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FR3017299B1 - Composition pharmaceutique comprenant des erythrocytes encapsulant une enzyme a plp et son cofacteur - Google Patents

Composition pharmaceutique comprenant des erythrocytes encapsulant une enzyme a plp et son cofacteur Download PDF

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Publication number
FR3017299B1
FR3017299B1 FR1451100A FR1451100A FR3017299B1 FR 3017299 B1 FR3017299 B1 FR 3017299B1 FR 1451100 A FR1451100 A FR 1451100A FR 1451100 A FR1451100 A FR 1451100A FR 3017299 B1 FR3017299 B1 FR 3017299B1
Authority
FR
France
Prior art keywords
cofactor
pharmaceutical composition
erythrocytes encapsulating
plp enzyme
plp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1451100A
Other languages
English (en)
Other versions
FR3017299A1 (fr
Inventor
Yann Godfrin
Vanessa Bourgeaux
Fabien GAY
Thomas CORTESE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phaxiam Therapeutics SA
Original Assignee
Erytech Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50729647&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR3017299(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Erytech Pharma SA filed Critical Erytech Pharma SA
Priority to FR1451100A priority Critical patent/FR3017299B1/fr
Priority to CN201580007812.1A priority patent/CN106255506B/zh
Priority to RU2019123935A priority patent/RU2744659C2/ru
Priority to BR112016017337-6A priority patent/BR112016017337B1/pt
Priority to MX2016010235A priority patent/MX378781B/es
Priority to AU2015217045A priority patent/AU2015217045B2/en
Priority to JP2016568136A priority patent/JP6563958B2/ja
Priority to CN202010182496.4A priority patent/CN111358941B/zh
Priority to EP20173043.9A priority patent/EP3718562A1/fr
Priority to JOP/2015/0030A priority patent/JO3522B1/ar
Priority to US15/117,588 priority patent/US10046009B2/en
Priority to KR1020167022067A priority patent/KR102354103B1/ko
Priority to PCT/EP2015/052962 priority patent/WO2015121348A2/fr
Priority to SG11201606264SA priority patent/SG11201606264SA/en
Priority to CA2938469A priority patent/CA2938469C/fr
Priority to RU2016133315A priority patent/RU2697086C2/ru
Priority to EP15705563.3A priority patent/EP3104875B1/fr
Priority to ES15705563T priority patent/ES2808849T3/es
Priority to SG10201907367QA priority patent/SG10201907367QA/en
Publication of FR3017299A1 publication Critical patent/FR3017299A1/fr
Priority to IL246941A priority patent/IL246941B/en
Priority to CL2016002020A priority patent/CL2016002020A1/es
Priority to AU2018201237A priority patent/AU2018201237B2/en
Publication of FR3017299B1 publication Critical patent/FR3017299B1/fr
Application granted granted Critical
Priority to US16/102,171 priority patent/US10780126B2/en
Priority to US17/028,383 priority patent/US11458170B2/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/18Erythrocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45Transferases (2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51Lyases (4)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5063Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068Cell membranes or bacterial membranes enclosing drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y206/00Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01Transaminases (2.6.1)
    • C12Y206/01005Tyrosine transaminase (2.6.1.5)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y404/00Carbon-sulfur lyases (4.4)
    • C12Y404/01Carbon-sulfur lyases (4.4.1)
    • C12Y404/01011Methionine gamma-lyase (4.4.1.11)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biophysics (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
FR1451100A 2014-02-12 2014-02-12 Composition pharmaceutique comprenant des erythrocytes encapsulant une enzyme a plp et son cofacteur Expired - Fee Related FR3017299B1 (fr)

Priority Applications (24)

