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NO20081151L - Derivater av 5-pyridinyl-1-azabicklo[3.2.1]oktan, fremgangsmate derav og anvendelse av de samme i terapi - Google Patents

Derivater av 5-pyridinyl-1-azabicklo[3.2.1]oktan, fremgangsmate derav og anvendelse av de samme i terapi

Info

Publication number
NO20081151L
NO20081151L NO20081151A NO20081151A NO20081151L NO 20081151 L NO20081151 L NO 20081151L NO 20081151 A NO20081151 A NO 20081151A NO 20081151 A NO20081151 A NO 20081151A NO 20081151 L NO20081151 L NO 20081151L
Authority
NO
Norway
Prior art keywords
azabicklo
pyridinyl
octane
therapy
derivatives
Prior art date
Application number
NO20081151A
Other languages
English (en)
Inventor
Frederic Galli
Odile Leclerc
Alistar Lochead
Julien Vache
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36273387&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20081151(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of NO20081151L publication Critical patent/NO20081151L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Oppfinnelsen vedrører forbindelser tilsvarende generell formel I, hvori R representerer en gruppe valgt fra pyrazolyl, imidazolyl, triazolyl, oksazolyl, oksadiazolyl, tiazolyl, isotiazolyl, tiadiazolyl og tetrazolyl, hvor denne gruppe eventuelt er substituert med en eller flere grupper valgt fra halogenatomer og (C-C)alkyl-, (C-C)alkoksy-, trifluorometoksy-, trifiuorometyl-, nitro-, cyano-, hydroksyl-, amino-, (C-C)alkylamino eller di(C-C)alkylaminogrupper; karbon-karbonbindingen mellom posisjoner 3 og 4 av azabisyklooktan-ringen er enkel eller dobbel; i form av base eller syreaddisjonssalt, samt i form av hydrat eller solvat. Fremgangsmåten ved fremstilling og anvendelse derav i terapi.
NO20081151A 2005-08-12 2008-03-04 Derivater av 5-pyridinyl-1-azabicklo[3.2.1]oktan, fremgangsmate derav og anvendelse av de samme i terapi NO20081151L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0508528A FR2889701B1 (fr) 2005-08-12 2005-08-12 Derives de 5-pyridinyl-1-azabicyclo[3.2.1]octane, leur preparation en therapeutique.
PCT/FR2006/001912 WO2007020344A1 (fr) 2005-08-12 2006-08-07 DÉRIVÉS DE δ-PYRIDINYL-i-AZABICYCLO[3.2.1]OCTANE, A LEUR PRÉPARATION ET LEUR APPLICATION EN THÉRAPEUTIQUE

Publications (1)

Publication Number Publication Date
NO20081151L true NO20081151L (no) 2008-05-13

Family

ID=36273387

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20081151A NO20081151L (no) 2005-08-12 2008-03-04 Derivater av 5-pyridinyl-1-azabicklo[3.2.1]oktan, fremgangsmate derav og anvendelse av de samme i terapi

Country Status (40)

