FI4268843T3 - Parannettuja il-6-vasta-aineita - Google Patents
Parannettuja il-6-vasta-aineitaInfo
- Publication number
- FI4268843T3 FI4268843T3 FIEP23189385.0T FI23189385T FI4268843T3 FI 4268843 T3 FI4268843 T3 FI 4268843T3 FI 23189385 T FI23189385 T FI 23189385T FI 4268843 T3 FI4268843 T3 FI 4268843T3
- Authority
- FI
- Finland
- Prior art keywords
- seq
- sequence
- antibody
- heavy chain
- light chain
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (14)
1. Anti-IL6-vasta-aine, joka käsittää (a) raskasketjun CDR1:n, joka käsittää sekvenssin GYVLPNYLIE (SEO ID NO:31), (b) raskasketjun CDR2:n, joka käsittää sekvenssin VTTPGGGTIN (SEQ ID NO:32), (c) raskasketjun CDR3:n, joka käsittää sekvenssin SRWDPLYYYALEY (SEO ID NO:33), (d) kevytketjun CDR1:n, joka käsittää sekvenssin RASESVDNYGIPFMN (SEQ ID NO:34), (e) kevytketjun CDR2:n, joka käsittää sekvenssin AASNRGS (SEQ ID NO:35) ja (f) kevytketjun CDR3:n, joka käsittää sekvenssin QQSEEVPLT (SEO ID NO:36).
2. Anti-IL6-vasta-aine, joka käsittää sekvenssin SEO ID NO:37 käsittävän raskasketjun vaihtelevan alueen ja sekvenssin SEO ID NO:38 käsittävän kevytketjun vaihtelevan alueen sillä poikkeuksella, että anti-IL6-vasta-aineessa on — yhteensä 1, 2 tai 3 mutaatiota, ja jossa raskasketjun vaihteleva alue käsittää aminohapposekvenssit GYVLPNYLIE (SEQ ID NO:31), VTTPGGGTIN (SEO ID NO:32) ja SRWDPLYYYALEY (SEQ ID NO: 33) ja jossa kevytketjun vaihteleva alue käsittää aminohapposekvenssit RASESVDNYGIPFMN (SEO ID NO:34), AASNRGS (SEO ID NO:35) ja QQSEEVPLT (SEQ ID NO:36).
3. Anti-IL6-vasta-aine, joka käsittää sekvenssin SEO ID NO:41 kanssa identtisen raskasketjun sekvenssin ja sekvenssin SEO ID NO:42 kanssa identtisen kevytketjusekvenssin sillä poikkeuksella, että vasta-aine käsittää yhteensä 1, 2, 3, 4 tai 5 mutaatiota suhteessa sekvenssiin SEO ID NO:41 ja/tai sekvenssiin SEO ID NO:42, ja jossa raskasketjun vaihteleva alue käsittää aminohapposekvenssit — GYVLPNYLIE (SEQ ID NO:31), VTTPGGGTIN (SEQ ID NO:32) ja SRWDPLYYYALEY (SEQ ID NO:33) ja jossa kevytketjun vaihteleva alue käsittää aminohapposekvenssit RASESVDNYGIPFMN (SEO ID NO:34), AASNRGS (SEO ID NO:35) ja QQSEEVPLT (SEQ ID NO:36).
4. Patenttivaatimuksen 2 mukainen anti-IL6-vasta-aine, jossa 1, 2, 3, 4 tai 5 mutaatio(ta) vähentää/vähentävät FcRn:n sitoutumista.
5. Patenttivaatimuksen 2 mukainen anti-IL6-vasta-aine, jossa yksi tai useampi — mutaatioista on yhdessä tai useammassa H311:tä, D313:a, 1254:44 tai H436:ta vastaavassa asemassa (numerointi sekvenssin SEO ID NO:41 mukainen).
6. Anti-IL6-vasta-aine, joka käsittää sekvenssin SEO ID NO:47 kanssa identtisen raskasketjun sekvenssin ja sekvenssin SEO ID NO:42 kanssa identtisen kevytketjun sekvenssin sillä poikkeuksella, että anti-IL6-vasta-aine käsittää — yhteensä 1, 2, 3, 4 tai 5 mutaatiota suhteessa sekvenssiin SEO ID NO:47 ja/tai sekvenssiin SEO ID NO:42 ja se käsittää raskasketjun CDR-aminohapposekvenssit GYVLPNYLIE (SEQ ID NO:31), VTTPGGGTIN (SEO ID NO:32), ja SRWDPLYYYALEY (SEQ ID NO:33) ja kevytketjun CDR-aminohapposekvenssit RASESVDNYGIPFMN (SEO ID NO:34) AASNRGS (SEO ID NO:35) ja — QQSEEVPLT (SEQ ID NO: 36).
7. Koostumus, joka käsittää jonkin patenttivaatimuksista 1-6 mukaista anti- IL6-vasta-ainetta ja valinnaisesti farmaseuttisesti hyväksyttävää kantajaa.
8. Patenttivaatimuksen 7 mukainen koostumus, jossa koostumus käsittää vähintään 60, 70, 80, 90, 95 tai 99 % anti-IL6-vasta-aineen IgG2-A- tai IgG2-A/B- — isoformeja tai niiden yhdistelmää.
9. Patenttivaatimuksen 7 tai 8 mukainen koostumus, jossa koostumus käsittää alle 10 %, 5 %, 2 %, 1 % tai 0,5 % anti-IL6-vasta-aineen IgG2-B-isoformeja.
10. — Jonkin patenttivaatimuksista 1-6 mukainen anti-IL6-vasta-aine tai jonkin patenttivaatimuksista 6-9 mukainen koostumus käytettäväksi — sellaisen — silmäsairauden hoidossa, jota karakterisoi kohonnut IL-6-taso.
