SI2658844T1 - Novi derivati pirimidina, njihova priprava in njihova farmacevtska uporaba kot inhibitorje AKT(PKB) fosforilacije - Google Patents
Novi derivati pirimidina, njihova priprava in njihova farmacevtska uporaba kot inhibitorje AKT(PKB) fosforilacijeInfo
- Publication number
- SI2658844T1 SI2658844T1 SI201131075A SI201131075A SI2658844T1 SI 2658844 T1 SI2658844 T1 SI 2658844T1 SI 201131075 A SI201131075 A SI 201131075A SI 201131075 A SI201131075 A SI 201131075A SI 2658844 T1 SI2658844 T1 SI 2658844T1
- Authority
- SI
- Slovenia
- Prior art keywords
- pkb
- akt
- preparation
- pharmaceutical use
- pyrimidine derivatives
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 230000026731 phosphorylation Effects 0.000 title 1
- 238000006366 phosphorylation reaction Methods 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- 150000003230 pyrimidines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1061300A FR2969610B1 (fr) | 2010-12-28 | 2010-12-28 | Nouveaux derives de (6-oxo-1,6-dihydro-pyrimidin-2-yl)-indolinamide, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| FR1061298A FR2969609B1 (fr) | 2010-12-28 | 2010-12-28 | Nouveaux derives de 6-oxo-dihydro-pyrimidine, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| FR1061301A FR2969614A1 (fr) | 2010-12-28 | 2010-12-28 | Nouveaux derives de pyrimidinones, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| FR1061297A FR2969608B1 (fr) | 2010-12-28 | 2010-12-28 | Nouveaux derives de (5-halo-6-oxo-1,6-dihydro-pyrimidin-2-yl)-amide, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| FR1061303A FR2969607B1 (fr) | 2010-12-28 | 2010-12-28 | Nouveaux derives de thiopyrimidinones, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| FR1159313 | 2011-10-14 | ||
| FR1159317 | 2011-10-14 | ||
| FR1159315 | 2011-10-14 | ||
| FR1159316 | 2011-10-14 | ||
| PCT/EP2011/073875 WO2012089633A1 (fr) | 2010-12-28 | 2011-12-22 | Nouveaux derives de pyrimidines, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| EP11805849.4A EP2658844B1 (fr) | 2010-12-28 | 2011-12-22 | Nouveaux derives de pyrimidines, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2658844T1 true SI2658844T1 (sl) | 2017-02-28 |
Family
ID=45464546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201131075A SI2658844T1 (sl) | 2010-12-28 | 2011-12-22 | Novi derivati pirimidina, njihova priprava in njihova farmacevtska uporaba kot inhibitorje AKT(PKB) fosforilacije |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9133168B2 (sl) |
| EP (1) | EP2658844B1 (sl) |
| CY (1) | CY1118858T1 (sl) |
| DK (1) | DK2658844T3 (sl) |
| ES (1) | ES2612492T3 (sl) |
| HR (1) | HRP20170119T1 (sl) |
| HU (1) | HUE030393T2 (sl) |
| LT (1) | LT2658844T (sl) |
| PL (1) | PL2658844T3 (sl) |
| PT (1) | PT2658844T (sl) |
| SI (1) | SI2658844T1 (sl) |
| WO (1) | WO2012089633A1 (sl) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103819422A (zh) * | 2014-03-18 | 2014-05-28 | 南通佰华生物医药研究有限公司 | 一种制备手性n-取代-2-吗啉甲醇类化合物的方法 |
| WO2015191754A2 (en) | 2014-06-13 | 2015-12-17 | Gilead Sciences, Inc. | Phosphatidylinositol 3-kinase inhibitors |
