[go: up one dir, main page]

FR2384765A1 - Derives amino-substitues du furanne et procede pour leur preparation - Google Patents

Derives amino-substitues du furanne et procede pour leur preparation

Info

Publication number
FR2384765A1
FR2384765A1 FR7814250A FR7814250A FR2384765A1 FR 2384765 A1 FR2384765 A1 FR 2384765A1 FR 7814250 A FR7814250 A FR 7814250A FR 7814250 A FR7814250 A FR 7814250A FR 2384765 A1 FR2384765 A1 FR 2384765A1
Authority
FR
France
Prior art keywords
furan
amino
preparation
substitute derivatives
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7814250A
Other languages
English (en)
Other versions
FR2384765B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allen and Hanburys Ltd
Original Assignee
Allen and Hanburys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27516213&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2384765(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from KR7701808A external-priority patent/KR810000355B1/ko
Application filed by Allen and Hanburys Ltd filed Critical Allen and Hanburys Ltd
Publication of FR2384765A1 publication Critical patent/FR2384765A1/fr
Application granted granted Critical
Publication of FR2384765B1 publication Critical patent/FR2384765B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/64—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne des dérivés du furanne. Il s'agit de composés de la formule générale :
FR7814250A 1976-08-04 1978-05-12 Derives amino-substitues du furanne et procede pour leur preparation Expired FR2384765B1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB32465/76A GB1565966A (en) 1976-08-04 1976-08-04 Aminoalkyl furan derivatives
GB5068576 1976-12-06
GB2018777 1977-05-13
GB28187/78A GB1565967A (en) 1976-08-04 1977-07-22 Aminoalkyl furan derivatives
KR7701808A KR810000355B1 (ko) 1977-05-13 1977-08-04 아미노 알킬푸란 유도체의 제조방법

Publications (2)

Publication Number Publication Date
FR2384765A1 true FR2384765A1 (fr) 1978-10-20
FR2384765B1 FR2384765B1 (fr) 1982-09-10

Family

ID=27516213

Family Applications (3)

Application Number Title Priority Date Filing Date
FR7724021A Expired FR2360587B1 (fr) 1976-08-04 1977-08-04 Nouveaux derives d'amino-alcoyl-furannes utiles comme medicaments
FR7814250A Expired FR2384765B1 (fr) 1976-08-04 1978-05-12 Derives amino-substitues du furanne et procede pour leur preparation
FR7814251A Expired FR2384753B1 (fr) 1976-08-04 1978-05-12 Nouveaux thiols et leur procede de preparation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR7724021A Expired FR2360587B1 (fr) 1976-08-04 1977-08-04 Nouveaux derives d'amino-alcoyl-furannes utiles comme medicaments

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7814251A Expired FR2384753B1 (fr) 1976-08-04 1978-05-12 Nouveaux thiols et leur procede de preparation

Country Status (10)

Country Link
US (3) US4128658A (fr)
JP (3) JPS5840956B2 (fr)
AU (1) AU515628B2 (fr)
BE (1) BE857388A (fr)
CA (1) CA1099268A (fr)
DE (1) DE2734070C2 (fr)
FR (3) FR2360587B1 (fr)
GB (2) GB1565966A (fr)
LU (1) LU77911A1 (fr)
NL (1) NL178320C (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2571723A1 (fr) * 1984-10-12 1986-04-18 Lipha Derives de thieno et furo-(2,3-c) pyrroles, procedes de preparation et medicaments les contenant
FR2619816A1 (fr) * 1987-08-28 1989-03-03 Toyama Chemical Co Ltd Derives d'amine et leurs sels, leurs procedes de fabrication, et agent anti-ulcere les contenant

