FR3066918B1 - CHINESE MEDICINE FOR THE TREATMENT OF HYPEROSTOSIS - Google Patents

Abstract

The present invention discloses a Chinese medicine for the treatment of hyperostosis, characterized in that it is prepared from the following material components expressed in parts by weight: 20 to 30 parts of sheep bone, 10 to 20 parts of Carthamus tinctorius, 10 to 20 parts of Angelica dahurica, 5 to 10 parts of Eucommia ulmoides, 5 to 10 parts of Magnolia Biondii flower, 4 to 8 parts of couch grass root and 3 to 9 parts of Glycyrrhiza uralensis. The Chinese medicament of the invention for the treatment of hyperostosis has inhibitory effects for the treatment of primary hyperostosis and secondary hyperostosis.

Description

TECHNICAL AREA

The present invention relates to a Chinese medicine for the treatment of hyperostosis.

BACKGROUND Hyperostosis, also known as proliferative bone arthritis, osteoarthritis (OA), degenerative osteoarthritis, senile arthritis, hypertrophic arthritis, is a disease with symptoms of arthralgia, loss of mobility etc. in case of excess load on the joint, and is caused by the degeneration and disappearance of the cartilage, intervertebral disc, ligament and other soft tissues, the bone spur and the thickening of the synovium appear at the edge of the joint, resulting in bone destruction to cause bone hyperplasia and dysarthritis that follow. It is of two types, primary hyperostosis and secondary hyperostosis. There is no effective treatment, and their treatment lies in providing a calcium-rich supplement.

Symptoms and signs: 1. Cervical vertebral hyperosteogenesis

Clinical manifestation: stiff neck, loss of mobility, click in case of neck movement, pain radiating to the shoulder and upper limbs, numbness and sensation of electric shock to hands and fingers, exacerbated by the movement of the neck, different lesions involving different parts showing different symptoms, and possibly leading to paralysis at the final stage; patients with severe cervical vertebral hyperosteogenesis also suffering from hypertension due to cervical spondylosis, cardiovascular and cerebrovascular diseases, gastritis, angina, dysphagia, etc. 2. Lumbar vertebral hyperosteogenesis:

The primary sites are most often the third and fourth lumbar vertebrae; clinical manifestations are acute soft tissue pain in waist and lumbar vertebrae, swelling pain, stiffness and fatigue, regular loss of flexion; pressing the adjacent nerve roots causes corresponding symptoms of local pain, stiffness, dorsal root neuralgia, numbness, etc. ; and pressing the sciatic nerve results in sciatic neuritis, numbness and severe pain, causalgia, pulsating pain, and erratic pain in the affected limb radiating to the total lower limb. 3. Hyperosteogenesis of knee joint:

In the early, early stage, the slow patient has no severe pain in the knee joints, but a dull ache may continue; as a result of climate change, the pain is exacerbated with decreasing temperature; at the beginning of movement in the morning, after a long walk, in case of intense exercise or in case of walking after sitting for a long time, the patient suffers from stiffness and pain in the joints knee, but will be better after a little movement; it is difficult for the patient to ascend or descend, the knee joint becomes weak and falls easily from the stairs; if he gets up from squatting, he has stiffness and pain in the knee joints, if it is severe, he has stiffness of the knee joint and pain due to swelling, and a limp; for the patient also having rheumatism, the knee joint is red, swollen and abnormal, with a functional limitation; there is click sound when stretching and flexing the knee joint; some patients have dropsy of the joint and obvious compression and swelling at the local part of the joint. Sheep bone contains calcium phosphate, calcium carbonate and collagen. It has the property and quality of warming the liver and the effects of improving the kidney and muscles. It can be used for the treatment of eclampsia diseases of thrombocytopenia, aplastic anemia, arthralgia and myalgia, weakening of the waist, gonorrhea, stranguria, chronic diarrhea, persistent dysentery, etc. In the book entitled Yin Shi Zheng Yao, a listed sheep bone slurry, which is prepared from a pair of mutton bones (fractured), 6 g dried mandarin peel, 6 g galangal, 6 g of Amomum tsao-ko, 30 g of fresh ginger, and a little salt, cooked with water, has a good effect on the treatment consumption and the weakness of the size.

