[go: up one dir, main page]

FI3853234T3 - Fuusioituja trisyklisiä rengasjohdannaisia SRC-homologia-2-fosfataasin estäjinä - Google Patents

Fuusioituja trisyklisiä rengasjohdannaisia SRC-homologia-2-fosfataasin estäjinä

Info

Publication number
FI3853234T3
FI3853234T3 FIEP19779687.3T FI19779687T FI3853234T3 FI 3853234 T3 FI3853234 T3 FI 3853234T3 FI 19779687 T FI19779687 T FI 19779687T FI 3853234 T3 FI3853234 T3 FI 3853234T3
Authority
FI
Finland
Prior art keywords
alkyl
optionally substituted
haloalkyl
cycloalkyl
hydrogen
Prior art date
Application number
FIEP19779687.3T
Other languages
English (en)
Swedish (sv)
Inventor
Jiping Fu
Yan Lou
Yigang He
Original Assignee
Nikang Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nikang Therapeutics Inc filed Critical Nikang Therapeutics Inc
Application granted granted Critical
Publication of FI3853234T3 publication Critical patent/FI3853234T3/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Claims (13)

EP3853234 1 Patenttivaatimukset
1. Yhdiste, jolla on kaava (IIB): R? 1 g ; ON 3 = VL R NY RS Zz pt R> (118) taisen farmaseuttisesti hyväksyttävä suola; jolloin: (a) Zon -Y-M, jolloin Y on sidos ja M on alkyyli, haloalkyyli, sykloalkyyli, heterosyklyyli tai heteroaryyli, jolloin alkyyli, haloalkyyli, sykloalkyyli, heterosyklyyli ja heteroaryyli on substituoitu -O(alkyleeni)OR2:lla, jolloin R on alkyyli, sykloalkyyli, sykloalkyylialkyyli, = aminoalkyyli, valinnaisesti substituoitu heterosyklyyli, valinnaisesti substituoitu heterosyklyylialkyyli, valinnaisesti substituoitu aryyli tai valinnaisesti substituoitu heteroaryyli; tai (b) Zon -Y-M, jolloin Y on sidos ja M on alkyyli, haloalkyyli, sykloalkyyli, heterosyklyyli tai heteroaryyli, jolloin alkyyli, haloalkyyli, sykloalkyyli, heterosyklyyli ja heteroaryyli on — substituoitu -O-R2%:lla, jolloin R2 on alkyyli, sykloalkyyli sykloalkyylialkyyli, aminoalkyyli, valinnaisesti substituoitu heterosyklyyli, valinnaisesti substituoitu heterosyklyylialkyyli, valinnaisesti substituoitu aryyli tai valinnaisesti substituoitu heteroaryyli; tai (c) Z on -OR3, jolloin R2 on alkyyli, sykloalkyyli, sykloalkyylialkyyli, aminoalkyyli, — valinnaisesti substituoitu heterosyklyyli, valinnaisesti substituoitu heterosyklyylialkyyli, valinnaisesti substituoitu aryyli tai valinnaisesti substituoitu heteroaryyli; tai (d) Z on -O(alkyleeni)OR®, jolloin RP on alkyyli, sykloalkyyli, sykloalkyylialkyyli, aminoalkyyli, valinnaisesti substituoitu heterosyklyyli, valinnaisesti substituoitu heterosyklyylialkyyli, valinnaisesti substituoitu aryyli tai valinnaisesti substituoitu — heteroaryyli; R', R?, R3 ja R* on valittu toisistaan riippumatta seuraavista: vety, alkyyli, sykloalkyyli, halo, haloalkyyli, haloalkoksi, alkoksi, syano, hydroksi, hydroksyylialkyyli, amino ja aminoalkyyli;
EP3853234 2 tai yksi ryhmistä R! ja R? ja R3 ja R? samaan hiileen kiinnittyessään yhdistyvät muodostaen okson, alkyylidienyylin, 3—6-jasenisen sykloalkyleenin tai 4-6-jäsenisen heterosyklyleenin; joko: R® ja RS on valittu toisistaan riippumatta seuraavista: vety, alkyyli, sykloalkyyli, halo, haloalkyyli, haloalkoksi, alkoksi, hydroksi, syano, hydroksyylialkyyli, amino ja aminoalkyyli; tai: toinen R>:stä ja RS:sta on valinnaisesti substituoitu heterosyklyyli ja toinen R5:stä ja R8:sta on valittu seuraavista: vety, alkyyli, sykloalkyyli, halo, haloalkyyli, haloalkoksi, alkoksi, hydroksi, syano, hydroksyylialkyyli, amino ja aminoalkyyli; Lon sidos, O, S, S(O), S(O)2 tai CR”R?, jossa R? ja R? ovat toisistaan riippumatta vety tai alkyyli; R? on vety, alkyyli, halo, hydroksi, amino tai haloalkyyli; R'0 on vety, alkyyli, halo, hydroksi, hydroksialkyyli, -CD2OH, alkyylisulfoksidi, alkyylisulfonyyli, amino, aminoalkyyli, aminosulfonyyli, aminokarbonyyli, karboksi, — syano tai alkoksikarbonyyli; R'! ja R'? yhdessä hiiliatomin kanssa, johon ne ovat kiinnittyneet, muodostavat kaavan (c) renkaan; jolloin kaavan (c) rengas on: mo NER 2 NH: e N NH; = NH; dD dD dD D DD O o wpe BZ one VH: n OH: a NH NH, iA v F Anne s < RR 0 DR p F OMe EF py X | Pp % o % O rr HN HSN "HSN HON N O tai o o — jolloin:
EP3853234 3
”alkenyyli” tarkoittaa lineaarista yksiarvoista hiilivetyradikaalia, jossa on kahdesta kuuteen hiiliatomia, tai haarautunutta yksiarvoista hiilivetyradikaalia, jossa on kolmesta kuuteen hiiliatomia, jossa on kaksoissidos;
”alkoksi” tarkoittaa -OR-radikaalia, jossa R on alkyyli;
”alkoksialkyyli” tarkoittaa lineaarista yksiarvoista hiilivetyradikaalia, jossa on yhdestä kuuteen hiiliatomia, tai haarautunutta yksiarvoista hiilivetyradikaalia, jossa on kolmesta kuuteen hiiliatomia, joka on substituoitu vähintään yhdellä alkoksiryhmällä; ”alkoksikarbonyyli” tarkoittaa -C(O)OR-radikaalia, jossa R on alkyyli;
”alkyyli” tarkoittaa lineaarista tyydyttynyttä yksiarvoista hiilivetyradikaalia, jossa on yhdestä kuuteen € hiiliatomia, tai haarautunutta tyydyttynyttä — yksiarvoista hiilivetyradikaalia, jossa on kolmesta kuuteen hiiliatomia;
”alkyyliamino” tarkoittaa -NHR-radikaalia, jossa R on alkyyli; ”alkyylidienyyli” on alkenyyli, joka on kiinnittynyt terminaalisen kaksiarvoisen hiilen kautta;
—”alkyleeni” tarkoittaa lineaarista tyydyttynyttä kaksiarvoista hiilivetyradikaalia, jossa on yhdestä kuuteen € hiiliatomia, tai haarautunutta tyydyttynyttä kaksiarvoista hiilivetyradikaalia, jossa on kolmesta kuuteen hiiliatomia;
”alkyylisulfonyyli” tarkoittaa -SO2R-radikaalia, jossa R on alkyyli; ”alkyylisulfoksidi” tarkoittaa -SOR-radikaalia, jossa R on alkyyli; —”alkyylitio” tarkoittaa -SR-radikaalia, jossa R on alkyyli; ”aminoalkyyli” tarkoittaa lineaarista yksiarvoista hiilivetyradikaalia, jossa on yhdestä kuuteen hiiliatomia, tai haarautunutta yksiarvoista hiilivetyradikaalia, jossa on kolmesta kuuteen hiiliatomia, joka on substituoitu ryhmällä -NR'R”, jossa R' ja R” ovat toisistaan riippumatta vety, alkyyli, haloalkyyli, hydroksialkyyli tai alkoksialkyyli, tai R'
ja R” yhdessä typpiatomin kanssa, johon ne ovat kiinnittyneet, muodostavat valinnaisesti substituoidun heterosyklyylin;
”aminosulfonyyli” tarkoittaa -SO2NRR’-radikaalia, jossa R ja R' ovat toisistaan riippumatta vety, alkyyli, haloalkyyli, hydroksialkyyli tai alkoksialkyyli; ”aryyli” — tarkoittaa — yksiarvoista — monosyklistä tai bisyklistä = aromaattista
— hiilivetyradikaalia, jossa on 6—10 rengasatomia;
”sykloalkyyli? tarkoittaa monosyklistä tyydyttynyttä, yksiarvoista hiilivetyradikaalia, jossa on kolmesta kymmeneen hiiliatomia, joka on valinnaisesti substituoitu yhdellä tai kahdella substituentilla, jotka on valittu toisistaan riippumatta alkyylin, halogeenin, alkoksin, hydroksin ja syanon joukosta;
EP3853234 4
”sykloalkyylialkyyli” tarkoittaa -(alkyleeni)-R-radikaalia, jossa R on sykloalkyyli;
”sykloalkyleeni” tarkoittaa monosyklistä tyydyttynyttä kaksiarvoista hiilivetyradikaalia,
jossa on kolmesta kuuteen hiiliatomia, joka on valinnaisesti substituoitu yhdellä tai kahdella substituentilla, jotka on valittu toisistaan riippumatta alkyylin, halogeenin, alkoksin, hydroksin ja syanon joukosta;
”dialkyyliamino? tarkoittaa -NRR'-radikaalia, jossa R ja R' ovat alkyyli;
”haloalkoksi” tarkoittaa -OR-radikaalia, jossa R on haloalkyyli;
”haloalkyyli” tarkoittaa alkyyliradikaalia, joka on substituoitu yhdellä tai useammalla halogeeniatomilla;
”heteroaryyli” tarkoittaa yksiarvoista monosyklistä tai bisyklistä aromaattista radikaalia, jossa on 5-10 rengasatomia, jolloin yksi tai useampi rengasatomeista on heteroatomi, joka on valittu N:stä, O:sta ja S:stä, jolloin loput rengasatomit ovat hiili; ”heterosyklyyli” tarkoittaa tyydyttynyttä tai tyydyttymätöntä yksiarvoista monosyklistä tai bisyklistä rengasta, jossa on 4-10 rengasatomia, jolloin yksi, kaksi tai kolme rengasatomia ovat heteroatomi, joka on valittu N:stä, O:sta ja S(O)n:stä, jolloin n on kokonaisluku 0-2, jolloin loput rengasatomit ovat C, ja yksi tai kaksi heterosyklyylirenkaan rengashiiliatomia voidaan valinnaisesti korvata -CO-ryhmällä; ”heterosyklyylialkyyli? tarkoittaa -(alkyleeni)-R-radikaalia, jossa R on heterosyklyylialkyyli;
—”heterosyklyleeni” tarkoittaa tyydyttynyttä tai tyydyttymätöntä = kaksiarvoista monosyklistä tai bisyklistä rengasta, jossa on 4-6 rengasatomia, jolloin yksi, kaksi tai kolme rengasatomia ovat heteroatomi, joka on valittu N:stä, O:sta ja S(O)n:stä, jolloin n on kokonaisluku 0—2, ja loput rengasatomit ovat C, ja on valinnaisesti substituoitu yhdellä tai kahdella substituentilla, jotka on valittu toisistaan riippumatta alkyylistä,
—halogeenista, haloalkyylistä, haloalkoksista, syanosta tai hydroksista; ”hydroksialkyyli” tarkoittaa lineaarista yksiarvoista hiilivetyradikaalia, jossa on yhdestä kuuteen hiiliatomia, tai haarautunutta yksiarvoista hiilivetyradikaalia, jossa on kolmesta kuuteen hiiliatomia, joka on substituoitu yhdellä tai kahdella hydroksiryhmällä, edellyttäen, että jos läsnä on kaksi hydroksiryhmää, ne eivät molemmat ole samassa hiiliatomissa;
"valinnaisesti substituoitu aryyli” tarkoittaa aryyliä, joka on valinnaisesti substituoitu yhdellä, kahdella tai kolmella substituentilla, jotka on valittu toisistaan riippumatta seuraavista: alkyyli, hydroksyyli, sykloalkyyli, karboksi, alkoksikarbonyyli, hydroksi,
EP3853234 5 alkoksi, alkyylitio, alkyylisulfonyyli, amino, alkyyliamino, dialkyyliamino, halo, haloalkyyli, haloalkoksi ja syano; "valinnaisesti substituoitu heteroaryyli” tarkoittaa heteroaryyliä, joka on valinnaisesti substituoitu yhdellä, kahdella tai kolmella substituentilla, jotka on valittu toisistaan — riippumatta seuraavista: alkyyli, alkyylitio, alkyylisulfonyyli, hydroksyyli, sykloalkyyli, karboksi, alkoksikarbonyyli, hydroksi, alkoksi, halo, haloalkyyli, haloalkoksi, amino, alkyyliamino, dialkyyliamino ja syano; "valinnaisesti substituoitu heterosyklyyli” tarkoittaa heterosyklyyliä, joka on valinnaisesti substituoitu yhdellä, kahdella tai kolmella substituentilla, jotka on valittu — toisistaan riippumatta seuraavista: alkyyli, alkyylitio, alkyylisulfonyyli, hydroksyyli, sykloalkyyli, karboksi, alkoksikarbonyyli, hydroksi, hydroksialkyyli, alkoksi, alkoksialkyyli, aminoalkyyli, halo, haloalkyyli, haloalkoksi ja syano; ja "valinnaisesti substituoitu heterosyklyylialkyyli” tarkoittaa ryhmää -(alkyleeni)-R, jossa R on valinnaisesti substituoitu heterosyklyyli.
2. Patenttivaatimuksen 1 mukainen yhdiste tai sen farmaseuttisesti hyväksyttävä suola, jolloin: Zon -Y-M, jolloin Y on sidos ja M on alkyyli, haloalkyyli, sykloalkyyli, heterosyklyyli tai heteroaryyli, jolloin alkyyli, haloalkyyli, sykloalkyyli, heterosyklyyli ja heteroaryyli on — substituoitu -O(alkyleeni)OR2:lla, jolloin R? on alkyyli, sykloalkyyli, sykloalkyylialkyyli, aminoalkyyli, valinnaisesti substituoitu heterosyklyyli, valinnaisesti substituoitu heterosyklyylialkyyli, valinnaisesti substituoitu aryyli tai valinnaisesti substituoitu heteroaryyli.
3. Patenttivaatimuksen 2 mukainen yhdiste tai sen farmaseuttisesti hyväksyttävä suola, jolloin: Z on metoksimetyylioksimetyyli, etoksimetyylioksimetyyli, metoksietyylioksimetyyli, syklopropyylimetyylioksimetyyli tai oksetan-3-yylimetyylioksimetyyli. 4 Jonkin patenttivaatimuksista 1-3 mukainen yhdiste tai sen farmaseuttisesti hyväksyttävä suola, jolloin: R? on vety, amino tai metyyli.
EP3853234 6
5. — Jonkin patenttivaatimuksista 1-4 mukainen yhdiste tai sen farmaseuttisesti hyväksyttävä suola, jolloin: L on S.
6. Jonkin patenttivaatimuksista 1-5 mukainen yhdiste tai sen farmaseuttisesti hyväksyttävä suola, jolloin: R'2 on hydroksialkyyli tai vety.
7. — Jonkin patenttivaatimuksista 1-5 mukainen yhdiste tai sen farmaseuttisesti — hyväksyttävä suola, jolloin: R'2 on hydroksimetyyli.
8. Jonkin patenttivaatimuksista 1-7 mukainen yhdiste tai sen farmaseuttisesti hyväksyttävä suola, jolloin: R', R? R3 ja R? valitaan toisistaan riippumatta seuraavista: vety, alkyyli, halo, haloalkyyli, haloalkoksi, alkoksi, syano, hydroksi ja amino.
9. Patenttivaatimuksen 8 mukainen yhdiste tai sen farmaseuttisesti hyväksyttävä suola, jolloin: yksi ryhmistä R!, R?, R3 ja R on vety: ja — loput kolme ryhmistä R', R?, R3 ja R? valitaan toisistaan riippumatta seuraavista: vety, metyyli, fluori, metoksi, hydroksi ja amino.
10. Patenttivaatimuksen 8 mukainen yhdiste tai sen farmaseuttisesti hyväksyttävä suola, jolloin: R1, R?, R3 ja R? ovat vety.
11. Jonkin patenttivaatimuksista 1-10 mukainen yhdiste tai sen farmaseuttisesti hyväksyttävä suola, jolloin: R> on vety, alkyyli, halo tai amino; ja R6 on vety, alkyyli, halo, haloalkyyli, haloalkoksi, alkoksi, hydroksi tai syano.
12. Patenttivaatimuksen 11 mukainen yhdiste tai sen farmaseuttisesti hyväksyttävä suola, jolloin: R® ja R$ ovat vety.
EP3853234 7
13. Patenttivaatimuksen 1 mukainen yhdiste, joka on seuraavista yhdisteistä valittu yhdiste: a oe Ås 00 N A N Ho” + H2N 00 S o” N ha NH; HO p 0 1 E CT 2 S SS OH rå Ö 3
FIEP19779687.3T 2018-09-18 2019-09-17 Fuusioituja trisyklisiä rengasjohdannaisia SRC-homologia-2-fosfataasin estäjinä FI3853234T3 (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862733061P 2018-09-18 2018-09-18
US201862749655P 2018-10-23 2018-10-23
US201962810911P 2019-02-26 2019-02-26
US201962883121P 2019-08-06 2019-08-06
US201962883120P 2019-08-06 2019-08-06
PCT/US2019/051592 WO2020061103A1 (en) 2018-09-18 2019-09-17 Fused tricyclic ring derivatives as src homology-2 phosphatase inhibitors