Families Citing this family (167)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1601459A (en) * 1977-05-17 1981-10-28 Allen & Hanburys Ltd Aminoalkyl thiophene derivatives
US5021429A (en) * 1977-05-17 1991-06-04 Allen & Hansburys Limited Pharmacologically active aminoalkylphenyl compounds and their use
JPS5444660A (en) * 1977-08-29 1979-04-09 Yamanouchi Pharmaceut Co Ltd Heterocyclic compound and its preparation
AU524143B2 (en) * 1977-10-11 1982-09-02 Glaxo Group Limited Aminoalkyl furan derivatives
US4233302A (en) * 1977-12-23 1980-11-11 Glaxo Group Limited Amine derivatives and pharmaceutical compositions containing them
US4539207A (en) * 1978-02-13 1985-09-03 Smith Kline & French Laboratories Limited Pyrimidine compounds
IN151188B (fr) * 1978-02-13 1983-03-05 Smith Kline French Lab
AR228941A1 (es) 1978-04-26 1983-05-13 Glaxo Group Ltd Procedimiento para preparar nuevos derivados de 3,5-diamino-1,2,4-triazol que son activos contra receptores histaminicos
IL57416A (en) * 1978-05-30 1983-03-31 Smith Kline French Lab Nitro compounds,processes for preparing them and compositions containing them
US4584384A (en) * 1978-05-30 1986-04-22 Smith Kline & French Laboratories Limited Nitro pyrroles
IL57415A (en) * 1978-05-30 1984-08-31 Smith Kline French Lab Nitropyrrole compounds,process for preparing them and pharmaceutical compositions containing them
US4405624A (en) * 1978-05-30 1983-09-20 Smith Kline & French Laboratories Limited Nitro-substituted dihydropyrroles and tetrahydropyridines, compositions, compounds, and medicinal use
ZA793443B (en) * 1978-07-26 1980-12-31 Glaxo Group Ltd Heterocyclic derivatives
US4203909A (en) * 1978-09-26 1980-05-20 Bristol-Myers Company Furan compounds
US4200760A (en) * 1978-09-26 1980-04-29 Bristol-Myers Company Imidazolylalkylthioalkylamino-ethylene derivatives
FR2446829A1 (fr) * 1978-11-16 1980-08-14 Glaxo Group Ltd Derives de polymethylene disubstitues en alpha, omega, procede pour leur preparation et compositions pharmaceutiques les contenant
US4282363A (en) * 1978-11-24 1981-08-04 Bristol-Myers Company 1-Nitro-2-(2-alkynylamino)-2-[(2-pyridylmethylthio)-ethylamino]ethylene derivatives
ZA801151B (en) * 1979-03-02 1981-02-25 Glaxo Group Ltd Heterocyclic derivatives
AU535701B2 (en) * 1979-03-02 1984-04-05 Glaxo Group Limited Amino trialole derivatives
JPS55120571A (en) * 1979-03-02 1980-09-17 Glaxo Group Ltd Heterocyclic derivative
US4220654A (en) * 1979-06-04 1980-09-02 Merck & Co., Inc. Cyclic imidazole cyanoguanidines
US4293557A (en) * 1979-07-03 1981-10-06 Teikoku Hormone Mfg. Co., Ltd. Antiulcer phenoxypropylamine derivatives
JPS5610175A (en) * 1979-07-06 1981-02-02 Fujisawa Pharmaceut Co Ltd Preparation of imidazole derivative
GB2063253B (en) * 1979-10-22 1983-09-14 Glaxo Group Ltd Triazole derivatives processes for their production and pharmaceutical compositions containing them
ES8203354A1 (es) * 1979-10-22 1982-04-01 Glaxo Group Ltd Un procedimiento para la produccion de nuevos derivados heterociclicos,.
US4238487A (en) * 1979-10-31 1980-12-09 Merck & Co., Inc. Aminoalkyl benzofuran derivatives
JPS5681578A (en) * 1979-12-07 1981-07-03 Shionogi & Co Ltd Novel thioalkyl amide derivative
US4239908A (en) * 1979-12-10 1980-12-16 G.D. Searle & Co. N-aralkenyl-N'-cyano-N"-(heterocyclylthioalkyl)-guanidines
