IL126701A - Inhaler system for inhalation of a dry powder drug - Google Patents

Inhaler system for inhalation of a dry powder drug

Info

Publication number: IL126701A
Authority: IL; Israel
Prior art keywords: inhaler; drug; microns; dry powder; inhalation
Prior art date: 1996-04-29

Application number

IL12670197A

Other languages

English (en)

Other versions

IL126701A0 (en

Original Assignee

Dura Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-29

Filing date

1997-04-21

Publication date

2001-08-08

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21777075&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL126701(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-04-21 Application filed by Dura Pharma Inc filed Critical Dura Pharma Inc

1999-08-17 Publication of IL126701A0 publication Critical patent/IL126701A0/xx

2001-08-08 Publication of IL126701A publication Critical patent/IL126701A/en

Links

239000003814 drug Substances 0.000 title claims abstract description 31
229940079593 drug Drugs 0.000 title claims abstract description 30
239000000843 powder Substances 0.000 title claims abstract description 25
239000002245 particle Substances 0.000 claims abstract description 30
239000000203 mixture Substances 0.000 claims abstract description 14
238000012384 transportation and delivery Methods 0.000 claims abstract description 9
108090000765 processed proteins & peptides Proteins 0.000 claims description 4
102000004169 proteins and genes Human genes 0.000 claims description 4
108090000623 proteins and genes Proteins 0.000 claims description 4
230000009885 systemic effect Effects 0.000 claims description 4
239000000443 aerosol Substances 0.000 claims description 3
208000006673 asthma Diseases 0.000 claims description 3
229940088597 hormone Drugs 0.000 claims description 3
239000005556 hormone Substances 0.000 claims description 3
229920001184 polypeptide Polymers 0.000 claims description 3
102000004196 processed proteins & peptides Human genes 0.000 claims description 3
230000000699 topical effect Effects 0.000 claims description 3
230000008021 deposition Effects 0.000 description 14
210000004072 lung Anatomy 0.000 description 11
125000003003 spiro group Chemical group 0.000 description 8
229940071648 metered dose inhaler Drugs 0.000 description 5
230000002093 peripheral effect Effects 0.000 description 5
229940112141 dry powder inhaler Drugs 0.000 description 4
238000000338 in vitro Methods 0.000 description 4
238000001727 in vivo Methods 0.000 description 4
102000055006 Calcitonin Human genes 0.000 description 3
108060001064 Calcitonin Proteins 0.000 description 3
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
229960004015 calcitonin Drugs 0.000 description 3
BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 description 3
230000003434 inspiratory effect Effects 0.000 description 3
239000008101 lactose Substances 0.000 description 3
229940092705 beclomethasone Drugs 0.000 description 2
NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 description 2
238000009472 formulation Methods 0.000 description 2
238000000034 method Methods 0.000 description 2
NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical group CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 1
230000036765 blood level Effects 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
238000012377 drug delivery Methods 0.000 description 1
239000013583 drug formulation Substances 0.000 description 1
229940023485 nasal product Drugs 0.000 description 1
230000000149 penetrating effect Effects 0.000 description 1
230000002028 premature Effects 0.000 description 1
230000000241 respiratory effect Effects 0.000 description 1
229960002052 salbutamol Drugs 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
238000012385 systemic delivery Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Anesthesiology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Otolaryngology (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Flow Control (AREA)

IL12670197A 1996-04-29 1997-04-21 Inhaler system for inhalation of a dry powder drug IL126701A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1642896P	1996-04-29	1996-04-29
PCT/US1997/006621 WO1997040819A1 (en)	1996-04-29	1997-04-21	Methods of dry powder inhalation

Publications (2)

Publication Number	Publication Date
IL126701A0 IL126701A0 (en)	1999-08-17
IL126701A true IL126701A (en)	2001-08-08

Family

ID=21777075

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12670197A IL126701A (en)	1996-04-29	1997-04-21	Inhaler system for inhalation of a dry powder drug

Country Status (16)