Publications (1)

Publication Number Publication Date
FI3853234T3 true FI3853234T3 (fi) 2025-07-28

Family

ID=68084982

Family Applications (1)

Application Number Title Priority Date Filing Date
FIEP19779687.3T FI3853234T3 (fi) 2018-09-18 2019-09-17 Fuusioituja trisyklisiä rengasjohdannaisia SRC-homologia-2-fosfataasin estäjinä

Country Status (22)

Country Link
US (6) US20200115389A1 (fi)
EP (2) EP3853234B1 (fi)
JP (2) JP7337174B2 (fi)
KR (2) KR102834408B1 (fi)
CN (2) CN112996795B (fi)
AU (2) AU2019344897B2 (fi)
BR (1) BR112021005082A2 (fi)
CA (2) CA3113234A1 (fi)
CL (1) CL2021000628A1 (fi)
CO (1) CO2021004436A2 (fi)
CR (1) CR20210175A (fi)
DK (1) DK3853234T3 (fi)
ES (1) ES3036496T3 (fi)
FI (1) FI3853234T3 (fi)
MX (1) MX2021003158A (fi)
PH (1) PH12021550604A1 (fi)
PL (1) PL3853234T3 (fi)
PT (1) PT3853234T (fi)
SA (1) SA521421505B1 (fi)
SG (1) SG11202102679QA (fi)
TW (1) TWI827677B (fi)
WO (2) WO2020061101A1 (fi)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202413340A (zh) 2016-07-12 2024-04-01 美商銳新醫藥公司 作為異位shp2抑制劑之2,5-雙取代型3-甲基吡嗪及2,5,6-三取代型3-甲基吡嗪
EP3515916B1 (en) 2016-09-22 2023-06-07 Relay Therapeutics, Inc. Shp2 phosphatase inhibitors and methods of use thereof
TW202500565A (zh) 2016-10-24 2025-01-01 美商傳達治療有限公司 Shp2磷酸酶抑制劑及其使用方法
SG11201906209SA (en) 2017-01-23 2019-08-27 Revolution Medicines Inc Bicyclic compounds as allosteric shp2 inhibitors
RU2019126455A (ru) 2017-01-23 2021-02-24 Революшн Медсинз, Инк. Пиридиновые соединения в качестве аллостерических ингибиторов shp2
EP3630770B1 (en) 2017-05-26 2024-08-28 Relay Therapeutics, Inc. Pyrazolo[3,4-b]pyrazine derivatives as shp2 phosphatase inhibitors
US11701354B2 (en) 2017-09-29 2023-07-18 D. E. Shaw Research, Llc Pyrazolo[3,4-b]pyrazine derivatives as SHP2 phosphatase inhibitors
JP2020536881A (ja) * 2017-10-12 2020-12-17 レヴォリューション・メディスンズ，インコーポレイテッド アロステリックｓｈｐ２阻害剤としてのピリジン、ピラジンおよびトリアジン化合物
RU2020123241A (ru) 2017-12-15 2022-01-17 Революшн Медсинз, Инк. Полициклические соединения в качестве аллостерических ингибиторов shp2
WO2019183364A1 (en) 2018-03-21 2019-09-26 Relay Therapeutics, Inc. Pyrazolo[3,4-b]pyrazine shp2 phosphatase inhibitors and methods of use thereof
CN112166110B (zh) 2018-03-21 2023-08-11 传达治疗有限公司 Shp2磷酸酶抑制剂及其使用方法
AU2019344897B2 (en) 2018-09-18 2024-01-18 Nikang Therapeutics, Inc. Tri-substituted heteroaryl derivatives AS SRC homology-2 phosphatase inhibitors
EP3860717A1 (en) 2018-10-03 2021-08-11 Gilead Sciences, Inc. Imidozopyrimidine derivatives
CN113365988B (zh) * 2019-01-31 2023-10-03 贝达药业股份有限公司 Shp2抑制剂及其应用
WO2021043077A1 (zh) * 2019-09-06 2021-03-11 四川科伦博泰生物医药股份有限公司 一种取代吡嗪化合物、其制备方法和用途
WO2021061515A1 (en) * 2019-09-23 2021-04-01 Synblia Therapeutics, Inc. Shp2 inhibitors and uses thereof
WO2021061706A1 (en) 2019-09-24 2021-04-01 Relay Therapeutics, Inc. Shp2 phosphatase inhibitors and methods of making and using the same
MX2022005525A (es) 2019-11-08 2022-06-08 Revolution Medicines Inc Compuestos de heteroarilo bicíclicos y usos de estos.
EP4076667A1 (en) 2019-12-20 2022-10-26 Erasca, Inc. Tricyclic pyridones and pyrimidones
TW202214253A (zh) 2020-06-18 2022-04-16 美商銳新醫藥公司 延遲、預防及治療對ｒａｓ抑制劑之後天抗性之方法
US20230212180A1 (en) * 2020-06-22 2023-07-06 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Substituted pyrazine compound, pharmaceutical composition comprising same, and use thereof
CN116113418A (zh) * 2020-08-25 2023-05-12 四川科伦博泰生物医药股份有限公司 杂环化合物及其制备方法和用途
CA3187757A1 (en) 2020-09-03 2022-03-24 Ethan AHLER Use of sos1 inhibitors to treat malignancies with shp2 mutations
PE20231207A1 (es) 2020-09-15 2023-08-17 Revolution Medicines Inc Derivados indolicos como inhibidores de ras en el tratamiento del cancer
KR20230094198A (ko) 2020-09-23 2023-06-27 에라스카, 아이엔씨. 3환식 피리돈 및 피리미돈
CN117120449A (zh) * 2020-12-11 2023-11-24 医睿世康药业研发公司 用于癌症治疗的联合疗法
CN117083283A (zh) * 2020-12-11 2023-11-17 医睿世康药业研发公司 用于癌症治疗的联合疗法
CN117098537A (zh) * 2020-12-11 2023-11-21 医睿世康药业研发公司 用于癌症治疗的联合疗法
WO2022125971A1 (en) * 2020-12-11 2022-06-16 Erasca, Inc. Combination therapies for the treatment of cancer
CA3201657A1 (en) * 2020-12-11 2022-06-16 Leenus MARTIN Combination therapies for the treatment of cancer
KR20230152652A (ko) * 2020-12-11 2023-11-03 에라스카, 아이엔씨. 암 치료를 위한 병용 요법
WO2022133345A1 (en) 2020-12-18 2022-06-23 Erasca, Inc. Tricyclic pyridones and pyrimidones
CN116848121A (zh) * 2020-12-18 2023-10-03 建新公司 制备shp2抑制剂的方法
WO2022133217A1 (en) * 2020-12-18 2022-06-23 Genzyme Corporation Process for preparing shp2 inhibitors
CN117083285A (zh) * 2021-03-31 2023-11-17 南京明德新药研发有限公司 一系列含Se的吡嗪类化合物及其应用
CN117500811A (zh) 2021-05-05 2024-02-02 锐新医药公司 共价ras抑制剂及其用途
MX2023013085A (es) 2021-05-05 2023-11-16 Revolution Medicines Inc Inhibidores de ras.
PE20240089A1 (es) 2021-05-05 2024-01-16 Revolution Medicines Inc Inhibidores de ras para el tratamiento del cancer
US20240293422A1 (en) * 2021-06-24 2024-09-05 Erasca, Inc. Shp2 and cdk4/6 inhibitors combination therapies for the treatment of cancer
US20240285624A1 (en) * 2021-06-24 2024-08-29 Erasca, Inc. Erk1/2 or shp2 inhibitors and flt3 inhibitors combination therapy
WO2022271964A1 (en) * 2021-06-24 2022-12-29 Erasca, Inc. Erk1/2 and shp2 inhibitors combination therapy
JP2024527535A (ja) * 2021-07-09 2024-07-25 カナプ セラピューティクス インコーポレイテッド Ｓｈｐ２阻害剤及びその使用
WO2023031781A1 (en) 2021-09-01 2023-03-09 Novartis Ag Pharmaceutical combinations comprising a tead inhibitor and uses thereof for the treatment of cancers
WO2023044065A1 (en) * 2021-09-17 2023-03-23 Erasca, Inc. Jak inhibitor with erk1/2 and/or shp2 inhibitors combination therapy
US20240415843A1 (en) * 2021-10-06 2024-12-19 Erasca, Inc. Uses of tri-substituted heteroaryl derivatives as src homology-2 phosphatase inhibitors
AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras
CN119136806A (zh) 2022-03-08 2024-12-13 锐新医药公司 用于治疗免疫难治性肺癌的方法
US11878958B2 (en) 2022-05-25 2024-01-23 Ikena Oncology, Inc. MEK inhibitors and uses thereof
CN120504682A (zh) 2022-06-10 2025-08-19 锐新医药公司 大环ras抑制剂
WO2024042361A1 (en) * 2022-08-24 2024-02-29 Sudo Biosciences Limited Tyk2 inhibitors and uses thereof
EP4646209A1 (en) * 2023-01-06 2025-11-12 Erasca, Inc. Raf inhibitor and erk1/2 and/or shp2 inhibitor combination therapy
KR20250164828A (ko) 2023-03-30 2025-11-25 레볼루션 메디슨즈, 인크. Ras gtp 가수분해 유도를 위한 조성물 및 이의 용도
WO2024211712A1 (en) 2023-04-07 2024-10-10 Revolution Medicines, Inc. Condensed macrocyclic compounds as ras inhibitors
AU2024253668A1 (en) 2023-04-07 2025-11-13 Revolution Medicines, Inc. Macrocyclic ras inhibitors
US20240352038A1 (en) 2023-04-14 2024-10-24 Revolution Medicines, Inc. Crystalline forms of ras inhibitors, compositions containing the same, and methods of use thereof
CN121100123A (zh) 2023-04-14 2025-12-09 锐新医药公司 Ras抑制剂的结晶形式
TW202508595A (zh) 2023-05-04 2025-03-01 美商銳新醫藥公司 用於ｒａｓ相關疾病或病症之組合療法
WO2025034702A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Rmc-6291 for use in the treatment of ras protein-related disease or disorder
WO2025080946A2 (en) 2023-10-12 2025-04-17 Revolution Medicines, Inc. Ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors

Family Cites Families (385)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6041077B2 (ja) 1976-09-06 1985-09-13 喜徳 喜谷 １，２‐ジアミノシクロヘキサン異性体のシス白金（２）錯体
US4261989A (en) 1979-02-19 1981-04-14 Kaken Chemical Co. Ltd. Geldanamycin derivatives and antitumor drug
JPS62135835A (ja) 1985-12-09 1987-06-18 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料の処理方法
JPS62135830A (ja) 1985-12-09 1987-06-18 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料及びその処理方法
JPS62135834A (ja) 1985-12-09 1987-06-18 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料の処理方法
JPS62135832A (ja) 1985-12-09 1987-06-18 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料の処理方法
JPS62136651A (ja) 1985-12-10 1987-06-19 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料の処理方法
JPS62136654A (ja) 1985-12-10 1987-06-19 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料の処理方法
JPS62136650A (ja) 1985-12-11 1987-06-19 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料及びその処理方法
JPS62206545A (ja) 1986-03-07 1987-09-11 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
GB8729614D0 (en) 1987-12-18 1988-02-03 Beecham Group Plc Novel compounds
US5266573A (en) 1989-08-07 1993-11-30 Elf Sanofi Trifluoromethylphenyltetrahydropyridines for the treatment and/or prophylaxis of intestinal motility disorders
US5360459A (en) 1991-05-13 1994-11-01 The Lubrizol Corporation Copper-containing organometallic complexes and concentrates and diesel fuels containing same
JPH05196976A (ja) 1991-11-18 1993-08-06 Toshiba Corp 有機非線形光学材料
JPH05181221A (ja) 1991-12-27 1993-07-23 Konica Corp ハロゲン化銀写真感光材料
GB9201755D0 (en) 1992-01-28 1992-03-11 British Bio Technology Compounds
FR2687932A1 (fr) 1992-02-27 1993-09-03 Oreal Dispersion huile-dans-l'eau susceptible de former des films composites.
EP0647450A1 (en) 1993-09-09 1995-04-12 BEHRINGWERKE Aktiengesellschaft Improved prodrugs for enzyme mediated activation
HRP970371A2 (en) 1996-07-13 1998-08-31 Kathryn Jane Smith Heterocyclic compounds
WO1998006709A1 (en) 1996-08-14 1998-02-19 Takeda Chemical Industries, Ltd. Cyclic urea compounds, their production and use as herbicides
US5977134A (en) 1996-12-05 1999-11-02 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6117973A (en) 1997-02-24 2000-09-12 Georgia Tech Research Corp. PNA monomers with electron donor or acceptor
FR2761687B1 (fr) 1997-04-08 2000-09-15 Centre Nat Rech Scient Derives de quinoleines, possedant notamment des proprietes antivirales, leurs preparations et leurs applications biologiques
JP2000072695A (ja) 1998-08-24 2000-03-07 Sumitomo Pharmaceut Co Ltd 環状化合物
US6465467B1 (en) 1999-05-21 2002-10-15 Biovitrum Ab Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
EP1178973B1 (en) 1999-05-21 2005-12-21 Biovitrum Ab Pyrazinyl-piperazine- compounds, their use and preparation
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
WO2001010842A2 (en) 1999-08-04 2001-02-15 Millennium Pharmaceuticals, Inc. Melanocortin-4 receptor binding compounds and methods of use thereof
US6699873B1 (en) 1999-08-04 2004-03-02 Millennium Pharmaceuticals, Inc. Melanocortin-4 receptor binding compounds and methods of use thereof
US6514964B1 (en) 1999-09-27 2003-02-04 Amgen Inc. Fused cycloheptane and fused azacycloheptane compounds and their methods of use
EP1217001B1 (en) 1999-09-28 2005-12-07 Eisai Co., Ltd. Quinuclidine compounds and drugs containing the same as the active ingredient
GB0018891D0 (en) 2000-08-01 2000-09-20 Novartis Ag Organic compounds
JP4548761B2 (ja) 2000-06-15 2010-09-22 富士フイルムホールディングス株式会社 潤滑剤組成物
AU2001273040A1 (en) 2000-06-27 2002-01-08 Du Pont Pharmaceuticals Company Factor xa inhibitors
DE10032633A1 (de) 2000-07-05 2002-01-17 Bayer Ag Verfahren zum Auffinden von Hemmstoffen der Protoporphyrinogen-Oxidase
JP2002122954A (ja) 2000-08-08 2002-04-26 Fuji Photo Film Co Ltd 感光性ハロゲン化銀写真乳剤、これを含有するハロゲン化銀写真感光材料および感光性ハロゲン化銀写真乳剤の感度向上方法
AU2001279955A1 (en) 2000-08-18 2002-03-04 Sterix Limited 2-substituted estradiol derivative for inhibiting superoxid dismutase
AU2001294865A1 (en) 2000-09-30 2002-04-15 Loctite Low shrinkage thermosetting resin compositions and methods of use therefor
US6963001B2 (en) 2000-09-30 2005-11-08 Henkel Corporation Low shrinkage thermosetting resin compositions and methods of use therefor
AU2002213467A1 (en) 2000-10-11 2002-04-22 Chemocentryx, Inc. Modulation of ccr4 function
EP1217000A1 (en) 2000-12-23 2002-06-26 Aventis Pharma Deutschland GmbH Inhibitors of factor Xa and factor VIIa
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
SE0103646D0 (sv) 2001-11-01 2001-11-01 Astrazeneca Ab Therapeutic chroman compounds
CN1592745A (zh) 2001-01-16 2005-03-09 阿斯特拉曾尼卡有限公司 治疗用苯并－γ－吡喃酮化合物
BR0206512A (pt) 2001-01-16 2004-01-06 Astrazeneca Ab Composto, método de tratamento de um ser humano ou animal que sofre de depressão, ansiedade generalizada, distúrbios da alimentação, demência, distúrbio do p nico, distúrbios do sono, distúrbios gastrointestinais, distúrbios motores, distúrbios endócrinos, vasoespasmo e disfunção sexual, uso de um composto, e, processo para preparar um composto.
WO2002070486A1 (en) 2001-03-01 2002-09-12 Shionogi & Co., Ltd. Nitrogen-containing heteroaryl compounds having hiv integrase inhibitory activity
DE60139510D1 (de) 2001-04-06 2009-09-17 Biocryst Pharm Inc Biarylverbindungen als serinproteaseinhibitoren
WO2003003009A1 (en) 2001-06-29 2003-01-09 7Tm Pharma A/S Use of metal-ion chelates in validating biological molecules as drug targets in test animal models
WO2003003008A1 (en) 2001-06-29 2003-01-09 7Tm Pharma A/S Chemical libraries useful for drug discovery processes
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
FR2831536A1 (fr) 2001-10-26 2003-05-02 Aventis Pharma Sa Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de kdr
US6897208B2 (en) 2001-10-26 2005-05-24 Aventis Pharmaceuticals Inc. Benzimidazoles
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
AU2003210787B2 (en) 2002-02-01 2009-04-23 Medinol Ltd. Phosphorus-containing compounds & uses thereof
WO2003075836A2 (en) 2002-03-05 2003-09-18 Merck Frosst Canada & Co. Cathepsin cysteine protease inhibitors
WO2003078446A2 (en) 2002-03-15 2003-09-25 Nuevolution A/S A building block forming a c-c or a c-hetero atom bond upon reaction
TWI275390B (en) 2002-04-30 2007-03-11 Wyeth Corp Process for the preparation of 7-substituted-3- quinolinecarbonitriles
JP2006511460A (ja) 2002-08-23 2006-04-06 ユニバーシティ オブ コネチカット 治療適応を持つケトカンナビノイド
US7071355B2 (en) 2002-12-23 2006-07-04 4 Sc Ag Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
EP2385040A1 (en) 2003-03-14 2011-11-09 ONO Pharmaceutical Co., Ltd. Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient
GB0306430D0 (en) 2003-03-20 2003-04-23 Bp Chem Int Ltd Polymerisation and oligomerisation catalysts
WO2004110350A2 (en) 2003-05-14 2004-12-23 Torreypines Therapeutics, Inc. Compouds and uses thereof in modulating amyloid beta
US20070010529A1 (en) 2003-05-19 2007-01-11 Kanji Takahashi Nitrogenous heterocyclic compounds and medical use thereof
US7399865B2 (en) 2003-09-15 2008-07-15 Wyeth Protein tyrosine kinase enzyme inhibitors
JP4231379B2 (ja) 2003-10-15 2009-02-25 富士フイルム株式会社 潤滑剤組成物
JP2005170939A (ja) 2003-11-20 2005-06-30 Takeda Chem Ind Ltd 糖尿病の予防・治療剤
DE10355066A1 (de) 2003-11-25 2005-06-23 Basf Ag Verfahren zur asymmetrischen Synthese
US7632946B2 (en) 2004-02-06 2009-12-15 Abbott Laboratories Naphthyridine-based antibacterial compositions
JP2005263787A (ja) 2004-02-17 2005-09-29 Ishihara Sangyo Kaisha Ltd アミド系化合物又はその塩、並びにそれらを含有するサイトカイン産生抑制剤
JP4790703B2 (ja) 2004-04-07 2011-10-12 武田薬品工業株式会社 環式化合物
EP1595888A1 (en) 2004-05-11 2005-11-16 Degussa AG Cycloolefin phosphine ligands and their use in catalysis
GB0412467D0 (en) 2004-06-04 2004-07-07 Astrazeneca Ab Chemical compounds
WO2006001463A1 (ja) 2004-06-23 2006-01-05 Ono Pharmaceutical Co., Ltd. Ｓ１ｐ受容体結合能を有する化合物およびその用途
GB0415879D0 (en) 2004-07-15 2004-08-18 Bp Chem Int Ltd Polymerisation catalyst
GB0418022D0 (en) 2004-08-12 2004-09-15 Bp Chem Int Ltd Polymerisation and oligomerisation catalyst
KR20160058972A (ko) 2004-09-02 2016-05-25 제넨테크, 인크. 헤지호그 신호전달에 대한 피리딜 억제제
GB0420396D0 (en) 2004-09-14 2004-10-13 Bp Chem Int Ltd Polyolefins
WO2006038594A1 (ja) 2004-10-04 2006-04-13 Ono Pharmaceutical Co., Ltd. Ｎ型カルシウムチャネル阻害薬
WO2006061094A1 (en) 2004-12-11 2006-06-15 Merck Patent Gmbh Liquid crystal compounds, liquid crystal medium and liquid crystal display
