MX9101346A - Proteasa de interleucina 1b e inhibidores de la proteasa de interleucina 1b. - Google Patents

Proteasa de interleucina 1b e inhibidores de la proteasa de interleucina 1b.

Info

Publication number: MX9101346A
Authority: MX; Mexico
Prior art keywords: protease; asp; interleukin; amino acid; beta
Prior art date: 1991-08-30

Application number

MX9101346A

Other languages

English (en)

Inventor

Roy A Black

Paul R Sleath

Shirley R Kronheim

Original Assignee

Immunex Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-08-30

Filing date

1991-09-30

Publication date

1993-02-01

1991-09-30 Application filed by Immunex Corp filed Critical Immunex Corp

1993-02-01 Publication of MX9101346A publication Critical patent/MX9101346A/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/8142—Aspartate protease (E.C. 3.4.23) inhibitors, e.g. HIV protease inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/545—IL-1
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6472—Cysteine endopeptidases (3.4.22)
- C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
Crystallography & Structural Chemistry (AREA)
Biotechnology (AREA)
AIDS & HIV (AREA)
Immunology (AREA)
Dermatology (AREA)
General Engineering & Computer Science (AREA)
Diabetes (AREA)
Toxicology (AREA)
Hematology (AREA)
Microbiology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Nutrition Science (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)

MX9101346A 1991-08-30 1991-09-30 Proteasa de interleucina 1b e inhibidores de la proteasa de interleucina 1b. MX9101346A (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US75064491A	1991-08-30	1991-08-30

Publications (1)

Publication Number	Publication Date
MX9101346A true MX9101346A (es)	1993-02-01

Family

ID=25018683

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MX9101346A MX9101346A (es)	1991-08-30	1991-09-30	Proteasa de interleucina 1b e inhibidores de la proteasa de interleucina 1b.

Country Status (21)

Country	Link
US (2)	US5756465A (es)
EP (2)	EP0600880B1 (es)
JP (3)	JP2759895B2 (es)
KR (1)	KR100226296B1 (es)
AT (1)	ATE257517T1 (es)
AU (1)	AU657701B2 (es)
CA (1)	CA2111100C (es)
DE (1)	DE69133354T2 (es)
DK (1)	DK0600880T3 (es)
ES (1)	ES2213138T3 (es)
FI (1)	FI935020L (es)
HU (1)	HU220098B (es)
IE (1)	IE913268A1 (es)
IL (2)	IL99598A (es)
MX (1)	MX9101346A (es)
MY (1)	MY131144A (es)
NO (1)	NO317129B1 (es)
NZ (3)	NZ239895A (es)
PT (1)	PT99118B (es)
RU (2)	RU2206611C2 (es)
WO (1)	WO1993005071A1 (es)