11. — Jonkin patenttivaatimuksista 1-6 mukainen anti-IL6-vasta-aine tai jonkin patenttivaatimuksista 6-9 mukainen koostumus käytettäväksi yhden seuraavista hoidossa: diabeettinen makulaturvotus (DME), diabeettinen retinopatia, silmien kuivuminen (esim. kuivasilmäisyys tai kuivasilmäisyysoireyhtymä), allerginen — sidekalvotulehdus, suonikalvoston tulehdus, ikään liittyvä makularappeuma (AMD), — proliferatiivinen — diabeettinen — retinopatia (PDR), reumaattinen verkkokalvon irtauma (RRD), verkkokalvon laskimotukos (RVO), neuromyelitis optica (NMO), sarveiskalvosiirre, sarveiskalvon kuluma tai silmän fyysinen vamma.
12. Nukleiinihappo, joka käsittää jonkin patenttivaatimuksista 1-6 mukaista anti-IL6-vasta-ainetta koodittavan sekvenssin.
13. Vektori, joka käsittää patenttivaatimuksen 12 mukaisen nukleiinihapon.
14 Solu, joka käsittää patenttivaatimuksen 13 mukaisen vektorin.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462077105P | 2014-11-07 | 2014-11-07 | |
| US201462087448P | 2014-12-04 | 2014-12-04 | |
| US201562247705P | 2015-10-28 | 2015-10-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI4268843T3 true FI4268843T3 (fi) | 2025-11-14 |
Family
ID=54602042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP23189385.0T FI4268843T3 (fi) | 2014-11-07 | 2015-11-06 | Parannettuja il-6-vasta-aineita |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US11142571B2 (fi) |
| EP (3) | EP3632931A1 (fi) |
| JP (1) | JP6594438B2 (fi) |
| KR (2) | KR102636726B1 (fi) |
| CN (1) | CN107249631B (fi) |
| AU (1) | AU2015342882B2 (fi) |
| CA (1) | CA2965689C (fi) |
| CL (1) | CL2017001135A1 (fi) |
| CO (1) | CO2017005404A2 (fi) |
| CR (1) | CR20170231A (fi) |
| DK (2) | DK4268843T3 (fi) |
| EA (1) | EA035199B1 (fi) |
| ES (1) | ES2756275T3 (fi) |
| FI (1) | FI4268843T3 (fi) |
| HR (1) | HRP20191945T1 (fi) |
| HU (1) | HUE046181T2 (fi) |
| IL (1) | IL251858B (fi) |
| LT (1) | LT4268843T (fi) |
| MA (1) | MA51554A (fi) |
| MX (2) | MX385206B (fi) |
| MY (1) | MY185114A (fi) |
| PE (1) | PE20171107A1 (fi) |
| PH (1) | PH12017500809B1 (fi) |
| PL (1) | PL3215530T3 (fi) |
| PT (2) | PT3215530T (fi) |
| RS (1) | RS59805B1 (fi) |
| SA (1) | SA517381458B1 (fi) |
| SG (2) | SG10202103420PA (fi) |
| SI (1) | SI3215530T1 (fi) |
| UA (1) | UA122673C2 (fi) |
| WO (1) | WO2016073890A1 (fi) |
| ZA (1) | ZA201702985B (fi) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3353203A2 (en) | 2015-09-23 | 2018-08-01 | H. Hoffnabb-La Roche Ag | Optimized variants of anti-vegf antibodies |
| AR107708A1 (es) * | 2016-02-23 | 2018-05-23 | Eleven Biotherapeutics Inc | Formulaciones de antagonista de il-6 y sus usos |
| MX2019007144A (es) * | 2016-12-19 | 2019-10-07 | Glenmark Pharmaceuticals Sa | Nuevos agonistas de tnfr y sus usos. |
| JP7216006B2 (ja) | 2017-03-22 | 2023-01-31 | ジェネンテック， インコーポレイテッド | ヒドロゲル架橋ヒアルロン酸プロドラッグ組成物及び方法 |
| UA129242C2 (uk) | 2017-03-22 | 2025-02-26 | Дженентек, Інк. | Оптимізована композиція антитіла для лікування захворювань очей |
| CN109867723B (zh) * | 2017-12-05 | 2022-06-17 | 南京金斯瑞生物科技有限公司 | 抗人il6单克隆抗体及其制备方法和用途 |
| PE20230252A1 (es) | 2020-03-13 | 2023-02-07 | Genentech Inc | Anticuerpos anti-interleucina-33 y sus usos de estos |
| BR112022018847A2 (pt) | 2020-03-24 | 2022-11-22 | Genentech Inc | Anticorpos, ácido nucleico, célula hospedeira, conjugados, composição farmacêutica, dispositivo de entrega de ação prolongada para entrega ocular, método para tratar um distúrbio e uso do anticorpo |
| EP4228706A1 (en) | 2020-10-15 | 2023-08-23 | Genentech, Inc. | Hyaluronic acid binding derivatives of versican (vg1) for long acting delivery of therapeutics |
| CN116554298A (zh) * | 2022-02-25 | 2023-08-08 | 南京工业大学 | 一种强化细菌卷曲菌毛提高人表皮生长因子分泌生产效率的方法 |
| CN115343483B (zh) * | 2022-08-12 | 2024-11-26 | 苏州邦器生物技术有限公司 | 一种自身免疫性糖尿病检测用试剂盒及其制备方法 |
| CN120112551A (zh) * | 2022-10-24 | 2025-06-06 | 豪夫迈·罗氏有限公司 | 预测对il-6拮抗剂的反应 |
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