FI935020L - Interleukin-1b-proteas och inhibitorer av interleukin-1b-proteas - Google Patents

Interleukin-1b-proteas och inhibitorer av interleukin-1b-proteas Download PDF

Info

Publication number: FI935020L
Authority: FI; Finland
Prior art keywords: proteas; interleukin; inhibitorer; och; proteas och
Prior art date: 1991-08-30

Application number

FI935020A

Other languages

English (en)

Other versions

FI935020A7 (fi

FI935020A0 (fi

Inventor

Roy A Black

Paul R Sleath

Shirley R Kronheim

Original Assignee

Sterling Winthrop Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-08-30

Filing date

1991-09-12

Publication date

1993-12-03

1991-09-12 Application filed by Sterling Winthrop Inc filed Critical Sterling Winthrop Inc

1993-11-12 Publication of FI935020A0 publication Critical patent/FI935020A0/fi

1993-12-03 Publication of FI935020A7 publication Critical patent/FI935020A7/fi

1993-12-03 Publication of FI935020L publication Critical patent/FI935020L/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/8142—Aspartate protease (E.C. 3.4.23) inhibitors, e.g. HIV protease inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/545—IL-1
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6472—Cysteine endopeptidases (3.4.22)
- C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
Crystallography & Structural Chemistry (AREA)
Biotechnology (AREA)
AIDS & HIV (AREA)
Immunology (AREA)
Dermatology (AREA)
General Engineering & Computer Science (AREA)
Diabetes (AREA)
Toxicology (AREA)
Hematology (AREA)
Microbiology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Nutrition Science (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)

FI935020A 1991-08-30 1991-09-12 Interleukin-1b-proteas och inhibitorer av interleukin-1b-proteas FI935020L (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US75064491A	1991-08-30	1991-08-30
PCT/US1991/006595 WO1993005071A1 (en)	1991-08-30	1991-09-12	INTERLEUKIN 1β PROTEASE AND INTERLEUKIN 1β PROTEASE INHIBITORS

Publications (3)

Publication Number	Publication Date
FI935020A0 FI935020A0 (fi)	1993-11-12
FI935020A7 FI935020A7 (fi)	1993-12-03
FI935020L true FI935020L (fi)	1993-12-03

Family

ID=25018683

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI935020A FI935020L (fi)	1991-08-30	1991-09-12	Interleukin-1b-proteas och inhibitorer av interleukin-1b-proteas

Country Status (21)