Country Link
US (2) US7863290B2 (no)
EP (1) EP1915375B1 (no)
JP (1) JP5164841B2 (no)
KR (1) KR101299339B1 (no)
CN (1) CN101238125B (no)
AT (1) ATE444964T1 (no)
AU (1) AU2006281341B2 (no)
BR (1) BRPI0614623A2 (no)
CA (1) CA2617828C (no)
CR (1) CR9625A (no)
CY (1) CY1109717T1 (no)
DE (1) DE602006009668D1 (no)
DK (1) DK1915375T3 (no)
DO (1) DOP2006000180A (no)
EA (1) EA014023B1 (no)
EC (1) ECSP088170A (no)
ES (1) ES2332472T3 (no)
FR (1) FR2889701B1 (no)
GT (1) GT200600368A (no)
HN (1) HN2008000090A (no)
HR (1) HRP20090677T1 (no)
IL (1) IL188796A (no)
JO (1) JO2583B1 (no)
MA (1) MA30200B1 (no)
ME (1) ME01750B (no)
MX (1) MX2008001968A (no)
MY (1) MY147846A (no)
NO (1) NO20081151L (no)
NZ (1) NZ565149A (no)
PE (1) PE20070339A1 (no)
PL (1) PL1915375T3 (no)
PT (1) PT1915375E (no)
RS (1) RS51068B (no)
SI (1) SI1915375T1 (no)
TN (1) TNSN07472A1 (no)
TW (1) TWI324158B (no)
UA (1) UA92917C2 (no)
UY (1) UY29744A1 (no)
WO (1) WO2007020344A1 (no)
ZA (1) ZA200800958B (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2912404B1 (fr) * 2007-02-09 2009-04-10 Sanofi Aventis Sa Derives d'azabicycloalkane,leur preparation et leur application en therapeutique.
GB0817424D0 (en) 2008-09-24 2008-10-29 Medivir Ab Protease inhibitors
JP2017114765A (ja) * 2014-04-25 2017-06-29 大正製薬株式会社 トリアゾリルで置換されたヘテロアリール化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817679A (en) * 1993-04-01 1998-10-06 University Of Virginia 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
EP0664293A1 (en) * 1993-12-24 1995-07-26 Duphar International Research B.V 2-Phenyl-7-azabicycloheptanes and 6-phenyl-8-azabicyclo
HUP0002713A3 (en) * 1997-05-30 2001-02-28 Neurosearch As 8-azabicyclo[3,2,1]oct-2-ene and octane derivatives, process for preparation thereof, pharmaceutical compositions comprising thereof and their use
FR2834511B1 (fr) * 2002-01-07 2004-02-13 Sanofi Synthelabo Derives de 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
CN101238125B (zh) 2012-07-04
ME01750B (me) 2010-10-31
IL188796A0 (en) 2008-08-07
HN2008000090A (es) 2010-08-19
EP1915375B1 (fr) 2009-10-07
JP5164841B2 (ja) 2013-03-21
EA014023B1 (ru) 2010-08-30
JP2009505971A (ja) 2009-02-12
AU2006281341A1 (en) 2007-02-22
TNSN07472A1 (en) 2009-03-17
HRP20090677T1 (hr) 2010-01-31
ES2332472T3 (es) 2010-02-05
TWI324158B (en) 2010-05-01
PE20070339A1 (es) 2007-04-18
DK1915375T3 (da) 2010-02-15
ATE444964T1 (de) 2009-10-15
DE602006009668D1 (de) 2009-11-19
US7863290B2 (en) 2011-01-04
CR9625A (es) 2008-04-10
GT200600368A (es) 2007-07-06
KR101299339B1 (ko) 2013-08-26
RS51068B (sr) 2010-10-31
IL188796A (en) 2012-09-24
HK1120788A1 (en) 2009-04-09
DOP2006000180A (es) 2007-02-28
UY29744A1 (es) 2007-03-30
ECSP088170A (es) 2008-03-26
AU2006281341B2 (en) 2012-04-19
WO2007020344A1 (fr) 2007-02-22
FR2889701A1 (fr) 2007-02-16
BRPI0614623A2 (pt) 2011-04-12
PT1915375E (pt) 2009-11-26
PL1915375T3 (pl) 2010-03-31
MX2008001968A (es) 2008-03-26
UA92917C2 (uk) 2010-12-27
ZA200800958B (en) 2009-04-29
CN101238125A (zh) 2008-08-06
EP1915375A1 (fr) 2008-04-30
TW200740810A (en) 2007-11-01
US20080146608A1 (en) 2008-06-19
CY1109717T1 (el) 2014-08-13
SI1915375T1 (sl) 2010-01-29
CA2617828C (fr) 2014-03-11
JO2583B1 (en) 2011-02-27
EA200800575A1 (ru) 2008-06-30
KR20080033378A (ko) 2008-04-16
MY147846A (en) 2013-01-31
US20110077264A1 (en) 2011-03-31
CA2617828A1 (fr) 2007-02-22
US8541440B2 (en) 2013-09-24
MA30200B1 (fr) 2009-02-02
FR2889701B1 (fr) 2007-10-05
NZ565149A (en) 2011-05-27

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