| JP6454736B2 (ja) | 2014-06-13 | 2019-01-16 | ギリアード サイエンシーズ， インコーポレイテッド | ホスファチジルイノシトール３−キナーゼ阻害剤 |
| CN106459005A (zh) | 2014-06-13 | 2017-02-22 | 吉利德科学公司 | 磷脂酰肌醇3‑激酶抑制剂 |
| BR112016028876A2 (pt) | 2014-06-13 | 2017-08-22 | Gilead Sciences Inc | composto, composição farmacêutica, método para tratar uma doença ou condição em um ser humano, kit, e, uso de um composto, um sal, isômero ou uma mistura farmaceuticamente aceitável dos mesmos. |
| ES2763103T3 (es) | 2014-06-13 | 2020-05-27 | Gilead Sciences Inc | Inhibidor de la fosfatidilinositol 3-quinasa |
| WO2018057808A1 (en) | 2016-09-23 | 2018-03-29 | Gilead Sciences, Inc. | Benzimidazole derivatives and their use as phosphatidylinositol 3-kinase inhibitors |
| TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| CN106966951B (zh) * | 2017-04-21 | 2020-01-31 | 常州佳德医药科技有限公司 | 4-氟-2-甲基吲哚及其制备方法和应用 |
| AU2021268345A1 (en) | 2020-05-05 | 2022-11-10 | Nuvalent, Inc. | Heteroaromatic macrocyclic ether chemotherapeutic agents |
| WO2021226208A2 (en) | 2020-05-05 | 2021-11-11 | Nuvalent, Inc. | Heteroaromatic macrocyclic ether chemotherapeutic agents |
| CN115707685A (zh) * | 2021-08-20 | 2023-02-21 | 中国石油化工股份有限公司 | 一种制备胺-环氧卤丙烷聚合单体的方法及产物和系统 |
| KR20240087788A (ko) | 2021-10-01 | 2024-06-19 | 뉴베일런트, 아이엔씨. | 헤테로방향족 매크로사이클릭 에테르 화합물의 고체 형태, 약학 조성물 및 제조 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4416884A (en) | 1978-04-12 | 1983-11-22 | Otsuka Pharmaceutical Co., Ltd. | Piperazinylbenzoheterocyclic compounds |
| DE60128655T2 (de) | 2000-01-24 | 2008-02-07 | Astrazeneca Ab | Durch einen morpholinrest substituierte therapeutische verbindungen |
| GB0119865D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
| CA2495661C (en) | 2002-08-16 | 2011-06-14 | Kinacia Pty Ltd. | Inhibition of phosphoinositide 3-kinase beta |
| AU2004235923B2 (en) | 2003-05-09 | 2008-01-24 | F. Hoffmann-La Roche Ag | Methyl indoles and methyl pyrrolopyridines as alpha-1 adrenergic agonists |
| US20070083053A1 (en) * | 2003-06-27 | 2007-04-12 | Nissan Chemical Industries, Ltd. | Process for producing indole compound |
| EA200700243A1 (ru) | 2004-07-14 | 2007-08-31 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Способы лечения гепатита с |
| ITMI20060621A1 (it) | 2006-03-31 | 2007-10-01 | Dac Srl | Nuova classe di inibitori delle istone deacetilasi |
| AR053358A1 (es) | 2005-04-15 | 2007-05-02 | Cancer Rec Tech Ltd | Inhibidores de adn - pk |
| JP2008542253A (ja) | 2005-05-26 | 2008-11-27 | クドス ファーマシューティカルズ リミテッド | Ｄｎａ損傷癌療法に対してａｔｍ欠損癌を感作するためのｄｎａ−ｐｋ阻害の使用 |
| BRPI0616459A2 (pt) | 2005-09-29 | 2011-06-21 | Wyeth Corp | compostos das fórmulas i, ii, e iii; processos para o tratamento ou para a prevenção de: um estado de saúde com melhora devido à recaptação de monoamina; pelo menos um sintoma vasomotor; pelo menos um distúrbio depressivo; pelo menos uma disfunção sexual; para a prevenção de dor; de distúrbio gastrointestinal ou genitourinário; de sìndrome de fadiga crÈnica; de sìndrome de fibromialgia; de esquizofrenia; e uso de um composto |