Country	Link
US (2)	US5756465A (fi)
EP (2)	EP0600880B1 (fi)
JP (3)	JP2759895B2 (fi)
KR (1)	KR100226296B1 (fi)
AT (1)	ATE257517T1 (fi)
AU (1)	AU657701B2 (fi)
CA (1)	CA2111100C (fi)
DE (1)	DE69133354T2 (fi)
DK (1)	DK0600880T3 (fi)
ES (1)	ES2213138T3 (fi)
FI (1)	FI935020L (fi)
HU (1)	HU220098B (fi)
IE (1)	IE913268A1 (fi)
IL (2)	IL99598A (fi)
MX (1)	MX9101346A (fi)
MY (1)	MY131144A (fi)
NO (1)	NO317129B1 (fi)
NZ (3)	NZ239895A (fi)
PT (1)	PT99118B (fi)
RU (2)	RU2206611C2 (fi)
WO (1)	WO1993005071A1 (fi)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5874424A (en) *	1995-12-20	1999-02-23	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β converting enzyme
US6008217A (en) *	1995-12-20	1999-12-28	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β converting enzyme
US6204261B1 (en)	1995-12-20	2001-03-20	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β Converting enzyme inhibitors
US6995141B1 (en)	1990-04-04	2006-02-07	Vertex Pharmaceuticals Incorporated	Interleukin 1β protease and interleukin 1β protease inhibitors
DK0600880T3 (da) *	1991-08-30	2004-04-13	Vertex Pharma	Interleukin 1-beta-protease og interleukin 1-beta-proteasehæmmere
IL105741A0 (en) *	1992-05-22	1993-09-22	Genta Inc	Pharmaceutical compositions for treating cellular hyperproliferation using interleukin-1 inhibitory compounds
US5462939A (en) *	1993-05-07	1995-10-31	Sterling Winthrop Inc.	Peptidic ketones as interleukin-1β-converting enzyme inhibitors
JPH0789951A (ja) *	1993-06-03	1995-04-04	Sterling Winthrop Inc	インターロイキン−１β転換酵素阻害剤
US5843905A (en) *	1993-06-04	1998-12-01	Vertex Pharmaceuticals, Incorporated	Peptidic phosphinyloxymethyl ketones as interleukin-1β-converting enzyme inhibitors
ATE170868T1 (de) *	1993-06-04	1998-09-15	Vertex Pharma	Peptid-phosphinyloxymethyl-ketonen als inhibitoren von interleukin-1 beta- konvertierenden enzymen
CA2165777A1 (en) *	1993-06-24	1995-01-05	Junying Yuan	Programmed cell death genes and proteins
US6087160A (en) *	1993-06-24	2000-07-11	The General Hospital Corporation	Programmed cell death genes and proteins
US6420522B1 (en)	1995-06-05	2002-07-16	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β converting enzyme
US5756466A (en) *	1994-06-17	1998-05-26	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1β converting enzyme
US5716929A (en) *	1994-06-17	1998-02-10	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1β converting enzyme
US5847135A (en) *	1994-06-17	1998-12-08	Vertex Pharmaceuticals, Incorporated	Inhibitors of interleukin-1β converting enzyme
US5955072A (en) *	1994-07-13	1999-09-21	Sankyo Company, Limited	Expression systems utilizing autolyzing fusion proteins and a reducing polypeptide
EP0786007A1 (en) *	1994-10-14	1997-07-30	Basf Aktiengesellschaft	Transgenic nonhuman animal having functionally disrupted interleukin-1-beta converting enzyme gene
CA2215211A1 (en) *	1995-03-31	1996-10-03	Takeda Chemical Industries, Ltd.	Cysteine protease inhibitor
US5869315A (en)	1995-12-18	1999-02-09	Basf Aktiengesellschaft	Modified interleukin-1β converting enzyme with increased stability
US5843904A (en) *	1995-12-20	1998-12-01	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1βconverting enzyme
US6288037B1 (en)	1996-01-29	2001-09-11	Basf Aktiengesellschaft	Substrates and inhibitors for cysteine protease ICH-1
US6416753B1 (en)	1996-03-15	2002-07-09	The General Hospital Corporation	Method for modulating apoptosis
US6200969B1 (en)	1996-09-12	2001-03-13	Idun Pharmaceuticals, Inc.	Inhibition of apoptosis using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors
US6531467B2 (en)	1996-09-12	2003-03-11	Idun Pharmaceuticals, Inc.	Inhibition of inflammation using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors
US6610683B2 (en) *	1996-09-12	2003-08-26	Idun Pharmaceuticals, Inc.	Treatment of infectious disease using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors
US6184244B1 (en)	1996-12-16	2001-02-06	Idun Pharmaceuticals, Inc.	C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US6054487A (en) *	1997-03-18	2000-04-25	Basf Aktiengesellschaft	Methods and compositions for modulating responsiveness to corticosteroids
EA200000409A1 (ru) *	1997-10-10	2000-10-30	Сайтовиэ, Инк.	Соединение, фармацевтическая композиция, способ ингибирования гибели клетки в одной клетке или ткани, способ лечения или снижения клеточной смерти, способ лечения или профилактики поликистозного заболевания почек или анемии/эритропоэза у животных, способ защиты органа или ткани млекопитающего от гибели клеток, способ снижения или профилактики гибели клеток в органе или ткани донора после их трансплантации, способ снижения или предотвращения гибели спермы или яйцеклеток
US6184210B1 (en)	1997-10-10	2001-02-06	Cytovia, Inc.	Dipeptide apoptosis inhibitors and the use thereof
DE69925581T2 (de)	1998-03-09	2006-04-27	Vertex Pharmaceuticals Inc., Cambridge	1,2-diazepanderivate als inhibitoren des interleukin-1beta umwandelnden enzyms
WO1999047154A1 (en) *	1998-03-16	1999-09-23	Cytovia, Inc.	Dipeptide caspase inhibitors and the use thereof
BRPI9909660B8 (pt)	1998-03-19	2021-05-25	Vertex Pharma	compostos inibidores de caspases, composição farmacêutica e uso de ditos compostos
EP1165490B1 (en) *	1999-03-16	2006-08-16	Cytovia, Inc.	Substituted 2-aminobenzamide caspase inhibitors and the use thereof
DE19915465A1 (de) *	1999-04-06	2000-10-19	Apotech Res & Dev Ltd	Verwendung eines Caspase-Inhibitors zur Proliferationshemmung von Zellen und Verwendung eines oder mehrerer Caspase-Inhibitors/en zur Behandlung von Erkrankungen beruhend auf Lymphozyten-Hyperproliferation oder zur Suppression einer Immunantwort durch Lymphozyten
AU4213500A (en) *	1999-04-09	2000-11-14	Cytovia, Inc.	Caspase inhibitors and the use thereof
AU770380B2 (en) *	1999-06-14	2004-02-19	Wisconsin Alumni Research Foundation	Oligomers and polymers of cyclic imino carboxylic acids
BR0013666A (pt)	1999-08-27	2002-05-14	Cytovia Inc	"alfa"-hidróxi-ácidos substituìdos inibidores de caspases e o seu uso
US6566338B1 (en)	1999-10-12	2003-05-20	Cytovia, Inc.	Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death
NZ521639A (en)	2000-03-29	2004-05-28	Vertex Pharma	Carbamate caspase inhibitors and uses thereof
EP1923386A3 (en)	2000-03-29	2008-05-28	Vertex Pharmceuticals Incorporated	Carbamate caspase inhibitors and uses thereof
US20010053764A1 (en) *	2000-05-12	2001-12-20	Sims John E.	Interleukin-1 inhibitors in the treatment of diseases
PE20011350A1 (es)	2000-05-19	2002-01-15	Vertex Pharma	PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
JP2005516054A (ja) *	2002-01-29	2005-06-02	ワイス	コネキシンヘミチャンネルを調節する組成物及びその方法
CN1304374C (zh)	2002-04-30	2007-03-14	永进药品工业株式会社	可用做caspase－3抑制剂的喹啉衍生物及其制备方法和药用组合物
KR20060088543A (ko) *	2003-09-25	2006-08-04	디엠아이 바이오사이언스 인코포레이티드	앤-아실-엘-아스파틱산을 이용하는 방법 및 제품
WO2005117846A2 (en)	2004-05-27	2005-12-15	Vertex Pharmaceuticals Incorporated	Ice inhibitors for the treatment of autoinflammatory diseases
US20060128696A1 (en) *	2004-05-15	2006-06-15	Annamaria Vezzani	Treating seizures using ice inhibitors
GB0411056D0 (en)	2004-05-18	2004-06-23	Novartis Ag	Organic compounds
US7618801B2 (en) *	2007-10-30	2009-11-17	Danison US Inc.	Streptomyces protease
JP6006908B2 (ja)	2010-11-05	2016-10-12	ブランダイスユニバーシティＢｒａｎｄｅｉｓＵｎｉｖｅｒｓｉｔｙ	Ｉｃｅ阻害化合物およびその使用
US9956260B1 (en)	2011-07-22	2018-05-01	The J. David Gladstone Institutes	Treatment of HIV-1 infection and AIDS
WO2025096931A1 (en) *	2023-11-01	2025-05-08	64-X, Inc.	Production technologies

