IL138670A - Trisubstituted 1,3,5-triazine derivatives for treatment of hiv infections - Google Patents

Trisubstituted 1,3,5-triazine derivatives for treatment of hiv infections

Info

Publication number: IL138670A
Authority: IL; Israel
Prior art keywords: trisubstituted; treatment; triazine derivatives; hiv infections; hiv
Prior art date: 1998-03-27

Application number

IL13867000A

Other languages

English (en)

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-27

Filing date

2000-09-25

Publication date

2005-12-18

2000-09-25 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2005-12-18 Publication of IL138670A publication Critical patent/IL138670A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/42—One nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C07D251/50—Two nitrogen atoms with a halogen atom attached to the third ring carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/54—Three nitrogen atoms
- C07D251/66—Derivatives of melamine in which a hetero atom is directly attached to a nitrogen atom of melamine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/54—Three nitrogen atoms
- C07D251/70—Other substituted melamines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Tropical Medicine & Parasitology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
AIDS & HIV (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IL13867000A 1998-03-27 2000-09-25 Trisubstituted 1,3,5-triazine derivatives for treatment of hiv infections IL138670A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US7963398P	1998-03-27	1998-03-27
EP98201589A EP0945447A1 (en)	1998-03-27	1998-05-14	Trisubstituted 1,3,5-triazine derivatives for treatment of HIV infections

Publications (1)

Publication Number	Publication Date
IL138670A true IL138670A (en)	2005-12-18

Family

ID=22151790

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL13867000A IL138670A (en)	1998-03-27	2000-09-25	Trisubstituted 1,3,5-triazine derivatives for treatment of hiv infections

Country Status (32)

Country	Link
US (3)	US6150360A (xx)
EP (2)	EP0945447A1 (xx)
JP (1)	JP2002511390A (xx)
KR (1)	KR100593396B1 (xx)
CN (1)	CN1157386C (xx)
AP (1)	AP1475A (xx)
AR (1)	AR018169A1 (xx)
AT (1)	ATE295355T1 (xx)
AU (1)	AU758624C (xx)
BG (1)	BG64903B1 (xx)
BR (1)	BR9909197A (xx)
CA (1)	CA2324921C (xx)
DE (1)	DE69925256T2 (xx)
DK (1)	DK1066269T3 (xx)
EA (1)	EA004540B1 (xx)
EE (1)	EE200000535A (xx)
ES (1)	ES2243056T3 (xx)
HR (1)	HRP20000621A2 (xx)
HU (1)	HUP0101372A3 (xx)
ID (1)	ID26043A (xx)
IL (1)	IL138670A (xx)
NO (1)	NO317425B1 (xx)
NZ (1)	NZ506787A (xx)
OA (1)	OA11493A (xx)
PL (1)	PL194660B1 (xx)
PT (1)	PT1066269E (xx)
SI (1)	SI1066269T1 (xx)
SK (1)	SK14052000A3 (xx)
TR (1)	TR200002761T2 (xx)
TW (1)	TW570917B (xx)
WO (1)	WO1999050256A1 (xx)
ZA (1)	ZA200006042B (xx)

