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EP2490693A4 - Inhibiteurs de pyrazolo[3,4-b]pyridin-4-one kinase - Google Patents

Inhibiteurs de pyrazolo[3,4-b]pyridin-4-one kinase

Info

Publication number
EP2490693A4
EP2490693A4 EP10825388A EP10825388A EP2490693A4 EP 2490693 A4 EP2490693 A4 EP 2490693A4 EP 10825388 A EP10825388 A EP 10825388A EP 10825388 A EP10825388 A EP 10825388A EP 2490693 A4 EP2490693 A4 EP 2490693A4
Authority
EP
European Patent Office
Prior art keywords
pyrazolo
pyridin
kinase
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10825388A
Other languages
German (de)
English (en)
Other versions
EP2490693A1 (fr
Inventor
Tony Siu
Christopher Dinsmore
Sathyajith E Kumarasinghe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme Ltd
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd, Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme Ltd
Publication of EP2490693A1 publication Critical patent/EP2490693A1/fr
Publication of EP2490693A4 publication Critical patent/EP2490693A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP10825388A 2009-10-19 2010-09-29 Inhibiteurs de pyrazolo[3,4-b]pyridin-4-one kinase Withdrawn EP2490693A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25280209P 2009-10-19 2009-10-19
PCT/US2010/050689 WO2011049722A1 (fr) 2009-10-19 2010-09-29 Inhibiteurs de pyrazolo[3,4-b]pyridin-4-one kinase

Publications (2)

Publication Number Publication Date
EP2490693A1 EP2490693A1 (fr) 2012-08-29
EP2490693A4 true EP2490693A4 (fr) 2013-02-27

Family

ID=43900615

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10825388A Withdrawn EP2490693A4 (fr) 2009-10-19 2010-09-29 Inhibiteurs de pyrazolo[3,4-b]pyridin-4-one kinase

Country Status (3)

Country Link
US (1) US20120220624A1 (fr)
EP (1) EP2490693A4 (fr)
WO (1) WO2011049722A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015357498B2 (en) * 2014-12-06 2019-09-12 Intra-Cellular Therapies, Inc. Organic compounds
HK1243936A1 (zh) 2014-12-06 2018-07-27 Intra-Cellular Therapies, Inc. 有机化合物
CN105777743A (zh) * 2014-12-19 2016-07-20 奥浦顿（上海）医药科技有限公司 一种吡唑并[3,4-b]吡啶类化合物中间体的制备方法和应用
TW202235075A (zh) * 2020-12-17 2022-09-16 美商艾伯維有限公司 雙環吡唑布魯頓氏酪胺酸激酶抑制劑

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009014620A1 (fr) * 2007-07-20 2009-01-29 Merck & Co., Inc. Dérivés de la pyrazolo[1,5-a]pyrimidine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3891630A (en) * 1974-03-04 1975-06-24 Abbott Lab Substituted pyrazolo{8 3,4-e{9 {8 1,4{9 thiazepines and isoxazolo{8 5,4-e{9 {8 1,4{9 thiazepines
US4038281A (en) * 1975-10-16 1977-07-26 E. R. Squibb & Sons, Inc. Certain 2,7-dihydro-4H-pyrazolo[3,4-b]pyridine-5-ketones
GB0024808D0 (en) * 2000-10-10 2000-11-22 Smithkline Beecham Plc Novel compounds
US8080546B2 (en) * 2007-10-26 2011-12-20 Amgen Inc. Pyrazolo-pyridinone derivatives and methods of use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009014620A1 (fr) * 2007-07-20 2009-01-29 Merck & Co., Inc. Dérivés de la pyrazolo[1,5-a]pyrimidine

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CASTRO A ET AL: "INHIBITION OF TAU PHOSPHORYLATION: A NEW THERAPEUTIC STRATEGY FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND OTHER NEURODEGENERATIVE DISORDERS", EXPERT OPINION ON THERAPEUTIC PATENTS, INFORMA HEALTHCARE, GB, vol. 10, no. 10, 1 January 2000 (2000-01-01), pages 1519 - 1527, XP008039626, ISSN: 1354-3776, DOI: 10.1517/13543776.10.10.1519 *
HANGER D P ET AL: "Mediators of tau phosphorylation in the pathogenesis of Alzheimer's disease", EXPERT REVIEW OF NEUROTHERAPEUTICS, FUTURE DRUGS, LONDON, GB, vol. 9, no. 11, 1 January 2009 (2009-01-01), pages 1647 - 1666, XP009157174, ISSN: 1473-7175, DOI: 10.1586/ERN.09.104 *
See also references of WO2011049722A1 *

Also Published As

Publication number Publication date
WO2011049722A1 (fr) 2011-04-28
US20120220624A1 (en) 2012-08-30
EP2490693A1 (fr) 2012-08-29

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20120521

AK Designated contracting states

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Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20130130

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/542 20060101AFI20130124BHEP

Ipc: A61K 31/53 20060101ALI20130124BHEP

Ipc: A61P 35/00 20060101ALI20130124BHEP

Ipc: C07D 471/04 20060101ALI20130124BHEP

STAA Information on the status of an ep patent application or granted ep patent

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Effective date: 20130829