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2124233B (en) *	1982-07-19	1985-09-18	Nat Res Dev	Synthetic peptides and their preparation
US4636492A (en) *	1984-08-29	1987-01-13	E. I. Du Pont De Nemours And Company	Inhibition of viral protease activity by peptide halomethyl ketones
US5104853A (en) *	1984-12-11	1992-04-14	California Biotechnology Inc.	Alveolar surfactant proteins having cys to ser mutations
JPS63145300A (ja) *	1984-12-17	1988-06-17	イ−・アイ・デユポン・デ・ニモアス・アンド・カンパニ−	ウイルスにより特定されているプロテア−ゼの特異的阻害剤を製造する方法
US4644055A (en) *	1984-12-17	1987-02-17	E. I. Du Pont De Nemours And Company	Method for preparing specific inhibitors of virus-specified proteases
US5225354A (en) *	1986-08-22	1993-07-06	Molecular Diagnostics, Inc.	Monoclonal antibodies specific for human glycoalbumin
WO1991000912A1 (en) *	1989-07-07	1991-01-24	Massachusetts Institute Of Technology	Production and use of hybrid protease inhibitors
WO1991015577A1 (en) *	1990-04-04	1991-10-17	Black, Roy, A.	INTERLEUKIN 1'beta' PROTEASE
US5298421A (en) *	1990-04-26	1994-03-29	Calgene, Inc.	Plant medium-chain-preferring acyl-ACP thioesterases and related methods
DE69229252T2 (de) *	1991-08-16	1999-12-16	Merck & Co., Inc.	DNS, welche das Interleukin-1B-Vorläufer-Converting-Enzym kodiert
DK0600880T3 (da) *	1991-08-30	2004-04-13	Vertex Pharma	Interleukin 1-beta-protease og interleukin 1-beta-proteasehæmmere

