IL83681A0 - Dihydropyridines,their preparation and pharmaceutical compositions containing them - Google Patents
Dihydropyridines,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL83681A0 IL83681A0 IL83681A IL8368187A IL83681A0 IL 83681 A0 IL83681 A0 IL 83681A0 IL 83681 A IL83681 A IL 83681A IL 8368187 A IL8368187 A IL 8368187A IL 83681 A0 IL83681 A0 IL 83681A0
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- aryl
- substituted
- heteroaryl
- cycloalkyl
- Prior art date
Links
- 125000004925 dihydropyridyl group Chemical group N1(CC=CC=C1)* 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- -1 piperidino, morpholino, piperazinyl Chemical group 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Dental Preparations (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868620880A GB8620880D0 (en) | 1986-08-29 | 1986-08-29 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL83681A0 true IL83681A0 (en) | 1988-01-31 |
Family
ID=10603368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL83681A IL83681A0 (en) | 1986-08-29 | 1987-08-28 | Dihydropyridines,their preparation and pharmaceutical compositions containing them |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4788205A (pt) |
| EP (1) | EP0258033B1 (pt) |
| JP (1) | JPS6363661A (pt) |
| KR (1) | KR880002829A (pt) |
| CN (1) | CN87106032A (pt) |
| AT (1) | ATE92486T1 (pt) |
| AU (1) | AU7767887A (pt) |
| DD (1) | DD262023A5 (pt) |
| DK (1) | DK450687A (pt) |
| FI (1) | FI873725A7 (pt) |
| GB (1) | GB8620880D0 (pt) |
| HU (1) | HUT45047A (pt) |
| IE (1) | IE872317L (pt) |
| IL (1) | IL83681A0 (pt) |
| NO (1) | NO873650L (pt) |
| PL (1) | PL267485A1 (pt) |
| PT (1) | PT85607B (pt) |
| ZA (1) | ZA876437B (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8712747D0 (en) * | 1987-05-30 | 1987-07-01 | Pfizer Ltd | Therapeutic agents |
| GB8716971D0 (en) * | 1987-07-17 | 1987-08-26 | Pfizer Ltd | Therapeutic agents |
| MY104933A (en) * | 1987-09-30 | 1994-07-30 | Pfizer Ltd | Platelet activating factor antagonists |
| US5070205A (en) * | 1987-09-30 | 1991-12-03 | Pfizer Inc. | Alkyl 2-benzylidene-4-(benzimidazol-1-yl) benzoylacetate esters as intermediates |
| GB8803963D0 (en) * | 1988-02-19 | 1988-03-23 | Pfizer Ltd | Therapeutic agents |
| GB8804439D0 (en) * | 1988-02-25 | 1988-03-23 | Pfizer Ltd | Dihydropyridines |
| US5030856A (en) * | 1989-05-04 | 1991-07-09 | International Business Machines Corporation | Receiver and level converter circuit with dual feedback |
| NO912475L (no) * | 1990-06-27 | 1991-12-30 | Sankyo Co | Tiazolidinkarboksylsyreamidderivater med antiallergisk aktivitet, og fremgangsmaate til fremstilling derav. |
| US5470851A (en) * | 1990-06-27 | 1995-11-28 | Sankyo Company, Limited | Thiazolidinecarboxylic acid amide derivatives and their therapeutic uses |
| US5478848A (en) * | 1994-01-26 | 1995-12-26 | Bayer Corporation | Inhibition of arthritis by L-type calcium channel antagonists nimodipine, nisoldipine and nifedipine |
| US5496855A (en) * | 1995-01-27 | 1996-03-05 | Smithkline Beecham Corp. | Anti-inflammatory compounds |
| JP4202250B2 (ja) | 2001-07-25 | 2008-12-24 | バイオマリン ファーマシューティカル インコーポレイテッド | 血液脳関門輸送を調節するための組成物および方法 |
| US6566359B1 (en) | 2002-05-20 | 2003-05-20 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | 2,4,6-trimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid esters as neuroprotective drugs |
| EP3827747A1 (en) | 2005-04-28 | 2021-06-02 | Otsuka Pharmaceutical Co., Ltd. | Pharma-informatics system |
| CN101594878A (zh) | 2006-09-18 | 2009-12-02 | 雷普特药品公司 | 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗 |
| DK3395372T3 (da) | 2009-02-20 | 2022-04-19 | Enhanx Biopharm Inc | System til afgivelse af glutathion-baseret medikament |