US4431802A (en) * 1979-12-10 1984-02-14 G. D. Searle & Co. N-Heterocyclyl-N-cyano-N-(heterocyclythioalkyl)-guanidines
PT72320B (en) * 1980-01-08 1982-07-23 Glaxo Group Ltd Process for preparation of a furan derivative
CA1171096A (fr) * 1980-01-08 1984-07-17 Glaxo Group Limited Methode de preparation d'un derive du furanne
CA1181084A (fr) * 1980-01-08 1985-01-15 Glaxo Group Limited Preparation d'un derive de furane
YU53681A (en) * 1980-03-08 1983-12-31 Smith Kline French Lab Process for obtaining 5-dimethylamino-methyl-2-furane methanol
CA1155842A (fr) * 1980-03-29 1983-10-25 Thomas H. Brown Composes
US4491586A (en) * 1980-06-05 1985-01-01 Glaxo Group Limited Amine derivatives
US4394508A (en) * 1980-06-07 1983-07-19 Bristol-Myers Company Chemical compounds
US4607107A (en) * 1980-10-01 1986-08-19 Smith Kline & French Laboratories Ltd. (4-aminoalkyl-2-pyridyl alkyl)guanidines
IL63968A (en) * 1980-10-01 1985-10-31 Glaxo Group Ltd Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it
AT407956B (de) * 1980-10-01 2001-07-25 Glaxo Group Ltd Verfahren zur herstellung eines arzneimittels
US4760075A (en) * 1980-10-02 1988-07-26 Eli Lilly And Company N-thiazolylmethylthioalkyl-N-alkyl-amidines and related compounds
US4904792A (en) * 1980-10-02 1990-02-27 Eli Lilly And Company N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds
US4490533A (en) * 1980-12-22 1984-12-25 Merck & Co., Inc. Aminoalkyl pyridine derivatives
DE3170348D1 (en) * 1980-12-30 1985-06-05 Glaxo Group Ltd Process for the preparation of a furan derivative
KR850001935B1 (ko) * 1980-12-30 1985-12-31 그랙소 그룹 리밋티드 푸란유도체의 제조방법
DK558181A (da) * 1981-01-30 1982-07-31 Smithkline Corp Fremgangsmaade til fremstilling af 3,5-diamino-1,2,4-triazoler
EP0057981A3 (fr) 1981-02-09 1982-08-25 Beecham Group Plc Composés aromatiques, procédés pour leur préparation et leur application
US4399293A (en) * 1981-02-20 1983-08-16 Glaxo Group Limited Process for the preparation of a furan derivative
DE3108753A1 (de) * 1981-03-07 1982-09-16 Degussa Ag, 6000 Frankfurt Neue substituierte alkyl-phenylsulfonylguanidine miteinem heterocyclischen rest
FR2501691A1 (fr) * 1981-03-11 1982-09-17 Sanofi Sa Thioalkylamides, procede de preparation et compositions pharmaceutiques en contenant
US4381395A (en) * 1981-04-03 1983-04-26 Sk & F Lab Co. Process for preparing an imidazole derivative
AR229878A1 (es) * 1981-05-07 1983-12-30 Glaxo Group Ltd Procedimiento para preparar ranitidina
US4390701A (en) * 1981-05-18 1983-06-28 Bristol-Myers Company 1-Amino-2-[3-(3-piperidinomethylphenoxy)propylamino]cyclobutene-3,4-dione
US5171860A (en) * 1981-06-15 1992-12-15 Merck & Co., Inc. Diamino isothiazole-1-oxides and 1,1 dioxides as gastric secretion inhibitors
BE894285A (fr) * 1981-09-04 1983-03-02 Glaxo Group Ltd Composition pharmaceutique contenant un medicament anti-inflammatoire et de la ranitidine ou un sel de ce compose
ES507180A0 (es) * 1981-11-16 1982-08-16 Pharmedical Sa Lab Procedimiento de preparacion de amino alcosi furanos o tio- fenos.
US4525477A (en) * 1981-12-02 1985-06-25 Smith Kline & French Laboratories Limited 2-Thiazolyl, isothiazolyl, oxazolyl and isoxazolyl alkylamino-3-nitro-heterocyclic compounds
GR77847B (fr) * 1981-12-14 1984-09-25 American Home Prod