1991
- 1991-09-12 DK DK91916780T patent/DK0600880T3/da active
- 1991-09-12 FI FI935020A patent/FI935020L/fi not_active Application Discontinuation
- 1991-09-12 KR KR1019940700644A patent/KR100226296B1/ko not_active Expired - Fee Related
- 1991-09-12 HU HU9303244A patent/HU220098B/hu not_active IP Right Cessation
- 1991-09-12 EP EP91916780A patent/EP0600880B1/en not_active Expired - Lifetime
- 1991-09-12 EP EP03018990A patent/EP1378573A1/en not_active Withdrawn
- 1991-09-12 AU AU85373/91A patent/AU657701B2/en not_active Expired
- 1991-09-12 JP JP3515380A patent/JP2759895B2/ja not_active Expired - Lifetime
- 1991-09-12 RU RU94028712/13A patent/RU2206611C2/ru not_active IP Right Cessation
- 1991-09-12 WO PCT/US1991/006595 patent/WO1993005071A1/en not_active Ceased
- 1991-09-12 ES ES91916780T patent/ES2213138T3/es not_active Expired - Lifetime
- 1991-09-12 CA CA002111100A patent/CA2111100C/en not_active Expired - Lifetime
- 1991-09-12 DE DE69133354T patent/DE69133354T2/de not_active Expired - Lifetime
- 1991-09-12 AT AT91916780T patent/ATE257517T1/de not_active IP Right Cessation
- 1991-09-16 IE IE326891A patent/IE913268A1/en not_active IP Right Cessation
- 1991-09-18 MY MYPI91001693A patent/MY131144A/en unknown
- 1991-09-23 NZ NZ239895A patent/NZ239895A/en not_active IP Right Cessation
- 1991-09-23 NZ NZ248377A patent/NZ248377A/xx not_active IP Right Cessation
- 1991-09-23 NZ NZ335312A patent/NZ335312A/en not_active IP Right Cessation
- 1991-09-27 IL IL9959891A patent/IL99598A/xx not_active IP Right Cessation
- 1991-09-30 PT PT99118A patent/PT99118B/pt not_active IP Right Cessation
- 1991-09-30 MX MX9101346A patent/MX9101346A/es not_active IP Right Cessation
1993
- 1993-11-30 NO NO19934335A patent/NO317129B1/no unknown
1995
- 1995-05-12 US US08/440,179 patent/US5756465A/en not_active Expired - Lifetime
1997
- 1997-03-03 JP JP9061701A patent/JPH1028588A/ja active Pending
1998
- 1998-03-16 US US09/039,657 patent/US6136787A/en not_active Expired - Lifetime
2000
- 2000-11-09 JP JP2000342474A patent/JP3445572B2/ja not_active Expired - Lifetime
2002
- 2002-10-25 RU RU2002128757/13A patent/RU2002128757A/ru not_active Application Discontinuation
2005
- 2005-02-09 IL IL16679105A patent/IL166791A0/xx unknown

Also Published As

Publication number	Publication date
AU8537391A (en)	1993-04-05
NO934335D0 (no)	1993-11-30
NZ239895A (en)	1996-01-26
DE69133354T2 (de)	2004-11-11
US5756465A (en)	1998-05-26
RU2002128757A (ru)	2004-07-27
EP0600880B1 (en)	2004-01-07
NO317129B1 (no)	2004-08-23
NZ248377A (en)	2000-01-28
IL166791A0 (en)	2006-01-15
RU2206611C2 (ru)	2003-06-20
DE69133354D1 (de)	2004-02-12
JP3445572B2 (ja)	2003-09-08
ATE257517T1 (de)	2004-01-15
WO1993005071A1 (en)	1993-03-18
JPH1028588A (ja)	1998-02-03
KR100226296B1 (ko)	1999-10-15
CA2111100A1 (en)	1993-03-18
PT99118B (pt)	1999-02-26
HUT66057A (en)	1994-09-28
RU94028712A (ru)	1997-03-10
NZ335312A (en)	2005-08-26
MY131144A (en)	2007-07-31
ES2213138T3 (es)	2004-08-16
US6136787A (en)	2000-10-24
HU220098B (hu)	2001-10-28
FI935020A7 (fi)	1993-12-03
EP1378573A1 (en)	2004-01-07
JPH08505280A (ja)	1996-06-11
EP0600880A1 (en)	1994-06-15
FI935020A0 (fi)	1993-11-12
IL99598A (en)	2005-06-19
IL99598A0 (en)	1992-08-18
CA2111100C (en)	2004-11-02
DK0600880T3 (da)	2004-04-13
AU657701B2 (en)	1995-03-23
EP0600880A4 (en)	1994-12-21
HK1014013A1 (en)	1999-09-17
NO934335L (no)	1993-11-30
JP2001192397A (ja)	2001-07-17
MX9101346A (es)	1993-02-01
JP2759895B2 (ja)	1998-05-28
HU9303244D0 (en)	1994-03-28
PT99118A (pt)	1993-02-26
IE913268A1 (en)	1993-03-10

