelulares y metodos de preparacion de las mismas.
EP0912726A4 (en) *	1996-05-10	2001-07-18	Phylomed Corp	METHODS FOR OXIDIZING BISULFIDE LINKS WITH OZONE
FR2754543B1 (fr) *	1996-10-11	1998-12-31	Pasteur Institut	Souche de bordetella deficiente dans la production de toxine et exprimant une proteine hydride, liposomes comprenant de la fha et leurs utilisations comme vaccins, et utilisation de la fha pour stimuler les reponses immunitaires
US6818222B1 (en)	1997-03-21	2004-11-16	Chiron Corporation	Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
US9453251B2 (en)	2002-10-08	2016-09-27	Pfenex Inc.	Expression of mammalian proteins in Pseudomonas fluorescens
GB0313916D0 (en)	2003-06-16	2003-07-23	Glaxosmithkline Biolog Sa	Vaccine composition
JP2008507294A (ja)	2004-07-26	2008-03-13	ダウグローバルテクノロジーズインコーポレイティド	菌株遺伝子操作による改善されたタンパク質発現のための方法
CN101203605B (zh) *	2004-12-17	2016-01-27	由卫生福利和体育大臣代表的荷兰王国	革兰氏阴性菌的lps的脱酰基化
US9580719B2 (en)	2007-04-27	2017-02-28	Pfenex, Inc.	Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
EP2615172A1 (en)	2007-04-27	2013-07-17	Pfenex Inc.	Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
ITMI20090946A1 (it)	2009-05-28	2010-11-29	Novartis Ag	Espressione di proteine ricombinanti
BR112012024898A2 (pt)	2010-03-30	2015-10-06	Pfenex Inc	expressão de nível elevado de proteínas recombinantes de toxinas
US9169304B2 (en)	2012-05-01	2015-10-27	Pfenex Inc.	Process for purifying recombinant Plasmodium falciparum circumsporozoite protein
US20140037680A1 (en)	2012-08-06	2014-02-06	Glaxosmithkline Biologicals, S.A.	Novel method
JP2015525794A (ja)	2012-08-06	2015-09-07	グラクソスミスクラインバイオロジカルズソシエテアノニム	乳児においてｒｓｖ及び百日咳菌に対する免疫応答を惹起するための方法
PE20151720A1 (es)	2013-03-08	2015-12-10	Crucell Holland Bv	Vacuna acelular contra pertussis
CA2919773A1 (en)	2013-08-05	2015-02-12	Glaxosmithkline Biologicals S.A.	Combination immunogenic compositions
CN109172818B (zh) *	2018-08-02	2021-10-22	浙江康佰裕生物科技有限公司	一种蛋白牛痘疫苗及其效力检测方法
WO2020081548A1 (en) *	2018-10-15	2020-04-23	Arizona Board Of Regents On Behalf Of The University Of Arizona	Vaccine polypeptide compositions and methods

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4704362A (en) *	1977-11-08	1987-11-03	Genentech, Inc.	Recombinant cloning vehicle microbial polypeptide expression
FR2590483B1 (fr) *	1985-11-22	1988-12-09	Pasteur Institut	Antigenes purifies ayant des proprietes vaccinantes contre b. pertussis, moyens notamment adns recombinants pour les produire et compositions de vaccins les contenant
CA1340373C (en) *	1986-01-28	1999-02-02	Rino Rappuoli	Cloning and sequencing of the dna fragment which codes for the five subunits of the pertussis toxin, a hybrid plasmid containing the dna fragment and micro-organisms transformed by the hybrid plasmid and capable of expressing all or some of the subunits of the pertussis toxin
ES2044959T3 (es) *	1986-12-23	1994-01-16	Univ Leland Stanford Junior	Exotoxina de tos ferina modificada.
IT1223334B (it) *	1987-11-02	1990-09-19	Sclavo Spa	Polipeptidi immunologicamente attivi con una tossicita' alterata utili per la preparazione di un vaccino antipertosse
GB8727489D0 (en) *	1987-11-24	1987-12-23	Connaught Lab	Detoxification of pertussis toxin
IT1223529B (it) *	1987-12-18	1990-09-19	Sclavo Spa	Epitopo immunodominante protettivo contenuto nella subunita' s1 della tossina della pertosse