WO1983002113A1 (fr) * 1981-12-17 1983-06-23 Yuki, Hiroshi Derives de propenylamine et medicaments les contenant
US4411899A (en) * 1981-12-21 1983-10-25 Merck & Co., Inc. Substituted derivatives of amino alkane diols as gastric secretion inhibitors
DE3213509A1 (de) * 1982-04-10 1983-10-20 Basf Ag, 6700 Ludwigshafen N-substituierte imidazol-derivate, ihre herstellung, diese enthaltende arzneimittel und ihre verwendung
PT76557B (en) * 1982-04-16 1986-01-21 Inke Sa Process for preparing furan derivatives and addition salts thereof and of pharmaceutical compositions containing the same
ATE21901T1 (de) * 1982-07-30 1986-09-15 Smith Kline French Lab Aminopyrimidinone und ihre herstellung.
EP0105732A3 (fr) * 1982-10-01 1985-09-04 Beecham Group Plc Antagonistes de récepteurs d'histamine H2 des séries benzisothiazole amino et benzothiadiazine amino
US4590192A (en) * 1982-10-01 1986-05-20 Beecham Group P.L.C. Benzisothiazoles, their pharmaceutical compositions, and method of use
JPS5988458A (ja) * 1982-11-12 1984-05-22 Toyama Chem Co Ltd アミン誘導体およびその塩
YU42819B (en) * 1982-11-22 1988-12-31 Lek Tovarna Farmacevtskih Process for preparing n-/2-///5-(dimethyl-amino)-methyl-2-furanyl/methyl/thio/ethyl-n'-methyl-2-nitro-1,1-ethene diamine
US4458077A (en) * 1982-11-22 1984-07-03 American Home Products Corporation Heterocyclic anti-ulcer agents
DE3343884A1 (de) * 1982-12-08 1984-06-14 Degussa Ag, 6000 Frankfurt Neue ethendiamin- und guanidin-derivate
NL8303965A (nl) * 1982-12-08 1984-07-02 Degussa Nieuwe etheendiamine- en guanidine-derivaten; werkwijze voor het bereiden daarvan; geneesmiddelen die ze bevatten; werkwijze voor het bereiden van dergelijke geneesmiddelen; toepassing van de verbindingen voor het bereiden van geneesmiddelen en in de geneeskunde.
US4814335A (en) * 1982-12-30 1989-03-21 Biomeasure, Incorporated Antiviral compounds
US4495193A (en) * 1982-12-30 1985-01-22 Biomeasure, Inc. Imidazole compounds which reduce gastric acid secretion
US4565815A (en) * 1982-12-30 1986-01-21 Biomeasure, Inc. Pyrazolo[1,5-a]-1,3,5-triazines
US4665172A (en) * 1983-01-28 1987-05-12 Ube Industries, Ltd. Process for producing heterocyclic compound having nitromethylene group as the side chain group
US4558044A (en) * 1983-02-19 1985-12-10 Beecham Group P.L.C. 1,2,4-Benzothiadiazines
DK169255B1 (da) * 1983-02-22 1994-09-26 American Home Prod Analogifremgangsmåde til fremstilling af thieno-isothiazol-1,1-dioxid-derivater og farmaceutisk acceptable salte heraf
DE3306102C1 (de) * 1983-02-22 1984-08-02 Ludwig Heumann & Co GmbH, 8500 Nürnberg Pyridin-Pyrimidinon-Derivate,Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US4772622A (en) * 1983-03-25 1988-09-20 Merck & Co., Inc. 3,5-diamino-1,2,4-oxidiazoles as gastric secretion inhibitors
ES521588A0 (es) * 1983-03-30 1984-08-16 Ferrer Int Procedimiento de obtencion de nuevas n-ciano-formamidinas.
GB8313217D0 (en) * 1983-05-13 1983-06-22 Glaxo Group Ltd Pharmaceutical compositions
US4567191A (en) * 1983-06-07 1986-01-28 Merck & Co., Inc. Amino-phenyl-thiadiazoledioxides as gastric secretion inhibitors
US4539416A (en) * 1983-06-10 1985-09-03 The Dow Chemical Company Processes for making thioalkyl carboxamides and amines
SE457082B (sv) * 1983-07-15 1988-11-28 Richter Gedeon Vegyeszet Foerfarande foer framstaellning av hydrokloriden av 1-/2-/5-dimetylaminometyl-2-(furylmetyltio)-etyl//-amino-1-metylamino-2-nitroetylen
