FI78119B - Foerfarande foer framstaellning av maenskligt insulin eller b-30-estrar daerav. - Google Patents
Foerfarande foer framstaellning av maenskligt insulin eller b-30-estrar daerav. Download PDFInfo
- Publication number
- FI78119B FI78119B FI831157A FI831157A FI78119B FI 78119 B FI78119 B FI 78119B FI 831157 A FI831157 A FI 831157A FI 831157 A FI831157 A FI 831157A FI 78119 B FI78119 B FI 78119B
- Authority
- FI
- Finland
- Prior art keywords
- insulin
- threonine
- derivative
- trypsin
- porcine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Claims (6)
1. Förfarande för framställning av humaninsulin eller en B-30-ester därav, i vilket förfarande ett karboxylskyddat och eventuellt hydroxylskyddat L-treoninderivat omsätts med ett insulinderivat med formeln (l-T-A-T-21) (I) (1_1_B-1-29)-R i vilken R är hydroxyl eller en aminosyraradikal, vilken är skild frän treonin, och -A- och -B- betecknar A- och B-ked-jorna, vilka uppvisar samma aminosyrasekvens som i humaninsulin, i närvaro av ett trypsinliknande proteolytiskt enzym i vatten vid ett pH-värde av frän 5 tili 9 och vid en tempe-ratur under 50 °C, varefter, om sä önskas, närvarande skydds-grupper avlägsnas, kännetecknat därav, att L-treoninderivatet 3r närvarande i reaktionsblandningen i en koncentration av 2 - 6 mol/1.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att L-treoninderivatet är närvarande i reaktionsblandningen i en koncentration av frän 3 tili 5 mol/1.
3. Förfarande enligt patentkravet 1 eller 2, kännetecknat därav, att det använda insulinderivatet är desalanin-B30-insulin (DAI) erhället frän svininsulin.
4. Förfarande enligt patentkravet 1 eller 2, kännetecknat därav, att man som insulinderivatet med formeln I använder svininsulin, varvid R är alanin.
5. Förfarande enligt n&got av patentkraven 1-4, kännetecknat därav, att L-treoninderivatet är en metyl-eller etylester av L-treonin. Il
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK254682 | 1982-06-07 | ||
| DK254682 | 1982-06-07 | ||
| DK254582 | 1982-06-07 | ||
| DK254582 | 1982-06-07 | ||
| PCT/DK1982/000082 WO1983001074A1 (en) | 1981-09-15 | 1982-09-14 | Enzymatic preparation of human insulin or b-30 esters thereof |
| DK8200082 | 1982-09-14 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI831157A0 FI831157A0 (fi) | 1983-04-06 |
| FI831157L FI831157L (fi) | 1983-04-06 |
| FI78119B true FI78119B (fi) | 1989-02-28 |
| FI78119C FI78119C (sv) | 1989-06-12 |
Family
ID=26066590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI831157A FI78119C (sv) | 1982-06-07 | 1983-04-06 | Förfarande för framställning av mänskligt insulin eller B-30-estrar dä rav |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4601979A (sv) |
| EP (1) | EP0088117B1 (sv) |
| JP (1) | JPS58501455A (sv) |
| AU (1) | AU551174B2 (sv) |
| CA (1) | CA1174623A (sv) |
| DK (1) | DK149457C (sv) |
| ES (1) | ES515713A0 (sv) |
| FI (1) | FI78119C (sv) |
| IT (1) | IT1189353B (sv) |
| NO (1) | NO156052C (sv) |
| WO (1) | WO1983001074A1 (sv) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0367302A3 (en) * | 1982-04-23 | 1991-06-19 | Wako Pure Chemical Industries, Ltd. | Process for semi-synthesis of human insulin, water-soluble cross-linked achromobacter protease i for use therein and a process for preparing the same |
| EP0294851A3 (de) * | 1987-06-12 | 1990-05-09 | Berlin-Chemie Ag | Verfahren zur Herstellung von Humaninsulin und seinen Derivaten |
| US5130236A (en) * | 1989-12-07 | 1992-07-14 | Eli Lilly And Company | Process for producing des(64,65)-proinsulin |
| EA200000453A1 (ru) | 1997-10-24 | 2000-10-30 | Эли Лилли Энд Компани | Композиции нерастворимого инсулина |
| CO4970787A1 (es) * | 1997-12-23 | 2000-11-07 | Lilly Co Eli | Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea |
| US6323311B1 (en) | 1999-09-22 | 2001-11-27 | University Of Utah Research Foundation | Synthesis of insulin derivatives |
| KR100925381B1 (ko) | 2001-11-19 | 2009-11-09 | 노보 노르디스크 에이/에스 | 인슐린 화합물의 제조 방법 |
| US7396903B2 (en) * | 2001-11-19 | 2008-07-08 | Novo Nordisk A/S | Process for preparing insulin compounds |
| US8173840B2 (en) * | 2003-07-29 | 2012-05-08 | Signature R&D Holdings, Llc | Compounds with high therapeutic index |
| US7589233B2 (en) * | 2003-07-29 | 2009-09-15 | Signature R&D Holdings, Llc | L-Threonine derivatives of high therapeutic index |
| MY177247A (en) * | 2013-12-23 | 2020-09-10 | Biocon Biologics Ltd | Method of production of human insulin methyl ester |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3276961A (en) * | 1963-04-08 | 1966-10-04 | Squibb & Sons Inc | Process for preparing human insulin |
| US3903068A (en) * | 1972-12-26 | 1975-09-02 | Us Health Education & Welfare | Facile synthesis of human insulin by modification of porcine insulin |
| JPS6339237B2 (sv) * | 1979-04-06 | 1988-08-04 | Karuruberugu Baiotekunorojii Ltd As | |
| JPS55138391A (en) * | 1979-04-13 | 1980-10-29 | Shionogi & Co Ltd | New synthetic method of peptide derivative |
| JPS55138392A (en) * | 1979-04-13 | 1980-10-29 | Shionogi & Co Ltd | Semisynthesis of insulin |
| EP0017938B1 (en) * | 1979-04-13 | 1983-08-03 | Shionogi & Co., Ltd. | Process for preparing a b30-threonine insulin |
| JPS55138393A (en) * | 1979-04-13 | 1980-10-29 | Shionogi & Co Ltd | Semisynthesis of insulin |
| DK147437A (en) * | 1980-02-11 | 1900-01-01 | Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof | |
| IE50892B1 (en) * | 1980-02-11 | 1986-08-06 | Novo Industri As | Process for preparing insulin esters |
| DK319780A (da) * | 1980-07-24 | 1982-01-25 | Forenede Bryggerier As | Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner |
| DE3101382A1 (de) * | 1981-01-17 | 1982-09-02 | Hoechst Ag, 6000 Frankfurt | "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten" |
-
1982
- 1982-09-14 JP JP57502836A patent/JPS58501455A/ja active Granted
- 1982-09-14 CA CA000411405A patent/CA1174623A/en not_active Expired
- 1982-09-14 EP EP82902901A patent/EP0088117B1/en not_active Expired
- 1982-09-14 AU AU89539/82A patent/AU551174B2/en not_active Ceased
- 1982-09-14 IT IT8249114A patent/IT1189353B/it active
- 1982-09-14 WO PCT/DK1982/000082 patent/WO1983001074A1/en not_active Ceased
- 1982-09-14 US US06/491,325 patent/US4601979A/en not_active Expired - Lifetime
- 1982-09-15 ES ES82515713A patent/ES515713A0/es active Granted
-
1983
- 1983-04-06 FI FI831157A patent/FI78119C/sv not_active IP Right Cessation
- 1983-05-13 NO NO83831730A patent/NO156052C/no unknown
- 1983-05-13 DK DK213983A patent/DK149457C/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IT8249114A1 (it) | 1984-03-14 |
| JPS58501455A (ja) | 1983-09-01 |
| EP0088117B1 (en) | 1986-09-24 |
| ES8400772A1 (es) | 1983-11-01 |
| EP0088117A1 (en) | 1983-09-14 |
| US4601979A (en) | 1986-07-22 |
| DK213983D0 (da) | 1983-05-13 |
| JPH0526469B2 (sv) | 1993-04-16 |
| FI831157A0 (fi) | 1983-04-06 |
| NO156052B (no) | 1987-04-06 |
| FI78119C (sv) | 1989-06-12 |
| NO156052C (no) | 1987-07-15 |
| IT1189353B (it) | 1988-02-04 |
| DK149457B (da) | 1986-06-16 |
| CA1174623A (en) | 1984-09-18 |
| ES515713A0 (es) | 1983-11-01 |
| AU551174B2 (en) | 1986-04-17 |
| IT8249114A0 (it) | 1982-09-14 |
| DK213983A (da) | 1983-05-13 |
| AU8953982A (en) | 1983-04-08 |
| FI831157L (fi) | 1983-04-06 |
| DK149457C (da) | 1991-11-25 |
| NO831730L (no) | 1983-05-13 |
| WO1983001074A1 (en) | 1983-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: NORDISK INSULINLABORATORIUM |