HRP20160638T1 - Antigen vezujući proteini sposobni vezati timusni stromalni limfopoetin - Google Patents
Antigen vezujući proteini sposobni vezati timusni stromalni limfopoetin Download PDFInfo
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- HRP20160638T1 HRP20160638T1 HRP20160638TT HRP20160638T HRP20160638T1 HR P20160638 T1 HRP20160638 T1 HR P20160638T1 HR P20160638T T HRP20160638T T HR P20160638TT HR P20160638 T HRP20160638 T HR P20160638T HR P20160638 T1 HRP20160638 T1 HR P20160638T1
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A61P31/14—Antivirals for RNA viruses
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- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07—ORGANIC CHEMISTRY
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C07—ORGANIC CHEMISTRY
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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Claims (17)
1. Anti-TSLP ljudsko protutijelo sadrži:
a. varijabilnu domenu lakog lanca koja sadrži:
i. CDR1 slijed lakog lanca koji sadrži aminokiselinski slijed SEQ ID NO:13;
ii. CDR2 slijed lakog lanca koji sadrži aminokiselinski slijed SEQ ID NO:60; i
iii. CDR3 slijed lakog lanca koji sadrži aminokiselinski slijed SEQ ID NO:105; i
b. varijabilnu domenu teškog lanca koja sadrži:
i. CDR1 slijed teškog lanca koji sadrži aminokiselinski slijed SEQ ID NO:145;
ii. CDR2 slijed teškog lanca koji sadrži aminokiselinski slijed SEQ ID NO:173; i
iii. CDR3 slijed teškog lanca koji sadrži aminokiselinski slijed SEQ ID NO:212.
2. Anti-TSLP ljudsko protutijelo iz patentnog zahtjeva 1, sadrži:
a. varijabilnu domenu lakog lanca izabranu iz grupe koja sadrži:
i. aminokiseline koje imaju slijed najmanje 80% identičan slijedu SEQ ID NO:363;
ii. slijed aminokiselina kodiran polinukleotidnim slijedom koji je najmanje 80% identičan slijedu SEQ ID NO:362;
iii. slijed aminokiselina kodiran polinukleotidnim slijedom koji hibridizira pod umjereno strogim uvjetima s komplementarnim polinukleotidom koji se sastoji od SEQ ID NO:362;
i
b. varijabilnu domenu teškog lanca izabranu iz grupe koja sadrži:
i. slijed aminokiselina najmanje 80% identičan slijedu SEQ ID NO:361;
ii. slijed aminokiselina kodiran polinukleotidnim slijedom koji je najmanje 80% identičan slijedu SEQ ID NO:360;
iii. slijed aminokiselina kodiran polinukleotidnim slijedom koji hibridizira pod umjereno strogim uvjetima s komplementarnim polinukleotidom koji se sastoji od SEQ ID NO:360;
3. Anti-TSLP ljudsko protutijelo iz patentnog zahtjeva 1, sadrži:
varijabilnu domenu lakog lanca koja sadrži SEQ ID NO:363 i
varijabilnu domenu teškog lanca koja sadrži SEQ ID NO:361.
4. Anti-TSLP ljudsko protutijelo iz bilo kojeg od patentnih zahtjeva 1-2, pri čemu
a. anti-TSLP ljudsko protutijelo veže se za TSLP sa značajno istom Kd kao referentno protutijelo, i/ili
b. pri čemu anti-TSLP ljudsko protutijelo inhibira TSLP aktivnost u skladu s primarnim OPG određivanjem s istim IC50 kao referentno protutijelo,
pri čemu je referentno protutijelo protutijelo koje se sastoji od varijabilne domene lakog lanca koja sadrži aminokiselinski slijed SEQ ID NO:363 i varijabilne domene teškog lanca koja sadrži aminokiselinski slijed SEQ ID NO:361.
5. Farmaceutski sastav koji sadrži anti-TSLP ljudsko protutijelo iz bilo kojeg od patentnih zahtjeva 1-4.
6. Nukleinska kiselina koja sadrži polinukleotidni slijed koji kodira varijabilnu domenu lakog lanca i varijabilnu domenu teškog lanca anti-TSLP ljudskog protutijela iz bilo kojeg od patentnih zahtjeva 1-4.