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US5874424A (en) *	1995-12-20	1999-02-23	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β converting enzyme
US6008217A (en) *	1995-12-20	1999-12-28	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β converting enzyme
US6204261B1 (en)	1995-12-20	2001-03-20	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β Converting enzyme inhibitors
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IL105741A0 (en) *	1992-05-22	1993-09-22	Genta Inc	Pharmaceutical compositions for treating cellular hyperproliferation using interleukin-1 inhibitory compounds
US5462939A (en) *	1993-05-07	1995-10-31	Sterling Winthrop Inc.	Peptidic ketones as interleukin-1β-converting enzyme inhibitors
JPH0789951A (ja) *	1993-06-03	1995-04-04	Sterling Winthrop Inc	インターロイキン−１β転換酵素阻害剤
US5843905A (en) *	1993-06-04	1998-12-01	Vertex Pharmaceuticals, Incorporated	Peptidic phosphinyloxymethyl ketones as interleukin-1β-converting enzyme inhibitors
ATE170868T1 (de) *	1993-06-04	1998-09-15	Vertex Pharma	Peptid-phosphinyloxymethyl-ketonen als inhibitoren von interleukin-1 beta- konvertierenden enzymen
CA2165777A1 (en) *	1993-06-24	1995-01-05	Junying Yuan	Programmed cell death genes and proteins
US6087160A (en) *	1993-06-24	2000-07-11	The General Hospital Corporation	Programmed cell death genes and proteins
US6420522B1 (en)	1995-06-05	2002-07-16	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β converting enzyme
US5756466A (en) *	1994-06-17	1998-05-26	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1β converting enzyme
US5716929A (en) *	1994-06-17	1998-02-10	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1β converting enzyme
US5847135A (en) *	1994-06-17	1998-12-08	Vertex Pharmaceuticals, Incorporated	Inhibitors of interleukin-1β converting enzyme
US5955072A (en) *	1994-07-13	1999-09-21	Sankyo Company, Limited	Expression systems utilizing autolyzing fusion proteins and a reducing polypeptide
EP0786007A1 (en) *	1994-10-14	1997-07-30	Basf Aktiengesellschaft	Transgenic nonhuman animal having functionally disrupted interleukin-1-beta converting enzyme gene
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US5869315A (en)	1995-12-18	1999-02-09	Basf Aktiengesellschaft	Modified interleukin-1β converting enzyme with increased stability
US5843904A (en) *	1995-12-20	1998-12-01	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1βconverting enzyme
US6288037B1 (en)	1996-01-29	2001-09-11	Basf Aktiengesellschaft	Substrates and inhibitors for cysteine protease ICH-1
US6416753B1 (en)	1996-03-15	2002-07-09	The General Hospital Corporation	Method for modulating apoptosis
US6200969B1 (en)	1996-09-12	2001-03-13	Idun Pharmaceuticals, Inc.	Inhibition of apoptosis using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors
US6531467B2 (en)	1996-09-12	2003-03-11	Idun Pharmaceuticals, Inc.	Inhibition of inflammation using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors
US6610683B2 (en) *	1996-09-12	2003-08-26	Idun Pharmaceuticals, Inc.	Treatment of infectious disease using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors
US6184244B1 (en)	1996-12-16	2001-02-06	Idun Pharmaceuticals, Inc.	C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US6054487A (en) *	1997-03-18	2000-04-25	Basf Aktiengesellschaft	Methods and compositions for modulating responsiveness to corticosteroids
EA200000409A1 (ru) *	1997-10-10	2000-10-30	Сайтовиэ, Инк.	Соединение, фармацевтическая композиция, способ ингибирования гибели клетки в одной клетке или ткани, способ лечения или снижения клеточной смерти, способ лечения или профилактики поликистозного заболевания почек или анемии/эритропоэза у животных, способ защиты органа или ткани млекопитающего от гибели клеток, способ снижения или профилактики гибели клеток в органе или ткани донора после их трансплантации, способ снижения или предотвращения гибели спермы или яйцеклеток
US6184210B1 (en)	1997-10-10	2001-02-06	Cytovia, Inc.	Dipeptide apoptosis inhibitors and the use thereof
DE69925581T2 (de)	1998-03-09	2006-04-27	Vertex Pharmaceuticals Inc., Cambridge	1,2-diazepanderivate als inhibitoren des interleukin-1beta umwandelnden enzyms
WO1999047154A1 (en) *	1998-03-16	1999-09-23	Cytovia, Inc.	Dipeptide caspase inhibitors and the use thereof
BRPI9909660B8 (pt)	1998-03-19	2021-05-25	Vertex Pharma	compostos inibidores de caspases, composição farmacêutica e uso de ditos compostos
EP1165490B1 (en) *	1999-03-16	2006-08-16	Cytovia, Inc.	Substituted 2-aminobenzamide caspase inhibitors and the use thereof
DE19915465A1 (de) *	1999-04-06	2000-10-19	Apotech Res & Dev Ltd	Verwendung eines Caspase-Inhibitors zur Proliferationshemmung von Zellen und Verwendung eines oder mehrerer Caspase-Inhibitors/en zur Behandlung von Erkrankungen beruhend auf Lymphozyten-Hyperproliferation oder zur Suppression einer Immunantwort durch Lymphozyten
AU4213500A (en) *	1999-04-09	2000-11-14	Cytovia, Inc.	Caspase inhibitors and the use thereof
AU770380B2 (en) *	1999-06-14	2004-02-19	Wisconsin Alumni Research Foundation	Oligomers and polymers of cyclic imino carboxylic acids
BR0013666A (pt)	1999-08-27	2002-05-14	Cytovia Inc	"alfa"-hidróxi-ácidos substituìdos inibidores de caspases e o seu uso
US6566338B1 (en)	1999-10-12	2003-05-20	Cytovia, Inc.	Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death
NZ521639A (en)	2000-03-29	2004-05-28	Vertex Pharma	Carbamate caspase inhibitors and uses thereof
EP1923386A3 (en)	2000-03-29	2008-05-28	Vertex Pharmceuticals Incorporated	Carbamate caspase inhibitors and uses thereof
US20010053764A1 (en) *	2000-05-12	2001-12-20	Sims John E.	Interleukin-1 inhibitors in the treatment of diseases
PE20011350A1 (es)	2000-05-19	2002-01-15	Vertex Pharma	PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
JP2005516054A (ja) *	2002-01-29	2005-06-02	ワイス	コネキシンヘミチャンネルを調節する組成物及びその方法
CN1304374C (zh)	2002-04-30	2007-03-14	永进药品工业株式会社	可用做caspase－3抑制剂的喹啉衍生物及其制备方法和药用组合物
KR20060088543A (ko) *	2003-09-25	2006-08-04	디엠아이 바이오사이언스 인코포레이티드	앤-아실-엘-아스파틱산을 이용하는 방법 및 제품
WO2005117846A2 (en)	2004-05-27	2005-12-15	Vertex Pharmaceuticals Incorporated	Ice inhibitors for the treatment of autoinflammatory diseases
US20060128696A1 (en) *	2004-05-15	2006-06-15	Annamaria Vezzani	Treating seizures using ice inhibitors
GB0411056D0 (en)	2004-05-18	2004-06-23	Novartis Ag	Organic compounds
US7618801B2 (en) *	2007-10-30	2009-11-17	Danison US Inc.	Streptomyces protease
JP6006908B2 (ja)	2010-11-05	2016-10-12	ブランダイスユニバーシティＢｒａｎｄｅｉｓＵｎｉｖｅｒｓｉｔｙ	Ｉｃｅ阻害化合物およびその使用
US9956260B1 (en)	2011-07-22	2018-05-01	The J. David Gladstone Institutes	Treatment of HIV-1 infection and AIDS
WO2025096931A1 (en) *	2023-11-01	2025-05-08	64-X, Inc.	Production technologies