Application Number Priority Date Filing Date Title
FR1451100A FR3017299B1 (fr) 2014-02-12 2014-02-12 Composition pharmaceutique comprenant des erythrocytes encapsulant une enzyme a plp et son cofacteur
PCT/EP2015/052962 WO2015121348A2 (fr) 2014-02-12 2015-02-12 Composition pharmaceutique comprenant des érythrocytes encapsulant une enzyme dépendante du plp et son cofacteur
CA2938469A CA2938469C (fr) 2014-02-12 2015-02-12 Composition pharmaceutique comprenant des erythrocytes encapsulant une enzyme dependante du plp et son cofacteur
BR112016017337-6A BR112016017337B1 (pt) 2014-02-12 2015-02-12 Composição farmacêutica
MX2016010235A MX378781B (es) 2014-02-12 2015-02-12 Composición farmacéutica que comprende eritrocitos que encapsulan una enzima dependiente de fosfato de piridoxal (plp) y su cofactor.
AU2015217045A AU2015217045B2 (en) 2014-02-12 2015-02-12 Pharmaceutical composition comprising erythrocytes encapsulating a PLP-dependent enzyme and its cofactor
JP2016568136A JP6563958B2 (ja) 2014-02-12 2015-02-12 Plp依存性酵素とその補因子をカプセル化する赤血球を含む医薬組成物
CN202010182496.4A CN111358941B (zh) 2014-02-12 2015-02-12 含包封有plp依赖性酶及其辅助因子的红细胞的药物组合物
EP20173043.9A EP3718562A1 (fr) 2014-02-12 2015-02-12 Composition pharmaceutique comprenant des érythrocytes encapsulant une enzyme dépendante du plp et son cofacteur
JOP/2015/0030A JO3522B1 (ar) 2014-02-12 2015-02-12 تركيب صيدلاني يتألف من كريات حمراء تغلف إنزيم يعتمد على بيريدكسال الفوسفات والعامل المساعد له
US15/117,588 US10046009B2 (en) 2014-02-12 2015-02-12 Method of treatment using a pharmaceutical composition comprising erythrocytes encapsulating a PLP-dependent enzyme and its cofactor
KR1020167022067A KR102354103B1 (ko) 2014-02-12 2015-02-12 Plp-의존성 효소 및 이의 보조인자를 캡슐화하는 적혈구를 포함하는 약학적 조성물
CN201580007812.1A CN106255506B (zh) 2014-02-12 2015-02-12 含包封有plp依赖性酶及其辅助因子的红细胞的药物组合物
SG11201606264SA SG11201606264SA (en) 2014-02-12 2015-02-12 Pharmaceutical composition comprising erythrocytes encapsulating a plp-dependent enzyme and its cofactor
RU2019123935A RU2744659C2 (ru) 2014-02-12 2015-02-12 Фармацевтическая композиция, содержащая эритроциты, в которых заключен фермент, зависимый от пиридоксальфосфата, и его кофактор
RU2016133315A RU2697086C2 (ru) 2014-02-12 2015-02-12 Фармацевтическая композиция, содержащая эритроциты, в которых заключен фермент, зависимый от пиридоксальфосфата, и его кофактор
EP15705563.3A EP3104875B1 (fr) 2014-02-12 2015-02-12 Composition pharmaceutique comprenant des érythrocytes encapsulant une enzyme dépendante du plp et son cofacteur
ES15705563T ES2808849T3 (es) 2014-02-12 2015-02-12 Composición farmacéutica que comprende eritrocitos que encapsulan una enzima dependiente de PLP y su cofactor
SG10201907367QA SG10201907367QA (en) 2014-02-12 2015-02-12 Pharmaceutical composition comprising erythrocytes encapsulating a plp-dependent enzyme and its cofactor
IL246941A IL246941B (en) 2014-02-12 2016-07-25 A pharmaceutical preparation containing erythrocyte thermalizing plp-dependent enzyme and its cofactor
CL2016002020A CL2016002020A1 (es) 2014-02-12 2016-08-10 Composición farmacéutica que consta de eritrocitos que encapsulan una encima plp dependiente y su cofactor
AU2018201237A AU2018201237B2 (en) 2014-02-12 2018-02-21 Pharmaceutical composition comprising erythrocytes encapsulating a PLP-dependent enzyme and its cofactor
US16/102,171 US10780126B2 (en) 2014-02-12 2018-08-13 Pharmaceutical kit comprising erythrocytes encapsulating a PLP-dependent enzyme and, a non-phosphate PLP precursor
US17/028,383 US11458170B2 (en) 2014-02-12 2020-09-22 Pharmaceutical composition comprising erythrocytes encapsulating a PLP-dependent enzyme and, a non-phosphate PLP precursor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1451100A FR3017299B1 (fr) 2014-02-12 2014-02-12 Composition pharmaceutique comprenant des erythrocytes encapsulant une enzyme a plp et son cofacteur
FR1451100 2014-02-12

Publications (2)

Publication Number Publication Date
FR3017299A1 FR3017299A1 (fr) 2015-08-14
FR3017299B1 true FR3017299B1 (fr) 2018-05-18

Family

ID=50729647

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1451100A Expired - Fee Related FR3017299B1 (fr) 2014-02-12 2014-02-12 Composition pharmaceutique comprenant des erythrocytes encapsulant une enzyme a plp et son cofacteur

Country Status (17)

Country Link
US (3) US10046009B2 (fr)
EP (2) EP3718562A1 (fr)
JP (1) JP6563958B2 (fr)
KR (1) KR102354103B1 (fr)
CN (2) CN111358941B (fr)
AU (2) AU2015217045B2 (fr)
BR (1) BR112016017337B1 (fr)
CA (1) CA2938469C (fr)
CL (1) CL2016002020A1 (fr)
ES (1) ES2808849T3 (fr)
FR (1) FR3017299B1 (fr)
IL (1) IL246941B (fr)
JO (1) JO3522B1 (fr)
MX (1) MX378781B (fr)
RU (2) RU2697086C2 (fr)
SG (2) SG11201606264SA (fr)
WO (1) WO2015121348A2 (fr)

