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FR3058995B1 - Procede et systeme de commande d'un dispositif microfluidique - Google Patents

Procede et systeme de commande d'un dispositif microfluidique Download PDF

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Publication number
FR3058995B1
FR3058995B1 FR1661227A FR1661227A FR3058995B1 FR 3058995 B1 FR3058995 B1 FR 3058995B1 FR 1661227 A FR1661227 A FR 1661227A FR 1661227 A FR1661227 A FR 1661227A FR 3058995 B1 FR3058995 B1 FR 3058995B1
Authority
FR
France
Prior art keywords
microfluidic
capsules
matrix
microfluidic device
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1661227A
Other languages
English (en)
Other versions
FR3058995A1 (fr
Inventor
Dulk Remco Den
Yves Fouillet
Olivier Fuchs
Charlotte Parent
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Commissariat a lEnergie Atomique CEA
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat a lEnergie Atomique CEA, Commissariat a lEnergie Atomique et aux Energies Alternatives CEA filed Critical Commissariat a lEnergie Atomique CEA
Priority to FR1661227A priority Critical patent/FR3058995B1/fr
Priority to PCT/FR2017/053096 priority patent/WO2018091813A1/fr
Priority to EP17808103.0A priority patent/EP3541514B1/fr
Publication of FR3058995A1 publication Critical patent/FR3058995A1/fr
Application granted granted Critical
Publication of FR3058995B1 publication Critical patent/FR3058995B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Control Of Non-Electrical Variables (AREA)

Abstract

L'invention concerne un procédé de commande d'un dispositif microfluidique qui comporte une matrice de capsules microfluidiques et des canaux reliant les capsules microfluidiques entre elles, chaque capsule microfluidique pouvant être commandée entre un premier état dans lequel elle est apte à se remplir d'un fluide et un deuxième état dans lequel elle est vide, bloquant le passage dudit fluide, ladite matrice comportant des capsules microfluidiques dites de mélange, des capsules microfluidiques dites d'isolation et des capsules dites de mélange-isolation . A partir d'une telle matrice, le procédé de commande de l'invention permet de réaliser un mélange d'un même échantillon avec un ou plusieurs réactifs distincts sans risque de contamination.
FR1661227A 2016-11-18 2016-11-18 Procede et systeme de commande d'un dispositif microfluidique Expired - Fee Related FR3058995B1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR1661227A FR3058995B1 (fr) 2016-11-18 2016-11-18 Procede et systeme de commande d'un dispositif microfluidique
PCT/FR2017/053096 WO2018091813A1 (fr) 2016-11-18 2017-11-13 Procédé et système de commande d'un dispositif microfluidique
EP17808103.0A EP3541514B1 (fr) 2016-11-18 2017-11-13 Procédé et système de commande d'un dispositif microfluidique

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1661227 2016-11-18
FR1661227A FR3058995B1 (fr) 2016-11-18 2016-11-18 Procede et systeme de commande d'un dispositif microfluidique

Publications (2)

Publication Number Publication Date
FR3058995A1 FR3058995A1 (fr) 2018-05-25
FR3058995B1 true FR3058995B1 (fr) 2021-02-19

Family

ID=57681661

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1661227A Expired - Fee Related FR3058995B1 (fr) 2016-11-18 2016-11-18 Procede et systeme de commande d'un dispositif microfluidique

Country Status (3)

Country Link
EP (1) EP3541514B1 (fr)
FR (1) FR3058995B1 (fr)
WO (1) WO2018091813A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3088430B1 (fr) * 2018-11-09 2023-12-08 Commissariat Energie Atomique Dispositif microfluidique de preparation d'echantillons offrant une grande repetabilite
FR3102558B1 (fr) * 2019-10-29 2024-11-29 Biomerieux Sa Système de dilution dans un dispositif et procédé de fabrication du dispositif
FR3153265A1 (fr) 2023-09-27 2025-03-28 Commissariat A L'energie Atomique Et Aux Energies Alternatives Procédé d'analyse d'un échantillon liquide dans un dispositif microfluidique

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1125129A1 (fr) * 1998-10-13 2001-08-22 Biomicro Systems, Inc. Composants de circuit fluidique bases sur la dynamique passive des fluides
US7832429B2 (en) 2004-10-13 2010-11-16 Rheonix, Inc. Microfluidic pump and valve structures and fabrication methods
US7763453B2 (en) 2005-11-30 2010-07-27 Micronics, Inc. Microfluidic mixing and analytic apparatus
US7976795B2 (en) 2006-01-19 2011-07-12 Rheonix, Inc. Microfluidic systems
WO2011094577A2 (fr) 2010-01-29 2011-08-04 Micronics, Inc. Cartouche microfluidique « de l'échantillon au résultat »
FR3035009B1 (fr) * 2015-04-20 2020-02-07 Commissariat A L'energie Atomique Et Aux Energies Alternatives Dispositif microfluidique de controle d'ecoulement d'un fluide

Also Published As

Publication number Publication date
EP3541514B1 (fr) 2021-01-20
WO2018091813A1 (fr) 2018-05-24
FR3058995A1 (fr) 2018-05-25
EP3541514A1 (fr) 2019-09-25

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