GR3001137T3 - Means for detecting peroxidase activity with a stabilizer, preparation process and its use - Google Patents
Means for detecting peroxidase activity with a stabilizer, preparation process and its useInfo
- Publication number
- GR3001137T3 GR3001137T3 GR90400904T GR900400904T GR3001137T3 GR 3001137 T3 GR3001137 T3 GR 3001137T3 GR 90400904 T GR90400904 T GR 90400904T GR 900400904 T GR900400904 T GR 900400904T GR 3001137 T3 GR3001137 T3 GR 3001137T3
- Authority
- GR
- Greece
- Prior art keywords
- peroxidase activity
- stabilizer
- preparation process
- detecting peroxidase
- detecting
- Prior art date
Links
- 102000003992 Peroxidases Human genes 0.000 title abstract 2
- 108040007629 peroxidase activity proteins Proteins 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 1
- 239000003381 stabilizer Substances 0.000 title 1
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 229930182555 Penicillin Natural products 0.000 abstract 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000012928 buffer substance Substances 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 229940049954 penicillin Drugs 0.000 abstract 1
- 150000002978 peroxides Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/721—Haemoglobin
- G01N33/725—Haemoglobin using peroxidative activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2326/00—Chromogens for determinations of oxidoreductase enzymes
- C12Q2326/10—Benzidines
- C12Q2326/12—3,3',5,5'-Tetramethylbenzidine, i.e. TMB
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/904—Oxidation - reduction indicators
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Enzymes And Modification Thereof (AREA)
- Dram (AREA)
- Peptides Or Proteins (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853541979 DE3541979A1 (de) | 1985-11-28 | 1985-11-28 | Mittel zur bestimmung von peroxidase-aktivitaet mit stabilisator, verfahren zur herstellung und seine verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3001137T3 true GR3001137T3 (en) | 1992-06-25 |
Family
ID=6287014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR90400904T GR3001137T3 (en) | 1985-11-28 | 1990-11-30 | Means for detecting peroxidase activity with a stabilizer, preparation process and its use |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4891314A (el) |
| EP (1) | EP0224813B1 (el) |
| JP (1) | JPH0722519B2 (el) |
| AT (1) | ATE56991T1 (el) |
| AU (1) | AU611629B2 (el) |
| CA (1) | CA1291401C (el) |
| DE (2) | DE3541979A1 (el) |
| DK (1) | DK571186A (el) |
| ES (1) | ES2018154B3 (el) |
| FI (1) | FI85504C (el) |
| GR (1) | GR3001137T3 (el) |
| MX (1) | MX170909B (el) |
| NO (1) | NO171417C (el) |
| PT (1) | PT83825B (el) |
| ZA (1) | ZA868981B (el) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3541978A1 (de) * | 1985-11-28 | 1987-06-04 | Behringwerke Ag | Mittel zur bestimmung von peroxidase-aktivitaet, verfahren zur herstellung und seine verwendung |
| US4895798A (en) * | 1987-11-13 | 1990-01-23 | Miles, Inc. | Test devices for determination of occult blood |
| IE68446B1 (en) * | 1989-07-19 | 1996-06-12 | Noctech Technology Limited | A colour stable chromogen composition |
| US5225325A (en) * | 1990-03-02 | 1993-07-06 | Ventana Medical Systems, Inc. | Immunohistochemical staining method and reagents therefor |
| US5532138A (en) * | 1990-04-26 | 1996-07-02 | Behringwerke Ag | Method and kits for determining peroxidatively active catalysts |
| US5215885A (en) * | 1990-10-23 | 1993-06-01 | Beckman Instruments, Inc. | Stable two-part chromogen substrate |
| US5206150A (en) * | 1990-10-26 | 1993-04-27 | University Of Kentucky Research Foundation | Composition of, method of producing and method of using a stabilized formulation for assaying peroxidase activity |
| DE4037776A1 (de) * | 1990-11-28 | 1992-06-04 | Behringwerke Ag | Waschloesung fuer festphasen-immunometrisches verfahren, die einen komplexbildner fuer metallionen enthaelt und ihre verwendung |
| DE4037764A1 (de) | 1990-11-28 | 1992-06-04 | Behringwerke Ag | Waschloesung fuer festphasen-immunometrische verfahren, die stabilisatoren fuer das markierungssystem enthaelt und ihre verwendung |
| GB9027131D0 (en) * | 1990-12-14 | 1991-02-06 | Rice Evans Catherine | Diagnostic test |
| US5332662A (en) * | 1992-07-31 | 1994-07-26 | Syntex (U.S.A.) Inc. | Methods for determining peroxidatively active substances |
| US5447868A (en) | 1993-09-14 | 1995-09-05 | Propper Manufacturing Co. Inc. | Method, reagent and kit for the detection of fecal occult blood |
| US5925532A (en) * | 1995-03-14 | 1999-07-20 | The Trustees Of Columbia University In The City Of New York | Enhancing the sensitivity of immunoassay procedures by use of antibodies directed to the product of a reaction between probe labels and assay substrates |
