[go: up one dir, main page]

HK1212235A1 - Antiviral azasugar-containing nucleosides - Google Patents

Antiviral azasugar-containing nucleosides Download PDF

Info

Publication number
HK1212235A1
HK1212235A1 HK16100301.6A HK16100301A HK1212235A1 HK 1212235 A1 HK1212235 A1 HK 1212235A1 HK 16100301 A HK16100301 A HK 16100301A HK 1212235 A1 HK1212235 A1 HK 1212235A1
Authority
HK
Hong Kong
Prior art keywords
azasugar
compounds
viral
pharmaceutically acceptable
antiviral
Prior art date
Application number
HK16100301.6A
Other languages
English (en)
Chinese (zh)
Inventor
Yarlagadda S. Babu
Pravin L. Kotian
Shanta Bantia
Minwan Wu
V. Satish Kumar
Original Assignee
Biocryst Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocryst Pharmaceuticals, Inc. filed Critical Biocryst Pharmaceuticals, Inc.
Publication of HK1212235A1 publication Critical patent/HK1212235A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK16100301.6A 2012-11-16 2013-11-18 Antiviral azasugar-containing nucleosides HK1212235A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261727468P 2012-11-16 2012-11-16
US61/727,468 2012-11-16
PCT/US2013/070537 WO2014078778A2 (fr) 2012-11-16 2013-11-18 Nucléosides antiviraux contenant de l'azasucre

Publications (1)

Publication Number Publication Date
HK1212235A1 true HK1212235A1 (en) 2016-06-10

Family

ID=50731836

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16100301.6A HK1212235A1 (en) 2012-11-16 2013-11-18 Antiviral azasugar-containing nucleosides

Country Status (9)

Country Link
US (2) US20150291596A1 (fr)
EP (2) EP3251674A3 (fr)
JP (1) JP2016504284A (fr)
AU (1) AU2013344422A1 (fr)
CA (1) CA2890905A1 (fr)
HK (1) HK1212235A1 (fr)
IL (1) IL238785A0 (fr)
MX (1) MX2015005949A (fr)
WO (1) WO2014078778A2 (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ME01528B (me) 2009-09-21 2014-04-20 Gilead Sciences Inc POSTUPCI l INTERMEDIJERI ZA PROIZVODNJU 1'-CIJANOKARBANUKLEOZIDIH ANALOGA
US20120027752A1 (en) 2010-07-22 2012-02-02 Gilead Sciences, Inc. Methods and compounds for treating paramyxoviridae virus infections
TWI767201B (zh) 2014-10-29 2022-06-11 美商基利科學股份有限公司 絲狀病毒科病毒感染之治療
EP3722297A1 (fr) 2015-03-04 2020-10-14 Gilead Sciences, Inc. Composés modulateurs de récepteurs de type toll
HRP20220355T1 (hr) * 2015-09-16 2022-05-13 Gilead Sciences, Inc. Postupci za liječenje infekcija coronaviridae
SG11201804674UA (en) 2015-12-16 2018-06-28 Bristol Myers Squibb Co Heteroarylhydroxypyrimidinones as agonists of the apj receptor
EP3436461B1 (fr) 2016-03-28 2023-11-01 Incyte Corporation Composés de pyrrolotriazine en tant qu'inhibiteurs de tam
US10640499B2 (en) 2016-09-02 2020-05-05 Gilead Sciences, Inc. Toll like receptor modulator compounds
ES2906581T3 (es) 2016-09-02 2022-04-19 Gilead Sciences Inc Compuestos moduladores de los receptores tipo Toll
TW201836615A (zh) 2017-03-14 2018-10-16 美商基利科學股份有限公司 治療貓冠狀病毒感染之方法
CN106834546A (zh) * 2017-03-20 2017-06-13 杭州迪安医学检验中心有限公司 一种基于熔解曲线法单管同时检测多种呼吸道病毒的引物及其应用
CA3059777C (fr) 2017-05-01 2023-02-21 Gilead Sciences, Inc. Formes cristallines de (s) 2 ethylbutyl 2 (((s) (((2r,3s,4r,5r) 5 (4 aminopyrrolo[2,1-f] [1,2,4]triazine-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2 yl)methoxy)(phenoxy) phosphor yl)amino)propanoate
WO2019014247A1 (fr) 2017-07-11 2019-01-17 Gilead Sciences, Inc. Compositions comprenant un inhibiteur d'arn polymérase et de la cyclodextrine pour le traitement d'infections virales
CN109053788A (zh) * 2018-09-20 2018-12-21 山东谛爱生物技术有限公司 一种吡唑类化合物的制备方法
TWI751516B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI751517B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI879779B (zh) 2019-06-28 2025-04-11 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法
CN118766947A (zh) 2020-01-27 2024-10-15 吉利德科学公司 用于治疗SARS CoV-2感染的方法
TWI785528B (zh) 2020-03-12 2022-12-01 美商基利科學股份有限公司 1’-氰基核苷之製備方法
KR20220164784A (ko) 2020-04-06 2022-12-13 길리애드 사이언시즈, 인코포레이티드 1'-시아노 치환된 카르바뉴클레오시드 유사체의 흡입 제형
AU2021281351A1 (en) 2020-05-29 2023-01-19 Gilead Sciences, Inc. Remdesivir treatment methods
PH12022553530A1 (en) 2020-06-24 2024-06-24 Gilead Sciences Inc 1'-cyano nucleoside analogs and uses thereof
CN111704619B (zh) * 2020-07-30 2021-10-19 四川大学 一种Forodesine的制备方法
ES2985995T3 (es) 2020-08-27 2024-11-08 Gilead Sciences Inc Compuestos y métodos para el tratamiento de infecciones víricas
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors
CN114588159A (zh) * 2020-12-07 2022-06-07 成都傲科新技术有限责任公司 一种治疗猫冠状病毒感染的化合物及其应用
CA3223875A1 (fr) * 2021-06-25 2022-12-29 Shigeru Matsuoka Derive de polyheteroazole substitue par heterocycloalkyle utilise en tant que medicament pour le traitement et/ou la prevention d'une maladie infectieuse a virus rs
WO2023022216A1 (fr) * 2021-08-20 2023-02-23 塩野義製薬株式会社 Dérivés nucléosidiques et leurs promédicaments ayant une action inhibitrice de la croissance virale
CN113666941B (zh) * 2021-09-01 2023-03-10 浙江珲达生物科技有限公司 一种2,3-O-异亚丙基-D-核糖酸-γ-内酯的重结晶方法
US20230295172A1 (en) 2022-03-02 2023-09-21 Gilead Sciences, Inc. Compounds and methods for treatment of viral infections
US12357577B1 (en) 2024-02-02 2025-07-15 Gilead Sciences, Inc. Pharmaceutical formulations and uses thereof

