PT2658844T - Novos derivados de pirimidinas, sua preparação e utilização farmacêutica como inibidores de fosforilação de akt (pkb) - Google Patents
Novos derivados de pirimidinas, sua preparação e utilização farmacêutica como inibidores de fosforilação de akt (pkb)Info
- Publication number
- PT2658844T PT2658844T PT118058494T PT11805849T PT2658844T PT 2658844 T PT2658844 T PT 2658844T PT 118058494 T PT118058494 T PT 118058494T PT 11805849 T PT11805849 T PT 11805849T PT 2658844 T PT2658844 T PT 2658844T
- Authority
- PT
- Portugal
- Prior art keywords
- pkb
- akt
- preparation
- pharmaceutical use
- pyrimidine derivatives
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 230000026731 phosphorylation Effects 0.000 title 1
- 238000006366 phosphorylation reaction Methods 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- 150000003230 pyrimidines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1061301A FR2969614A1 (fr) | 2010-12-28 | 2010-12-28 | Nouveaux derives de pyrimidinones, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| FR1061298A FR2969609B1 (fr) | 2010-12-28 | 2010-12-28 | Nouveaux derives de 6-oxo-dihydro-pyrimidine, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| FR1061300A FR2969610B1 (fr) | 2010-12-28 | 2010-12-28 | Nouveaux derives de (6-oxo-1,6-dihydro-pyrimidin-2-yl)-indolinamide, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| FR1061297A FR2969608B1 (fr) | 2010-12-28 | 2010-12-28 | Nouveaux derives de (5-halo-6-oxo-1,6-dihydro-pyrimidin-2-yl)-amide, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| FR1061303A FR2969607B1 (fr) | 2010-12-28 | 2010-12-28 | Nouveaux derives de thiopyrimidinones, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| FR1159317 | 2011-10-14 | ||
| FR1159313 | 2011-10-14 | ||
| FR1159316 | 2011-10-14 | ||
| FR1159315 | 2011-10-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2658844T true PT2658844T (pt) | 2017-01-24 |
Family
ID=45464546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT118058494T PT2658844T (pt) | 2010-12-28 | 2011-12-22 | Novos derivados de pirimidinas, sua preparação e utilização farmacêutica como inibidores de fosforilação de akt (pkb) |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9133168B2 (pt) |
| EP (1) | EP2658844B1 (pt) |
| CY (1) | CY1118858T1 (pt) |
| DK (1) | DK2658844T3 (pt) |
| ES (1) | ES2612492T3 (pt) |
| HR (1) | HRP20170119T1 (pt) |
| HU (1) | HUE030393T2 (pt) |
| LT (1) | LT2658844T (pt) |
| PL (1) | PL2658844T3 (pt) |
| PT (1) | PT2658844T (pt) |
| SI (1) | SI2658844T1 (pt) |
| WO (1) | WO2012089633A1 (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103819422A (zh) * | 2014-03-18 | 2014-05-28 | 南通佰华生物医药研究有限公司 | 一种制备手性n-取代-2-吗啉甲醇类化合物的方法 |
| CN106573922A (zh) | 2014-06-13 | 2017-04-19 | 吉利德科学公司 | 磷脂酰肌醇3‑激酶抑制剂 |
| CA2952025A1 (en) | 2014-06-13 | 2015-12-17 | Gilead Sciences, Inc. | Phosphatidylinositol 3-kinase inhibitors |
| EP3154958B1 (en) | 2014-06-13 | 2020-10-07 | Gilead Sciences, Inc. | Phosphatidylinositol 3-kinase inhibitors |
| CA2952018A1 (en) | 2014-06-13 | 2015-12-17 | Gilead Sciences, Inc. | Quinazolinone derivatives as phosphatidylinositol 3-kinase inhibitors |
| JP6455995B2 (ja) | 2014-06-13 | 2019-01-23 | ギリアード サイエンシーズ， インコーポレイテッド | ホスファチジルイノシトール３−キナーゼ阻害剤 |
| WO2018057808A1 (en) | 2016-09-23 | 2018-03-29 | Gilead Sciences, Inc. | Benzimidazole derivatives and their use as phosphatidylinositol 3-kinase inhibitors |
| TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| CN106966951B (zh) * | 2017-04-21 | 2020-01-31 | 常州佳德医药科技有限公司 | 4-氟-2-甲基吲哚及其制备方法和应用 |
| BR112022022530A2 (pt) | 2020-05-05 | 2023-02-23 | Nuvalent Inc | Composto, composição farmacêutica, método de tratamento de câncer, método de inibição seletiva, método de redução de um nível de ros1 ou alk |
| EP4146626A4 (en) | 2020-05-05 | 2024-05-29 | Nuvalent, Inc. | CHEMOTHERAPEUTIC AGENTS BASED ON HETEROAROMATIC MACROCYCLIC ETHERS |
| CN115707685A (zh) * | 2021-08-20 | 2023-02-21 | 中国石油化工股份有限公司 | 一种制备胺-环氧卤丙烷聚合单体的方法及产物和系统 |
| IL311444A (en) | 2021-10-01 | 2024-05-01 | Nuvalent Inc | Solid forms, pharmaceutical compositions and preparation of heteroaromatic macrocyclic ether compounds |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4416884A (en) | 1978-04-12 | 1983-11-22 | Otsuka Pharmaceutical Co., Ltd. | Piperazinylbenzoheterocyclic compounds |