Therefore, it is necessary to develop a Chinese medicine with sheep bone as the main component of material to treat hyperostosis.

SUMMARY OF THE INVENTION The object of the invention is to provide a Chinese medicament with sheep bone as the main component, formulated by combination with the effects of traditional medicinal material and the research result of modern pharmacology, and having a good property of global medicine and a good development effect. On the one hand, the invention provides a Chinese medicine for the treatment of hyperostosis, characterized in that it is prepared from the following material components expressed in parts by weight: 20 to 30 parts of sheep bone , 10 to 20 parts of Carthamus tinctorius, 10 to 20 parts of Angelica dahurica, 5 to 10 parts of Eucommia ulmoides, 5 to 10 parts of Magnolia Biondii Flower, 4 to 8 parts of quackgrass root and 3 to 9 parts of Glycyrrhiza uralensis.

The process for the preparation of the above Chinese medicine comprises the following steps: Preparation step of the material: prepare the following components expressed in parts by weight: 20 to 30 parts of sheep bone, 10 to 20 parts of Dioscorea opposita, to 20 parts of Angelica dahurica, 5 to 10 parts of Eucommia ulmoides, 5 to 10 parts of Magnolia Biondii flower, 4-8 parts of quackgrass root, 3-9 parts of Glycyrrhiza uralensis; Grinding step: mix the above components evenly, grind them into powders; Decoction step: place the above powders in boiling water 10 to 20 times the part by weight of powder, boil for 3 to 5 minutes, and make a decoction at a reduced temperature for 30 to 50 minutes to obtain the Chinese medicine of the invention to treat hyperostosis.

The method of applying the Chinese medicament of the invention comprises: an external application: uniformly applying the Chinese medicine to the affected part, three times a day, for a five-day course of treatment; oral administration: take 50 ml of the Chinese medicine, mix in 40 ml hot boiling water, shake evenly and take it.

The medicinal properties of the constituent materials used in the preparation are as follows:

Sheep bone: sheep bone contains calcium phosphate, calcium carbonate and collagen; it has the property and quality of warming the liver and the effect of improving the kidney and muscles; it can be prescribed for eclampsia diseases of thrombocytopenia, aplastic anemia, arthralgia and myalgia, weakening of the waist, gonorrhea, stranguria, chronic diarrhea , persistent dysentery, etc. The chemical components of the bone are different according to the parts and the age. Among the components, the most obvious are water and lipids. Bone contains a large amount of inorganic substances, with calcium phosphate accounting for more than half. In addition, it also contains a small amount of calcium carbonate, magnesium phosphate and trace amounts of fluoride, chlorine, sodium, potassium, iron, aluminum, etc. Although the fluoride content is low, it is an important component of bone. The organic substances contained in the bone are collagen, the osseomucoid, an elastin-type substance; there is also neutral fat (more in content), phospholipids and less glycogen, etc.

The Chinese medicament of the invention for the treatment of hyperostosis has inhibitory effects for the treatment of primary hyperostosis and secondary hyperostosis, furthermore, the invention also has technical effects of pain relief and strengthening the movement capacity of the joint. The Chinese drug of the invention can be both externally applied and taken orally; and it will provide a better treatment effect by combining the external application with oral administration. Other features and advantages of the invention will be described in detail from the following embodiments.

DETAILED DESCRIPTION OF THE EMBODIMENTS

While still general, the invention provides a Chinese medicine for the treatment of hyperostosis whose components comprise the following in parts by weight: 20 to 30 parts of sheep bone, 10 to 20 parts of Dioscorea opposita, to 20 parts of Angelica dahurica, 5 to 10 parts of Eucommia ulmoides, 5 to 10 parts of Magnolia Biondii flower, 4 to 8 parts of quackgrass root, 3 to 9 parts of Glycyrrhiza uralensis.