1988
- 1988-08-26 WO PCT/US1988/002983 patent/WO1989001976A1/en not_active Ceased
- 1988-08-26 KR KR1019890700803A patent/KR0168039B1/ko not_active Expired - Fee Related
- 1988-08-26 JP JP63507460A patent/JP2918895B2/ja not_active Expired - Lifetime
- 1988-08-30 IL IL87608A patent/IL87608A0/xx not_active IP Right Cessation
- 1988-08-30 IL IL10312188A patent/IL103121A/en not_active IP Right Cessation
- 1988-09-01 ES ES88308124T patent/ES2076160T5/es not_active Expired - Lifetime
- 1988-09-01 AT AT88308124T patent/ATE125568T1/de not_active IP Right Cessation
- 1988-09-01 EP EP94109317A patent/EP0629696A1/en not_active Withdrawn
- 1988-09-01 EP EP88308124A patent/EP0306318B2/en not_active Expired - Lifetime
- 1988-09-01 DE DE3854213T patent/DE3854213T3/de not_active Expired - Lifetime
- 1988-09-02 CA CA 576469 patent/CA1341560C/en not_active Expired - Fee Related
- 1988-09-02 IE IE266888A patent/IE69753B1/en not_active IP Right Cessation
- 1988-09-05 CN CN88107056A patent/CN1033866C/zh not_active Expired - Lifetime
1989
- 1989-05-03 NO NO891842A patent/NO301844B1/no not_active IP Right Cessation
- 1989-05-03 FI FI892131A patent/FI101632B1/fi not_active IP Right Cessation
- 1989-05-03 DK DK198902162A patent/DK175821B1/da active
1992
- 1992-09-09 IL IL103121A patent/IL103121A0/xx unknown
1995
- 1995-06-06 US US08/468,679 patent/US5773600A/en not_active Expired - Lifetime
- 1995-09-21 GR GR950402614T patent/GR3017497T3/el unknown
1997
- 1997-06-09 NO NO19972642A patent/NO325016B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE3854213T2 (de)	1995-12-07
DE3854213D1 (de)	1995-08-31
ES2076160T3 (es)	1995-11-01
ES2076160T5 (es)	2004-12-01
IE882668L (en)	1989-03-04
DK216289D0 (da)	1989-05-03
DK216289A (da)	1989-06-30
AU623867B2 (en)	1992-05-28
ATE125568T1 (de)	1995-08-15
EP0306318A1 (en)	1989-03-08
NO301844B1 (no)	1997-12-15
FI101632B (fi)	1998-07-31
IL103121A (en)	1995-08-31
GR3017497T3 (en)	1995-12-31
US5773600A (en)	1998-06-30
KR0168039B1 (ko)	1999-01-15
EP0629696A1 (en)	1994-12-21
JP2918895B2 (ja)	1999-07-12
EP0306318B1 (en)	1995-07-26
DK175821B1 (da)	2005-03-14
NO325016B1 (no)	2008-01-14
FI892131A0 (fi)	1989-05-03
NO891842L (no)	1989-06-21
WO1989001976A1 (en)	1989-03-09
EP0306318B2 (en)	2004-04-28
CN1033072A (zh)	1989-05-24
IL103121A0 (en)	1993-02-21
NO891842D0 (no)	1989-05-03
AU2386488A (en)	1989-03-31
KR890701758A (ko)	1989-12-21
NO972642D0 (no)	1997-06-09
FI892131L (fi)	1989-05-03
DE3854213T3 (de)	2004-10-21
NO972642L (no)	1997-07-28
CN1033866C (zh)	1997-01-22
FI101632B1 (fi)	1998-07-31
JPH04501051A (ja)	1992-02-27
IE69753B1 (en)	1996-10-02
CA1341560C (en)	2007-10-30

Publication	Publication Date	Title
IL87608A0 (en)	1989-01-31	Recombinant dna-derived bordetella toxin subunit analogs
ES2156110T3 (es)	2001-06-16	Analogos de sub-unidades de toxina del colera derivados de adn recombinante.
ATE181572T1 (de)	1999-07-15	Ospa proteine von borrelia burgdorferi untergruppen, dafür kodierende gene sowie impfstoffe
IL107474A0 (en)	1994-02-27	Urease-based vaccine against helicobacter infection
NO164177C (no)	1990-09-12	Rekombinant dna-fremgangsmaate for fremstilling av et polypeptid med funksjon av human immun (gamma)-interferon.
AU2785089A (en)	1989-07-19	Chimeric glycoproteins containing immunogenic segments of the glycoproteins of human respiratory syncytial virus
HUP9901254A2 (hu)	1999-07-28	Nemdendrites szerkezetű gerincet alkotó peptid hordozó
LU91595I2 (fr)	2009-10-12	Combinaison d'anatoxine diphtérique, d'anatoxine tétanique, d'anatoxine coquelucheuse, d'hémagglutinine filamenteuse, de pertactine et de polyoside capsulaire d'haemophilus influenzae type b (InfanrixHib)
KR970009347B1 (en)	1997-06-10	Chimeric glycoproteins containing immunogenic segments of human parainfluenza virus type 3
HUP9801266A2 (hu)	1998-08-28	Multimer, rekombináns ureázvakcina
DE69228944D1 (de)	1999-05-20	Bovines herpesvirus typ 1rekombinantenpolypeptide und vakzine
DK0425082T3 (da)	1995-07-03	Vacciner
ATE157258T1 (de)	1997-09-15	Zubereitungen und behandlungen von pneumonia in tieren
ZA965586B (en)	1997-01-31	Coccidiosis poultry vaccine
ATE182270T1 (de)	1999-08-15	Mukosale verabreichung von pneumokokken-antigenen
EP0498804A4 (en)	1992-12-09	A method of vaccine or toxoid preparation and immunization by colonization with recombinant microorganisms
ZA919907B (en)	1992-08-26	Use of il-4 to enhance immune response to immunogens in vaccines
EP0636030A4 (en)	1996-02-07	VACCINE AGAINST THE -I BACTERIAL OXIDE (PASTEURELLIA HAEMOLYTICA).
NZ224251A (en)	1991-09-25	Synthetic rhinovirus (hrv) peptides and vaccines
BURNETTE et al.	1989	Pertussis Toxin SI Mutant with Reduced Enzyme Activity and a Conserved Protective Epitope
DK230890A (da)	1990-09-24	Dna-fragment, der koder for et pasteurella multocida-toxin eller for en subsekvens eller analog deraf, ekspressionsvektor, der omfatter dna-fragmentet, mikroorganisme, der udtrykker dette, fremgangsmaade til fremstilling af et pasteurella-multocida-toxin, diagnostisk middel samt anvendelse heraf, vaccine indeholdende et pasteurella-multocida-toxinderivat, anvendelse af pasteurella multocida-t m.m.

Legal Events

Date	Code	Title
1998-12-27	KB	Patent renewed
2001-06-14	RH	Patent void
2002-11-10	KB	Patent renewed
2006-10-04	KB	Patent renewed
2009-02-11	EXP	Patent expired
2010-04-14	EXP	Patent expired