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FR2919804B1 - Composition et vaccin therapeutique anti-tumoral - Google Patents

Composition et vaccin therapeutique anti-tumoral

Info

Publication number
FR2919804B1
FR2919804B1 FR0705767A FR0705767A FR2919804B1 FR 2919804 B1 FR2919804 B1 FR 2919804B1 FR 0705767 A FR0705767 A FR 0705767A FR 0705767 A FR0705767 A FR 0705767A FR 2919804 B1 FR2919804 B1 FR 2919804B1
Authority
FR
France
Prior art keywords
red blood
blood cells
composition
cells
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0705767A
Other languages
English (en)
Other versions
FR2919804A1 (fr
Inventor
Yann Godfrin
Alice Marchand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phaxiam Therapeutics SA
Original Assignee
Erytech Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0705767A priority Critical patent/FR2919804B1/fr
Application filed by Erytech Pharma SA filed Critical Erytech Pharma SA
Priority to HUE08787072A priority patent/HUE035983T2/hu
Priority to PT87870721T priority patent/PT2185164T/pt
Priority to DK08787072.1T priority patent/DK2185164T3/da
Priority to HRP20171566TT priority patent/HRP20171566T1/hr
Priority to PCT/EP2008/060492 priority patent/WO2009019317A1/fr
Priority to PL08787072T priority patent/PL2185164T3/pl
Priority to CN200880110270.0A priority patent/CN101873862B/zh
Priority to NO08787072A priority patent/NO2185164T3/no
Priority to KR1020107004794A priority patent/KR101666041B1/ko
Priority to US12/672,094 priority patent/US9364504B2/en
Priority to AU2008285595A priority patent/AU2008285595B2/en
Priority to ES08787072.1T priority patent/ES2649761T3/es
Priority to HK11102915.5A priority patent/HK1148688B/xx
Priority to JP2010519476A priority patent/JP6077195B2/ja
Priority to CA2695478A priority patent/CA2695478C/fr
Priority to EP08787072.1A priority patent/EP2185164B1/fr
Publication of FR2919804A1 publication Critical patent/FR2919804A1/fr
Priority to IL203714A priority patent/IL203714A/en
Application granted granted Critical
Publication of FR2919804B1 publication Critical patent/FR2919804B1/fr
Priority to US15/154,273 priority patent/US9950049B2/en
Priority to JP2016170936A priority patent/JP6352996B2/ja
Priority to US15/961,226 priority patent/US10780151B2/en
Priority to US17/000,007 priority patent/US20210077602A1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/18—Erythrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
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    • A61K39/0005—Vertebrate antigens
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    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103—Receptors for growth factors
    • A61K39/001106—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
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    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001122—Ephrin Receptors [Eph]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K39/001188—NY-ESO
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
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    • A61K39/0005—Vertebrate antigens
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    • A61K39/00119—Melanoma antigens
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    • A—HUMAN NECESSITIES
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    • A61K39/001196—Fusion proteins originating from gene translocation in cancer cells
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    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2806—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD2
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6056—Antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FR0705767A 2007-08-08 2007-08-08 Composition et vaccin therapeutique anti-tumoral Expired - Fee Related FR2919804B1 (fr)

Priority Applications (22)