The process for the preparation of the above Chinese medicament comprises the following steps: Preparation step of the materials: prepare the following components expressed in parts by weight: 20 to 30 parts of sheep bone, 10 to 20 parts of Dioscorea opposita, to 20 parts of Angelica dahurica, 5 to 10 parts of Eucommia ulmoides, 5 to 10 parts of Magnolia Biondii flower pentadactyla, 4-8 parts of quackgrass root, 3-9 parts of Glycyrrhiza uralensis; Grinding step: mix the above components evenly, grind them into powders; Decoction step: place the above powders in boiling water 10 to 20 times the part by weight of powder, boil for 3 to 5 minutes, and make a decoction at a reduced temperature for 30 to 50 minutes to obtain the Chinese medicine of the invention to treat hyperostosis.

The method of applying the Chinese medicament of the invention comprises: an external application: uniformly applying the Chinese medicine to the affected part, three times a day, for a five-day course of treatment; oral administration: take 50 ml of Chinese medicine, mix in 40 ml hot boiling water, shake evenly and take it.

The Chinese medicament of the invention for the treatment of hyperostosis has inhibitory effects for the treatment of primary hyperostosis and secondary hyperostosis, furthermore, the invention also has technical effects of pain relief and strengthening the movement capacity of the joint. The Chinese drug of the invention can be both externally applied and taken orally, it will provide a better treatment effect by combining the external application with oral administration. The invention is described in more detail by the following examples.

Example 1

Treatment of mild primary hyperostosis:

The Chinese medicament of the invention for the treatment of hyperostosis is obtained by having 20 g of sheep bone, 10 g of Dioscorea opposita, 10 g of Angelica dahurica, 5 g of Eucommia ulmoides, 5 g of Biondii Magnolia Flower, 4 g of quackgrass root, 3 g of Glycyrrhiza uralensis; uniformly mix the above components, grind them into powders; place the above powders in boiling water 10 to 20 times the part by weight of powder, boil for 3 to 5 minutes, and make a decoction at a reduced temperature for 30 to 50 minutes.

The above Chinese medicine is uniformly applied to the affected part three times a day for a five-day course of treatment; the pain is clearly relieved after three therapeutic courses; the pain is eliminated after eight therapeutic courses; and healed after continuous application for fifteen therapeutic cures.

Example 2

Treatment of moderate primary hyperostosis:

The Chinese medicament of the invention for the treatment of hyperostosis is obtained by having 22 g of sheep bone, 10 g of Dioscorea opposita, 13 g of Angelica dahurica, 6 g of Eucommia ulmoides, 6 g of Biondii Magnolia Flower, 4 g of quackgrass root, 3 g of Glycyrrhiza uralensis; uniformly mix the above components, grind them into powders; place the above powders in boiling water 10 to 20 times the part by weight of powder, boil for 3 to 5 minutes, and make a decoction at a reduced temperature for 30 to 50 minutes.

Preferably, in a preferred technical solution of this example, the components also comprise 4 g of Rhizoma Curcumae and 5 g of Ostrea gigas.

The above Chinese medicine is uniformly applied to the affected part three times a day for a five-day course of treatment; the pain is clearly relieved after four therapeutic courses; the pain is eliminated after ten therapeutic courses; and healed after continuous application for twenty therapeutic cures.

Example 3

Treatment of severe primary hyperostosis:

The Chinese medicament of the invention for the treatment of hyperostosis is obtained by having 25 g of sheep bone, 15 g of Dioscorea opposita, 15 g of Angelica dahurica, 7 g of Eucommia ulmoides, 8 g of Biondii Magnolia Flower, 6 g of quackgrass root, 6 g of Glycyrrhiza uralensis; uniformly mix the above components, grind them into powders; place the above powders in boiling water 10 to 20 times the part by weight of powder, boil for 3 to 5 minutes, and make a decoction at a reduced temperature for 30 to 50 minutes.

Preferably, in a preferred technical solution of this example, the components also comprise 5 g of Rhizoma Curcumae and 8 g of Ostrea gigas.

The above Chinese medicine is uniformly applied to the affected part, three times a day, while 50 ml of the above Chinese medicine are mixed in hot boiling water and taken after uniform mixing, four times a day and for a five-day therapeutic cure; the pain is clearly relieved after four therapeutic courses; the pain is eliminated after ten therapeutic courses; and healed after continuous application for twenty therapeutic cures.

