GT200600368A - Derivados de 5-piridinil-1-azabiciclo[3.2.1]octano, su preparación y su aplicación en terapeutica - Google Patents
Derivados de 5-piridinil-1-azabiciclo[3.2.1]octano, su preparación y su aplicación en terapeuticaInfo
- Publication number
- GT200600368A GT200600368A GT200600368A GT200600368A GT200600368A GT 200600368 A GT200600368 A GT 200600368A GT 200600368 A GT200600368 A GT 200600368A GT 200600368 A GT200600368 A GT 200600368A GT 200600368 A GT200600368 A GT 200600368A
- Authority
- GT
- Guatemala
- Prior art keywords
- therapeutics
- piridinil
- azabiciclo
- octano
- derivatives
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
LA INVENCIÓN SE REFIERE A LOS COMPUESTOS DE FÓRMULA GENERAL I, EN LA QUE R REPRESENTA UN GRUPO ELEGIDO ENTRE PIRAZOLILO, IMIDAZOLILO, TRIAZOLILO, OXAZOLILO, AXADIAZOLILO, TIAZOLILO, ISOTIAZOLILO, TIADIAZOLILO O TETRAZOLILO, PUDIENDO ESTAR ESTE GRUPO SUSTITUIDO OPCIONALMENTE CON UNO O VARIOS GRUPOS ELEGIDOS ENTRE ÁTOMOS DE HALÓGENOS, GURPOS ALQUILO (C1-C6), ALCOXI (C1-C6), TRIFLUOROMETOXI, TRIFLUOROMETILO, NITRO, CIANO, HIDROXI, AMINO, ALQUILAMINO (C1-C6) O DIALQUILAMINO (C1-C6); EL ENLACE CARBONO-CARBONO ENTRE LAS POSICIONES 3 Y 4 DEL CICLO AZABICICLOOCTANO ES SENCILLO O DOBLE; EN FORMA DE BASE O DE SAL DE ADICIÓN DE ÁCIDO, ASÍ COMO EN FORMA DE HIDRATO O DE SOLVATO. TAMBIÉN SE REFIERA A SU PROCESO DE PREPARACIÓN Y A SU APLICACIÓN TERAPÉUTICA. DICHOS COMPUESTOS PRESENTAN UNA BUENA AFINIDAD POR LOS RECEPTORES NICOTÍNICOS Y UNA BUENA SELECTIVIDAD FRENTE A LOS RECEPTORES NICOTÍNICOS QUE CONTIENE LA SUBUNIDAD ALFA-7.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0508528A FR2889701B1 (fr) | 2005-08-12 | 2005-08-12 | Derives de 5-pyridinyl-1-azabicyclo[3.2.1]octane, leur preparation en therapeutique. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GT200600368A true GT200600368A (es) | 2007-07-06 |
Family
ID=36273387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GT200600368A GT200600368A (es) | 2005-08-12 | 2006-08-10 | Derivados de 5-piridinil-1-azabiciclo[3.2.1]octano, su preparación y su aplicación en terapeutica |
Country Status (40)
| Country | Link |
|---|---|
| US (2) | US7863290B2 (es) |
| EP (1) | EP1915375B1 (es) |
| JP (1) | JP5164841B2 (es) |
| KR (1) | KR101299339B1 (es) |
| CN (1) | CN101238125B (es) |
| AT (1) | ATE444964T1 (es) |
| AU (1) | AU2006281341B2 (es) |
| BR (1) | BRPI0614623A2 (es) |
| CA (1) | CA2617828C (es) |
| CR (1) | CR9625A (es) |
| CY (1) | CY1109717T1 (es) |
| DE (1) | DE602006009668D1 (es) |
| DK (1) | DK1915375T3 (es) |
| DO (1) | DOP2006000180A (es) |
| EA (1) | EA014023B1 (es) |
| EC (1) | ECSP088170A (es) |
| ES (1) | ES2332472T3 (es) |
| FR (1) | FR2889701B1 (es) |
| GT (1) | GT200600368A (es) |
| HN (1) | HN2008000090A (es) |
| HR (1) | HRP20090677T1 (es) |
| IL (1) | IL188796A (es) |
| JO (1) | JO2583B1 (es) |
| MA (1) | MA30200B1 (es) |
| ME (1) | ME01750B (es) |
| MX (1) | MX2008001968A (es) |
| MY (1) | MY147846A (es) |
| NO (1) | NO20081151L (es) |
| NZ (1) | NZ565149A (es) |
| PE (1) | PE20070339A1 (es) |
| PL (1) | PL1915375T3 (es) |
| PT (1) | PT1915375E (es) |
| RS (1) | RS51068B (es) |
| SI (1) | SI1915375T1 (es) |
| TN (1) | TNSN07472A1 (es) |
| TW (1) | TWI324158B (es) |
| UA (1) | UA92917C2 (es) |
| UY (1) | UY29744A1 (es) |
| WO (1) | WO2007020344A1 (es) |
| ZA (1) | ZA200800958B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2912404B1 (fr) * | 2007-02-09 | 2009-04-10 | Sanofi Aventis Sa | Derives d'azabicycloalkane,leur preparation et leur application en therapeutique. |
| GB0817424D0 (en) | 2008-09-24 | 2008-10-29 | Medivir Ab | Protease inhibitors |