Application Number Priority Date Filing Date Title
FR0705767A FR2919804B1 (fr) 2007-08-08 2007-08-08 Composition et vaccin therapeutique anti-tumoral
HK11102915.5A HK1148688B (en) 2007-08-08 2008-08-08 Composition and therapeutic anti-tumour vaccine
DK08787072.1T DK2185164T3 (da) 2007-08-08 2008-08-08 Sammensætning og terapeutisk antitumorvaccine
HRP20171566TT HRP20171566T1 (hr) 2007-08-08 2008-08-08 Pripravak i terapeutsko anti-tumorsko cjepivo
PCT/EP2008/060492 WO2009019317A1 (fr) 2007-08-08 2008-08-08 Composition et vaccin anti-tumoral thérapeutique
PL08787072T PL2185164T3 (pl) 2007-08-08 2008-08-08 Kompozycja i terapeutyczna szczepionka przeciwnowotworowa
CN200880110270.0A CN101873862B (zh) 2007-08-08 2008-08-08 组合物和治疗性抗肿瘤疫苗
PT87870721T PT2185164T (pt) 2007-08-08 2008-08-08 Composição e vacina anti-tumoral terapêutica
KR1020107004794A KR101666041B1 (ko) 2007-08-08 2008-08-08 조성물 및 치료용 항종양 백신
US12/672,094 US9364504B2 (en) 2007-08-08 2008-08-08 Compostition and therapeutic anti-tumour vaccine
AU2008285595A AU2008285595B2 (en) 2007-08-08 2008-08-08 Composition and therapeutic anti-tumour vaccine
ES08787072.1T ES2649761T3 (es) 2007-08-08 2008-08-08 Composición y vacuna antitumoral terapéutica
HUE08787072A HUE035983T2 (hu) 2007-08-08 2008-08-08 Készítmény és terápiás tumorellenes oltóanyag
JP2010519476A JP6077195B2 (ja) 2007-08-08 2008-08-08 組成物と治療用抗腫瘍ワクチン
CA2695478A CA2695478C (fr) 2007-08-08 2008-08-08 Composition et vaccin anti-tumoral therapeutique
EP08787072.1A EP2185164B1 (fr) 2007-08-08 2008-08-08 Composition et vaccin anti-tumoral thérapeutique
NO08787072A NO2185164T3 (fr) 2007-08-08 2008-08-08
IL203714A IL203714A (en) 2007-08-08 2010-02-04 A drug containing red blood cell remedy, anti-tumor vaccine containing it and its uses
US15/154,273 US9950049B2 (en) 2007-08-08 2016-05-13 Composition and therapeutic anti-tumour vaccine
JP2016170936A JP6352996B2 (ja) 2007-08-08 2016-09-01 組成物と治療用抗腫瘍ワクチン
US15/961,226 US10780151B2 (en) 2007-08-08 2018-04-24 Composition and therapeutic anti-tumour vaccine
US17/000,007 US20210077602A1 (en) 2007-08-08 2020-08-21 Composition and therapeutic anti-tumour vaccine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0705767A FR2919804B1 (fr) 2007-08-08 2007-08-08 Composition et vaccin therapeutique anti-tumoral

Publications (2)

Publication Number Publication Date
FR2919804A1 FR2919804A1 (fr) 2009-02-13
FR2919804B1 true FR2919804B1 (fr) 2010-08-27

