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GT200200124A - Formulaciones autoemulsionantes de inhibidores de la proteina de transferencia de colesteril ester - Google Patents

Formulaciones autoemulsionantes de inhibidores de la proteina de transferencia de colesteril ester

Info

Publication number
GT200200124A
GT200200124A GT200200124A GT200200124A GT200200124A GT 200200124 A GT200200124 A GT 200200124A GT 200200124 A GT200200124 A GT 200200124A GT 200200124 A GT200200124 A GT 200200124A GT 200200124 A GT200200124 A GT 200200124A
Authority
GT
Guatemala
Prior art keywords
formulations
cholesterile
ester
inhibitors
emulsioning
Prior art date
Application number
GT200200124A
Other languages
English (en)
Inventor
Michael GUMKOWSKI
Sharad Balasaheb
Michael Ellis Perlman
Franco LOMBARDO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200200124A publication Critical patent/GT200200124A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Colloid Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A FORMULACIONES ENCAPSULADAS DE LA PROTEINA DE TRANSFERENCIA DE COLESTERIL ESTER (CETP), DE FORMULA GENERAL (I) EN DONDE RI1,RI3,RI4,RI5,RI6,RI7,RI8, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTAS FORMULACIONES PROPORCIONAN MAYORES CONCENTRACIONES DE INHIBIDORES DE CETP PARA LA ABSORCION Y, POR LO TANTO, UNA MAYOR BIODISPONIBILIDAD.
GT200200124A 2001-06-21 2002-06-19 Formulaciones autoemulsionantes de inhibidores de la proteina de transferencia de colesteril ester GT200200124A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30002801P 2001-06-21 2001-06-21

Publications (1)

Publication Number Publication Date
GT200200124A true GT200200124A (es) 2003-09-22

Family

ID=23157363

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200200124A GT200200124A (es) 2001-06-21 2002-06-19 Formulaciones autoemulsionantes de inhibidores de la proteina de transferencia de colesteril ester

Country Status (33)

Country Link
US (2) US6962931B2 (es)
EP (1) EP1453544A2 (es)
JP (1) JP2005500314A (es)
KR (1) KR20040015746A (es)
CN (1) CN1635911A (es)
AP (1) AP2002002559A0 (es)
AR (1) AR034599A1 (es)
BG (1) BG108486A (es)
BR (1) BR0210505A (es)
CA (1) CA2455288A1 (es)
CR (1) CR7163A (es)
CZ (1) CZ20033341A3 (es)
EA (1) EA200301139A1 (es)
EC (1) ECSP034875A (es)
EE (1) EE200400024A (es)
GT (1) GT200200124A (es)
HN (1) HN2002000153A (es)
HU (1) HUP0400263A2 (es)
IL (1) IL158765A0 (es)
IS (1) IS7014A (es)
MA (1) MA27034A1 (es)
MX (1) MXPA04000014A (es)
NO (1) NO20035632L (es)
OA (1) OA12619A (es)
PA (1) PA8548601A1 (es)
PE (1) PE20030128A1 (es)
PL (1) PL368850A1 (es)
SK (1) SK15172003A3 (es)
SV (1) SV2003001103A (es)
TN (1) TNSN03139A1 (es)
UY (1) UY27344A1 (es)
WO (1) WO2003000295A2 (es)
ZA (1) ZA200308561B (es)

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JP2005500314A (ja) 2005-01-06
IL158765A0 (en) 2004-05-12
ZA200308561B (en) 2004-11-17
MXPA04000014A (es) 2004-05-21
BG108486A (bg) 2005-03-31
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WO2003000295A2 (en) 2003-01-03
EP1453544A2 (en) 2004-09-08
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CZ20033341A3 (cs) 2004-10-13
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US20060014788A1 (en) 2006-01-19
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CA2455288A1 (en) 2003-01-03
BR0210505A (pt) 2004-05-18
CN1635911A (zh) 2005-07-06
OA12619A (en) 2006-06-12
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