EP1841736A1 (en) 2005-01-19 2007-10-10 Biolipox AB Indoles useful in the treatment of inflammation
JP4749000B2 (ja) 2005-02-22 2011-08-17 富士フイルム株式会社 グリース組成物
US20070135437A1 (en) 2005-03-04 2007-06-14 Alsgen, Inc. Modulation of neurodegenerative diseases
US20080134938A1 (en) 2005-03-15 2008-06-12 Fujifilm Corporation Surface Treatment Method Employing Discotic Compound, (Lubricant) Composition to Be Used Surface Treatments, and Surface-Treated Articles
US20060156481A1 (en) 2005-03-22 2006-07-20 The Procter & Gamble Company Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
US20070260062A1 (en) 2005-03-31 2007-11-08 Goetz Frederick J Heterocyclical Chromophore Architectures with Novel Electronic Acceptor Systems
ATE524182T1 (de) 2005-04-21 2011-09-15 Merck Serono Sa 2,3-substituierte pyrazinsulfonamide als crth2- hemmer
CA2605738C (en) 2005-04-25 2013-10-01 Merck Patent Gesellschaft Mit Beschraenkter Haftung Novel azaheterocyclic compounds as kinase inhibitors
WO2006119800A1 (en) 2005-05-09 2006-11-16 Technische Universität Braunschweig Light emitting compound for electroluminescent applications
GB0510139D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B1
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
KR20080027890A (ko) 2005-06-27 2008-03-28 브리스톨-마이어스 스큅 컴퍼니 혈전성 증상의 치료에 유용한 ｐ2ｙ1 수용체의 ｎ-연결헤테로시클릭 길항제
DE602006017694D1 (de) 2005-06-27 2010-12-02 Bristol Myers Squibb Co C-verknüpfte zyklische antagonisten des p2y1-rezeptors mit eignung bei der behandlung thrombotischer leiden
WO2007011759A2 (en) 2005-07-15 2007-01-25 Kalypsys, Inc. Inhibitors of mitotic kinesin
WO2007011721A1 (en) 2005-07-15 2007-01-25 Kalypsys, Inc. Inhibitors of mitotic kinesin
JP2007056213A (ja) 2005-08-26 2007-03-08 Fujifilm Corp 焼結含油軸受油用組成物、並びにそれを用いた軸受け装置及び摺動部材
CN103382176A (zh) 2005-10-19 2013-11-06 格吕伦塔尔有限公司 新颖的辣椒素受体配体和它们用于生产药物的用途
FR2892859B1 (fr) 2005-10-27 2008-06-06 Commissariat Energie Atomique Procede de greffage de molecules d'interet sur des surfaces inorganiques, surfaces obtenues et applications
EP1962892A4 (en) 2005-11-22 2011-10-12 Univ South Florida INHIBITION OF CELL PROLIFERATION
WO2007064869A2 (en) 2005-12-01 2007-06-07 Yale University Catalysts for aryl sulfide synthesis and method of producing aryl sulfides
JP2008007634A (ja) 2006-06-29 2008-01-17 Fujifilm Corp 潤滑剤組成物
CA2677001A1 (en) 2006-08-23 2008-02-28 Xtl Biopharmaceuticals Ltd. 4-thio substituted quinoline and naphthyridine compounds
WO2008028553A1 (en) 2006-09-02 2008-03-13 Merck Patent Gmbh Particle beam process for the alignment of reactive mesogens
WO2008118626A2 (en) 2007-03-08 2008-10-02 Burnham Institute For Medical Research Inhibitors of jnk and methods for identifying inhibitors of jnk
US7956020B2 (en) 2007-03-29 2011-06-07 Fujifilm Corporation Lubricant composition, mechanical element, and method for producing triazine derivatives
WO2008125811A1 (en) 2007-04-11 2008-10-23 Astrazeneca Ab N-[HETEROARYLCARBONYL]-S-THIENYL-L-ALANINE DERIVATIVES AS α5β1 ANTAGONISTS
WO2008154642A2 (en) 2007-06-12 2008-12-18 Achaogen, Inc. Antibacterial agents
US8063165B2 (en) 2007-06-18 2011-11-22 Bridgestone Corporation Functional polymers prepared with sulfur-containing initiators
JP2009013314A (ja) 2007-07-06 2009-01-22 Toyo Ink Mfg Co Ltd 光硬化型インキ
WO2009025793A2 (en) 2007-08-21 2009-02-26 Senomyx, Inc. Human t2r bitterness receptors and uses thereof
US8143276B2 (en) 2007-08-22 2012-03-27 Xtl Biopharmaceuticals Ltd. 4-thio substituted quinoline and naphthyridine compounds
ES2593279T3 (es) 2007-08-29 2016-12-07 Methylgene Inc. Procesos e intermedios para preparar inhibidores de cinasa heterocíclicos condensados
US8999459B2 (en) 2007-08-29 2015-04-07 Merck Patent Gmbh Liquid crystal display
TWI471134B (zh) 2007-09-12 2015-02-01 Genentech Inc 肌醇磷脂３－激酶抑制劑化合物及化療劑之組合及使用方法
ES2446932T3 (es) 2007-10-08 2014-03-10 Advinus Therapeutics Private Limited Derivados de acetamida como activadores de glucoquinasa, su procedimiento y aplicaciones en medicina
US9340506B2 (en) 2007-10-08 2016-05-17 Advinus Therapeutics Limited Acetamide derivatives as glucokinase activators, their process and medicinal applications
CA2701292C (en) 2007-10-25 2015-03-24 Genentech, Inc. Process for making thienopyrimidine compounds
RU2501787C2 (ru) 2007-11-02 2013-12-20 Метилджен Инк. Ингибиторы гистондеацетилазы
US8304553B2 (en) 2007-12-19 2012-11-06 Nanyang Technological University Method of forming oseltamivir and derivatives thereof
EP2098226A1 (de) 2008-03-06 2009-09-09 Forschungsverbund Berlin e.V. AKAP-PKA-Interaktionshemmer zur Anwendung in der Behandlung von Herzkrankheiten
US8822513B2 (en) 2010-03-01 2014-09-02 Gtx, Inc. Compounds for treatment of cancer
US8168784B2 (en) 2008-06-20 2012-05-01 Abbott Laboratories Processes to make apoptosis promoters
WO2010011666A2 (en) 2008-07-21 2010-01-28 University Of South Florida Indoline scaffold shp-2 inhibitors and cancer treatment method
JP5847580B2 (ja) 2008-07-28 2016-01-27 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 液晶ディスプレイ
WO2010048149A2 (en) 2008-10-20 2010-04-29 Kalypsys, Inc. Heterocyclic modulators of gpr119 for treatment of disease
DE102009055829A1 (de) 2008-12-22 2010-06-24 Merck Patent Gmbh Flüssigkristallanzeige
WO2010075273A1 (en) 2008-12-23 2010-07-01 Schering Corporation Bicyclic heterocycle derivatives and methods of use thereof
DE102010006691A1 (de) 2009-02-06 2010-10-28 Merck Patent Gmbh Flüssigkristallines Medium und Flüssigkristallanzeige
US20120077959A1 (en) 2009-02-16 2012-03-29 Zhang X Peter Asymmetric Cobalt-Catalyzed Cyclopropanation With Succinimidyl Diazoacetate
CA2753313A1 (en) 2009-02-23 2010-08-26 Presidio Pharmaceuticals, Inc. Inhibitors of hcv ns5a
JP2010217692A (ja) 2009-03-18 2010-09-30 Konica Minolta Holdings Inc 表示素子
PL2414369T3 (pl) 2009-04-02 2016-04-29 Fundacion Centro Nac De Investigaciones Oncologicas Carlos Iii Pochodne imidazo[2,1-b][1,3,4]tiadiazolu
EP2414317A2 (en) 2009-04-03 2012-02-08 The Scripps Research Institute Palladium-catalyzed ortho-fluorination
DE102010012900A1 (de) 2009-04-23 2010-11-25 Merck Patent Gmbh Flüssigkristallanzeige
JP5918693B2 (ja) 2009-05-05 2016-05-18 ダナ ファーバー キャンサー インスティテュート インコーポレイテッド Ｅｇｆｒ阻害剤及び疾患の治療方法
WO2011005355A1 (en) 2009-05-07 2011-01-13 Achaogen, Inc. Combinations comprising a lpxc inhibitor and an antibiotic for use in the treatment of infections caused by gram-negative bacteria
EP2443119A1 (en) 2009-06-16 2012-04-25 Schering Corporation Gamma secretase modulators
US20120238546A1 (en) 2009-06-16 2012-09-20 Zhaoning Zhu Gamma secretase modulators
US20120232108A1 (en) 2009-06-16 2012-09-13 Xianhai Huang Gamma secretase modulators
WO2010148422A1 (en) 2009-06-25 2010-12-29 Walter And Eliza Hall Institute Of Medical Research Compounds and methods for treating parasitic infestations
AU2010266040B2 (en) 2009-06-25 2015-01-15 Alkermes Pharma Ireland Limited Prodrugs of NH-acidic compounds
WO2011022502A1 (en) 2009-08-18 2011-02-24 Georgetown University Boronic acid compositions and methods related to cancer
CN102596932A (zh) 2009-09-04 2012-07-18 拜耳医药股份有限公司 作为酪氨酸苏氨酸激酶抑制剂的取代氨基喹喔啉
EP2292720A1 (en) 2009-09-08 2011-03-09 Merck Patent GmbH Liquid-crystal display
US8877930B2 (en) 2009-11-04 2014-11-04 Massachusetts Institute Of Technology Continuous flow synthesis of amino alcohols using microreactors
KR20110088098A (ko) 2010-01-28 2011-08-03 다우어드밴스드디스플레이머티리얼 유한회사 신규한 유기 발광 화합물 및 이를 채용하고 있는 유기 전계 발광 소자
JP2013519719A (ja) 2010-02-18 2013-05-30 セントロ ナシオナル デ インベスティガシオネス オンコロヒカス（セエネイオ） トリアゾロ［４，５−ｂ］ピリジン誘導体
AU2010347233B2 (en) 2010-03-01 2015-06-18 Oncternal Therapeutics, Inc. Compounds for treatment of cancer
KR20110101444A (ko) 2010-03-08 2011-09-16 다우어드밴스드디스플레이머티리얼 유한회사 신규한 유기 발광 화합물 및 이를 포함하는 유기 발광 소자
KR20110104765A (ko) 2010-03-17 2011-09-23 다우어드밴스드디스플레이머티리얼 유한회사 신규한 유기 발광 화합물 및 이를 채용하고 있는 유기 전계 발광 소자
US9725479B2 (en) 2010-04-22 2017-08-08 Ionis Pharmaceuticals, Inc. 5′-end derivatives
WO2011140425A1 (en) 2010-05-06 2011-11-10 Vertex Pharmaceuticals Incorporated Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels
WO2011150156A2 (en) 2010-05-26 2011-12-01 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
NZ605079A (en) 2010-06-03 2015-08-28 Alnylam Pharmaceuticals Inc Biodegradable lipids for the delivery of active agents