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Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2919804B1 (fr) 2007-08-08 2010-08-27 Erytech Pharma Composition et vaccin therapeutique anti-tumoral
WO2010087335A1 (fr) * 2009-01-27 2010-08-05 学校法人産業医科大学 GÈNE DE RÉCEPTEUR D'ANTIGÈNE DE LYMPHOCYTES T, VECTEUR POUR L'EXPRESSION D'UNE CHAÎNE α ET D'UNE CHAÎNE β DE RÉCEPTEUR, ET LYMPHOCYTE T CYTOTOXIQUE
JP5731488B2 (ja) * 2009-05-29 2015-06-10 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 癌のマーカーとしてのセセルニン‐１
JP5944318B2 (ja) * 2009-10-27 2016-07-05 エリテック・ファルマ 特異的免疫寛容を誘導するための組成物
CN107058231A (zh) * 2010-02-11 2017-08-18 中国人民解放军第二军医大学 携带融合蛋白基因的重组腺病毒及其制备方法和应用
CN108117586A (zh) 2010-08-10 2018-06-05 洛桑聚合联合学院 红细胞结合性治疗剂
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
WO2012059112A1 (fr) * 2010-11-01 2012-05-10 Mahmoud Abdel Wahed Rafea Développement de produits médicaux fondés sur une fonction nouvellement découverte des érythrocytes
KR102473834B1 (ko) * 2011-05-31 2022-12-02 바이오젠 엠에이 인코포레이티드 Pml의 위험을 판단하는 방법
EP2734621B1 (fr) 2011-07-22 2019-09-04 President and Fellows of Harvard College Évaluation et amélioration de la spécificité de clivage des nucléases
CN102973950B (zh) * 2011-09-06 2015-05-27 四川百利药业有限责任公司 Prame、wt1双价肿瘤dna疫苗
WO2013035208A1 (fr) * 2011-09-09 2013-03-14 株式会社トランスジェニック ANTICORPS CONTRE L'α-ACTININE-4 MUTANTE
CN107058101B (zh) 2011-10-17 2021-06-01 麻省理工学院 细胞内传递
US20150044192A1 (en) 2013-08-09 2015-02-12 President And Fellows Of Harvard College Methods for identifying a target site of a cas9 nuclease
KR102386122B1 (ko) 2013-08-16 2022-04-14 메사추세츠 인스티튜트 오브 테크놀로지 세포로의 선택적 물질 전달
CN104415335A (zh) 2013-09-02 2015-03-18 北京中康万达医药科技有限公司 体内个体化系统免疫治疗方法和装置
US9340800B2 (en) 2013-09-06 2016-05-17 President And Fellows Of Harvard College Extended DNA-sensing GRNAS
EP3071515A2 (fr) 2013-11-18 2016-09-28 Rubius Therapeutics, Inc. Complexes membrane synthétique- récepteur
US9840699B2 (en) 2013-12-12 2017-12-12 President And Fellows Of Harvard College Methods for nucleic acid editing
FR3017299B1 (fr) 2014-02-12 2018-05-18 Erytech Pharma Composition pharmaceutique comprenant des erythrocytes encapsulant une enzyme a plp et son cofacteur
US10046056B2 (en) 2014-02-21 2018-08-14 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
EA201691686A1 (ru) 2014-02-21 2017-03-31 Эколь Политекник Федераль Де Лозан (Эпфл) Терапевтические средства с углевод-опосредованной адресной доставкой
US10946079B2 (en) 2014-02-21 2021-03-16 Ecole Polytechnique Federale De Lausanne Glycotargeting therapeutics
US10953101B2 (en) 2014-02-21 2021-03-23 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
RU2736495C2 (ru) 2014-04-01 2020-11-17 Рубиус Терапьютикс, Инк. Способ и композиции для иммуномодуляции
WO2016022363A2 (fr) 2014-07-30 2016-02-11 President And Fellows Of Harvard College Protéines cas9 comprenant des intéines dépendant de ligands
CA2964392A1 (fr) 2014-10-31 2016-05-06 Massachussetts Institute Of Technology Administration de biomolecules en direction de cellules du systeme immunitaire
CA2964138C (fr) 2014-11-14 2023-11-14 Massachusetts Institute Of Technology Acheminement de composes et de compositions dans des cellules active par des perturbations et un champ
AU2016206870B2 (en) 2015-01-12 2022-02-17 Massachusetts Institute Of Technology Gene editing through microfluidic delivery
CA2988996A1 (fr) 2015-07-09 2017-01-12 Massachusetts Institute Of Technology Administration de substances a des cellules anucleees
EP3344575B1 (fr) 2015-09-04 2020-04-15 SQZ Biotechnologies Company Administration intracellulaire de biomolécules à des cellules comprenant une paroi cellulaire
CA2999094A1 (fr) * 2015-09-18 2017-03-23 The General Hospital Corporation Dba Massachusetts General Hospital Compositions possedant des proprietes antichimiorepulsion pour le traitement du cancer
CA3001154C (fr) 2015-10-07 2023-10-17 Sangui Bio Pty. Ltd Preparation et profilage sanguins
IL258821B (en) 2015-10-23 2022-07-01 Harvard College Nucleobase editors and their uses
EP3393482A4 (fr) * 2015-12-22 2019-08-21 Sangui Bio Pty. Ltd Méthodes thérapeutiques utilisant les érythrocytes
RS62939B1 (sr) 2016-01-11 2022-03-31 Rubius Therapeutics Inc Kompozicije i metode u vezi sa multimodalnim terapijskim ćelijskim sistemima u indikacijama kancera
CN105646676A (zh) * 2016-03-17 2016-06-08 南通大学 小分子多肽Prdx5截短体及其载体和应用