Country	Link
US (1)	US6116237A (xx)
EP (1)	EP0896525B1 (xx)
JP (2)	JP2000510109A (xx)
AT (1)	ATE247948T1 (xx)
AU (1)	AU724503B2 (xx)
BR (1)	BR9709748A (xx)
CA (1)	CA2252814A1 (xx)
CZ (1)	CZ343798A3 (xx)
DE (1)	DE69724420T2 (xx)
DK (1)	DK0896525T3 (xx)
ES (1)	ES2205210T3 (xx)
HU (1)	HUP9901575A3 (xx)
IL (1)	IL126701A (xx)
NO (1)	NO984999D0 (xx)
NZ (1)	NZ332669A (xx)
WO (1)	WO1997040819A1 (xx)

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1997
- 1997-04-21 EP EP97921298A patent/EP0896525B1/en not_active Revoked
- 1997-04-21 HU HU9901575A patent/HUP9901575A3/hu unknown
- 1997-04-21 DE DE69724420T patent/DE69724420T2/de not_active Expired - Lifetime
- 1997-04-21 BR BR9709748-9A patent/BR9709748A/pt not_active IP Right Cessation
- 1997-04-21 AT AT97921298T patent/ATE247948T1/de active
- 1997-04-21 WO PCT/US1997/006621 patent/WO1997040819A1/en not_active Ceased
- 1997-04-21 ES ES97921298T patent/ES2205210T3/es not_active Expired - Lifetime
- 1997-04-21 CZ CZ983437A patent/CZ343798A3/cs unknown
- 1997-04-21 JP JP09538984A patent/JP2000510109A/ja active Pending
- 1997-04-21 CA CA002252814A patent/CA2252814A1/en not_active Abandoned
- 1997-04-21 DK DK97921298T patent/DK0896525T3/da active
- 1997-04-21 IL IL12670197A patent/IL126701A/en not_active IP Right Cessation
- 1997-04-21 AU AU27371/97A patent/AU724503B2/en not_active Ceased
- 1997-04-21 NZ NZ332669A patent/NZ332669A/xx unknown
- 1997-04-24 US US08/847,287 patent/US6116237A/en not_active Expired - Lifetime
1998
- 1998-10-27 NO NO984999A patent/NO984999D0/no not_active Application Discontinuation
2009
- 2009-02-24 JP JP2009040744A patent/JP2009148586A/ja active Pending

Also Published As

Publication number	Publication date
DK0896525T3 (da)	2003-12-01
DE69724420D1 (de)	2003-10-02
ES2205210T3 (es)	2004-05-01
EP0896525B1 (en)	2003-08-27
DE69724420T2 (de)	2004-06-09
IL126701A0 (en)	1999-08-17
EP0896525A4 (en)	2001-01-10
NZ332669A (en)	1999-02-25
JP2009148586A (ja)	2009-07-09
ATE247948T1 (de)	2003-09-15
BR9709748A (pt)	2000-01-11
CZ343798A3 (cs)	1999-02-17
CA2252814A1 (en)	1997-11-06
AU724503B2 (en)	2000-09-21
AU2737197A (en)	1997-11-19
EP0896525A1 (en)	1999-02-17
JP2000510109A (ja)	2000-08-08
NO984999L (no)	1998-10-27
HUP9901575A3 (en)	1999-11-29
US6116237A (en)	2000-09-12
NO984999D0 (no)	1998-10-27
WO1997040819A1 (en)	1997-11-06
HUP9901575A2 (hu)	1999-08-30

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US6250300B1 (en)	2001-06-26	System for dispensing pharmaceutically active compounds
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Hardy	2002	Drug delivery to the respiratory tract
Ganderton	1992	Patients, devices and formulations
Elwood	1997	Extrafine CFC-free beclomethasone aerosol hits the right spot

Legal Events

Date	Code	Title
2002-02-10	FF	Patent granted
2002-02-10	KB	Patent renewed
2004-01-04	RH1	Patent not in force