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FR2951173B1 - Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) - Google Patents

Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb)

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Publication number
FR2951173B1
FR2951173B1 FR0957067A FR0957067A FR2951173B1 FR 2951173 B1 FR2951173 B1 FR 2951173B1 FR 0957067 A FR0957067 A FR 0957067A FR 0957067 A FR0957067 A FR 0957067A FR 2951173 B1 FR2951173 B1 FR 2951173B1
Authority
FR
France
Prior art keywords
pkb
imidazo
pyrimidin
dihydro
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0957067A
Other languages
English (en)
Other versions
FR2951173A1 (fr
Inventor
Maurice Brollo
Ahmad Youssef El
Romme Bruno Filoche
Frank Halley
Andreas Karlsson
Laurent Schio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0957067A priority Critical patent/FR2951173B1/fr
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to AU2010267814A priority patent/AU2010267814B2/en
Priority to HRP20170827TT priority patent/HRP20170827T1/hr
Priority to EP10742012.7A priority patent/EP2448939B1/fr
Priority to MX2012000097A priority patent/MX2012000097A/es
Priority to LTEP10742012.7T priority patent/LT2448939T/lt
Priority to PL10742012T priority patent/PL2448939T3/pl
Priority to CA2767051A priority patent/CA2767051C/fr
Priority to SG10201403138WA priority patent/SG10201403138WA/en
Priority to BRPI1015949A priority patent/BRPI1015949A2/pt
Priority to HUE10742012A priority patent/HUE034503T2/en
Priority to SI201031451A priority patent/SI2448939T1/sl
Priority to JP2012518118A priority patent/JP5663571B2/ja
Priority to US13/381,571 priority patent/US8828997B2/en
Priority to ARP100102346A priority patent/AR077446A1/es
Priority to PT107420127T priority patent/PT2448939T/pt
Priority to PCT/FR2010/051373 priority patent/WO2011001112A1/fr
Priority to SG2011097227A priority patent/SG177421A1/en
Priority to RU2012103460/04A priority patent/RU2554868C2/ru
Priority to ES10742012.7T priority patent/ES2627428T3/es
Priority to CN201080039104.3A priority patent/CN102482285B/zh
Priority to DK10742012.7T priority patent/DK2448939T3/en
Priority to KR1020127002797A priority patent/KR101745028B1/ko
Priority to UY0001032753A priority patent/UY32753A/es
Priority to TW099121898A priority patent/TWI458730B/zh
Publication of FR2951173A1 publication Critical patent/FR2951173A1/fr
Application granted granted Critical
Publication of FR2951173B1 publication Critical patent/FR2951173B1/fr
Priority to IL217294A priority patent/IL217294A/en
Priority to CY20171100567T priority patent/CY1119442T1/el
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR0957067A 2009-07-02 2009-10-09 Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) Expired - Fee Related FR2951173B1 (fr)

Priority Applications (27)