7. Rekombinantni ekspresijski vektor koji sadrži nukleinsku kiselinu iz patentnog zahtjeva 6.
8. Stanica domaćin koja sadrži
a) ekspresijski vektor koji sadrži polinukleotid koji kodira varijabilnu domenu lakog lanca i varijabilnu domenu teškog lanca anti-TSLP ljudskog protutijela iz bilo kojeg od patentnih zahtjeva 1-4; ili
b) ekspresijski vektor koji sadrži polinukleotid koji kodira varijabilnu domenu lakog lanca anti-TSLP ljudskog protutijela iz bilo kojeg od patentnih zahtjeva 1-4 i ekspresijski vektor koji sadrži polinukleotid koji kodira varijabilnu domenu teškog lanca anti-TSLP ljudskog protutijela iz bilo kojeg od patentnih zahtjeva 1-4.
9. Hibridoma sposobna za stvaranje anti-TSLP ljudskog protutijela iz bilo kojeg od patentnih zahtjeva 1-4.
10. Metoda za stvaranje anti-TSLP ljudskog protutijela iz bilo kojeg od patentnih zahtjeva 1-4, obuhvaća inkubiranje stanice domaćina iz patentnog zahtjeva 8 pod uvjetima koji joj omogućavaju ekspresiju protutijela.
11. Sastav u skladu s patentnim zahtjevom 5 za uporabu u liječenju
a. TSLP-povezanog upalnog stanja kod subjekta kojem je takvo liječenje potrebno; ili
b. TSLP-povezanog fibrotičnog poremećaja kod subjekta kojem je takvo liječenje potrebno.
12. Sastav za uporabu u skladu s patentnim zahtjevom 11, pri čemu je upalno stanje odabrano iz grupe koja se sastoji od alergijske astme, alergijskog rinosinusitisa, alergijskog konjuktivitisa i atopijskog dermatitisa.
13. Sastav za uporabu u skladu s patentnim zahtjevom 11, pri čemu je fibrotično stanje odabrano iz grupe koja se sastoji od skleroderme, intersticijske bolesti pluća, idopatske plućne fibroze, fibroze koja nastaje iz kroničnog hepatitisa B ili C, zračenjem inducirane fibroze i fibroze koja nastaje zacjeljivanjem rana.
14. Anti-TSLP ljudsko protutijelo iz patentnog zahtjeva 1, pri čemu je navedeno anti-TSLP ljudsko protutijelo monoklonsko protutijelo.
15. Anti-TSLP ljudsko protutijelo iz patentnog zahtjeva 1, pri čemu navedeno anti-TSLP ljudsko protutijelo sadrži a) laki lanac koji sadrži varijabilnu domenu lakog lanca koja sadrži aminokiselinski slijed pretpostavljen u SEQ ID NO:363 i konstantnu domenu lambda lakog lanca koja sadrži aminokiselinski slijed pretpostavljen u SEQ ID NO: 369; i b) teški lanac koji sadrži varijabilnu domenu teškog lanca koja sadrži aminokiselinski slijed pretpostavljen u SEQ ID NO:361 i konstantnu domenu IgG2 teškog lanca koja sadrži aminokiselinski slijed pretpostavljen u SEQ ID NO: 365.