| CN110075069A (zh) | 2009-05-06 | 2019-08-02 | 实验室护肤股份有限公司 | 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| DE102013021933A1 (de) | 2013-12-20 | 2015-06-25 | Skw Stickstoffwerke Piesteritz Gmbh | Verwendung von Pyrazol-Derivaten als Mittel zur Verbesserung der Trockenstresstoleranz |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2210674C3 (de) * | 1972-03-06 | 1981-09-24 | Bayer Ag, 5090 Leverkusen | 2-Amino-6-methyl-1,4-dihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel |
| DE2228377A1 (de) * | 1972-06-10 | 1974-01-03 | Bayer Ag | Dihydropyridin-carbonsaeureamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| EP0100189B1 (en) * | 1982-07-22 | 1986-05-28 | Pfizer Limited | Dihydropyridine anti-ischaemic and antihypertensive agents |
| EP0111453A1 (de) * | 1982-12-10 | 1984-06-20 | Ciba-Geigy Ag | Amid-Verbindungen |
| US4515799A (en) * | 1983-02-02 | 1985-05-07 | Pfizer Inc. | Dihydropyridine anti-ischaemic and antihypertensive agents |
| EP0174131A3 (en) * | 1984-09-01 | 1989-06-07 | FISONS plc | Dihydropyridines, processes and intermediates for their production, and pharmaceutical formulations containing them |
-
1986
- 1986-08-29 GB GB868620880A patent/GB8620880D0/en active Pending
-
1987
- 1987-07-20 US US07/075,379 patent/US4788205A/en not_active Expired - Fee Related
- 1987-08-25 EP EP87307494A patent/EP0258033B1/en not_active Expired - Lifetime
- 1987-08-25 AT AT87307494T patent/ATE92486T1/de active
- 1987-08-27 JP JP62214129A patent/JPS6363661A/ja active Pending
- 1987-08-27 PL PL1987267485A patent/PL267485A1/xx unknown
- 1987-08-27 CN CN198787106032A patent/CN87106032A/zh active Pending
- 1987-08-27 DD DD87306414A patent/DD262023A5/de unknown
- 1987-08-27 PT PT85607A patent/PT85607B/pt not_active IP Right Cessation
- 1987-08-27 FI FI873725A patent/FI873725A7/fi not_active Application Discontinuation
- 1987-08-28 ZA ZA876437A patent/ZA876437B/xx unknown
- 1987-08-28 KR KR870009443A patent/KR880002829A/ko not_active Ceased
- 1987-08-28 HU HU873795A patent/HUT45047A/hu unknown
- 1987-08-28 AU AU77678/87A patent/AU7767887A/en not_active Abandoned
- 1987-08-28 IL IL83681A patent/IL83681A0/xx unknown
- 1987-08-28 DK DK450687A patent/DK450687A/da not_active Application Discontinuation
- 1987-08-28 NO NO873650A patent/NO873650L/no unknown
- 1987-08-28 IE IE872317A patent/IE872317L/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE872317L (en) | 1988-02-29 |
| EP0258033A3 (en) | 1990-11-07 |
| AU7767887A (en) | 1988-03-10 |
| FI873725A0 (fi) | 1987-08-27 |
| EP0258033B1 (en) | 1993-08-04 |
| PT85607B (pt) | 1990-05-31 |
| ATE92486T1 (de) | 1993-08-15 |
| US4788205A (en) | 1988-11-29 |
| CN87106032A (zh) | 1988-03-23 |
| DK450687A (da) | 1988-03-01 |
| NO873650L (no) | 1988-03-01 |
| DD262023A5 (de) | 1988-11-16 |
| DK450687D0 (da) | 1987-08-28 |
| ZA876437B (en) | 1989-03-29 |
| PL267485A1 (en) | 1988-09-01 |
| EP0258033A2 (en) | 1988-03-02 |
| GB8620880D0 (en) | 1986-10-08 |
| KR880002829A (ko) | 1988-05-11 |
| PT85607A (en) | 1987-09-01 |
| FI873725A7 (fi) | 1988-03-01 |
| JPS6363661A (ja) | 1988-03-22 |
| NO873650D0 (no) | 1987-08-28 |
| HUT45047A (en) | 1988-05-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL83681A0 (en) | Dihydropyridines,their preparation and pharmaceutical compositions containing them | |
| IL88122A0 (en) | Heterocyclic derivatives and pharmaceutical compositions containing them | |
| EP0013612A3 (en) | (piperidinylalkyl)quinazoline derivatives and intermediates, process for their preparation and pharmaceutical compositions containing them | |
| IL86529A0 (en) | Dihydropyridines,their preparation and pharmaceutical compositions containing them | |
| GR3003118T3 (en) | Therapeutic agents | |
| ATE78252T1 (de) | Dihydropyridine und ihre verwendung als antiallergische und entzuendungshemmende mittel. | |
| AU3247800A (en) | New diazole derivatives as serotonergic agents | |
| IE870141L (en) | Dihydropyridine anti-ischaemic antihypertensive¹agents |