IL262677B2 (en) 2016-05-03 2025-08-01 Sqz Biotechnologies Co Intracellular delivery of biomolecules to suppress an immune response or to induce tolerance to an antigen in an individual
KR20250103795A (ko) 2016-08-03 2025-07-07 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 아데노신 핵염기 편집제 및 그의 용도
CA3033327A1 (fr) 2016-08-09 2018-02-15 President And Fellows Of Harvard College Proteines de fusion cas9-recombinase programmables et utilisations associees
WO2018039438A1 (fr) 2016-08-24 2018-03-01 President And Fellows Of Harvard College Incorporation d'acides aminés non naturels dans des protéines au moyen de l'édition de bases
JP6314201B1 (ja) * 2016-11-21 2018-04-18 テラファーマ株式会社 樹状細胞洗浄液及びこれを用いた樹状細胞の洗浄方法、並びに樹状細胞含有組成物の調製方法
AU2017379367B2 (en) 2016-12-20 2023-12-07 Sangui Bio Pty. Ltd Blood profiling with protease inhibitors
WO2018119359A1 (fr) 2016-12-23 2018-06-28 President And Fellows Of Harvard College Édition du gène récepteur ccr5 pour protéger contre l'infection par le vih
WO2018165504A1 (fr) 2017-03-09 2018-09-13 President And Fellows Of Harvard College Suppression de la douleur par édition de gène
CN110662556A (zh) * 2017-03-09 2020-01-07 哈佛大学的校长及成员们 癌症疫苗
JP2020510439A (ja) 2017-03-10 2020-04-09 プレジデント アンド フェローズ オブ ハーバード カレッジ シトシンからグアニンへの塩基編集因子
WO2018232176A1 (fr) 2017-06-16 2018-12-20 The University Of Chicago Compositions et procédés d'induction d'une tolérance immunitaire
JP2020534795A (ja) 2017-07-28 2020-12-03 プレジデント アンド フェローズ オブ ハーバード カレッジ ファージによって支援される連続的進化（ｐａｃｅ）を用いて塩基編集因子を進化させるための方法および組成物
US10960071B2 (en) 2017-08-07 2021-03-30 The Regents Of The University Of California Platform for generating safe cell therapeutics
EP3664830A4 (fr) 2017-08-07 2020-07-01 The Regents of the University of California Plate-forme de génération d'agents thérapeutiques cellulaires sans risque
US11319532B2 (en) 2017-08-30 2022-05-03 President And Fellows Of Harvard College High efficiency base editors comprising Gam
KR20250107288A (ko) 2017-10-16 2025-07-11 더 브로드 인스티튜트, 인코퍼레이티드 아데노신 염기 편집제의 용도
WO2019118949A1 (fr) 2017-12-15 2019-06-20 The Broad Institute, Inc. Systèmes et procédés de prédiction des résultats de la réparation en ingénierie génétique
CN110078811B (zh) * 2018-01-25 2022-02-11 中国医学科学院医药生物技术研究所 一种具有抗肿瘤活性的多肽imb-p1及其应用
JP6385607B2 (ja) * 2018-02-13 2018-09-05 テラファーマ株式会社 樹状細胞ワクチン
CN112105723A (zh) * 2018-03-08 2020-12-18 鲁比厄斯治疗法股份有限公司 用于治疗癌症和传染病的治疗性细胞系统和方法
EA202092723A1 (ru) 2018-05-09 2021-04-09 Зе Юниверсити Оф Чикаго Композиции и способы, касающиеся иммунной толерантности
WO2019226953A1 (fr) 2018-05-23 2019-11-28 The Broad Institute, Inc. Éditeurs de bases et leurs utilisations
WO2020092453A1 (fr) 2018-10-29 2020-05-07 The Broad Institute, Inc. Éditeurs de nucléobases comprenant geocas9 et utilisations associées
US12351837B2 (en) 2019-01-23 2025-07-08 The Broad Institute, Inc. Supernegatively charged proteins and uses thereof
EP3931309A4 (fr) 2019-02-28 2022-12-21 SQZ Biotechnologies Company Administration de biomolécules à des pbmc pour modifier une réponse immunitaire
EP3942042A1 (fr) 2019-03-19 2022-01-26 The Broad Institute, Inc. Procédés et compositions pour l'édition de séquences nucléotidiques
CN113840906B (zh) 2019-04-08 2024-09-06 Sqz生物技术公司 用于在将有效载荷递送至细胞中的系统中使用的试剂盒
EP3956349A1 (fr) 2019-04-17 2022-02-23 The Broad Institute, Inc. Éditeurs de base d'adénine présentant des effets hors cible réduits
US12435330B2 (en) 2019-10-10 2025-10-07 The Broad Institute, Inc. Methods and compositions for prime editing RNA
TWI776276B (zh) * 2019-11-13 2022-09-01 中國醫藥大學 異種組織細胞組合物治療癌症之用途
AU2020414040A1 (en) * 2019-12-27 2022-08-18 Zeria Pharmaceutical Co., Ltd. Cancer treatment method and medicine
WO2021226558A1 (fr) 2020-05-08 2021-11-11 The Broad Institute, Inc. Méthodes et compositions d'édition simultanée des deux brins d'une séquence nucléotidique double brin cible
AU2021270347A1 (en) 2020-05-11 2022-12-15 Erytech Pharma Red cell extracellular vesicles (RCEVs) containing cargoes and methods of use and production thereof
KR20230058388A (ko) * 2020-07-29 2023-05-03 에스큐지 바이오테크놀로지스 컴퍼니 무핵 세포를 사용해 돌연변이체 ras에 대한 면역 반응을 자극하는 방법
CN113350499B (zh) * 2021-06-29 2022-06-14 贵州医科大学 鸡卵清蛋白OVA mRNA在制备非特异性免疫刺激剂中的应用
CN114432261B (zh) * 2022-02-24 2023-11-28 初源汇企业管理(深圳)合伙企业(有限合伙) 一种靶向递送疫苗的制备方法及红细胞疫苗
CN117965442A (zh) * 2022-10-26 2024-05-03 北京睿脉医药科技有限公司 一种将治疗性分子偶联至成熟红细胞表面的方法及应用
WO2024170101A1 (fr) * 2023-02-17 2024-08-22 Pdc Line Pharma Cellules dendritiques plasmacytoïdes pour le traitement du cancer