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3719667A (en) 1970-08-24 1973-03-06 Lilly Co Eli Epimerization of 6-acylamido and 6-imido penicillin sulfoxide esters
US3840556A (en) 1971-05-28 1974-10-08 Lilly Co Eli Penicillin conversion by halogen electrophiles and anti-bacterials derived thereby
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
WO1994004547A1 (fr) * 1992-08-26 1994-03-03 Japan Tobacco Inc. Nouveau derive de nicotine
US7098334B2 (en) * 2002-03-25 2006-08-29 Industrial Research Limited 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
WO2003100009A2 (fr) * 2002-05-23 2003-12-04 Biocryst Pharmaceuticals, Inc. Augmentation de l'efficacite d'inhibiteurs de la transcriptase inverse et d'adn polymerase (analogues de nucleoside) a l'aide d'inhibiteurs de pnp et/ou de 2'-deoxyguanosine et/ou d'un promedicament de ceux-ci
US7745417B2 (en) * 2002-07-17 2010-06-29 Riken Nucleosides or nucleotides having novel unnatural bases and use thereof
US7351863B2 (en) 2002-12-04 2008-04-01 Mitsubishi Gas Chemical Company, Inc. Method of fluorination
US6780993B1 (en) * 2003-02-19 2004-08-24 Biocryst Pharmaceuticals, Inc. Preparation of deazaguanine analog
TWI345568B (en) 2004-04-02 2011-07-21 Mitsubishi Tanabe Pharma Corp Tetrahydronaphthyridine derivatives and a process for preparing the same
US7560434B2 (en) * 2004-06-22 2009-07-14 Biocryst Pharmaceuticals, Inc. AZA nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
CN101166750A (zh) * 2004-10-29 2008-04-23 拜奥克里斯特制药公司 治疗用呋喃并嘧啶类化合物和噻吩并嘧啶类化合物
WO2006124447A2 (fr) * 2005-05-13 2006-11-23 Eli Lilly And Company N-arylpyrrolidines substituees utilisees comme modulateurs selectifs du recepteur des androgenes
CN101287472B (zh) * 2005-08-15 2011-10-12 弗·哈夫曼-拉罗切有限公司 抗病毒的4'-取代前核苷酸的氨基磷酸酯类化合物
US20090137557A1 (en) * 2005-11-22 2009-05-28 Thomas Wen Fu Ku Calcilytic Compounds
EP1957485B1 (fr) 2005-12-02 2013-02-13 Bayer HealthCare, LLC Derives substitues de 4-amino-pyrrolotriazine utiles dans le traitement de troubles hyperproliferatifs et de maladies associees a l'angiogenese
WO2007109459A2 (fr) 2006-03-21 2007-09-27 Janssen Pharmaceutica, Nv Pyridines et n-oxydes de pyridine en tant que modulateurs de la thrombine
EP2010523A1 (fr) 2006-04-27 2009-01-07 Glaxo Group Limited Composés spiro utiles en tant que modulateurs de récepteurs de la dopamine d3
NZ598927A (en) * 2007-01-12 2013-09-27 Biocryst Pharm Inc Antiviral nucleoside analogs
PT2155758E (pt) * 2007-05-10 2012-11-12 Biocryst Pharm Inc Compostos de tetrahidrofuro[3,4-d]dioxolano para utilização no tratamento de infecções virais e do cancro
EP2313102A2 (fr) * 2008-07-03 2011-04-27 Biota Scientific Management Nucléosides bicycliques et nucléotides convenant comme agents thérapeutiques
EP2348854A4 (fr) * 2008-09-22 2012-03-14 Einstein Coll Med Procédés et compositions pour le traitement d infections bactériennes par l inhibition de la détection du quorum
WO2011094450A1 (fr) 2010-01-27 2011-08-04 Anacor Pharmaceuticals, Inc Petites molecules contenant du bore
WO2011132017A1 (fr) 2010-04-19 2011-10-27 Glenmark Pharmaceuticals S.A. Dérivés de pyrido[3,4-d]pyrimidinyl acétamide comme modulateurs de trpa1
DK2627334T3 (en) * 2010-10-15 2015-05-18 Biocryst Pharm Inc A composition for use in the treatment of viral infections
AR090699A1 (es) * 2012-04-18 2014-12-03 Biocryst Pharm Inc Compuestos inhibidores de la actividad de la arn polimerasa viral

