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GT199900198A - Azalidas de 13 miembros y su uso como agentes antibioticos. - Google Patents

Azalidas de 13 miembros y su uso como agentes antibioticos.

Info

Publication number
GT199900198A
GT199900198A GT199900198A GT199900198A GT199900198A GT 199900198 A GT199900198 A GT 199900198A GT 199900198 A GT199900198 A GT 199900198A GT 199900198 A GT199900198 A GT 199900198A GT 199900198 A GT199900198 A GT 199900198A
Authority
GT
Guatemala
Prior art keywords
members
new
birds
mammals
azalidas
Prior art date
Application number
GT199900198A
Other languages
English (en)
Inventor
Robert John Rafka
Barry James Morton
Colman Brendan Ragan
Peter Bertinato
John Philip Dirlam
Alan Elwood Blize
Carl Bernard Ziegler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22327457&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GT199900198(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of GT199900198A publication Critical patent/GT199900198A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

ESTA INVENCION SE REFIERE A NUEVAS AZALIDAS DE L3 MIEMBROS (ESTRUCTURA REPRESENTADA POR LA "FORMULA I", DONDE LAS LETRAS"R" REPRESENTAN POSIBLES GRUPOS FUNCIONALES QUE PUEDEN INTERCAMBIARSE Y CUYOS NOMBRES ESPECIFICOS SE HALLAN LISTADOS EN EL DOCUMENTO ORIGINAL), QUE SON UTILES COMO AGENTES ANTIBACTERIANOS Y ANTIPROTOZOARIOS EN LOS MAMIFEROS, INCLUYENDO AL SER HUMANO, ASI COMO EN PECES Y AVES. ESTA INVENCION TAMBIEN SE REFIERE A COMPOSICIONES FARMACEUTICAS QUE CONTIENEN LOS NUEVOS COMPUESTOS Y A PROCEDIMIENTOS PARA EL TRATAMIENTO DE INFECCIONES BACTERIANAS E INFECCIONES PROTOZOARIAS EN MAMIFEROS, PECES Y AVES, MEDIANTE LA ADMINISTRACION DE LOS NUEVOS COMPUESTOS A LOS MAMIFEROS, PECES Y AVES QUE REQUIEREN TAL TRATAMIENTO.
GT199900198A 1998-11-20 1999-11-18 Azalidas de 13 miembros y su uso como agentes antibioticos. GT199900198A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10939998P 1998-11-20 1998-11-20

Publications (1)

Publication Number Publication Date
GT199900198A true GT199900198A (es) 2001-05-11

Family

ID=22327457

Family Applications (1)

Application Number Title Priority Date Filing Date
GT199900198A GT199900198A (es) 1998-11-20 1999-11-18 Azalidas de 13 miembros y su uso como agentes antibioticos.

Country Status (46)