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1051382A (fr) 1900-01-01
DE2740053A1 (de) 1977-09-06 1979-05-03 Klaus Prof Dr Med Gersonde Verwendung von allosterischen effektoren mit hilfe von lipidvesikeln ueber eine irreversible inkorporierung zwecks verbesserter o tief 2 -entladung des haemoglobins in erythrozyten
US4327710A (en) 1980-06-18 1982-05-04 The United States Of America As Represented By The Secretary Of Agriculture Process for encapsulating additives in resealed erythrocytes for disseminating chemicals via the circulatory system
FR2529463B1 (fr) 1982-07-05 1986-01-10 Centre Nat Rech Scient Procede et dispositif pour l'encapsulation dans les erythrocytes d'au moins une substance a activite biologique, notamment des effecteurs allosteriques de l'hemoglobine et erythrocytes ainsi obtenus
US4478824A (en) 1983-08-08 1984-10-23 Franco Robert S Method for altering red blood cell function and survival
JPH0235081A (ja) 1988-07-26 1990-02-05 Agency Of Ind Science & Technol アルギニン・デイミナーゼおよびその用途
JPH0253490A (ja) 1988-08-16 1990-02-22 Agency Of Ind Science & Technol アルギニン・デイミナーゼ遺伝子
DE58908768D1 (de) 1988-09-30 1995-01-26 Siemens Ag Verfahren zum synchronisierten Umtasten eines Polarisationszustandes eines optischen Sendesignals eines optischen Übertragungssystems mit Überlagerungsempfang und Vorrichtung zur Durchführung des Verfahrens.
JP2900279B2 (ja) 1989-08-02 1999-06-02 株式会社ジャパンエナジー 新規なアルギニンデイミナーゼ、その製造法及び該酵素を有効成分とする制癌剤
FR2678512B1 (fr) 1991-07-03 1995-06-30 Novacell Machine a internaliser.
JP3004788B2 (ja) 1991-10-28 2000-01-31 株式会社ジャパンエナジー アルギニンデイミナーゼ発現ベクター、形質転換微生物およびアルギニンデイミナーゼの製造法
US5372942A (en) 1992-02-10 1994-12-13 Coriell Institute For Medical Research Protease K resistant arginine deiminase, its method of preparation and its use as an anti-neoplastic agent
AU680890B2 (en) 1993-03-23 1997-08-14 Cbr Laboratories, Inc. Method and apparatus for encapsulation of biologically-active substances in cells
US6218166B1 (en) * 1994-12-09 2001-04-17 John Wayne Cancer Institute Adjuvant incorporation into antigen carrying cells: compositions and methods
US5804183A (en) 1997-01-31 1998-09-08 Enzon, Inc. Arginine deminase derived from mycoplasma arthritidis and polymer conjugates containing the same
WO1998039027A2 (fr) * 1997-03-05 1998-09-11 John Wayne Cancer Institute Antigenes de sialyl lewis uilises comme cibles en immunotherapie
EP0882448B1 (fr) 1997-05-05 2005-01-12 DIDECO S.r.l. Méthode d'encapsulation d'agents biologiquement actifs dans des erythrocytes et appareil
US6183738B1 (en) 1997-05-12 2001-02-06 Phoenix Pharamacologics, Inc. Modified arginine deiminase
DE60026313D1 (de) * 1999-07-23 2006-04-27 Uutech Ltd Sensibilisierung von roten blutkörperchen gegenüber ultraschall durch einwirkung eines elektrischen feldes
WO2002009741A1 (fr) 2000-07-27 2002-02-07 Angiolab, Inc. Composition pharmaceutique comprenant une arginine deiminase destinee a inhiber l'angiogenese
AU2001279118A1 (en) 2000-08-01 2002-02-13 Gmp Companies, Inc. Ammonium salts of inositol hexaphosphate and uses thereof
US7037500B1 (en) * 2000-09-08 2006-05-02 The Trustees Of Columbia University In The City Of New York Method for using phagocytic particles and ATP receptors to deliver antigens to MHC class I receptors to induce immunity against microbial pathogens or tumors or to suppress immunity
DE10335833A1 (de) * 2003-08-05 2005-03-03 Curevac Gmbh Transfektion von Blutzellen mit mRNA zur Immunstimulation und Gentherapie
FR2873925B1 (fr) 2004-08-05 2006-10-13 Erytech Pharma Soc Par Actions Procede et dispositif de lyse-rescellement pour l'incorporation de principe actif notamment asparaginase ou inositol hexaphosphate, dans des erythrocytes
FR2884717B1 (fr) 2005-04-25 2009-07-03 Erytech Pharma Soc Par Actions Erythrocytes renfermant de l'arginine deiminase
FR2919804B1 (fr) 2007-08-08 2010-08-27 Erytech Pharma Composition et vaccin therapeutique anti-tumoral
JP5944318B2 (ja) 2009-10-27 2016-07-05 エリテック・ファルマ 特異的免疫寛容を誘導するための組成物
US8530011B2 (en) 2010-12-13 2013-09-10 Southwall Technologies Inc. Insulating glass unit with crack-resistant low-emissivity suspended film

