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GT200800005A - Nuevos compuestos 1,1-piridinilamino-ciclopropanaminas polisustituidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contiene - Google Patents

Nuevos compuestos 1,1-piridinilamino-ciclopropanaminas polisustituidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contiene

Info

Publication number
GT200800005A
GT200800005A GT200800005A GT200800005A GT200800005A GT 200800005 A GT200800005 A GT 200800005A GT 200800005 A GT200800005 A GT 200800005A GT 200800005 A GT200800005 A GT 200800005A GT 200800005 A GT200800005 A GT 200800005A
Authority
GT
Guatemala
Prior art keywords
pyridinylamine
cyclopropanamine
composites
new
pharmaceutical compositions
Prior art date
Application number
GT200800005A
Other languages
English (en)
Inventor
Solo Goldstein
Claude Guillonneau
Yves Charton
Brian Lockhart
Pierre Lestage
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200800005A publication Critical patent/GT200800005A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE LA FORMULA GENERAL I EN LA QUE R1,R2,R3,R4,R5,R6,R7,N, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS PRESENTAN UNA INTERACCION ESPECIFICA CON LOS RECEPTORES NICOTINICOS CENTRALES DE TIPO ALFA4BETA2 POR LO QUE SON DE UTILIDAD EN CUADROS DE NEUROPATOLOGIAS ASOCIADAS AL ENVEJECIMIENTO CEREBRAL, TRASTORNOS DEL HUMOR, DOLOR Y PROCESO DE ABANDONO DEL TABACO.
GT200800005A 2005-07-28 2008-06-23 Nuevos compuestos 1,1-piridinilamino-ciclopropanaminas polisustituidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contiene GT200800005A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0508032A FR2889188B1 (fr) 2005-07-28 2005-07-28 Nouveaux composes 1,1-pyridinylaminocyclopropanamines polysubstitues, leur procede de preparation et les compositions phamaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
GT200800005A true GT200800005A (es) 2008-09-24

Family

ID=36169157

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200800005A GT200800005A (es) 2005-07-28 2008-06-23 Nuevos compuestos 1,1-piridinilamino-ciclopropanaminas polisustituidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contiene

Country Status (31)

Country Link
US (2) US7388022B2 (es)
EP (1) EP1757586B1 (es)
JP (1) JP2007031439A (es)
KR (1) KR100824831B1 (es)
CN (1) CN100448848C (es)
AR (1) AR055589A1 (es)
AT (1) ATE416166T1 (es)
AU (1) AU2006203237A1 (es)
BR (1) BRPI0603027A (es)
CA (1) CA2552831A1 (es)
CR (1) CR9679A (es)
DE (1) DE602006003956D1 (es)
DK (1) DK1757586T3 (es)
EA (1) EA011124B1 (es)
EC (1) ECSP088127A (es)
ES (1) ES2318700T3 (es)
FR (1) FR2889188B1 (es)
GE (1) GEP20084506B (es)
GT (1) GT200800005A (es)
HR (1) HRP20090090T3 (es)
MA (1) MA28425B1 (es)
MX (1) MXPA06008541A (es)
NO (1) NO20063462L (es)
NZ (1) NZ548746A (es)
PL (1) PL1757586T3 (es)
PT (1) PT1757586E (es)
SG (1) SG129412A1 (es)
SI (1) SI1757586T1 (es)
TN (1) TNSN08023A1 (es)
WO (1) WO2007012761A1 (es)
ZA (1) ZA200606276B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2896800B1 (fr) * 2006-01-30 2008-04-11 Servier Lab Nouveaux composes pyridinylaminoalkylene-et pyridinyloxyalkylene-cyclopropanamines polysubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US10288289B2 (en) * 2014-12-12 2019-05-14 United Technologies Corporation Gas turbine engine diffuser-combustor assembly inner casing

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2095350C1 (ru) * 1993-10-13 1997-11-10 Центр по химии лекарственных средств (ЦХЛС-ВНИХФИ) 3-(n,n-диметилкарбамоилокси)-2-этил-6-метилпиридина сукцинат, обладающий антигипоксической активностью
TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
BR9813279B1 (pt) * 1997-10-27 2010-11-16 derivado de homopiperazina, composição farmacêutica, e, uso do derivado de homopiperazina.
AU5326100A (en) * 1999-06-07 2000-12-28 Targacept, Inc. Pharmaceutical compositions and methods for use
JP2001261652A (ja) * 2000-03-21 2001-09-26 Suntory Ltd 二置換イミノヘテロサイクリック化合物
US6448276B1 (en) * 2000-05-17 2002-09-10 Inspire Pharmaceuticals, Inc. Method for treating vaginal dryness with nicotinic acetylcholine receptor agonists
FR2810664B1 (fr) * 2000-06-27 2004-12-24 Adir Nouveaux composes cyclopropaniques 1,1 et 1,2-dissubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
EP1757586A1 (fr) 2007-02-28
EP1757586B1 (fr) 2008-12-03
KR20070015012A (ko) 2007-02-01
MXPA06008541A (es) 2007-01-29
HK1098146A1 (zh) 2007-07-13
DE602006003956D1 (en) 2009-01-15
CN1903844A (zh) 2007-01-31
EA200601247A1 (ru) 2007-04-27
PT1757586E (pt) 2009-02-17
NO20063462L (no) 2007-01-29
CA2552831A1 (fr) 2007-01-28
CN100448848C (zh) 2009-01-07
KR100824831B1 (ko) 2008-04-23
AR055589A1 (es) 2007-08-29
FR2889188A1 (fr) 2007-02-02
WO2007012761A8 (fr) 2007-12-21
ATE416166T1 (de) 2008-12-15
WO2007012761A1 (fr) 2007-02-01
ZA200606276B (en) 2007-12-27
AU2006203237A1 (en) 2007-02-15
SG129412A1 (en) 2007-02-26
TNSN08023A1 (en) 2009-07-14
EA011124B1 (ru) 2008-12-30
ES2318700T3 (es) 2009-05-01
DK1757586T3 (da) 2009-03-09
US20080146621A1 (en) 2008-06-19
GEP20084506B (en) 2008-10-10
ECSP088127A (es) 2008-02-20
US7388022B2 (en) 2008-06-17
FR2889188B1 (fr) 2007-09-07
BRPI0603027A (pt) 2007-03-13
MA28425B1 (fr) 2007-02-01
HRP20090090T3 (en) 2009-03-31
PL1757586T3 (pl) 2009-04-30
CR9679A (es) 2008-02-20
US20070027192A1 (en) 2007-02-01
NZ548746A (en) 2007-06-29
SI1757586T1 (sl) 2009-04-30
JP2007031439A (ja) 2007-02-08

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