Also Published As

Publication number Publication date
EP3251674A2 (fr) 2017-12-06
US20170267681A1 (en) 2017-09-21
EP2919785A2 (fr) 2015-09-23
EP3251674A3 (fr) 2018-02-21
AU2013344422A1 (en) 2015-07-02
US20150291596A1 (en) 2015-10-15
WO2014078778A3 (fr) 2014-10-09
WO2014078778A2 (fr) 2014-05-22
MX2015005949A (es) 2015-09-08
IL238785A0 (en) 2015-06-30
JP2016504284A (ja) 2016-02-12
CA2890905A1 (fr) 2014-05-22
EP2919785A4 (fr) 2016-10-05

Similar Documents

Publication Publication Date Title
WO2014078778A3 (fr) Nucléosides antiviraux contenant de l'azasucre
WO2015081133A3 (fr) Nucléotides pour le traitement du cancer du foie
WO2010084115A3 (fr) Agents antiviraux
WO2010038081A3 (fr) Dérivés hétérocycliques et procédés d’utilisation associés
MX2020003055A (es) Compuestos de carbamoilpiridona policiclicos y su uso farmaceutico.
IL295418B1 (en) Beta-d-2'-deoxy-2' alpha-fluoro-2'-bata-c-modified-2-different-n6-purine modified nucleotides for the treatment of hepatitis c virus
GEP20156417B (en) Pyrrolo [2,3-d] pyrimidine derivatives as inhibitors of tropomyosin-related kinases
HK1207647A1 (en) 2'-chloro nucleoside analogs for hcv infection
CA2862755A1 (fr) Composes antiviraux avec une fraction dibenzooxaheterocycle
IL197393A (en) History of pyridine-4-ram, containing and using pharmaceutical preparations for the preparation of drugs for the treatment of immune-related diseases
WO2014045162A8 (fr) Composés d'hexahydropyrano[3,4-d][1,3]thiazine-2-amine alkyl-substitués
GEP201706698B (en) Inhibitors of influenza viruses replication
MX2013008359A (es) Aminas de c-28 de derivados de acido betulinico modificado de c-3 como inhibidores de la maduracion del virus de inmunodeficiencia humana.
IL208355A (en) Annotations 7,3-Dihydroporin-6,2-Discussion, Processes for their Preparation, Pharmaceutical Preparations Containing them and their Use in Medication Preparation
WO2013004995A8 (fr) Composés pyrimidinones et leur utilisation
MX2009013501A (es) Compuestos piperidinicos y sus usos.
WO2014062838A3 (fr) Modulateurs de pkm2 et procédés pour les utiliser
EP2583962A4 (fr) Nouvelle thio-urée ou nouveau dérivé d'urée, procédé permettant leur préparation, et composition pharmaceutique destinée à prévenir ou à traiter le sida, les contenant en tant que principe actif
MX2010013310A (es) Derivados de heterociclil urea para el tratamiento de infecciones bacterianas.
WO2013019091A3 (fr) Composé d'inhibition de la 11β-hydroxystéroïde déshydrogénase de type 1, et composition pharmaceutique le comprenant
WO2015002755A3 (fr) Composés pour le traitement du paludisme
EP2722322B8 (fr) Dérivé de 1,3-di-oxo-indène, son isomère optique ou son sel pharmaceutiquement acceptable, son procédé de préparation, et composition pharmaceutique le contenant en tant que principe actif antiviral
WO2009108017A3 (fr) Nouveaux dérivés de pyruvate avec effet neuroprotecteur, processus de préparation de ceux-ci et composition pharmaceutique comprenant ces dérivés
WO2014184248A3 (fr) Composés antagonistes de trpa1
EP2842938A4 (fr) Nouveaux dérivés de bêta-alanine, leurs sels pharmaceutiquement acceptables et composition pharmaceutique les comprenant en tant qu'ingrédient actif