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KR100820605B1 (ko) *	1999-09-24	2008-04-08	얀센 파마슈티카 엔.브이.	항바이러스 조성물
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JP5230050B2 (ja)	2000-05-08	2013-07-10	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｈｉｖ複製阻害剤
US7034019B2 (en)	2000-05-08	2006-04-25	Janssen Pharmaceutica N.V.	Prodrugs of HIV replication inhibiting pyrimidines
US6858608B2 (en) *	2001-01-09	2005-02-22	Aventis Pharma S.A.	Chemical derivatives and their application as antitelomerase agents
US6887873B2 (en) *	2001-03-23	2005-05-03	Aventis Pharma S.A.	Triazine derivatives and their application as antitelomerase agents
US6958211B2 (en)	2001-08-08	2005-10-25	Tibotech Bvba	Methods of assessing HIV integrase inhibitor therapy
JO3429B1 (ar) *	2001-08-13	2019-10-20	Janssen Pharmaceutica Nv	مشتقات برميدينات مثبطة فيروس الايدز
US7112587B2 (en)	2001-09-21	2006-09-26	Reddy Us Therapeutics, Inc.	Methods and compositions of novel triazine compounds
US7163943B2 (en) *	2001-09-21	2007-01-16	Reddy Us Therapeutics, Inc.	Methods and compositions of novel triazine compounds
US7132423B2 (en) *	2001-09-21	2006-11-07	Reddy Us Therapeutics, Inc.	Methods and compositions of novel triazine compounds
US7173032B2 (en) *	2001-09-21	2007-02-06	Reddy Us Therapeutics, Inc.	Methods and compositions of novel triazine compounds
CN1578773A (zh) *	2001-09-21	2005-02-09	雷迪美国治疗公司	新三嗪化合物的方法和组合物
US7169785B2 (en) *	2001-09-21	2007-01-30	Reddy Us Therapeutics, Inc.	Methods and compositions of novel triazine compounds
EP1441683A4 (en) *	2001-10-12	2005-10-26	Univ New York	TRISUBSTITUTED TRIAZIN COMPOUNDS AND METHOD FOR THE PREPARATION AND USE OF THE COMPOUNDS WITH ANTITUBULIN EFFECT
WO2003037346A1 (en)	2001-10-31	2003-05-08	Cell Therapeutics, Inc.	6-phenyl-n-phenyl-(1,3,5) -triazine-2,4-diamine derivatives and related compounds with lysophphosphatidic acid acyltransferase beta (lpaat-beta) inhibitory activity for use in the treatment of cancer
AU2003244463A1 (en)	2002-02-05	2003-09-02	Yamanouchi Pharmaceutical Co., Ltd.	2,4,6-triamino-1,3,5-triazine derivative
AR039540A1 (es)	2002-05-13	2005-02-23	Tibotec Pharm Ltd	Compuestos microbicidas con contenido de pirimidina o triazina
US7419984B2 (en) *	2002-10-17	2008-09-02	Cell Therapeutics, Inc.	Pyrimidines and uses thereof
DE602004015254D1 (de) *	2003-02-07	2008-09-04	Janssen Pharmaceutica Nv	Hiv-inhibierende1,2,4-triazine
US20070232572A1 (en) *	2003-02-07	2007-10-04	Aventis Pharma S.A.	Chemical derivatives as antitelomerase agents which bind specifically to the G-quadruplex DNA structures and their application as a specific anticancer agent
CL2004000303A1 (es) *	2003-02-20	2005-04-08	Tibotec Pharm Ltd	Compuestos derivados de pirimidinas y triazinas; proceso de preparacion; composicion farmaceutica; y su uso para inhibir la replicacion del vih.