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PL2185164T3 (pl) 2018-01-31
DK2185164T3 (da) 2017-11-13
HK1148688A1 (en) 2011-09-16
KR20100075832A (ko) 2010-07-05
NO2185164T3 (fr) 2018-01-27
KR101666041B1 (ko) 2016-10-13
US20120009140A1 (en) 2012-01-12
CN101873862B (zh) 2014-10-01
PT2185164T (pt) 2017-11-28
US9950049B2 (en) 2018-04-24
JP6077195B2 (ja) 2017-02-08
CN101873862A (zh) 2010-10-27
HUE035983T2 (hu) 2018-06-28
ES2649761T3 (es) 2018-01-15
EP2185164B1 (fr) 2017-08-30
US9364504B2 (en) 2016-06-14
AU2008285595B2 (en) 2012-08-09
CA2695478C (fr) 2018-05-08
US20180344822A1 (en) 2018-12-06
JP2010535744A (ja) 2010-11-25
AU2008285595A1 (en) 2009-02-12
FR2919804A1 (fr) 2009-02-13
US10780151B2 (en) 2020-09-22
EP2185164A1 (fr) 2010-05-19
JP2016196517A (ja) 2016-11-24
IL203714A (en) 2014-05-28
CA2695478A1 (fr) 2009-02-12
US20160324946A1 (en) 2016-11-10
WO2009019317A1 (fr) 2009-02-12
US20210077602A1 (en) 2021-03-18
JP6352996B2 (ja) 2018-07-04

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