PT2598483T (pt) 2010-07-29 2020-10-12 Rigel Pharmaceuticals Inc Compostos heterocíclicos de ativação de ampk e métodos de utilização dos mesmos
WO2012016133A2 (en) 2010-07-29 2012-02-02 President And Fellows Of Harvard College Ros1 kinase inhibitors for the treatment of glioblastoma and other p53-deficient cancers
US20130202652A1 (en) 2010-07-30 2013-08-08 Alnylam Pharmaceuticals, Inc. Methods and compositions for delivery of active agents
WO2012020215A1 (en) 2010-08-09 2012-02-16 Centro Nacional De Investigaciones Oncológicas (Cnio) Amino- imidazolothiadiazoles for use as protein or lipid kinase inhibitors
WO2012020357A1 (en) 2010-08-09 2012-02-16 Advinus Therapeutics Ltd. Acetamide compounds, their process and pharmaceutical application
WO2012022487A1 (de) 2010-08-20 2012-02-23 Grünenthal GmbH Substituierte cyclische carboxamid- und harnstoff-derivate als liganden des vanilloid-rezeptors
JP6063384B2 (ja) 2010-10-14 2017-01-18 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． プレターゲットキット、プレターゲット方法及びその使用試薬
WO2012052540A1 (en) 2010-10-21 2012-04-26 Universitaet Des Saarlandes Selective cyp11b1 inhibitors for the treatment of cortisol dependent diseases
US20120108819A1 (en) 2010-10-28 2012-05-03 Basf Se N-Heterocyclic Carbene Complexes, Their Preparation And Use
WO2012056419A1 (en) 2010-10-28 2012-05-03 Basf Se N-heterocyclic carbene complexes, their preparation and use
KR20120045905A (ko) 2010-11-01 2012-05-09 한국화학연구원 헤테로고리 축합된 피리도 화합물 및 이의 제조방법
US9090633B2 (en) 2010-11-18 2015-07-28 Kasina Laila Innova Pharmaceuticals Private Limited Substituted 4-(arylamino) selenophenopyrimidine compounds and methods of use thereof
WO2012080729A2 (en) 2010-12-14 2012-06-21 Electrophoretics Limited CASEIN KINASE 1δ (CK1δ) INHIBITORS
RU2013133813A (ru) 2010-12-21 2015-01-27 Конинклейке Филипс Электроникс Н.В. Средства для выведения биомолекул из кровотока
EP2655334B1 (en) 2010-12-22 2018-10-03 Eutropics Pharmaceuticals, Inc. Compositions and methods useful for treating diseases
JP5618815B2 (ja) 2010-12-24 2014-11-05 富士フイルム株式会社 感活性光線性又は感放射線性樹脂組成物、並びに、この組成物を用いた感活性光線性又は感放射線性膜及びパターン形成方法
TWI450891B (zh) 2010-12-29 2014-09-01 Dev Center Biotechnology 新穎微管蛋白抑制劑
US9295754B2 (en) 2011-02-24 2016-03-29 Emory University Noggin inhibitory compositions for ossification and methods related thereto
CN103502218B (zh) 2011-03-04 2016-08-17 生命科技公司 用于缀合生物分子的化合物和方法
DE102012003796A1 (de) 2011-03-18 2012-09-20 Merck Patent Gmbh Flüssigkristallines Medium
US9464065B2 (en) 2011-03-24 2016-10-11 The Scripps Research Institute Compounds and methods for inducing chondrogenesis
KR102250082B1 (ko) 2011-03-29 2021-05-11 메르크 파텐트 게엠베하 액정 매질
JP2014511865A (ja) 2011-04-07 2014-05-19 コーネル ユニバーシティー 水溶液中で多量化できるシリル単量体、およびその使用法
EP2522369A1 (en) 2011-05-09 2012-11-14 Koninklijke Philips Electronics N.V. Pretargeting kit, method and agents used therein
US9556166B2 (en) 2011-05-12 2017-01-31 Proteostasis Therapeutics, Inc. Proteostasis regulators
JP6215194B2 (ja) 2011-05-16 2017-10-18 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 生体直交型薬物活性化
EP2524918A1 (en) 2011-05-19 2012-11-21 Centro Nacional de Investigaciones Oncológicas (CNIO) Imidazopyrazines derivates as kinase inhibitors
JP5782836B2 (ja) 2011-05-27 2015-09-24 コニカミノルタ株式会社 有機エレクトロルミネッセンス素子材料、有機エレクトロルミネッセンス素子、表示装置、照明装置、並びに化合物
WO2012167171A2 (en) 2011-06-03 2012-12-06 Massachusetts Institute Of Technology Z-selective ring-closing metathesis reactions
US9520565B2 (en) 2011-06-28 2016-12-13 Merck Patent Gmbh Indaceno derivatives as organic semiconductors
JP6193226B2 (ja) 2011-07-07 2017-09-06 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 液晶媒体
JP2014532084A (ja) 2011-07-08 2014-12-04 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 共役ポリマー
BR122019017259B1 (pt) 2011-09-09 2022-05-10 Lantheus Medical Imaging, Inc Compostos úteis como agentes de imageamento, composições que os compreende, métodos, e uso de agentes de imageamento
JP6093770B2 (ja) 2011-09-27 2017-03-08 アムジエン・インコーポレーテツド 癌の治療のためのｍｄｍ２阻害剤としての複素環化合物
EP2615083A1 (en) 2012-01-10 2013-07-17 Studiengesellschaft Kohle mbH Process for the asymmetric oxidation of organic compounds with peroxides in the presence of a chiral acid catalyst
JP5814141B2 (ja) 2012-01-23 2015-11-17 ユー・ディー・シー アイルランド リミテッド 合成法、その合成法を用いて合成された化合物および有機電界発光素子
CN104136576B (zh) 2012-02-22 2020-10-16 默克专利股份有限公司 液晶介质
WO2013151739A1 (en) 2012-04-03 2013-10-10 3M Innovative Properties Company Crosslinkable composition comprising photobase generators
MX374868B (es) 2012-04-20 2025-03-06 Bayer Cropscience Ag Derivados de n-cicloalquil-n-[(heterociclilfenil)metilen]-(tio)carboxamida.
FR2992317B1 (fr) 2012-06-22 2016-05-13 Diverchim Procede de preparation de peptides chiraux
US8575283B1 (en) 2012-06-28 2013-11-05 Formosa Plastics Corporation, U.S.A. Heterocyclic organic compounds as electron donors for polyolefin catalysts
WO2014031872A2 (en) 2012-08-23 2014-02-27 The Broad Institute, Inc. Small molecule inhibitors for treating parasitic infections
RU2639145C2 (ru) 2012-09-04 2017-12-20 Шанхай Хэнжуй Фармасьютикал Ко., Лтд. Производные оксотиоимидазолидина, способы их получения и их применение в медицине в качестве ингибиторов андрогенного рецептора
JP2015529242A (ja) 2012-09-21 2015-10-05 アドヴィヌス セラピューティクス リミテッドＡｄｖｉｎｕｓ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ 置換された縮合三環式化合物、組成物およびその医薬用途
KR101677866B1 (ko) 2012-10-29 2016-11-18 코니카 미놀타 가부시키가이샤 위상차 필름, 원편광판 및 화상 표시 장치
WO2014078702A1 (en) 2012-11-16 2014-05-22 Basf Se Lubricant compositions comprising epoxide compounds to improve fluoropolymer seal compatibility
EP2922538B1 (en) * 2012-11-20 2016-10-19 Principia Biopharma Inc. Azaindole derivatives as jak3 inhibitors
WO2014081299A1 (en) 2012-11-22 2014-05-30 Tagworks Pharmaceuticals B.V. Activatable liposomes
WO2014081301A1 (en) 2012-11-22 2014-05-30 Tagworks Pharmaceuticals B.V. Bio-orthogonal drug activation
WO2014081300A1 (en) 2012-11-22 2014-05-30 Tagworks Pharmaceuticals B.V. Channel protein activatable liposomes
DK2922574T3 (da) 2012-11-22 2023-08-21 Tagworks Pharmaceuticals B V Kemisk spaltbar gruppe
JP6472755B2 (ja) 2012-12-12 2019-02-20 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 液晶媒体
JP6335428B2 (ja) 2012-12-21 2018-05-30 出光興産株式会社 有機エレクトロルミネッセンス素子および電子機器
EP2941469A2 (de) 2013-01-03 2015-11-11 Merck Patent GmbH Materialien für elektronische vorrichtungen
WO2014122933A1 (ja) 2013-02-08 2014-08-14 ソニー株式会社 有機エレクトロルミネッセンス素子
EP2956441A4 (en) 2013-02-18 2016-11-02 Scripps Research Inst MODULATORS OF VASOPRESSIN RECEPTORS WITH THERAPEUTIC POTENTIAL
US9580400B2 (en) 2013-02-26 2017-02-28 Northeastern University Cannabinergic nitrate esters and related analogs
WO2014134141A1 (en) 2013-02-26 2014-09-04 President And Fellows Of Harvard College Synthesis of acyclic and cyclic amines using iron-catalyzed nitrene group transfer
WO2014141129A2 (en) 2013-03-14 2014-09-18 Grueneberg Dorre A Novel methods, compounds, and compositions for inhibition of ros
US9290528B1 (en) 2013-03-15 2016-03-22 University Of Kentucky Research Foundation Light-activated compounds
JP5902641B2 (ja) 2013-03-27 2016-04-13 富士フイルム株式会社 光干渉顔料およびその製造方法
WO2014165827A1 (en) 2013-04-05 2014-10-09 Salk Institute For Biological Studies Ppar agonists
KR102361072B1 (ko) 2013-04-08 2022-02-09 메르크 파텐트 게엠베하 열 활성화 지연 형광 재료를 갖는 유기 전계발광 디바이스
KR102177883B1 (ko) 2013-04-08 2020-11-12 메르크 파텐트 게엠베하 유기 전계발광 디바이스
US9522881B2 (en) 2013-04-26 2016-12-20 Indiana University Research And Technology Corporation Hydroxyindole carboxylic acid based inhibitors for oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2)
JP2014232188A (ja) 2013-05-29 2014-12-11 コニカミノルタ株式会社 セルロースアシレートフィルム、円偏光板及び画像表示装置
WO2015003146A1 (en) 2013-07-03 2015-01-08 Georgetown University Boronic acid derivatives of resveratrol for activating deacetylase enzymes
EP3016652A4 (en) 2013-07-03 2017-03-08 Indiana University Research and Technology Corporation Shp2 inhibitors and methods of treating autoimmune and/or glomerulonephritis-associated diseases using shp2 inhibitors
WO2015003137A1 (en) 2013-07-03 2015-01-08 University Of Connecticut Polymerization of diene monomers
GB201312991D0 (en) 2013-07-19 2013-09-04 Isis Innovation Process
KR102252761B1 (ko) 2013-08-02 2021-05-18 메르크 파텐트 게엠베하 액정 매질
WO2015042375A1 (en) 2013-09-20 2015-03-26 Idenix Pharmaceuticals, Inc. Hepatitis c virus inhibitors