US6875781B2 (en) *	2003-04-04	2005-04-05	Cell Therapeutics, Inc.	Pyridines and uses thereof
WO2005011702A1 (en)	2003-07-17	2005-02-10	Tibotec Pharmaceuticals Ltd.	Process for preparing particles containing an antiviral
WO2005009980A1 (en) *	2003-07-22	2005-02-03	Neurogen Corporation	Substituted pyridin-2-ylamine analogues
US7335770B2 (en) *	2004-03-24	2008-02-26	Reddy U5 Therapeutics, Inc.	Triazine compounds and their analogs, compositions, and methods
EP1797050B1 (en) *	2004-08-10	2013-10-23	Janssen Pharmaceutica NV	Hiv inhibiting 1.2.4-triazin-6-one derivates
WO2006035067A2 (en)	2004-09-30	2006-04-06	Tibotec Pharmaceuticals Ltd.	Hiv inhibiting 5-heterocyclyl pyrimidines
AU2005288865B2 (en)	2004-09-30	2012-07-19	Janssen Sciences Ireland Uc	HIV inhibiting 5-carbo- or heterocyclic substituted pyrimidines
ES2380631T3 (es)	2004-09-30	2012-05-17	Tibotec Pharmaceuticals	Pirimidinas sustituidas en posición 5 inhibidoras de VIH
CA2577588C (en)	2004-10-29	2013-09-10	Tibotec Pharmaceuticals Ltd.	Hiv inhibiting bicyclic pyrimidine derivatives
US7592451B2 (en) *	2005-06-23	2009-09-22	New York University	Treatment for diabetes and obesity as well as method of screening compounds useful for such treatments
WO2007071199A1 (en) *	2005-12-22	2007-06-28	Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences	2,4-disubstituted amido-6-substituted-[1,3,5]triazine or 1,3-pyrimidine compounds, their processes for preparation, their pharmaceutical compositions and uses thereof
WO2007113254A1 (en)	2006-03-30	2007-10-11	Tibotec Pharmaceuticals Ltd.	Hiv inhibiting 5-amido substituted pyrimidines
WO2008080965A2 (en)	2006-12-29	2008-07-10	Tibotec Pharmaceuticals Ltd.	Hiv inhibiting 5,6-substituted pyrimidines
JP5185283B2 (ja)	2006-12-29	2013-04-17	テイボテク・フアーマシユーチカルズ	Ｈｉｖ阻害６−置換ピリミジン
CA2814120C (en)	2010-10-27	2018-08-07	The Walter And Eliza Hall Institute Of Medical Research	Novel anti-cancer agents
GB201119358D0 (en)	2011-11-10	2011-12-21	Lewi Paulus J	Disubstituted triazine dimers for treatment and/or prevention of infectious diseases
GB201204756D0 (en)	2012-03-19	2012-05-02	Lewi Paulus J	Triazines with suitable spacers for treatment and/or prevention of HIV infections
WO2014072419A1 (en)	2012-11-08	2014-05-15	Universiteit Antwerpen	Novel anti-hiv compounds
US9914709B2 (en) *	2013-06-21	2018-03-13	Yale University	Compositions and methods of treating HIV-1 infections using same
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CA3009510A1 (en) *	2015-12-24	2017-06-29	The Regents Of The University Of California	Phenylamino-1,3,5- triazine derivatives and use thereof as cftr regulators
EP3672598A4 (en)	2017-08-24	2021-04-28	The Regents of The University of California	OCULAR PHARMACEUTICAL COMPOSITIONS
CN109053613A (zh) *	2018-07-04	2018-12-21	复旦大学	含有联苯结构的二芳基三嗪类化合物及其制备方法和用途