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1991
- 1991-09-12 DK DK91916780T patent/DK0600880T3/da active
- 1991-09-12 FI FI935020A patent/FI935020L/fi not_active Application Discontinuation
- 1991-09-12 KR KR1019940700644A patent/KR100226296B1/ko not_active Expired - Fee Related
- 1991-09-12 HU HU9303244A patent/HU220098B/hu not_active IP Right Cessation
- 1991-09-12 EP EP91916780A patent/EP0600880B1/en not_active Expired - Lifetime
- 1991-09-12 EP EP03018990A patent/EP1378573A1/en not_active Withdrawn
- 1991-09-12 AU AU85373/91A patent/AU657701B2/en not_active Expired
- 1991-09-12 JP JP3515380A patent/JP2759895B2/ja not_active Expired - Lifetime
- 1991-09-12 RU RU94028712/13A patent/RU2206611C2/ru not_active IP Right Cessation
- 1991-09-12 WO PCT/US1991/006595 patent/WO1993005071A1/en not_active Ceased
- 1991-09-12 ES ES91916780T patent/ES2213138T3/es not_active Expired - Lifetime
- 1991-09-12 CA CA002111100A patent/CA2111100C/en not_active Expired - Lifetime
- 1991-09-12 DE DE69133354T patent/DE69133354T2/de not_active Expired - Lifetime
- 1991-09-12 AT AT91916780T patent/ATE257517T1/de not_active IP Right Cessation
- 1991-09-16 IE IE326891A patent/IE913268A1/en not_active IP Right Cessation
- 1991-09-18 MY MYPI91001693A patent/MY131144A/en unknown
- 1991-09-23 NZ NZ239895A patent/NZ239895A/en not_active IP Right Cessation
- 1991-09-23 NZ NZ248377A patent/NZ248377A/xx not_active IP Right Cessation
- 1991-09-23 NZ NZ335312A patent/NZ335312A/en not_active IP Right Cessation
- 1991-09-27 IL IL9959891A patent/IL99598A/xx not_active IP Right Cessation
- 1991-09-30 PT PT99118A patent/PT99118B/pt not_active IP Right Cessation
- 1991-09-30 MX MX9101346A patent/MX9101346A/es not_active IP Right Cessation
1993
- 1993-11-30 NO NO19934335A patent/NO317129B1/no unknown
1995
- 1995-05-12 US US08/440,179 patent/US5756465A/en not_active Expired - Lifetime
1997
- 1997-03-03 JP JP9061701A patent/JPH1028588A/ja active Pending
1998
- 1998-03-16 US US09/039,657 patent/US6136787A/en not_active Expired - Lifetime
2000
- 2000-11-09 JP JP2000342474A patent/JP3445572B2/ja not_active Expired - Lifetime
2002
- 2002-10-25 RU RU2002128757/13A patent/RU2002128757A/ru not_active Application Discontinuation
2005
- 2005-02-09 IL IL16679105A patent/IL166791A0/xx unknown