| DE60128655T2 (de) | 2000-01-24 | 2008-02-07 | Astrazeneca Ab | Durch einen morpholinrest substituierte therapeutische verbindungen |
| GB0119865D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
| US7598377B2 (en) | 2002-08-16 | 2009-10-06 | Astrazeneca Ab | Inhibition of phosphoinositide 3-kinase β |
| WO2004099189A1 (en) | 2003-05-09 | 2004-11-18 | F. Hoffmann-La Roche Ag | Methyl indoles and methyl pyrrolopyridines as alph-1 adrenergic agonists |
| WO2005000812A1 (ja) * | 2003-06-27 | 2005-01-06 | Nissan Chemical Industries, Ltd. | インドール化合物の製造方法 |
| EP1771169A1 (en) | 2004-07-14 | 2007-04-11 | PTC Therapeutics, Inc. | Methods for treating hepatitis c |
| ITMI20060621A1 (it) | 2006-03-31 | 2007-10-01 | Dac Srl | Nuova classe di inibitori delle istone deacetilasi |
| AR053358A1 (es) | 2005-04-15 | 2007-05-02 | Cancer Rec Tech Ltd | Inhibidores de adn - pk |
| WO2006126010A2 (en) | 2005-05-26 | 2006-11-30 | Kudos Pharmaceuticals Limited | Use of dna-pk inhibition to sensitise atm deficient cancers to dna-damaging cancer therapies |
| CN101309904A (zh) | 2005-09-29 | 2008-11-19 | 惠氏公司 | 作为单胺再摄取调节剂用于治疗血管舒缩症状(vasomotorsymptoms，vms)的1－(1h－吲哚－1－基)－3－(甲基氨基)－1－苯基丙－2－醇衍生物和相关化合物 |
| TWI418556B (zh) | 2006-07-27 | 2013-12-11 | Mitsubishi Tanabe Pharma Corp | 吲哚衍生物 |
| WO2008064244A2 (en) | 2006-11-20 | 2008-05-29 | The Trustees Of Columbia University In The City Of New York | Phosphoinositide modulation for the treatment of neurodegenerative diseases |
| WO2008148074A2 (en) | 2007-05-24 | 2008-12-04 | Research Foundation Of State University Of New York | Inhibitors of mtor and methods of treatment using same |
| AU2008273889B2 (en) | 2007-07-09 | 2012-03-08 | Astrazeneca Ab | Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases |
| EP2178866A2 (en) | 2007-07-09 | 2010-04-28 | AstraZeneca AB | Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases |
| AU2008273892A1 (en) | 2007-07-09 | 2009-01-15 | Astrazeneca Ab | Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases |
| EP2176238B1 (en) | 2007-07-09 | 2012-04-18 | AstraZeneca AB | Morpholino pyrimidine derivatives used in diseases linked to mtor kinase and/or pi3k |
| EP2190841B1 (en) | 2007-08-14 | 2013-05-15 | Concert Pharmaceuticals Inc. | Substituted oxazolidinone derivatives |
| EP2062889A1 (de) | 2007-11-22 | 2009-05-27 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verbindungen |
| WO2009092590A2 (en) | 2008-01-25 | 2009-07-30 | Syngenta Participations Ag | Chemical compounds |
| JP2012508692A (ja) * | 2008-11-12 | 2012-04-12 | シェーリング コーポレイション | 脂肪酸結合タンパク質（ｆａｂｐ）の阻害薬 |
| TWI469965B (zh) | 2008-12-22 | 2015-01-21 | Ono Pharmaceutical Co | 乙炔基吲哚化合物 |
| JP5680638B2 (ja) * | 2009-07-02 | 2015-03-04 | サノフイ | 新規な（６−オキソ−１，６−ジヒドロピリミジン−２−イル）アミド誘導体、この調製およびａｋｔ（ｐｋｂ）リン酸化インヒビターとしてのこの医薬的な使用 |
-
2011
- 2011-12-22 ES ES11805849.4T patent/ES2612492T3/es active Active
- 2011-12-22 EP EP11805849.4A patent/EP2658844B1/fr active Active
- 2011-12-22 PT PT118058494T patent/PT2658844T/pt unknown
- 2011-12-22 PL PL11805849T patent/PL2658844T3/pl unknown
- 2011-12-22 US US13/977,396 patent/US9133168B2/en active Active
- 2011-12-22 LT LTEP11805849.4T patent/LT2658844T/lt unknown
- 2011-12-22 HR HRP20170119TT patent/HRP20170119T1/hr unknown
- 2011-12-22 DK DK11805849.4T patent/DK2658844T3/en active
- 2011-12-22 SI SI201131075A patent/SI2658844T1/sl unknown
- 2011-12-22 WO PCT/EP2011/073875 patent/WO2012089633A1/fr not_active Ceased
- 2011-12-22 HU HUE11805849A patent/HUE030393T2/en unknown
-
2017
- 2017-01-26 CY CY20171100117T patent/CY1118858T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20130274253A1 (en) | 2013-10-17 |
| US9133168B2 (en) | 2015-09-15 |
| EP2658844A1 (fr) | 2013-11-06 |
| WO2012089633A9 (fr) | 2012-08-23 |
| LT2658844T (lt) | 2017-02-10 |
| SI2658844T1 (sl) | 2017-02-28 |
| DK2658844T3 (en) | 2017-02-06 |
| CY1118858T1 (el) | 2018-01-10 |
| ES2612492T3 (es) | 2017-05-17 |
| PL2658844T3 (pl) | 2017-04-28 |
| HRP20170119T1 (hr) | 2017-03-24 |
| EP2658844B1 (fr) | 2016-10-26 |
| WO2012089633A1 (fr) | 2012-07-05 |
| HUE030393T2 (en) | 2017-05-29 |
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