| JP2017114765A (ja) * | 2014-04-25 | 2017-06-29 | 大正製薬株式会社 | トリアゾリルで置換されたヘテロアリール化合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5817679A (en) * | 1993-04-01 | 1998-10-06 | University Of Virginia | 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands |
| EP0664293A1 (en) * | 1993-12-24 | 1995-07-26 | Duphar International Research B.V | 2-Phenyl-7-azabicycloheptanes and 6-phenyl-8-azabicyclo |
| HUP0002713A3 (en) * | 1997-05-30 | 2001-02-28 | Neurosearch As | 8-azabicyclo[3,2,1]oct-2-ene and octane derivatives, process for preparation thereof, pharmaceutical compositions comprising thereof and their use |
| FR2834511B1 (fr) * | 2002-01-07 | 2004-02-13 | Sanofi Synthelabo | Derives de 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique |
-
2005
- 2005-08-12 FR FR0508528A patent/FR2889701B1/fr not_active Expired - Lifetime
-
2006
- 2006-07-08 UA UAA200802988A patent/UA92917C2/uk unknown
- 2006-07-26 JO JO2006252A patent/JO2583B1/en active
- 2006-08-02 DO DO2006000180A patent/DOP2006000180A/es unknown
- 2006-08-07 JP JP2008525599A patent/JP5164841B2/ja not_active Expired - Fee Related
- 2006-08-07 KR KR1020087003271A patent/KR101299339B1/ko not_active Expired - Fee Related
- 2006-08-07 WO PCT/FR2006/001912 patent/WO2007020344A1/fr not_active Ceased
- 2006-08-07 RS RSP-2009/0576A patent/RS51068B/sr unknown
- 2006-08-07 DE DE602006009668T patent/DE602006009668D1/de active Active
- 2006-08-07 ME MEP-2009-576A patent/ME01750B/me unknown
- 2006-08-07 NZ NZ565149A patent/NZ565149A/en not_active IP Right Cessation
- 2006-08-07 AU AU2006281341A patent/AU2006281341B2/en not_active Ceased
- 2006-08-07 AT AT06794298T patent/ATE444964T1/de active
- 2006-08-07 EP EP06794298A patent/EP1915375B1/fr active Active
- 2006-08-07 CN CN2006800291833A patent/CN101238125B/zh not_active Expired - Fee Related
- 2006-08-07 EA EA200800575A patent/EA014023B1/ru not_active IP Right Cessation
- 2006-08-07 SI SI200630515T patent/SI1915375T1/sl unknown
- 2006-08-07 ES ES06794298T patent/ES2332472T3/es active Active
- 2006-08-07 ZA ZA200800958A patent/ZA200800958B/xx unknown
- 2006-08-07 PT PT06794298T patent/PT1915375E/pt unknown
- 2006-08-07 DK DK06794298.7T patent/DK1915375T3/da active
- 2006-08-07 BR BRPI0614623-6A patent/BRPI0614623A2/pt not_active IP Right Cessation
- 2006-08-07 HR HR20090677T patent/HRP20090677T1/hr unknown
- 2006-08-07 MX MX2008001968A patent/MX2008001968A/es active IP Right Grant
- 2006-08-07 PL PL06794298T patent/PL1915375T3/pl unknown
- 2006-08-07 CA CA2617828A patent/CA2617828C/fr not_active Expired - Fee Related
- 2006-08-10 GT GT200600368A patent/GT200600368A/es unknown
- 2006-08-10 PE PE2006000974A patent/PE20070339A1/es not_active Application Discontinuation
- 2006-08-10 MY MYPI20063888A patent/MY147846A/en unknown
- 2006-08-11 UY UY29744A patent/UY29744A1/es not_active Application Discontinuation
- 2006-08-11 TW TW095129651A patent/TWI324158B/zh not_active IP Right Cessation
-
2007
- 2007-12-14 TN TNP2007000472A patent/TNSN07472A1/en unknown
- 2007-12-20 CR CR9625A patent/CR9625A/es unknown
-
2008
- 2008-01-15 IL IL188796A patent/IL188796A/en not_active IP Right Cessation
- 2008-01-22 HN HN2008000090A patent/HN2008000090A/es unknown
- 2008-02-11 EC EC2008008170A patent/ECSP088170A/es unknown
- 2008-02-11 US US12/028,999 patent/US7863290B2/en not_active Expired - Fee Related
- 2008-03-04 NO NO20081151A patent/NO20081151L/no not_active Application Discontinuation
- 2008-03-07 MA MA30724A patent/MA30200B1/fr unknown
-
2010
- 2010-01-05 CY CY20101100013T patent/CY1109717T1/el unknown
- 2010-11-29 US US12/955,389 patent/US8541440B2/en not_active Expired - Fee Related
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