Also Published As

Publication number	Publication date
AU8537391A (en)	1993-04-05
NO934335D0 (no)	1993-11-30
NZ239895A (en)	1996-01-26
DE69133354T2 (de)	2004-11-11
US5756465A (en)	1998-05-26
RU2002128757A (ru)	2004-07-27
EP0600880B1 (en)	2004-01-07
NO317129B1 (no)	2004-08-23
NZ248377A (en)	2000-01-28
IL166791A0 (en)	2006-01-15
RU2206611C2 (ru)	2003-06-20
DE69133354D1 (de)	2004-02-12
JP3445572B2 (ja)	2003-09-08
ATE257517T1 (de)	2004-01-15
WO1993005071A1 (en)	1993-03-18
JPH1028588A (ja)	1998-02-03
KR100226296B1 (ko)	1999-10-15
CA2111100A1 (en)	1993-03-18
PT99118B (pt)	1999-02-26
HUT66057A (en)	1994-09-28
RU94028712A (ru)	1997-03-10
NZ335312A (en)	2005-08-26
MY131144A (en)	2007-07-31
ES2213138T3 (es)	2004-08-16
US6136787A (en)	2000-10-24
HU220098B (hu)	2001-10-28
FI935020A7 (fi)	1993-12-03
EP1378573A1 (en)	2004-01-07
JPH08505280A (ja)	1996-06-11
EP0600880A1 (en)	1994-06-15
FI935020A0 (fi)	1993-11-12
IL99598A (en)	2005-06-19
FI935020L (fi)	1993-12-03
IL99598A0 (en)	1992-08-18
CA2111100C (en)	2004-11-02
DK0600880T3 (da)	2004-04-13
AU657701B2 (en)	1995-03-23
EP0600880A4 (en)	1994-12-21
HK1014013A1 (en)	1999-09-17
NO934335L (no)	1993-11-30
JP2001192397A (ja)	2001-07-17
JP2759895B2 (ja)	1998-05-28
HU9303244D0 (en)	1994-03-28
PT99118A (pt)	1993-02-26
IE913268A1 (en)	1993-03-10

Publication	Publication Date	Title
MX9101346A (es)	1993-02-01	Proteasa de interleucina 1b e inhibidores de la proteasa de interleucina 1b.
DE10075019I2 (de)	2005-06-23	Neue Proteine mit TNF-Hemmender Wirkung und ihre Herstellung.
KR900017607A (ko)	1990-12-19	프로테이나아제 억제제, 이것의 제조방법 및 이들을 함유한 의약품
FI842166L (fi)	1984-05-30	Bukspottskoertelns grf hos maenniskan.
ATE153029T1 (de)	1997-05-15	Verwendung von peptidase-hemmer zur herstellung von medikamenten für die behandlung von schlaganfällen
DK66391D0 (da)	1991-04-12	Terapeutisk virksomme peptider
GR860398B (en)	1986-06-12	Process for obtaining peptidic derivatives of renine inhibitors and proteases acids
DE3788216D1 (de)	1993-12-23	Gentechnologisch hergestellter pankreatischer sekretorischer Trypsininhibitor und seine Varianten.
EP0202853A3 (en)	1988-07-20	A polypeptide which neutralises the activity of factor viii inhibitor and a therapeutic composition containing it
EP0187721A3 (en)	1988-11-23	Preparation of peptide substrates for virus-specified proteases
BR9306272A (pt)	1998-06-23	Peptídeo e composiçao farmacêutica
LV10108A (lv)	1994-05-10	Sunu proliferacijas inhibitori farmaceitiska kompozicija savienojumu iegusanas metode sunu proliferacijas inhibesanas panemieni
AU5232886A (en)	1986-07-01	Serine protease inhibitors and methods for isolation of same
EP0210279A4 (en)	1987-06-19	Stabilized human prourokinase.
ES2135398T3 (es)	1999-11-01	Compuesto y composiciones de inhibicion de la resorcion osea.
EP0352816A3 (en)	1991-03-20	Il-1alpha derivates and medicament for treating thrombocytopenia
NO893507L (no)	1990-03-02	Fremgangsmaate for fremstilling av nye peptidaseinhibitorer
ATE82984T1 (de)	1992-12-15	Hemmende peptide.
ES2097368T3 (es)	1997-04-01	Nuevas proteinas inhibidoras de trombina a partir de sanguijuelas terrestres.
ATE94168T1 (de)	1993-09-15	Peptide.
MX9206055A (es)	1993-04-01	Nuevas proteinas inhibidoras de trombina de garrapatas

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2004-12-31	GB	Transfer or rights
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