US20160257657A1 (en) 2013-09-20 2016-09-08 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer
US20150087673A1 (en) 2013-09-26 2015-03-26 Rigel Pharmaceuticals, Inc. Methods for using and biomarkers for ampk-activating compounds
KR101628288B1 (ko) 2013-09-30 2016-06-08 주식회사 엘지화학 음성 광학 분산도를 갖는 광학 소자 제조용 조성물 및 이로부터 제조된 광학 이방체
EP2857405A1 (en) 2013-10-01 2015-04-08 Studiengesellschaft Kohle mbH Process for the trans-selective hydroboration of internal alkynes
TR201911140T4 (tr) 2013-10-21 2019-08-21 Merck Patent Gmbh Btk inhibitörleri olarak heteroaril bileşikleri ve bunların kullanımları.
JP6522313B2 (ja) 2013-10-24 2019-05-29 出光興産株式会社 有機エレクトロルミネッセンス素子および電子機器
JP6088995B2 (ja) 2013-10-24 2017-03-01 出光興産株式会社 有機エレクトロルミネッセンス素子および電子機器
KR101537860B1 (ko) 2013-11-22 2015-07-20 롯데케미칼 주식회사 내감마선 성능이 향상된 폴리카보네이트 수지 조성물 및 이를 이용한 성형품
JP6215674B2 (ja) 2013-11-29 2017-10-18 出光興産株式会社 有機エレクトロルミネッセンス素子および電子機器
JP6309834B2 (ja) 2013-12-11 2018-04-11 株式会社Adeka 着色性組成物
JP2015163671A (ja) 2013-12-13 2015-09-10 株式会社Adeka ラジカル重合性組成物
KR20150070027A (ko) 2013-12-16 2015-06-24 메르크 파텐트 게엠베하 액정 매질
US10020455B2 (en) 2014-01-07 2018-07-10 Arizona Board Of Regents On Behalf Of Arizona State University Tetradentate platinum and palladium complex emitters containing phenyl-pyrazole and its analogues
CA2935944A1 (en) 2014-01-09 2015-07-16 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Substituted benzoxazine and related compounds
CN105899491B (zh) 2014-01-17 2019-04-02 诺华股份有限公司 用于抑制shp2活性的1-哒嗪-/三嗪-3-基-哌(-嗪)/啶/吡咯烷衍生物及其组合物
CN105899493B (zh) 2014-01-17 2019-03-29 诺华股份有限公司 用于抑制shp2活性的1-(三嗪-3-基/哒嗪-3-基)-哌(-嗪)啶衍生物及其组合物
JO3517B1 (ar) 2014-01-17 2020-07-05 Novartis Ag ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2
KR20150091942A (ko) 2014-02-04 2015-08-12 삼성전자주식회사 유기금속 화합물 및 이를 포함한 유기 발광 소자
JP6313604B2 (ja) 2014-02-05 2018-04-18 富士フイルム株式会社 感活性光線性又は感放射線性樹脂組成物、感活性光線性又は感放射線性膜、感活性光線性又は感放射線性膜を備えたマスクブランクス、パターン形成方法、及び電子デバイスの製造方法
WO2015130905A1 (en) 2014-02-27 2015-09-03 Merck Patent Gmbh Heterocyclic compounds as nav channel inhibitors and uses thereof
AU2015226881A1 (en) 2014-03-07 2016-09-29 Intonation Research Laboratories Inhibitors of histone lysine specific demethylase (LSD1) and histone deacetylases (HDACs)
RU2696492C2 (ru) 2014-05-13 2019-08-02 Ф. Хоффманн-Ля Рош Аг Дейтрированные гетероциклические соединения и их применение в качестве средств визуализации
PT3142637T (pt) 2014-05-16 2020-10-15 Olaplex Inc Formulações e métodos de tratamento de queratina
US10045979B2 (en) 2014-05-19 2018-08-14 Merial Inc. Anthelmintic compounds
US9399623B2 (en) 2014-06-05 2016-07-26 Merck Patent Gmbh Quinoline derivatives and their use in neurodegenerative diseases
WO2016010485A1 (en) 2014-07-16 2016-01-21 Agency For Science, Technology And Research Donor-acceptor polymers
US9818959B2 (en) 2014-07-29 2017-11-14 Arizona Board of Regents on behlaf of Arizona State University Metal-assisted delayed fluorescent emitters containing tridentate ligands
WO2016022645A1 (en) 2014-08-06 2016-02-11 Merck Sharp & Dohme Corp. Heterocyclic cgrp receptor antagonists
EP2985334B1 (en) 2014-08-15 2018-06-20 Merck Patent GmbH Liquid-crystalline medium
JP6742236B2 (ja) 2014-08-26 2020-08-19 出光興産株式会社 有機エレクトロルミネッセンス素子および電子機器
EP2991153B1 (en) 2014-08-28 2023-08-23 Samsung Electronics Co., Ltd. Composite electrolyte and lithium battery including the same
WO2016049565A1 (en) 2014-09-25 2016-03-31 Araxes Pharma Llc Compositions and methods for inhibition of ras
WO2016094688A1 (en) 2014-12-10 2016-06-16 Massachusetts Institute Of Technology Fused 1,3-azole derivatives useful for the treatment of proliferative diseases
KR102384224B1 (ko) 2014-12-30 2022-04-08 삼성전자주식회사 축합환 화합물 및 이를 포함한 유기 발광 소자
WO2016145383A1 (en) 2015-03-11 2016-09-15 Board Of Regents, University Of Texas System Mth1 inhibitors for treating disease
KR102434696B1 (ko) 2015-03-13 2022-08-22 삼성전자주식회사 유기금속 화합물 및 이를 포함한 유기 발광 소자
EA201792214A1 (ru) 2015-04-10 2018-01-31 Араксис Фарма Ллк Соединения замещенного хиназолина
EP3283462B1 (en) 2015-04-15 2020-12-02 Araxes Pharma LLC Fused-tricyclic inhibitors of kras and methods of use thereof
UY36673A (es) 2015-05-07 2016-11-30 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware Sulfonas tricíclicas como moduladores de ror y composiciones farmacéuticas que las contienen
US9458308B1 (en) 2015-05-12 2016-10-04 Lotte Chemical Corporation Polycarbonate resin composition with increased gamma-radiation resistant property and molded article using the same
US9879039B2 (en) 2015-06-03 2018-01-30 Arizona Board Of Regents On Behalf Of Arizona State University Tetradentate and octahedral metal complexes containing naphthyridinocarbazole and its analogues
CN112625028B (zh) 2015-06-19 2024-10-29 诺华股份有限公司 用于抑制shp2活性的化合物和组合物
EP3310779B1 (en) 2015-06-19 2019-05-08 Novartis AG Compounds and compositions for inhibiting the activity of shp2
EP3310771B1 (en) * 2015-06-19 2020-07-22 Novartis AG Compounds and compositions for inhibiting the activity of shp2
FR3037952B1 (fr) 2015-06-24 2019-01-25 Compagnie Generale Des Etablissements Michelin Procede de synthese d'oximes aromatiques
EP3112440B1 (en) 2015-07-02 2019-07-24 Merck Patent GmbH Liquid-crystal medium
WO2017015562A1 (en) 2015-07-22 2017-01-26 Araxes Pharma Llc Substituted quinazoline compounds and their use as inhibitors of g12c mutant kras, hras and/or nras proteins
GB201514015D0 (en) 2015-08-07 2015-09-23 Arnér Elias S J And Dept Of Health And Human Services Novel pyridazinones and their use in the treatment of cancer
GB201514018D0 (en) 2015-08-07 2015-09-23 Arnér Elias S J And United States Of America Asrepresented By The Sec Dep Of Health And Human Servic Novel tricyclic compounds and their use in the treatment of cancer
CA2995325A1 (en) 2015-08-12 2017-02-16 Mochida Pharmaceutical Co., Ltd. Isothiazole derivative
EP3133078B1 (en) 2015-08-18 2019-01-30 Samsung Electronics Co., Ltd. Organometallic compound and organic light-emitting device including the same
KR101796227B1 (ko) 2015-08-21 2017-11-10 삼성디스플레이 주식회사 유기 발광 소자
US10240085B2 (en) 2015-08-27 2019-03-26 Samsung Electronics Co., Ltd. Thin film and organic light-emitting device including the same
KR102542465B1 (ko) 2015-09-22 2023-06-12 삼성전자주식회사 유기금속 화합물 및 이를 포함한 유기 발광 소자
US10858343B2 (en) 2015-09-28 2020-12-08 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
EP3356339A1 (en) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
WO2017058915A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
US10730867B2 (en) 2015-09-28 2020-08-04 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
WO2017058792A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
US10647703B2 (en) 2015-09-28 2020-05-12 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
US10875842B2 (en) 2015-09-28 2020-12-29 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
SE541053C2 (sv) 2015-09-30 2019-03-19 Epiroc Rock Drills Ab System och förfarande för borrplansgenerering, borrigg, datorprogram samt datorprogramprodukt
WO2017066705A1 (en) 2015-10-14 2017-04-20 Aquinnah Pharmaceuticals, Inc. Compounds, compositions and methods of use against stress granules
JP2018533939A (ja) 2015-10-19 2018-11-22 アラクセス ファーマ エルエルシー Ｒａｓの阻害剤をスクリーニングするための方法
EP3162875B1 (en) 2015-10-30 2018-05-23 Merck Patent GmbH Polymerisable compounds and the use thereof in liquid-crystal displays
CN108349947B (zh) 2015-11-02 2021-10-01 格纳赛治疗有限公司 四氢吲唑及其医药用途
TW201726656A (zh) * 2015-11-16 2017-08-01 亞瑞克西斯製藥公司 包含經取代雜環基團之２－經取代喹唑啉化合物及其使用方法
WO2017100546A1 (en) 2015-12-09 2017-06-15 Araxes Pharma Llc Methods for preparation of quinazoline derivatives
KR20170069342A (ko) 2015-12-10 2017-06-21 삼성디스플레이 주식회사 유기 발광 소자
CN106892924B (zh) 2015-12-17 2021-01-08 四川科伦博泰生物医药股份有限公司 短效苯并二氮*衍生物、其制备方法及其用途
KR102579752B1 (ko) 2015-12-22 2023-09-19 삼성디스플레이 주식회사 유기 발광 소자
KR20170075118A (ko) 2015-12-22 2017-07-03 삼성디스플레이 주식회사 유기 발광 소자
US10336772B2 (en) 2015-12-28 2019-07-02 Samsung Electronics Co., Ltd. Bicarbazole compound, material for organic light-emitting device including bicarbazole compound, and organic light-emitting device including bicarbazole compound
KR102419178B1 (ko) 2015-12-29 2022-07-11 삼성디스플레이 주식회사 유기 발광 소자
KR102396293B1 (ko) 2015-12-29 2022-05-11 삼성디스플레이 주식회사 유기 발광 소자
US10072017B2 (en) 2015-12-30 2018-09-11 Flatley Discovery Lab, Llc Compounds and methods for the treatment of cystic fibrosis
KR20170082126A (ko) 2016-01-05 2017-07-13 삼성전자주식회사 조성물, 상기 조성물을 포함한 박막 및 이를 포함한 유기 발광 소자