| US5650284A (en) * | 1995-03-14 | 1997-07-22 | The Trustees Of Columbia University In The City Of New York | Enhancing the sensitivity of immunoassay procedures by use of antibodies directed to the product of a reaction between probe labels and assay substrates |
| DE19544150C2 (de) * | 1995-11-16 | 2002-06-13 | Seramun Diagnostica Gmbh | Stabile 3,3',5,5'-Tetramethylbenzidin-Lösungen |
| US5804404A (en) * | 1996-01-22 | 1998-09-08 | Dako Corporation | Stable substrate-chromogen solutions for enenzyme activity detection |
| CN1114830C (zh) * | 1997-06-18 | 2003-07-16 | 金红军 | 过氧化物酶测定用显色底物组合物 |
| WO1999004261A1 (en) | 1997-07-15 | 1999-01-28 | Kem-En-Tec A/S | Pre-stained 3,3',5,5'-tetramethylbenzidine substrates for the detection of enzyme activity |
| CN101354354B (zh) * | 2007-07-23 | 2010-06-23 | 深圳市生科源技术有限公司 | 一种过氧化物酶测定用显色液体系及其制备方法 |
| US9393249B2 (en) | 2008-03-26 | 2016-07-19 | Institute Of Technology Sligo | Antimicrobial composition |
| CN103712982B (zh) * | 2013-12-13 | 2016-02-03 | 山东博科生物产业有限公司 | 一种高灵敏度的tmb显色液及其制备方法 |
| CN103884563B (zh) * | 2014-04-10 | 2016-08-17 | 上海太阳生物技术有限公司 | 过氧化物酶（pox）染色液（化学染色法） |
| CN105116141B (zh) * | 2015-07-02 | 2016-09-14 | 深圳市卫光生物制品股份有限公司 | 一种单组份tmb显色液及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2460903C3 (de) * | 1974-12-21 | 1981-12-24 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue 3,3',5,5'-Tetraalkylbenzidine |
| JPS5263794A (en) * | 1975-11-21 | 1977-05-26 | Shionogi Seiyaku Kk | Test piece for latent blood |
| US4077772A (en) * | 1977-05-31 | 1978-03-07 | Baxter Travenol Laboratories, Inc. | Method for the determination of hemoglobin in trace amounts |
| US4340394A (en) * | 1979-11-13 | 1982-07-20 | Miles Laboratories, Inc. | Stabilization of benzidine-type indicators with various enhancers |
| US4503143A (en) * | 1982-08-20 | 1985-03-05 | Btc Diagnostics Limited Partnership | Enzyme immunoassay with two-part solution of tetramethylbenzidine as chromogen |
| US4504579A (en) * | 1982-11-08 | 1985-03-12 | Abbott Laboratories | Stabilized peroxidase compositions |
| ZA841078B (en) * | 1983-03-01 | 1984-09-26 | Warner Lambert Co | Peroxidase activity detection composition |
| EP0121137A1 (en) * | 1983-04-04 | 1984-10-10 | Combustion Engineering, Inc. | Seal welded tube sleeve |
| US4789630A (en) * | 1985-10-04 | 1988-12-06 | Cetus Corporation | Ionic compounds containing the cationic meriquinone of a benzidine |
| DE3541978A1 (de) * | 1985-11-28 | 1987-06-04 | Behringwerke Ag | Mittel zur bestimmung von peroxidase-aktivitaet, verfahren zur herstellung und seine verwendung |
-
1985
- 1985-11-28 DE DE19853541979 patent/DE3541979A1/de not_active Withdrawn
-
1986
- 1986-11-21 DE DE8686116138T patent/DE3674549D1/de not_active Expired - Lifetime
- 1986-11-21 ES ES86116138T patent/ES2018154B3/es not_active Expired - Lifetime
- 1986-11-21 AT AT86116138T patent/ATE56991T1/de not_active IP Right Cessation
- 1986-11-21 EP EP86116138A patent/EP0224813B1/de not_active Expired - Lifetime
- 1986-11-26 US US06/935,332 patent/US4891314A/en not_active Expired - Lifetime
- 1986-11-26 FI FI864815A patent/FI85504C/fi not_active IP Right Cessation
- 1986-11-27 AU AU65779/86A patent/AU611629B2/en not_active Ceased
- 1986-11-27 DK DK571186A patent/DK571186A/da not_active Application Discontinuation
- 1986-11-27 MX MX004450A patent/MX170909B/es unknown
- 1986-11-27 JP JP61280950A patent/JPH0722519B2/ja not_active Expired - Lifetime
- 1986-11-27 ZA ZA868981A patent/ZA868981B/xx unknown
- 1986-11-27 PT PT83825A patent/PT83825B/pt not_active IP Right Cessation
- 1986-11-27 NO NO864775A patent/NO171417C/no not_active IP Right Cessation
- 1986-11-28 CA CA000524124A patent/CA1291401C/en not_active Expired - Lifetime
-
1990
- 1990-11-30 GR GR90400904T patent/GR3001137T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO864775D0 (no) | 1986-11-27 |
| ATE56991T1 (de) | 1990-10-15 |
| ES2018154B3 (es) | 1991-04-01 |
| DK571186A (da) | 1987-05-29 |
| MX170909B (es) | 1993-09-22 |
| US4891314A (en) | 1990-01-02 |
| EP0224813A1 (de) | 1987-06-10 |
| NO171417C (no) | 1993-03-10 |
| AU611629B2 (en) | 1991-06-20 |
| AU6577986A (en) | 1987-06-04 |
| PT83825B (pt) | 1989-06-30 |
| JPH0722519B2 (ja) | 1995-03-15 |
| DE3674549D1 (de) | 1990-10-31 |
| CA1291401C (en) | 1991-10-29 |
| FI864815A0 (fi) | 1986-11-26 |
| DK571186D0 (da) | 1986-11-27 |
| DE3541979A1 (de) | 1987-06-04 |
| ZA868981B (en) | 1987-07-29 |
| FI85504C (fi) | 1992-04-27 |
| NO171417B (no) | 1992-11-30 |
| FI85504B (fi) | 1992-01-15 |
| FI864815L (fi) | 1987-05-29 |
| JPS62130700A (ja) | 1987-06-12 |
| EP0224813B1 (de) | 1990-09-26 |
| PT83825A (de) | 1986-12-01 |
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