Country Link
US (1) US6329345B1 (es)
EP (1) EP1131331B1 (es)
JP (1) JP3842973B2 (es)
KR (1) KR100477774B1 (es)
CN (2) CN101367853A (es)
AP (1) AP2001002142A0 (es)
AR (3) AR019496A1 (es)
AT (1) ATE260927T1 (es)
AU (1) AU766106B2 (es)
BG (1) BG65107B1 (es)
BR (2) BRPI9915480B1 (es)
CA (1) CA2351429C (es)
CO (1) CO5380019A1 (es)
CZ (1) CZ303099B6 (es)
DE (1) DE69915336T2 (es)
DK (1) DK1131331T3 (es)
DZ (1) DZ2944A1 (es)
EA (2) EA009729B1 (es)
EG (1) EG23823A (es)
ES (1) ES2216581T3 (es)
GT (1) GT199900198A (es)
HK (1) HK1041269A1 (es)
HR (1) HRP20010374B1 (es)
HU (1) HU229008B1 (es)
ID (1) ID28548A (es)
IL (3) IL142631A0 (es)
IS (1) IS2350B (es)
MA (1) MA26707A1 (es)
ME (1) ME00467B (es)
MY (1) MY122353A (es)
NO (3) NO319796B1 (es)
NZ (1) NZ511199A (es)
OA (1) OA11713A (es)
PA (1) PA8485601A1 (es)
PE (1) PE20001378A1 (es)
PL (1) PL198580B1 (es)
PT (1) PT1131331E (es)
RS (1) RS50302B (es)
SI (1) SI1131331T1 (es)
SK (1) SK284607B6 (es)
TN (1) TNSN99214A1 (es)
TW (2) TWI243824B (es)
UA (1) UA70972C2 (es)
UY (1) UY25805A1 (es)
WO (1) WO2000031097A1 (es)
ZA (1) ZA200104019B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN1998000086A (es) 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
UA70972C2 (uk) * 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків
IL145739A0 (en) * 1999-05-24 2002-07-25 Pfizer Prod Inc 13-methyl-erythromycin derivatives
US6465437B1 (en) * 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
CZ20023409A3 (cs) * 2000-04-27 2004-01-14 Pfizer Products Inc. Použití kompozic na bázi azalidových antibiotik pro léčení nebo prevenci bakteriálních nebo protozoálních infekcí u savců
BR0209241A (pt) * 2001-04-27 2004-06-15 Pfizer Prod Inc Processo para preparação de derivados de9-deoxo-9a-aza-9a-homoeritromicina a 4-substituida
JP4311203B2 (ja) * 2001-08-08 2009-08-12 大正製薬株式会社 １１ａ−アザライド化合物及びその製造方法
EP3738591A3 (en) * 2003-03-10 2021-03-24 Merck Sharp & Dohme Corp. Novel antibacterial agents
WO2004108744A2 (en) * 2003-05-19 2004-12-16 Prasad K Deshpande Azalides and azaketolides having antimicrobial activity
BRPI0416205A (pt) * 2003-11-21 2006-12-26 Pfizer Prod Inc uso de antibióticos como adjuvantes de vacina
EP1985620A4 (en) * 2006-02-07 2012-08-15 Taisho Pharmaceutical Co Ltd COMPOUND 10a-AZALIDE
JPWO2009019868A1 (ja) * 2007-08-06 2010-10-28 大正製薬株式会社 １０ａ、１２位架橋型１０ａ−アザライド化合物
US8299035B2 (en) 2008-05-15 2012-10-30 Taisho Pharmaceutucal Co., Ltd. 10a-azalide compound having 4-membered ring structure
CN103080121B (zh) * 2010-09-20 2015-11-25 瑞士诺华动物保健有限公司 用于制备在二脱氧甲基己糖环的C-4”处被环氧基团修饰的9-脱氧-9a-氮杂-9a-高红霉素A的新方法
CN102295672B (zh) * 2011-07-13 2014-06-04 武汉回盛生物科技有限公司 一种泰拉菌素的合成方法
EP2736915A1 (en) 2011-07-27 2014-06-04 Farma GRS, d.o.o. New crystalline forms of tulathromycin
CN102786569B (zh) * 2012-09-07 2016-12-07 安徽中升药业有限公司 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法
SI3027634T1 (sl) * 2013-07-31 2018-10-30 Farma Grs, D.O.O. Proces za pripravo tulatromicina
CN105085590A (zh) * 2014-05-16 2015-11-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
US20220177508A1 (en) * 2018-11-19 2022-06-09 Zikani Therapeutics, Inc. C10-Cyclic Substituted 13-Membered Macrolides and Uses Thereof
IL283194B2 (en) * 2018-11-19 2025-03-01 Zikani Therapeutics Inc C10-alkylene substituted 13-membered macrolides and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI7910768A8 (en) 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
YU43006B (en) * 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
SI8611592A8 (en) * 1986-09-12 1995-04-30 Pliva Pharm & Chem Works Process for preparing complexes of N-methyl-11-aza-10-deoxo-10-dihydroeritromicine A and 11-aza-10-deoxo-10-dihydroeritromicine A with metals
US5106961A (en) 1987-05-26 1992-04-21 Eli Lilly And Company Erythromycin ring-contracted derivatives
SI9011409A (en) 1990-07-18 1995-10-31 Pliva Pharm & Chem Works O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
HRP931480B1 (en) * 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
GB2327084A (en) * 1997-07-08 1999-01-13 Merck & Co Inc 9a-Aza-3-ketolide antibiotics
UA70972C2 (uk) * 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків

Also Published As

Publication number Publication date
ID28548A (id) 2001-05-31
ES2216581T3 (es) 2004-10-16
TWI243824B (en) 2005-11-21
NO20012464L (no) 2001-07-17
JP3842973B2 (ja) 2006-11-08
CN101367853A (zh) 2009-02-18
BR9915480A (pt) 2001-07-31
DZ2944A1 (fr) 2004-03-15
AR059524A2 (es) 2008-04-09
BRPI9915480B1 (pt) 2015-12-29
IS5918A (is) 2001-04-17
PL347784A1 (en) 2002-04-22
UY25805A1 (es) 2001-08-27
TW200404077A (en) 2004-03-16
SK284607B6 (sk) 2005-07-01
EA200400701A1 (ru) 2004-12-30
OA11713A (en) 2005-01-25
TWI243825B (en) 2005-11-21
EP1131331B1 (en) 2004-03-03
HRP20010374A2 (en) 2002-06-30
PA8485601A1 (es) 2000-09-29
ZA200104019B (en) 2002-06-17
AP2001002142A0 (en) 2001-05-09
NZ511199A (en) 2003-08-29
EA005156B1 (ru) 2004-12-30
CN1326460A (zh) 2001-12-12
CO5380019A1 (es) 2004-03-31
SI1131331T1 (en) 2004-08-31
NO319796B1 (no) 2005-09-19
SK6632001A3 (en) 2002-07-02
BG105600A (en) 2001-12-29
JP2002530422A (ja) 2002-09-17
CA2351429A1 (en) 2000-06-02
PE20001378A1 (es) 2000-12-14
HUP0104313A3 (en) 2003-12-29
WO2000031097A1 (en) 2000-06-02
ATE260927T1 (de) 2004-03-15
AU766106B2 (en) 2003-10-09
IL142631A (en) 2010-05-31
UA70972C2 (uk) 2004-11-15
HU229008B1 (en) 2013-07-29
HRP20010374B1 (en) 2006-09-30
PL198580B1 (pl) 2008-06-30
HK1041269A1 (zh) 2002-07-05
IS2350B (is) 2008-04-15
NO20050904L (no) 2001-07-17
KR100477774B1 (ko) 2005-03-21
CZ20011754A3 (cs) 2002-03-13
EG23823A (en) 2007-09-19
DK1131331T3 (da) 2004-06-14
PT1131331E (pt) 2004-06-30
HUP0104313A2 (hu) 2002-02-28
NO329629B1 (no) 2010-11-22
NO20012464D0 (no) 2001-05-18
TNSN99214A1 (fr) 2005-11-10
IL142631A0 (en) 2002-03-10
MA26707A1 (fr) 2004-12-20
BRPI9915480B8 (pt) 2022-05-10
US6329345B1 (en) 2001-12-11
IL189430A (en) 2010-05-31
EA009729B1 (ru) 2008-02-28
EP1131331A1 (en) 2001-09-12
AR059523A2 (es) 2008-04-09
CA2351429C (en) 2005-07-12
CZ303099B6 (cs) 2012-04-04
AU1068600A (en) 2000-06-13
AR019496A1 (es) 2002-02-20
NO330249B1 (no) 2011-03-14
DE69915336D1 (de) 2004-04-08
MY122353A (en) 2006-04-29
YU33401A (sh) 2004-05-12
NO20050893L (no) 2001-07-17
ME00467B (me) 2011-10-10
BG65107B1 (bg) 2007-02-28
IL189430A0 (en) 2008-06-05
DE69915336T2 (de) 2005-01-13
RS50302B (sr) 2009-09-08
EA200100416A1 (ru) 2001-10-22
KR20010086043A (ko) 2001-09-07

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