Example 4

Treatment of severe secondary hyperostosis:

The Chinese medicament of the invention for the treatment of hyperostosis is obtained by having 28 g of sheep bone, 16 g of Dioscorea opposita, 18 g of Angelica dahurica, 9 g of Eucommia ulmoides, 8 g of Biondii Magnolia Flower, 8 g of quackgrass root, 8 g of Glycyrrhiza uralensis; uniformly mix the above components, grind them into powders; place the above powders in boiling water 10 to 20 times the part by weight of powder, boil for 3 to 5 minutes, and make a decoction at a reduced temperature for 30 to 50 minutes.

Preferably, in a preferred technical solution of this example, the components also comprise 6 g of Rhizoma Curcumae and 12 g of Ostrea gigas.

The above Chinese medicine is uniformly applied to the affected part, three times a day, while 50 ml of the above Chinese medicine are mixed in hot boiling water and taken after uniform mixing, four times a day and for a five-day therapeutic cure; the pain is clearly relieved after four therapeutic courses; the pain is eliminated after ten therapeutic courses; and healed after continuous application for twenty therapeutic cures.

Example 5

Treatment of mild or moderate secondary hyperostosis:

The Chinese medicament of the invention for the treatment of hyperostosis is obtained by having 30 g of sheep bone, 20 g of Dioscorea opposita, 20 g of Angelica dahurica, 10 g of Eucommia ulmoides, 10 g of Biondii Magnolia Flower, 8 g of quackgrass root, 9 g of Glycyrrhiza uralensis; uniformly mix the above components, grind them into powders; place the above powders in boiling water 10 to 20 times the part by weight of powder, boil for 3 to 5 minutes, and make a decoction at a reduced temperature for 30 to 50 minutes.

The above Chinese medicine is uniformly applied to the affected part three times a day and for a five-day course of treatment; the pain is clearly relieved after four therapeutic courses; the pain is eliminated after eight therapeutic courses; and healed after continuous application for fifteen therapeutic cures. From the above test examples, it can be seen that the Chinese drug compound of the invention can have a special effect on hyperostosis. According to statistics, nearly 200 patients with any type of hyperostosis can be effectively cured after application of the Chinese drug of the invention. In addition, it will not cause skin irritation after application, and has virtually no adverse reactions after oral administration.

Claims (5)

A Chinese medicine for the treatment of hyperostosis, characterized in that it is prepared from the following components expressed in parts by weight: 20 to 30 parts of sheep bone, 10 to 20 parts of Carthamus tinctorius, to 20 parts of Angelica dahurica, 5 to 10 parts of Eucommia ulmoides, 5 to 10 parts of Magnolia Biondii flower, 4 to 8 parts of quackgrass root and 3 to 9 parts of Glycyrrhiza uralensis. 2. Chinese medicament according to claim 1, characterized in that it is prepared from the following components expressed in parts by weight: 22 parts of sheep bone, 10 parts of Carthamus tinctorius, 13 parts of Angelica dahurica, 6 parts of Eucommia ulmoides, 6 parts of Magnolia Biondii flower, 4 parts of quack grass root and 3 parts of Glycyrrhiza uralensis. 3. Chinese medicament according to claim 1, characterized in that it is prepared from the following components expressed in parts by weight: 25 parts of sheep bone, 15 parts of Carthamus tinctorius, 15 parts of Angelica dahurica, 7 parts of Eucommia ulmoides, 8 parts of Magnolia Biondii flower, 6 parts of couch grass root and 6 parts of Glycyrrhiza uralensis. 4. Chinese medicament according to claim 1, characterized in that it is prepared from the following components expressed in parts by weight: 28 parts of sheep bone, 16 parts of Carthamus tinctorius, 18 parts of Angelica dahurica, 9 parts of Eucommia ulmoides, 8 parts of Magnolia Biondii flower, 8 parts of couch grass root and 8 parts of Glycyrrhiza uralensis. The Chinese medicament according to any one of claims 1 to 4, wherein the material components further comprise 4-6 g of Rhizoma Curcumae and 5-12 g of Ostrea gigas.