JPS6067474A (ja) * 1983-09-24 1985-04-17 Wakamoto Pharmaceut Co Ltd 新規な１，３，４−チアジアゾ−ル誘導体及びそれを有効成分とする抗潰瘍剤
BG39661A1 (en) * 1984-04-13 1986-08-29 Ivanova Antiulcer means
HU198196B (en) * 1984-05-02 1989-08-28 Gyogyszerkutato Intezet Process for production of basic tioether and its salts
IT1196133B (it) * 1984-06-06 1988-11-10 Ausonia Farma Srl Derivati furanici con attivita' antiulcera
DE3546858C2 (de) * 1984-06-15 1995-04-20 Glaxo Group Ltd Verfahren zur Herstellung von Ranitidin
GB8415254D0 (en) 1984-06-15 1984-07-18 Glaxo Group Ltd Amine derivatives
GB8423804D0 (en) * 1984-09-20 1984-10-24 Glaxo Group Ltd Chemical process
IT1178026B (it) * 1984-10-05 1987-09-03 Medosan Ind Biochimi Derivati del 2-amino-tiazolo
EP0269650A1 (fr) * 1986-03-28 1988-06-08 Recordati Farma Srl Synthese de composes a action anti-ulcere
US4814341A (en) * 1986-08-26 1989-03-21 Reiter Lawrence A 2-guanidino-4-(2-furyl) thiazoles as antiulcer agents
JPH0725745B2 (ja) * 1986-11-11 1995-03-22 株式会社日本触媒 アミン化合物の製造方法
GB8629781D0 (en) * 1986-12-12 1987-01-21 Glaxo Group Ltd Pharmaceutical compositions
EP0285681B1 (fr) * 1987-04-06 1993-03-10 HEUMANN PHARMA GMBH & CO Procédé pour la préparation de dérivés de nitroéthène
JPH01131172A (ja) * 1987-08-28 1989-05-24 Toyama Chem Co Ltd アミン誘導体およびその塩、それらの製造法、並びにそれらを含有する抗潰瘍剤
SE8704436D0 (sv) * 1987-11-13 1987-11-13 Pm Konsult Handelsbolag Anvendning av antisekretoriska substanser for nya indikationer
JPH01138013U (fr) * 1988-03-16 1989-09-21
IL90245A (en) * 1988-05-11 1994-04-12 Glaxo Group Ltd Resin adsorbate comprising ranitidine together with a synthetic cation exchange resin, its preparation and pharmaceutical compositions containing it
US4880636A (en) * 1988-05-13 1989-11-14 Franz Robert M Film coated tablet of ranitidine HCl
CH679582A5 (fr) * 1988-07-18 1992-03-13 Glaxo Group Ltd
NL8902338A (nl) * 1988-09-20 1990-04-17 Glaxo Group Ltd Farmaceutische preparaten.
GB8904182D0 (en) * 1989-02-23 1989-04-05 Glaxo Canada Pharmaceutical compositions
ES2012285A6 (es) * 1989-03-09 1990-03-01 Vinas Lab Procedimiento para la obtencion de derivados furanicos.
JPH0730064B2 (ja) * 1989-08-17 1995-04-05 協和醗酵工業株式会社 フラン誘導体
GB9004328D0 (en) * 1990-02-27 1990-04-25 Glaxo Group Ltd Chemical compounds
GB9009437D0 (en) * 1990-04-26 1990-06-20 Glaxo Group Ltd Chemical compounds
HU210849B (en) * 1990-11-09 1995-08-28 Richter Gedeon Vegyeszet Process for preparing furil derivatives
US5169864A (en) * 1991-11-15 1992-12-08 Baxter International Inc. Unbuffered premixed ranitidine formulation
US5294433A (en) * 1992-04-15 1994-03-15 The Procter & Gamble Company Use of H-2 antagonists for treatment of gingivitis
WO1993023360A1 (fr) * 1992-05-12 1993-11-25 Zeria Pharmaceutical Co., Ltd. Nouveaux sels d'ammonium quaternaires et utilisation de ces sels comme medicament
JPH0649615U (ja) * 1992-12-14 1994-07-08 日本建鐵株式会社 ドライシールカーテンウォールの排水構造
WO1995010274A1 (fr) * 1993-10-14 1995-04-20 F.H. Faulding & Co. Limited Composition pharmaceutique aqueuse
DE4341310A1 (de) * 1993-12-03 1995-06-08 Hexal Pharma Gmbh Tablette oder Kapsel mit einem Gehalt an stabilem Ranitidinhydrochlorid Form 1
US5407687A (en) * 1994-02-22 1995-04-18 Glaxo Inc. Ranitidine solid dosage form
EP0754182A1 (fr) 1994-04-08 1997-01-22 Brantford Chemicals Inc. Hydrochlorure de ranitidine de forme 1 a densite accrue