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1998
- 1998-05-14 EP EP98201589A patent/EP0945447A1/en not_active Withdrawn
1999
- 1999-03-24 CA CA002324921A patent/CA2324921C/en not_active Expired - Fee Related
- 1999-03-24 AU AU35997/99A patent/AU758624C/en not_active Ceased
- 1999-03-24 DK DK99917863T patent/DK1066269T3/da active
- 1999-03-24 EE EEP200000535A patent/EE200000535A/xx unknown
- 1999-03-24 EA EA200000993A patent/EA004540B1/ru not_active IP Right Cessation
- 1999-03-24 ID IDW20001895A patent/ID26043A/id unknown
- 1999-03-24 ES ES99917863T patent/ES2243056T3/es not_active Expired - Lifetime
- 1999-03-24 SK SK1405-2000A patent/SK14052000A3/sk unknown
- 1999-03-24 JP JP2000541160A patent/JP2002511390A/ja active Pending
- 1999-03-24 DE DE69925256T patent/DE69925256T2/de not_active Expired - Fee Related
- 1999-03-24 HR HR20000621A patent/HRP20000621A2/hr not_active Application Discontinuation
- 1999-03-24 AT AT99917863T patent/ATE295355T1/de not_active IP Right Cessation
- 1999-03-24 KR KR1020007007971A patent/KR100593396B1/ko not_active Expired - Fee Related
- 1999-03-24 CN CNB998044474A patent/CN1157386C/zh not_active Expired - Fee Related
- 1999-03-24 SI SI9930807T patent/SI1066269T1/xx unknown
- 1999-03-24 WO PCT/EP1999/002044 patent/WO1999050256A1/en not_active Ceased
- 1999-03-24 PT PT99917863T patent/PT1066269E/pt unknown
- 1999-03-24 PL PL99343195A patent/PL194660B1/pl not_active IP Right Cessation
- 1999-03-24 BR BR9909197-6A patent/BR9909197A/pt not_active Application Discontinuation
- 1999-03-24 HU HU0101372A patent/HUP0101372A3/hu unknown
- 1999-03-24 AP APAP/P/2000/001913A patent/AP1475A/en active
- 1999-03-24 TR TR2000/02761T patent/TR200002761T2/xx unknown
- 1999-03-24 NZ NZ506787A patent/NZ506787A/xx unknown
- 1999-03-24 EP EP99917863A patent/EP1066269B1/en not_active Expired - Lifetime
- 1999-03-25 US US09/276,362 patent/US6150360A/en not_active Expired - Fee Related
- 1999-03-26 AR ARP990101363A patent/AR018169A1/es unknown
- 1999-03-26 TW TW088104756A patent/TW570917B/zh not_active IP Right Cessation
2000
- 2000-08-08 US US09/634,340 patent/US6372729B1/en not_active Expired - Fee Related
- 2000-08-28 BG BG104716A patent/BG64903B1/bg unknown
- 2000-09-25 IL IL13867000A patent/IL138670A/xx not_active IP Right Cessation
- 2000-09-26 NO NO20004809A patent/NO317425B1/no unknown
- 2000-09-27 OA OA1200000266A patent/OA11493A/en unknown
- 2000-10-26 ZA ZA200006042A patent/ZA200006042B/xx unknown
2002
- 2002-02-05 US US10/067,383 patent/US6774235B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2324921A1 (en)	1999-10-07
BG104716A (en)	2001-04-30
HRP20000621A2 (en)	2001-04-30
NO20004809L (no)	2000-11-24
TW570917B (en)	2004-01-11
US6150360A (en)	2000-11-21
AR018169A1 (es)	2001-10-31
EP1066269A1 (en)	2001-01-10
JP2002511390A (ja)	2002-04-16
OA11493A (en)	2004-05-07
SK14052000A3 (sk)	2001-06-11
HUP0101372A2 (hu)	2001-10-28
DE69925256T2 (de)	2006-02-23
EE200000535A (et)	2002-04-15
CA2324921C (en)	2009-05-12
ATE295355T1 (de)	2005-05-15
NO317425B1 (no)	2004-10-25
EA200000993A1 (ru)	2001-04-23
HUP0101372A3 (en)	2003-02-28
EA004540B1 (ru)	2004-06-24
US6774235B2 (en)	2004-08-10
BG64903B1 (bg)	2006-08-31
PT1066269E (pt)	2005-09-30
PL343195A1 (en)	2001-07-30
DE69925256D1 (de)	2005-06-16
DK1066269T3 (da)	2005-09-05
NZ506787A (en)	2003-02-28
HK1032394A1 (en)	2001-07-20
AU758624C (en)	2004-03-11
ZA200006042B (en)	2001-10-26
AP2000001913A0 (en)	2000-09-30
WO1999050256A1 (en)	1999-10-07
ID26043A (id)	2000-11-16
NO20004809D0 (no)	2000-09-26
PL194660B1 (pl)	2007-06-29
TR200002761T2 (tr)	2001-01-22
CN1295566A (zh)	2001-05-16
EP0945447A1 (en)	1999-09-29
ES2243056T3 (es)	2005-11-16
AU3599799A (en)	1999-10-18
AP1475A (en)	2005-10-03
US20020115668A1 (en)	2002-08-22
KR20010034270A (ko)	2001-04-25
US6372729B1 (en)	2002-04-16
BR9909197A (pt)	2000-12-05
KR100593396B1 (ko)	2006-06-28
SI1066269T1 (en)	2005-10-31
EP1066269B1 (en)	2005-05-11
AU758624B2 (en)	2003-03-27
CN1157386C (zh)	2004-07-14

Publication	Publication Date	Title
HUP0101372A3 (en)	2003-02-28	Trisubstituted 1,3,5-triazine derivatives for treatment of hiv infections
ZA991578B (en)	2000-08-28	Compounds for the treatment of ischemia.
IL143958A0 (en)	2002-04-21	Heteroaromatic derivatives having an inhibitory activity against hiv integrase
ZA200202461B (en)	2003-05-28	Compounds for the treatment of ischemia.
CY2429B1 (en)	2004-11-12	Substituted 3,5-diphenyl-1,2,4-triazoles and theiruse as pharmaceutical metal chelators.
HUP0204170A3 (en)	2005-03-29	5-thia-omega-substituted phenyl-prostaglandin e derivatives, process for producing the same and drugs containing the same as the active ingredient
EP1128832A4 (en)	2003-03-05	COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS AND RELATED DISEASES
PL342060A1 (en)	2001-05-21	Derivatives of 1,3,4-oxadiaxolone
IL116925A0 (en)	1996-05-14	Compounds for treating hiv infection
IL139023A0 (en)	2001-11-25	Process for the preparation of 2,3,5-trimethyl-p- benzoquinone
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