KR102633852B1 (ko) 2016-01-25 2024-02-07 삼성디스플레이 주식회사 카바졸계 화합물 및 이를 포함한 유기 발광 소자
CN109071374A (zh) 2016-02-08 2018-12-21 Aaa化学公司 脂肪胺的芳基化
KR102628850B1 (ko) 2016-03-07 2024-01-25 삼성디스플레이 주식회사 축합환 화합물 및 이를 포함한 유기 발광 소자
US11179710B2 (en) 2016-03-09 2021-11-23 President And Fellows Of Harvard College Direct palladium-catalyzed aromatic fluorination
EP3429591B1 (en) 2016-03-16 2023-03-15 Kura Oncology, Inc. Substituted thieno[2,3-d]pyrimidine derivatives as inhibitors of menin-mll and methods of use
US10822312B2 (en) 2016-03-30 2020-11-03 Araxes Pharma Llc Substituted quinazoline compounds and methods of use
CN108780273B (zh) 2016-03-31 2022-06-28 Dnp精细化工股份有限公司 感光性着色树脂组合物、滤色器及其制造方法以及显示设备
KR102606277B1 (ko) 2016-04-06 2023-11-27 삼성디스플레이 주식회사 유기 발광 소자
KR102642199B1 (ko) 2016-04-07 2024-03-05 삼성디스플레이 주식회사 유기 발광 소자
KR102444509B1 (ko) 2016-05-18 2022-09-19 미라티 테라퓨틱스, 인크. Kras g12c 억제제
WO2017210134A1 (en) 2016-05-31 2017-12-07 Board Of Regents, University Of Texas System Heterocyclic inhibitors of ptpn11
KR102666178B1 (ko) 2016-06-07 2024-05-14 삼성디스플레이 주식회사 유기 발광 소자
EA202092442A3 (ru) 2016-06-07 2021-08-31 Джакобио Фармасьютикалс Ко., Лтд. Новые гетероциклические производные, применимые в качестве ингибиторов shp2
WO2017216706A1 (en) 2016-06-14 2017-12-21 Novartis Ag Compounds and compositions for inhibiting the activity of shp2
CN109661228A (zh) 2016-06-20 2019-04-19 库拉肿瘤学公司 用erk抑制剂治疗鳞状细胞癌
US20180002604A1 (en) 2016-06-30 2018-01-04 Merck Patent Gmbh Liquid-crystalline medium
TW202413340A (zh) 2016-07-12 2024-04-01 美商銳新醫藥公司 作為異位shp2抑制劑之2,5-雙取代型3-甲基吡嗪及2,5,6-三取代型3-甲基吡嗪
US11299673B2 (en) 2016-08-12 2022-04-12 Merck Patent Gmbh Liquid-crystal medium
WO2018027892A1 (en) 2016-08-12 2018-02-15 Eli Lilly And Company Amino pyrimidine ssao inhibitors
KR102721990B1 (ko) 2016-08-16 2024-10-29 삼성디스플레이 주식회사 유기 발광 소자
EA038219B1 (ru) 2016-08-19 2021-07-26 Арена Фармасьютикалз, Инк. Агонисты рецептора 5-ht2c и композиции, а также способ их применения
EP3515916B1 (en) 2016-09-22 2023-06-07 Relay Therapeutics, Inc. Shp2 phosphatase inhibitors and methods of use thereof
JP6589795B2 (ja) 2016-09-27 2019-10-16 信越化学工業株式会社 スルホニウム塩、レジスト組成物及びパターン形成方法
KR102458810B1 (ko) 2016-09-28 2022-10-26 메르크 파텐트 게엠베하 중합가능 액정 물질 및 중합된 액정 필름
JP2019529484A (ja) 2016-09-29 2019-10-17 アラクセス ファーマ エルエルシー Ｋｒａｓ ｇ１２ｃ変異体タンパク質の阻害剤
KR102394146B1 (ko) 2016-09-29 2022-05-09 스미또모 가가꾸 가부시키가이샤 발광 소자
US10377743B2 (en) 2016-10-07 2019-08-13 Araxes Pharma Llc Inhibitors of RAS and methods of use thereof
EP3526218B1 (en) 2016-10-13 2021-04-21 Bristol-Myers Squibb Company Heterocyclic sulfones as ror gamma modulators
TW202500565A (zh) 2016-10-24 2025-01-01 美商傳達治療有限公司 Shp2磷酸酶抑制劑及其使用方法
CA3042877A1 (en) 2016-11-09 2018-05-17 Bristol-Myers Squibb Company Tricyclic sulfones as ror gamma modulators
EP3558955B1 (en) 2016-12-22 2021-08-11 Amgen Inc. Benzisothiazole, isothiazolo[3,4-b]pyridine, quinazoline, phthalazine, pyrido[2,3-d]pyridazine and pyrido[2,3-d]pyrimidine derivatives as kras g12c inhibitors for treating lung, pancreatic or colorectal cancer
WO2018119263A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Heterocyclic compounds derivatives as pd-l1 internalization inducers
KR102571130B1 (ko) 2017-01-10 2023-08-28 노파르티스 아게 Alk 저해제 및 shp2 저해제를 포함하는 약제학적 조합
RU2019126455A (ru) 2017-01-23 2021-02-24 Революшн Медсинз, Инк. Пиридиновые соединения в качестве аллостерических ингибиторов shp2
SG11201906209SA (en) 2017-01-23 2019-08-27 Revolution Medicines Inc Bicyclic compounds as allosteric shp2 inhibitors
MA47452A (fr) 2017-02-07 2019-12-18 Oblique Therapeutics Ab Pyridines à substitution hétérocyclylsulfonyle et leur utilisation dans le traitement du cancer
AU2018218519B2 (en) 2017-02-07 2021-08-05 Oblique Therapeutics Ab Heteroarylsulfonyl-substituted pyridines and their use in the treatment of cancer
WO2018161033A1 (en) 2017-03-02 2018-09-07 Wright, Adrian Small molecule ire1-alpha inhibitors
KR102317480B1 (ko) 2017-03-23 2021-10-25 자코바이오 파마슈티칼스 컴퍼니 리미티드 Shp2 억제제로서 유용한 신규한 헤테로환형 유도체
KR102395784B1 (ko) 2017-03-27 2022-05-10 삼성전자주식회사 유기금속 화합물 및 이를 포함한 유기 발광 소자
KR102461719B1 (ko) 2017-05-23 2022-11-01 삼성전자주식회사 유기금속 화합물, 이를 포함한 유기 발광 소자 및 이를 포함한 진단용 조성물
EP3630770B1 (en) 2017-05-26 2024-08-28 Relay Therapeutics, Inc. Pyrazolo[3,4-b]pyrazine derivatives as shp2 phosphatase inhibitors
JP6907312B2 (ja) 2017-06-14 2021-07-21 富士フイルム株式会社 組成物、膜、レンズ、固体撮像素子、化合物
KR20180137311A (ko) 2017-06-16 2018-12-27 삼성전자주식회사 유기금속 화합물, 이를 포함한 유기 발광 소자 및 이를 포함한 진단용 조성물
WO2019002173A1 (en) 2017-06-26 2019-01-03 Esteve Pharmaceuticals, S.A. COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN
WO2019018119A1 (en) 2017-07-18 2019-01-24 Pairnomix, Llc METHODS FOR TREATING EPILEPSY AND DISORDERS ASSOCIATED WITH KCNTI
KR20190014187A (ko) 2017-07-27 2019-02-12 삼성디스플레이 주식회사 유기금속 화합물 및 이를 포함하는 유기 발광 소자
GB201712110D0 (en) 2017-07-27 2017-09-13 Thomas Helledays Stiftelse För Medicinsk Forskning New compounds and uses
JP7346015B2 (ja) 2017-09-06 2023-09-19 住友化学株式会社 発光素子
EP3678703A1 (en) 2017-09-07 2020-07-15 Revolution Medicines, Inc. Shp2 inhibitor compositions and methods for treating cancer
TWI851542B (zh) 2017-09-11 2024-08-11 美商克魯松藥物公司 Ｓｈｐ２之八氫環戊烷并[c]吡咯別構抑制劑
KR102526756B1 (ko) 2017-09-29 2023-04-27 삼성전자주식회사 유기금속 화합물, 이를 포함한 유기 발광 소자 및 이를 포함한 진단용 조성물
US11701354B2 (en) 2017-09-29 2023-07-18 D. E. Shaw Research, Llc Pyrazolo[3,4-b]pyrazine derivatives as SHP2 phosphatase inhibitors
KR20200062261A (ko) 2017-09-29 2020-06-03 메르크 파텐트 게엠베하 중합성 화합물 및 이의 액정 디스플레이에서의 용도
JP2020536881A (ja) 2017-10-12 2020-12-17 レヴォリューション・メディスンズ，インコーポレイテッド アロステリックｓｈｐ２阻害剤としてのピリジン、ピラジンおよびトリアジン化合物
KR102518722B1 (ko) 2017-11-21 2023-04-07 삼성디스플레이 주식회사 유기금속 화합물 및 이를 포함한 유기 발광 소자
RU2020123241A (ru) 2017-12-15 2022-01-17 Революшн Медсинз, Инк. Полициклические соединения в качестве аллостерических ингибиторов shp2
ES2971712T3 (es) 2017-12-22 2024-06-06 Hibercell Inc Derivados de cromenopiridina como inhibidores de la fosfatidilinositol fosfato cinasa
WO2019136442A1 (en) 2018-01-08 2019-07-11 Kleo Pharmaceuticals, Inc. Cd16a binding agents and uses thereof
KR102595918B1 (ko) 2018-01-18 2023-11-14 삼성디스플레이 주식회사 유기금속 화합물, 이를 포함한 유기 발광 소자 및 상기 유기 발광 소자를 포함한 유기 발광 장치
CN110066276B (zh) 2018-01-24 2020-09-18 上海璎黎药业有限公司 芳香杂环化合物、其中间体、制备方法、药物组合物和应用
CN110066277B (zh) 2018-01-24 2021-07-23 上海璎黎药业有限公司 芳香杂环取代烯烃化合物、其制备方法、药物组合物和应用
KR102824606B1 (ko) 2018-02-13 2025-06-25 삼성디스플레이 주식회사 유기 발광 소자 및 이를 포함한 표시 장치
US11498930B2 (en) 2018-02-13 2022-11-15 Blueray Therapeutics (Shanghai) Co., Ltd Pyrimidine-fused cyclic compound, preparation method therefor and application thereof
US20200392161A1 (en) 2018-02-21 2020-12-17 Relay Therapeutics, Inc. Shp2 phosphatase inhibitors and methods of use thereof
MY210086A (en) 2018-03-02 2025-08-26 Otsuka Pharma Co Ltd Pharmaceutical compounds
EP3537495B1 (en) 2018-03-08 2025-02-12 Samsung Display Co., Ltd. Organic light-emitting device
US11004918B2 (en) 2018-03-09 2021-05-11 Samsung Display Co., Ltd. Electronic apparatus
WO2019183364A1 (en) 2018-03-21 2019-09-26 Relay Therapeutics, Inc. Pyrazolo[3,4-b]pyrazine shp2 phosphatase inhibitors and methods of use thereof
CN112166110B (zh) 2018-03-21 2023-08-11 传达治疗有限公司 Shp2磷酸酶抑制剂及其使用方法
KR102724968B1 (ko) 2018-03-21 2024-10-31 수조우 푸허 바이오파마 컴퍼니 리미티드 Shp2 억제제 및 이의 용도
CN108794485B (zh) 2018-04-28 2020-04-24 北京施安泰医药技术开发有限公司 一类toll样受体调节剂、其药物组合物、制备方法与用途
KR102611661B1 (ko) 2018-05-02 2023-12-08 나비레 파르마, 인코퍼레이티드 Ptpn11의 치환된 헤테로사이클릭 억제제
CN110492006B (zh) 2018-05-14 2020-06-12 江苏三月光电科技有限公司 一种基于含硼有机化合物的电致发光器件
CN108840886A (zh) 2018-06-22 2018-11-20 南京工业大学 一种铂配合物蓝光材料以及有机发光器件
KR102579709B1 (ko) 2018-07-24 2023-09-15 다이호야쿠힌고교 가부시키가이샤 Shp2의 활성을 억제하기 위한 헤테로이환식 화합물
CN108863982B (zh) 2018-08-04 2022-02-01 南昌航空大学 一种吩噻嗪/吩恶嗪类化合物的有机电合成方法
WO2020033286A1 (en) 2018-08-06 2020-02-13 Purdue Research Foundation Novel sesquiterpenoid analogs
PE20211050A1 (es) 2018-08-10 2021-06-04 Navire Pharma Inc Inhibidores de ptpn11
AU2019344897B2 (en) 2018-09-18 2024-01-18 Nikang Therapeutics, Inc. Tri-substituted heteroaryl derivatives AS SRC homology-2 phosphatase inhibitors
CA3113379A1 (en) 2018-09-29 2020-04-02 Novartis Ag Process of manufacture of a compound for inhibiting the activity of shp2
CN112867718B (zh) 2018-09-29 2025-03-04 诺华股份有限公司 用于抑制shp2活性的化合物和组合物的制造
CN113473990A (zh) 2018-10-08 2021-10-01 锐新医药公司 用于治疗癌症的shp2抑制剂组合物