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KR20200095507A (ko) 2017-12-01 2020-08-10 사노피 글루코오스 감지 단백질에 결합할 수 있는 모이어티 및 약제의 신규 접합체
US11510901B2 (en) 2018-01-08 2022-11-29 Epicentrx, Inc. Methods and compositions utilizing RRx-001 combination therapy for radioprotection
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
US20210403571A1 (en) 2018-11-15 2021-12-30 Erytech Pharma Synergistic combinations of methionine depletion agents and immune checkpoint modulators
CN114007627A (zh) 2019-04-26 2022-02-01 鲁比厄斯治疗法股份有限公司 包含去核类红细胞的缓冲组合物
KR20220016480A (ko) 2019-05-24 2022-02-09 루비우스 테라퓨틱스, 아이엔씨. 탈핵 적혈구를 생성하는 방법
CN114901804A (zh) 2019-11-04 2022-08-12 鲁比厄斯治疗法股份有限公司 使用牛磺酸或亚牛磺酸产生去核红系细胞的方法
EP4055149A1 (fr) 2019-11-04 2022-09-14 Rubius Therapeutics, Inc. Procédés de génération de cellules érythroïdes énucléées à l'aide de myo-inositol
CA3178252A1 (fr) 2020-05-11 2021-11-18 Erytech Pharma Vesicules extracellulaires de globules rouges (vecgr) contenant des cargos et procedes d'utilisation et de production de celles-ci
WO2022150578A1 (fr) 2021-01-08 2022-07-14 Rubius Therapeutics, Inc. Méthodes de traitement d'une tumeur chez un patient humain
TW202241471A (zh) 2021-01-08 2022-11-01 美商盧比亞斯治療公司 提高個體中NKp30陽性淋巴球的方法及其用途
TW202304482A (zh) 2021-03-14 2023-02-01 美商盧比亞斯治療公司 於個體中增加nkg2d陽性淋巴球之方法及其用途
AU2022279241A1 (en) * 2021-05-21 2023-11-30 Codexis, Inc. Engineered methionine gamma lyase variants
TW202317179A (zh) 2021-06-03 2023-05-01 美商盧比亞斯治療公司 在個體中治療hpv16-陽性或hpv16-相關的癌症之方法
CN113481253B (zh) * 2021-06-09 2022-05-24 连云港杰瑞药业有限公司 生物催化制备磷酸吡哆醛的方法
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FR2925339B1 (fr) 2007-12-24 2010-03-05 Erytech Pharma Medicament pour le traitement du cancer du pancreas
CA2715379A1 (fr) 2008-02-13 2009-08-20 Erytech Pharma Formulation et procede pour la prevention et le traitement de manifestation squelettique de la maladie de gaucher
FR2928270B1 (fr) 2008-03-10 2011-01-21 Erytech Pharma Formulation methode pour la prevention ou le traitement des metastases osseuses et autres maladies de l'os
FR2938332B1 (fr) 2008-11-07 2011-11-25 Erytech Pharma Test predictif de la neutralisation de l'activite asparaginase
CN101429506A (zh) * 2008-12-15 2009-05-13 吉林大学 基于红细胞载体的fish-in-net固定化酶
FR2944106B1 (fr) 2009-04-03 2012-09-28 Erytech Pharma Methode de dosage de l'inositol hexaphosphate (ihp).
PL2493487T3 (pl) 2009-10-27 2017-02-28 Erytech Pharma Kompozycja do indukowania swoistej tolerancji immunologicznej
US20150086521A1 (en) 2012-03-21 2015-03-26 Erytech Pharma Medicament for the Treatment of Acute Myeloid Leukemia (AML)
FR3005420B1 (fr) 2013-05-07 2015-09-18 Erytech Pharma Procede de stabilisation de suspensions d'erythrocytes encapsulant un principe actif, suspensions obtenues.
EP2813234A1 (fr) 2013-06-11 2014-12-17 Erytech Pharma Composition d'érythrocytes encapsulant phenylalanine hydroxylase et l'emploi thérapeutique
FR3017299B1 (fr) * 2014-02-12 2018-05-18 Erytech Pharma Composition pharmaceutique comprenant des erythrocytes encapsulant une enzyme a plp et son cofacteur
EP3187190A1 (fr) * 2015-12-31 2017-07-05 Erytech Pharma Procédé de traitement d'un mammifère, y compris l'être humain, contre le cancer au moyen de la méthionine et la déplétion de l'asparagine

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US10046009B2 (en) 2018-08-14
CA2938469A1 (fr) 2015-08-20
KR102354103B1 (ko) 2022-01-24
SG10201907367QA (en) 2019-09-27
CN111358941A (zh) 2020-07-03
JO3522B1 (ar) 2020-07-05
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BR112016017337B1 (pt) 2022-08-09
CN111358941B (zh) 2023-12-01
RU2744659C2 (ru) 2021-03-12
ES2808849T3 (es) 2021-03-02
US20210008114A1 (en) 2021-01-14
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US11458170B2 (en) 2022-10-04
EP3718562A1 (fr) 2020-10-07
WO2015121348A2 (fr) 2015-08-20
AU2018201237B2 (en) 2019-09-26
JP6563958B2 (ja) 2019-08-21
JP2017506260A (ja) 2017-03-02
US10780126B2 (en) 2020-09-22
FR3017299A1 (fr) 2015-08-14
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AU2015217045A1 (en) 2016-08-18
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US20160361361A1 (en) 2016-12-15
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RU2697086C2 (ru) 2019-08-12
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