CA2120874E (fr) * 1994-04-08 2002-01-08 Keshava Murthy Forme de la ranitidine de forme 1
IN181699B (fr) * 1994-05-13 1998-09-05 Ranbaxy Lab Ltd
IN181698B (fr) * 1994-05-13 1998-09-05 Ranbaxy Lab Ltd
NZ272054A (en) * 1994-05-13 1996-05-28 Ranbaxy Lab Ltd Process for producing form 1 ranitidine hydrochloride
EP0694540B1 (fr) 1994-06-24 1998-08-19 Ranbaxy Laboratories Limited Procédé pour la préparation de l'hydrochlorure de ranitidine de forme 1
ES2119268T3 (es) * 1994-06-24 1998-10-01 Ranbaxy Lab Ltd Procedimiento para fabricar ranitidina base de calidad farmaceutica.
US5538737A (en) * 1994-11-30 1996-07-23 Applied Analytical Industries, Inc. Oral compositions of H2 -antagonists
HU222502B1 (hu) * 1994-12-08 2003-07-28 Aventis Pharmaceuticals Inc. Új eljárás ranitidin előállítására
US5672724A (en) * 1994-12-08 1997-09-30 Hoechst Marion Roussel, Inc. Processes for preparing ranitidine
US5663381A (en) * 1995-04-21 1997-09-02 Hexal Pharmaceuticals, Inc. Process for preparing form 1 ranitidine hydrochloride
US5686588A (en) * 1995-08-16 1997-11-11 Yoo; Seo Hong Amine acid salt compounds and process for the production thereof
US5837716A (en) * 1995-11-13 1998-11-17 Albany Medical College Analgesic heterocyclic compounds
WO1997035853A1 (fr) * 1996-03-25 1997-10-02 Hoechst Marion Roussel, Inc. Procede de preparation de chlorhydrate de ranitidine de forme 1
RU2131264C1 (ru) * 1996-06-04 1999-06-10 Московское производственное химико-фармацевтическое объединение им.Н.А.Семашко Противоязвенное средство в виде таблеток и способ его получения
EP1047683A1 (fr) * 1998-01-16 2000-11-02 Centaur Pharmaceuticals, Inc. Composes de nitrone thioether furane
IE990387A1 (en) * 1998-06-17 2000-12-13 Russinsky Ltd A ranitidine base water adduct
YU52598A (sh) * 1998-11-19 2001-05-28 D.D. Zdravlje- sektor za istraživanje i razvoj POSTUPAK ZA sintezu N-[2[[[5=[(DIALKILAMINO)METIL]-2= FURANIL]METIL]TIO]ETIL]-N'-ALKIL-2-NITRO 1,1 ALKENDIAMINA I NJIHOVIH HIDROHLORIDA
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
DE10300325A1 (de) * 2003-01-09 2004-07-22 Hexal Ag Granulat mit öliger Substanz, Herstellungsverfahren und Tablette
US7632521B2 (en) * 2003-07-15 2009-12-15 Eurand, Inc. Controlled release potassium chloride tablets
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
EP1579862A1 (fr) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Utilisation des inhibiteurs de PDE III pour la réduction de la taille du coeur chez des mammifères souffrant d'insufficances cardiaques
US20060088593A1 (en) * 2004-10-27 2006-04-27 Bunick Frank J Dosage forms having a microreliefed surface and methods and apparatus for their production
US20060087051A1 (en) * 2004-10-27 2006-04-27 Bunick Frank J Dosage forms having a microreliefed surface and methods and apparatus for their production
US20070190133A1 (en) * 2004-10-27 2007-08-16 Bunick Frank J Dosage forms having a microreliefed surface and methods and apparatus for their production
US20060088587A1 (en) * 2004-10-27 2006-04-27 Bunick Frank J Dosage forms having a microreliefed surface and methods and apparatus for their production
US8383159B2 (en) * 2004-10-27 2013-02-26 Mcneil-Ppc, Inc. Dosage forms having a microreliefed surface and methods and apparatus for their production