| TWI418556B (zh) * | 2006-07-27 | 2013-12-11 | Mitsubishi Tanabe Pharma Corp | 吲哚衍生物 |
| WO2008064244A2 (en) | 2006-11-20 | 2008-05-29 | The Trustees Of Columbia University In The City Of New York | Phosphoinositide modulation for the treatment of neurodegenerative diseases |
| WO2008148074A2 (en) | 2007-05-24 | 2008-12-04 | Research Foundation Of State University Of New York | Inhibitors of mtor and methods of treatment using same |
| CA2692720A1 (en) | 2007-07-09 | 2009-01-15 | Astrazeneca Ab | Morpholino pyrimidine derivatives used in diseases linked to mtor kinase and/or pi3k |
| BRPI0814818A2 (pt) | 2007-07-09 | 2019-09-10 | Astrazeneca Ab | composto, uso de um composto, métodos para produzir um efeito anti-proliferativo e um efeito inibitório de mtor quinase em uma animal de sangue quente, método para tratar doenças, e, composição farmacêutica |
| WO2009007749A2 (en) | 2007-07-09 | 2009-01-15 | Astrazeneca Ab | Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases |
| CA2692725A1 (en) | 2007-07-09 | 2009-01-15 | Astrazeneca Ab | Compound - 946 |
| CN101821260B (zh) | 2007-08-14 | 2013-07-31 | 康塞特医药品有限公司 | 取代的噁唑烷酮衍生物 |
| EP2062889A1 (de) | 2007-11-22 | 2009-05-27 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verbindungen |
| JP2011510033A (ja) | 2008-01-25 | 2011-03-31 | シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト | 化合物 |
| AU2009314299A1 (en) * | 2008-11-12 | 2010-05-20 | Merck Sharp & Dohme Corp. | Inhibitors of fatty acid binding protein (FABP) |
| TWI469965B (zh) | 2008-12-22 | 2015-01-21 | Ono Pharmaceutical Co | 乙炔基吲哚化合物 |
| NZ597579A (en) * | 2009-07-02 | 2013-06-28 | Sanofi Sa | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors |
-
2011
- 2011-12-22 WO PCT/EP2011/073875 patent/WO2012089633A1/fr not_active Ceased
- 2011-12-22 LT LTEP11805849.4T patent/LT2658844T/lt unknown
- 2011-12-22 PT PT118058494T patent/PT2658844T/pt unknown
- 2011-12-22 HU HUE11805849A patent/HUE030393T2/en unknown
- 2011-12-22 PL PL11805849T patent/PL2658844T3/pl unknown
- 2011-12-22 US US13/977,396 patent/US9133168B2/en active Active
- 2011-12-22 ES ES11805849.4T patent/ES2612492T3/es active Active
- 2011-12-22 DK DK11805849.4T patent/DK2658844T3/en active
- 2011-12-22 SI SI201131075A patent/SI2658844T1/sl unknown
- 2011-12-22 HR HRP20170119TT patent/HRP20170119T1/hr unknown
- 2011-12-22 EP EP11805849.4A patent/EP2658844B1/fr active Active
-
2017
- 2017-01-26 CY CY20171100117T patent/CY1118858T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012089633A9 (fr) | 2012-08-23 |
| HRP20170119T1 (hr) | 2017-03-24 |
| WO2012089633A1 (fr) | 2012-07-05 |
| HUE030393T2 (en) | 2017-05-29 |
| ES2612492T3 (es) | 2017-05-17 |
| LT2658844T (lt) | 2017-02-10 |
| PT2658844T (pt) | 2017-01-24 |
| CY1118858T1 (el) | 2018-01-10 |
| US9133168B2 (en) | 2015-09-15 |
| EP2658844B1 (fr) | 2016-10-26 |
| EP2658844A1 (fr) | 2013-11-06 |
| DK2658844T3 (en) | 2017-02-06 |
| US20130274253A1 (en) | 2013-10-17 |
| PL2658844T3 (pl) | 2017-04-28 |
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