16. Metoda iz patentnog zahtejva 10, pri čemu je stanica domaćin CHO stanica.
17. Anti-TSLP ljudsko protutijelo dostižno metodom iz patentnog zahtjeva 16.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97117807P | 2007-09-10 | 2007-09-10 | |
| US9167608P | 2008-08-25 | 2008-08-25 | |
| EP08830362.3A EP2205635B1 (en) | 2007-09-10 | 2008-09-09 | Antigen binding proteins capable of binding thymic stromal lymphopoietin |
| PCT/US2008/010510 WO2009035577A1 (en) | 2007-09-10 | 2008-09-09 | Antigen binding proteins capable of binding thymic stromal lymphopoietin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20160638T1 true HRP20160638T1 (hr) | 2016-07-01 |
Family
ID=40242598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20160638TT HRP20160638T1 (hr) | 2007-09-10 | 2008-09-09 | Antigen vezujući proteini sposobni vezati timusni stromalni limfopoetin |
Country Status (36)
| Country | Link |
|---|---|
| US (6) | US7982016B2 (hr) |
| EP (3) | EP2703414A1 (hr) |
| JP (8) | JP5956716B2 (hr) |
| KR (2) | KR101597371B1 (hr) |
| CN (2) | CN104231081B (hr) |
| AR (1) | AR068508A1 (hr) |
| AU (1) | AU2008300028B2 (hr) |
| CA (1) | CA2698382C (hr) |
| CL (2) | CL2008002668A1 (hr) |
| CR (2) | CR11319A (hr) |
| CY (2) | CY1117702T1 (hr) |
| DK (1) | DK2205635T3 (hr) |
| EA (2) | EA022796B1 (hr) |
| ES (1) | ES2581229T3 (hr) |
| FR (1) | FR22C1059I2 (hr) |
| HR (1) | HRP20160638T1 (hr) |
| HU (2) | HUE028361T2 (hr) |
| IL (3) | IL204069A (hr) |
| JO (1) | JO3351B1 (hr) |
| LT (1) | LT2205635T (hr) |
| LU (1) | LUC00289I2 (hr) |
| MX (1) | MX2010002590A (hr) |
| MY (1) | MY150242A (hr) |
| NL (1) | NL301207I2 (hr) |
| NO (1) | NO2022055I1 (hr) |
| NZ (1) | NZ583933A (hr) |
| PE (2) | PE20140232A1 (hr) |
| PH (1) | PH12017501025B1 (hr) |
| PL (1) | PL2205635T3 (hr) |
| PT (1) | PT2205635T (hr) |
| RS (1) | RS54950B1 (hr) |
| SG (2) | SG10201506251YA (hr) |
| SI (1) | SI2205635T1 (hr) |
| TW (2) | TWI449709B (hr) |
| WO (1) | WO2009035577A1 (hr) |
| ZA (1) | ZA201001895B (hr) |
Families Citing this family (162)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0603683D0 (en) * | 2006-02-23 | 2006-04-05 | Novartis Ag | Organic compounds |
| AR064333A1 (es) | 2006-12-14 | 2009-04-01 | Schering Corp | Anticuerpo anti-tslp de diseno |
| EP2247618B1 (en) * | 2008-01-25 | 2014-06-11 | Amgen, Inc | Ferroportin antibodies and methods of use |
| PE20121646A1 (es) * | 2009-11-04 | 2012-12-02 | Merck Sharp & Dohme | Anticuerpo anti-tslp modificado por tecnicas de ingeneria genetica |
| JP6159660B2 (ja) * | 2010-09-22 | 2017-07-05 | アムジエン・インコーポレーテツド | 担体としての免疫グロブリンおよびその使用 |
| WO2013067051A1 (en) * | 2011-11-03 | 2013-05-10 | Merck Sharp & Dohme Corp. | Biomarkers for tslp treatment |
| KR20180137614A (ko) * | 2012-04-27 | 2018-12-27 | 노보 노르디스크 에이/에스 | 사람 cd30 리간드 항원 결합 단백질 |
| UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
| US9708375B2 (en) | 2013-03-15 | 2017-07-18 | Amgen Inc. | Inhibitory polypeptides specific to WNT inhibitors |
| CN104371019B (zh) * | 2013-08-13 | 2019-09-10 | 鸿运华宁（杭州）生物医药有限公司 | 一种能与glp-1r特异性结合的抗体及其与glp-1的融合蛋白质 |
| TW201605896A (zh) | 2013-08-30 | 2016-02-16 | 安美基股份有限公司 | Gitr抗原結合蛋白 |
| CA2923145A1 (en) | 2013-09-05 | 2015-03-12 | Amgen Inc. | Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles |
| WO2015118124A1 (en) * | 2014-02-06 | 2015-08-13 | Vib Vzw | Thymic stromal lymphopoietin receptor antagonist |
| MX388536B (es) | 2014-05-07 | 2025-03-20 | Amgen Inc | Autoinyector con elementos reductores del shock. |
| US10156562B2 (en) | 2014-05-16 | 2018-12-18 | Amgen Inc. | Assay for detecting Th1 and Th2 cell populations |
| CN106470717B (zh) | 2014-06-03 | 2020-09-11 | 安姆根有限公司 | 药物递送系统和使用方法 |
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