US20070281022A1 (en) * 2004-10-27 2007-12-06 Bunick Frank J Dosage forms having a microreliefed surface and methods and apparatus for their production
US20060088586A1 (en) * 2004-10-27 2006-04-27 Bunick Frank J Dosage forms having a microreliefed surface and methods and apparatus for their production
US20080045575A1 (en) * 2004-12-29 2008-02-21 Van Dyke Thomas E Delivery of H2 Antagonists
CA2500676A1 (fr) * 2005-03-11 2006-09-11 Apotex Pharmachem Inc. Synthese de sels d'addition acide de bases aminees au moyen de reactions solide-gaz
EP1920785A1 (fr) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Préparation liquide contenant un complexe du pimobendane et de la cyclodextrine
EP2572713B1 (fr) 2011-09-22 2014-08-13 King Saud University Extraits et flavonoïdes isolés provenant d'Euphorbia cuneata utiles en tant qu'agents anti-ulcère
EP2825159B1 (fr) 2012-03-15 2022-06-22 Boehringer Ingelheim Vetmedica GmbH Formulation de comprimé pharmaceutique pour le secteur médical vétérinaire, son procédé de production et d'utilisation
EP3865120B1 (fr) 2013-07-19 2025-06-25 Boehringer Ingelheim Vetmedica GmbH Dérivés de la cyclodextrine éthérifiée préservés contenant une composition pharmaceutique liquide aqueuse
WO2015082389A1 (fr) 2013-12-04 2015-06-11 Boehringer Ingelheim Vetmedica Gmbh Compositions pharmaceutiques améliorées de pimobendan
US9457011B2 (en) 2014-02-25 2016-10-04 Muslim D. Shahid Compositions and methods for the treatment of acid-related gastrointestinal disorders containing a dithiolane compound and a gastric acid secretion inhibitor
EP2929884A1 (fr) 2014-04-11 2015-10-14 Sanovel Ilac Sanayi ve Ticaret A.S. Combinaisons pharmaceutiques de dabigatran et antagonistes du récepteur de h2
WO2015169957A1 (fr) 2014-05-09 2015-11-12 Sanovel Ilac Sanayi Ve Ticaret A.S. Combinaisons pharmaceutiques de rivaroxaban et d'antagonistes du récepteur h2
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
CN108864001A (zh) * 2018-06-30 2018-11-23 郑州明泽医药科技有限公司 一种合成雷尼替丁的新方法
WO2022034121A1 (fr) 2020-08-11 2022-02-17 Université De Strasbourg Bloqueurs de h2 ciblant des macrophages du foie pour la prévention et le traitement d'une maladie du foie et du cancer
CN114605360B (zh) * 2022-03-09 2023-05-05 河北海力恒远新材料股份有限公司 一种2-[[[5-(二甲氨基)甲基-2-呋喃基]甲基]硫代]乙胺的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2989546A (en) * 1961-06-20 Synthesis of furans
US3097206A (en) * 1962-03-19 1963-07-09 Smith Kline French Lab Aminomethylthienyl and furyl alcohol derivatives
US3433807A (en) * 1963-09-26 1969-03-18 Merck & Co Inc Aminopropoxymethylfurans and intermediates therefor
US3393209A (en) * 1965-10-04 1968-07-16 Dow Chemical Co Furfuryl and tetrahydrofurfuryl phenyl ureas
GB1307539A (en) 1970-06-25 1973-02-21 Smith Kline French Lab Thiourea derivatives
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
GB1397436A (en) 1972-09-05 1975-06-11 Smith Kline French Lab Heterocyclic n-cyanoguinidines
US4000164A (en) * 1973-04-02 1976-12-28 Richardson-Merrell Inc. Hypolipidemic agents
US4110351A (en) * 1973-04-02 1978-08-29 Richardson-Merrell Inc. Hypolipidemic agents RO- or RS- substituted furoic acids, esters and salts
GB1421792A (en) 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
AU524143B2 (en) * 1977-10-11 1982-09-02 Glaxo Group Limited Aminoalkyl furan derivatives