Publication	Publication Date	Title
FI923321L (fi)	1993-01-23	Komposition foer ihaollande och kontrollerad avgivning av medikamentartad aemne
FI921663A7 (fi)	1992-10-18	Foerfarande och anordning foer behandling av goedsel
FI935020L (fi)	1993-12-03	Interleukin-1b-proteas och inhibitorer av interleukin-1b-proteas
FI922023L (fi)	1992-11-07	Ultrafiltreringsfoerfaranden foer aotervinning av polymerlatexer fraon bakvatten och anordning foer dessa
FI935017A0 (fi)	1993-11-12	Foerfarande och anordning foer maetning av effekt
FI914848L (fi)	1993-04-15	Gaongjaernsanordning och anvaendning av densamma
FI933418A7 (fi)	1993-09-22	Foerfarande foer defibrering av lignocellulosamaterial och aotervinning av biprodukter
FI935397L (fi)	1993-12-02	Foerfarande och anordning foer utloesning av en roentgenbildsensor
FI88744B (fi)	1993-03-15	Foerfarande och anordning foer reglering av bergborrning
FI935445L (fi)	1994-01-27	Foerfarande och anordning foer tillverkning av rutverk av fibrer
FI920396A7 (fi)	1992-09-02	Foerfarande foer reglering av en reaktiv sputteringsprocess och anordning foer utfoerande av foerfarandet
FI920716L (fi)	1992-09-10	Haellanordning foer foerpackningar innehaollande flytande aemnen och foerfarande foer framstaellning av en saodan anordning
FI921866L (fi)	1992-10-27	Foerfarande foer framstaellning av laegre polyoler och blandningar daerav
FI912537L (fi)	1992-09-02	Fluffig organisk isoleringsmassa och foerfarande foer framstaellning och anvaendning av densamma
FI920424A7 (fi)	1992-09-09	Foerfarande foer anvaendning av metalliseringsanlaeggning och anordning foer utfoerande av foerfarandet
FI921839A7 (fi)	1992-10-27	Foerfarande och anordning foer bearbetning av tryckalster
FI922459L (fi)	1992-12-01	Foerfarande foer framstaellning av substituerade diaminoftalimider och deras analoger
FI921284L (fi)	1992-10-04	Framstaellnin av styva skum och komposition anvaendbar daeri
FI914551A7 (fi)	1993-03-28	Foerfarande och anordning foer boejning och haerdning av en glasskiva
FI921122L (fi)	1992-09-19	Kloning och uttryckning av acetylxylanesteraser av svampursprung
FI933901A7 (fi)	1993-10-29	Foerfarande och anordning foer uppsamling av oljeflaeckar fraon vattenytan
FI921575A7 (fi)	1992-10-12	Foerfarande och anordning foer tillslutning av behaollare
FI925741L (fi)	1993-06-18	Anordning och foerfarande foer kontinuerlig framstaellning av mineralullfibermattor
FI921861L (fi)	1992-10-27	Konverter och foerfarande foer inblaosning av ickejaernmetall uppifraon
FI923399L (fi)	1993-02-14	Foerfarande och anordning foer minskande av kvaeveoksidutslaepp av foerbraenningsmotorer

Legal Events

Date	Code	Title	Description
1997-07-01	GB	Transfer or assigment of application	Owner name: VERTEX PHARMACEUTICALS INCORPORATED
1999-07-11	GB	Transfer or assigment of application	Owner name: VERTEX PHARMACEUTICALS INCORPORATED
2006-02-28	FD	Application lapsed