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GT201800095A - Aglutinantes de tnf mejoradas - Google Patents

Aglutinantes de tnf mejoradas

Info

Publication number
GT201800095A
GT201800095A GT201800095A GT201800095A GT201800095A GT 201800095 A GT201800095 A GT 201800095A GT 201800095 A GT201800095 A GT 201800095A GT 201800095 A GT201800095 A GT 201800095A GT 201800095 A GT201800095 A GT 201800095A
Authority
GT
Guatemala
Prior art keywords
tnf
alpha
isvd
bind
compounds
Prior art date
Application number
GT201800095A
Other languages
English (en)
Inventor
Marie-Ange Buyse
Joachim Boucneau
Peter Casteels
Heeke Gino Van
Original Assignee
Ablynx Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ablynx Nv filed Critical Ablynx Nv
Publication of GT201800095A publication Critical patent/GT201800095A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Insulating Materials (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A SECUENCIAS DE AMINOÁCIDOS, COMPUESTOS Y POLIPÉPTIDOS QUE SE UNEN AL FACTOR DE NECROSIS TUMORAL ALFA ("TNF" O "TNF-ALFA"). EN PARTICULAR, LA PRESENTE INVENCIÓN SE REFIERE A DOMINIOS VARIABLES ÚNICOS DE INMUNOGLOBULINA DE CADENA PESADA MEJORADOS (TAMBIÉN DENOMINADOS AQUÍ COMO "ISV" O "ISVD") QUE SE UNEN AL FACTOR DE NECROSIS TUMORAL ALFA, ASÍ COMO A PROTEÍNAS, POLIPÉPTIDOS Y OTROS CONSTRUCTOS, COMPUESTOS, MOLÉCULAS O ENTIDADES QUÍMICAS QUE COMPRENDEN TALES ISVD, COLECTIVAMENTE AGLUTINANTES DE TNF. OTROS ASPECTOS, REALIZACIONES, CARACTERÍSTICAS, USOS Y VENTAJAS DE LA INVENCIÓN SERÁN CLAROS PARA EL EXPERTO EN LA MATERIA CON BASE EN LA DESCRIPCIÓN EN ESTE DOCUMENTO.
GT201800095A 2015-11-12 2018-05-11 Aglutinantes de tnf mejoradas GT201800095A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562254375P 2015-11-12 2015-11-12

Publications (1)

Publication Number Publication Date
GT201800095A true GT201800095A (es) 2019-08-15

Family

ID=57348648

Family Applications (1)

Application Number Title Priority Date Filing Date
GT201800095A GT201800095A (es) 2015-11-12 2018-05-11 Aglutinantes de tnf mejoradas

Country Status (37)

Country Link
US (2) US10544211B2 (es)
EP (2) EP3191511B1 (es)
JP (2) JP6962915B2 (es)
KR (2) KR20240029115A (es)
CN (1) CN108473563B (es)
AU (2) AU2016352943B2 (es)
BR (1) BR112018009714A8 (es)
CA (2) CA3234178A1 (es)
CL (1) CL2018001291A1 (es)
CO (1) CO2018005915A2 (es)
CR (1) CR20180311A (es)
CY (1) CY1120303T1 (es)
DK (1) DK3191511T3 (es)
DO (1) DOP2018000122A (es)
EC (1) ECSP18042569A (es)
ES (1) ES2662418T3 (es)
GT (1) GT201800095A (es)
HK (1) HK1248716A1 (es)
HR (1) HRP20171949T1 (es)
HU (1) HUE035805T2 (es)
IL (2) IL310373A (es)
LT (1) LT3191511T (es)
MA (1) MA41653A (es)
MD (1) MD3191511T2 (es)
ME (1) ME02954B (es)
MX (1) MX385207B (es)
NO (1) NO2768984T3 (es)
PE (1) PE20181317A1 (es)
PH (1) PH12018501025A1 (es)
PL (1) PL3191511T3 (es)
PT (1) PT3191511T (es)
RS (1) RS56676B1 (es)
SG (1) SG11201803975SA (es)
SI (1) SI3191511T1 (es)
SM (1) SMT201700590T1 (es)
TN (1) TN2018000159A1 (es)
WO (1) WO2017081320A1 (es)

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Also Published As

Publication number Publication date
CA3005085A1 (en) 2017-05-18
CL2018001291A1 (es) 2018-09-14
PH12018501025A1 (en) 2019-01-28
CN108473563A (zh) 2018-08-31
CY1120303T1 (el) 2019-07-10
DK3191511T3 (en) 2018-01-08
PE20181317A1 (es) 2018-08-14
RS56676B1 (sr) 2018-03-30
EP3266798A3 (en) 2018-03-28
EP3191511B1 (en) 2017-09-20
JP6962915B2 (ja) 2021-11-10
KR102641194B1 (ko) 2024-02-26
ES2662418T3 (es) 2018-04-06
LT3191511T (lt) 2018-01-10
IL310373A (en) 2024-03-01
JP2022020666A (ja) 2022-02-01
NO2768984T3 (es) 2018-06-09
ECSP18042569A (es) 2018-07-31
EP3266798A2 (en) 2018-01-10
IL259269B2 (en) 2024-07-01
US9745372B2 (en) 2017-08-29
EP3191511A1 (en) 2017-07-19
HUE035805T2 (en) 2018-05-28
ME02954B (me) 2018-07-20
IL259269A (en) 2018-07-31
PT3191511T (pt) 2017-11-30
US20170267752A1 (en) 2017-09-21
CN108473563B (zh) 2022-06-14
JP7357038B2 (ja) 2023-10-05
HRP20171949T1 (hr) 2018-01-26
WO2017081320A1 (en) 2017-05-18
DOP2018000122A (es) 2018-09-30
JP2019506839A (ja) 2019-03-14
US10544211B2 (en) 2020-01-28
BR112018009714A8 (pt) 2019-02-26
RU2018120524A (ru) 2019-12-13
AU2023200113A1 (en) 2023-02-16
MA41653A (fr) 2018-01-09
HK1248716A1 (en) 2018-10-19
SG11201803975SA (en) 2018-06-28
AU2016352943B2 (en) 2022-10-20
KR20240029115A (ko) 2024-03-05
MX385207B (es) 2025-03-04
CO2018005915A2 (es) 2018-06-20
KR20180083382A (ko) 2018-07-20
BR112018009714A2 (en) 2018-11-21
AU2016352943A1 (en) 2018-06-07
US20170190769A1 (en) 2017-07-06
CA3234178A1 (en) 2017-05-18
SI3191511T1 (en) 2018-01-31
MX2018005992A (es) 2019-01-31
IL259269B1 (en) 2024-03-01
RU2018120524A3 (es) 2020-09-24
MD3191511T2 (ro) 2018-03-31
CR20180311A (es) 2018-10-18
SMT201700590T1 (it) 2018-01-11
PL3191511T3 (pl) 2018-03-30
CA3005085C (en) 2024-09-10
TN2018000159A1 (en) 2019-10-04

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