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2571723A1 (fr) * 1984-10-12 1986-04-18 Lipha Derives de thieno et furo-(2,3-c) pyrroles, procedes de preparation et medicaments les contenant
EP0180500A1 (fr) * 1984-10-12 1986-05-07 Lipha, Lyonnaise Industrielle Pharmaceutique Dérivés de thiéno et furo - [2,3-c]pyrroles, procédés de préparation et médicaments les contenant
FR2619816A1 (fr) * 1987-08-28 1989-03-03 Toyama Chemical Co Ltd Derives d'amine et leurs sels, leurs procedes de fabrication, et agent anti-ulcere les contenant
BE1003231A4 (fr) * 1987-08-28 1992-02-04 Toyama Chemical Co Ltd Derives d'amine et leurs sels, leurs procedes de fabrication, et agent anti-ulcere les contenant.

Also Published As

Publication number Publication date
JPS5840956B2 (ja) 1983-09-08
GB1565966A (en) 1980-04-23
US4255440A (en) 1981-03-10
GB1565967A (en) 1980-04-23
DE2734070A1 (de) 1978-02-09
FR2384753A1 (fr) 1978-10-20
LU77911A1 (fr) 1979-05-23
JPS55153779A (en) 1980-11-29
CA1099268A (fr) 1981-04-14
FR2384765B1 (fr) 1982-09-10
JPS6132315B2 (fr) 1986-07-25
DE2734070C2 (de) 1983-12-29
FR2384753B1 (fr) 1981-06-12
FR2360587B1 (fr) 1981-07-17
FR2360587A1 (fr) 1978-03-03
JPS5318557A (en) 1978-02-20
JPS55153761A (en) 1980-11-29
AU515628B2 (en) 1981-04-16
BE857388A (fr) 1978-02-02
NL178320C (nl) 1986-03-03
US4128658A (en) 1978-12-05
NL7708601A (nl) 1978-02-07
US4279819A (en) 1981-07-21
AU2751977A (en) 1979-02-08

Similar Documents

Publication Publication Date Title
FR2384765A1 (fr) Derives amino-substitues du furanne et procede pour leur preparation
FR2405946A1 (fr) Nouveaux derives de l'acide 3-methyl-crotonique et procede pour leur preparation
FR2385722A1 (fr) Nouveaux derives de cephalosporine, leur procede de preparation et leur application en therapeutique
FR2442839A1 (fr) Derives substitues de morpholine utiles comme medicaments et procede de leur preparation
FR2357541A1 (fr) Composes polyeniques et leur procede de preparation
FR2433504A1 (fr) Procede de preparation de derives du biphenyle
FR2366270A1 (fr) Nouveaux derives de benzenesulfonamide utiles comme herbicides et procede pour leur preparation
FR2383183A1 (fr) Derives de benzodiazepine
FR2386544A1 (fr) Procede pour la preparation de derives d'imidazodiazepine
FR2401144A1 (fr) Derives de benzimidazole contenant du soufre, procede pour leur preparation et intermediaires utiles pour leur production
FR2399431A1 (fr) Derives du thiophene et procede pour leur preparation
FR2397411A1 (fr) Composes tricycliques derives du norbornane, leur utilisation et procede pour leur preparation
FR2374291A1 (fr)
FR2383931A1 (fr) Derives d'oxadiazolopyrimidine
FR2355849A1 (fr) Derives de l'acide 7 b-acylamidoceph-3-eme 4-carboxyliques, leur procede de preparation et application therapeutique
FR2356657A1 (fr) Nouveaux derives phospholipidiques de prostaglandines et leur procede de preparation
FR2400020A1 (fr) Procede pour la preparation de furannones
FR2358401A1 (fr) Nouveaux derives d'oxadiazine, leur procede de preparation et leur application comme insecticides
FR2359111A1 (fr) Nouveaux derives d'acides phenoxyphenoxy-alcanecarboxyliques utiles comme herbicides
FR2402644A1 (fr) Nouveaux nitroethylcyclopentanes utiles comme intermediaires pour la synthese des prostaglandines, et leur procede de preparation
FR2383941A1 (fr) Nouveaux derives pyrimidinyliques et leur procede de preparation
FR2433522A1 (fr) Nouveau derive de tetrahydrofurannol, son procede de preparation et parfum le contenant
FR2359133A1 (fr) Procede de preparation de (vinyl 2,2-disubstitue)-g-butyrolactones
FR2433009A1 (fr) Procede pour la preparation de dicyclopentylene(2,2'-bis(4-alkyl-6-t-butylphenols))
FR2355823A1 (fr) Derives isoindoliques