Application Number Priority Date Filing Date Title
FR0957067A FR2951173B1 (fr) 2009-10-09 2009-10-09 Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb)
PT107420127T PT2448939T (pt) 2009-07-02 2010-07-01 Derivados de 2,3-dihidro-1h-imidazo{1,2-a}pirimidin-5-ona, sua preparação e sua utilização farmacêutica
EP10742012.7A EP2448939B1 (fr) 2009-07-02 2010-07-01 Derives de 2,3-dihydro-1h-imidazo {1,2-a} pyrimidin-5-one, leur preparation et leur utilisation pharmaceutique
MX2012000097A MX2012000097A (es) 2009-07-02 2010-07-01 Nuevos derivados de 2,3-dihidro-1h-imidazo {1,2-a} pirimidin-5-ona, su preparacion y su uso en farmaceutica.
LTEP10742012.7T LT2448939T (lt) 2009-07-02 2010-07-01 2,3-dihidro-1h-imidazo {1,2-a} pirimidin-5-ono dariniai, jų gamyba ir farmacinis panaudojimas
PL10742012T PL2448939T3 (pl) 2009-07-02 2010-07-01 Pochodne 2,3-dihydro-1h-imidazo {1,2-a} pirymidyn-5-onu, ich wytwarzanie i ich zastosowanie farmaceutyczne
CA2767051A CA2767051C (fr) 2009-07-02 2010-07-01 Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one, leur preparation et leur utilisation pharmaceutique
SG10201403138WA SG10201403138WA (en) 2009-07-02 2010-07-01 Novel 2,3-dihydro-1h-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof and pharmaceutical use thereof
BRPI1015949A BRPI1015949A2 (pt) 2009-07-02 2010-07-01 derivados de 2,3-di-hidro-1h-imidazo [1,2-a] pirimidin-5-ona, o respectivo preparo e a respectiva utilização farmacêutica
HUE10742012A HUE034503T2 (en) 2009-07-02 2010-07-01 2,3-Dihydro-1-imidazo [1,2-a] pyrimidin-5-one derivatives, their preparation process and their use in medicine
SI201031451A SI2448939T1 (sl) 2009-07-02 2010-07-01 Derivati 2,3-dihidro-1H-imidazo(1,2-a)pirimidin-5-ona, njihova priprava in farmacevtska uporaba
JP2012518118A JP5663571B2 (ja) 2009-07-02 2010-07-01 新規２，３−ジヒドロ−１Ｈ−イミダゾ｛１，２−ａ｝ピリミジン−５−オン誘導体、これらの調製およびこれらの薬学的使用
US13/381,571 US8828997B2 (en) 2009-07-02 2010-07-01 2,3-dihydro-1H-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof, and pharmaceutical use thereof
ARP100102346A AR077446A1 (es) 2009-07-02 2010-07-01 Derivados de 2,3-dihidro-1h-imidazo(1,2-a) pirimidin-5-ona. su preparacion y su utilizacion farmaceutica
AU2010267814A AU2010267814B2 (en) 2009-07-02 2010-07-01 Novel 2,3-dihydro-1H-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof, and pharmaceutical use thereof
ES10742012.7T ES2627428T3 (es) 2009-07-02 2010-07-01 Nuevos derivados de 2,3-dihidro-1H-imidazo{1,2-a}pirimidin-5-ona, su preparación y su utilización farmacéutica
HRP20170827TT HRP20170827T1 (hr) 2009-07-02 2010-07-01 Derivati 2,3-dihidro-1h-imidazo {1,2-a} pirimidin-5-ona, njihova priprava i farmaceutska primjena
RU2012103460/04A RU2554868C2 (ru) 2009-07-02 2010-07-01 НОВЫЕ ПРОИЗВОДНЫЕ 2,3-ДИГИДРО-1Н-ИМИДАЗО[1,2-а]ПИРИМИДИН-5-ОНА, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЕ В ФАРМАЦИИ
SG2011097227A SG177421A1 (en) 2009-07-02 2010-07-01 Novel 2,3-dihydro-1h-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof, and pharmaceutical use thereof
CN201080039104.3A CN102482285B (zh) 2009-07-02 2010-07-01 2,3-二氢-1H-咪唑并{1,2-a}嘧啶-5-酮衍生物,其制备和其药物用途
DK10742012.7T DK2448939T3 (en) 2009-07-02 2010-07-01 DERIVATIVES OF 2,3-DIHYDRO-1H-IMIDAZO {1,2-A} PYRIMIDIN-5-ON, PREPARATION AND PHARMACEUTICAL USE thereof
KR1020127002797A KR101745028B1 (ko) 2009-07-02 2010-07-01 신규 ２,３-디히드로-１ｈ-이미다조（１,２-ａ）피리미딘-５-온 유도체, 그의 제조법 및 그의 제약 용도
PCT/FR2010/051373 WO2011001112A1 (fr) 2009-07-02 2010-07-01 NOUVEAUX DERIVES DE 2,3-DIHYDRO-1H-IMIDAZO{1,2-a}PYRIMIDIN-5-ONE, LEUR PREPARATION ET LEUR UTILISATION PHARMACEUTIQUE
UY0001032753A UY32753A (es) 2009-07-02 2010-07-02 NUEVOS DERIVADOS DE 2,3-DIHIDRO-1H-IMIDAZO{1,2-a}PIRIMIDIN-5-ONA, SU PREPARACIÓN Y SU UTILIZACIÓN EN FARMACÉUTICA
TW099121898A TWI458730B (zh) 2009-07-02 2010-07-02 新穎２，３－二氫－１Ｈ－咪唑并｛１，２－ａ｝嘧啶－５－酮衍生物，其製法及其醫藥用途
IL217294A IL217294A (en) 2009-07-02 2011-12-29 History 3,2 - Dihydro - 1h - Imidazo [1, 2 - a] - Pyrimidin - 5 - On, process for their preparation, pharmaceutical preparations containing them and their use in the preparation of medicines
CY20171100567T CY1119442T1 (el) 2009-07-02 2017-05-31 Παραγωγα 2,3-διϋδρο-1η-ιμιδαζο {1,2-α} πυριμιδιν-5-ονης, παρασκευη αυτων και φαρμακευτικη χρηση αυτων

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0957067A FR2951173B1 (fr) 2009-10-09 2009-10-09 Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb)

Publications (2)

Publication Number Publication Date
FR2951173A1 FR2951173A1 (fr) 2011-04-15
FR2951173B1 true FR2951173B1 (fr) 2011-12-02

Family

ID=42077171

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0957067A Expired - Fee Related FR2951173B1 (fr) 2009-07-02 2009-10-09 Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb)

Country Status (1)

Country Link
FR (1) FR2951173B1 (fr)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008148074A2 (fr) * 2007-05-24 2008-12-04 Research Foundation Of State University Of New York Inhibiteurs de mtor et methodes de traitement mettant en œuvre ces inhibiteurs

Also Published As

Publication number Publication date
FR2951173A1 (fr) 2011-04-15

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Effective date: 20160630