Also Published As

Publication number Publication date
CN112996795A (zh) 2021-06-18
DK3853234T3 (da) 2025-07-21
KR102834408B1 (ko) 2025-07-15
AU2019344899B2 (en) 2025-04-03
TW202026299A (zh) 2020-07-16
US20200277308A1 (en) 2020-09-03
BR112021005082A2 (pt) 2021-06-08
WO2020061103A1 (en) 2020-03-26
US11459340B2 (en) 2022-10-04
CR20210175A (es) 2021-06-01
US20210188876A1 (en) 2021-06-24
WO2020061101A1 (en) 2020-03-26
PL3853234T3 (pl) 2025-09-22
US10894797B2 (en) 2021-01-19
US20200115389A1 (en) 2020-04-16
US20230167134A1 (en) 2023-06-01
SG11202102679QA (en) 2021-04-29
US11034705B2 (en) 2021-06-15
CL2021000628A1 (es) 2021-09-20
US12264167B2 (en) 2025-04-01
CN113227103B (zh) 2024-10-01
PH12021550604A1 (en) 2022-02-14
ES3036496T3 (en) 2025-09-19
EP3853233A1 (en) 2021-07-28
KR20210060556A (ko) 2021-05-26
CA3113233A1 (en) 2020-03-26
CN112996795B (zh) 2024-11-12
MX2021003158A (es) 2021-07-16
JP7337174B2 (ja) 2023-09-01
US11518772B2 (en) 2022-12-06
US20210380604A1 (en) 2021-12-09
AU2019344899A1 (en) 2021-04-15
EP3853234B1 (en) 2025-04-23
AU2019344897B2 (en) 2024-01-18
JP2022501431A (ja) 2022-01-06
JP2022501430A (ja) 2022-01-06
CO2021004436A2 (es) 2021-04-30
US20210040122A1 (en) 2021-02-11
CN113227103A (zh) 2021-08-06
KR20210060555A (ko) 2021-05-26
SA521421505B1 (ar) 2024-02-28
AU2019344897A1 (en) 2021-04-15
EP3853234A1 (en) 2021-07-28
PT3853234T (pt) 2025-07-29
JP7542538B2 (ja) 2024-08-30
TWI827677B (zh) 2024-01-01
CA3113234A1 (en) 2020-03-26

Similar Documents

Publication Publication Date Title
FI3853234T3 (fi) Fuusioituja trisyklisiä rengasjohdannaisia SRC-homologia-2-fosfataasin estäjinä
RU2495044C2 (ru) Ингибиторы активности протеинтирозинкиназы
CL2023001461A1 (es) Inhibidores de prmt5 novedosos
MX2023007192A (es) Inhibidores de prmt5.
PH12021551257A1 (en) Cyclic pantetheine derivatives and uses thereof
EA202091491A1 (ru) Новые бензиламинозамещенные пиридопиримидиноны и производные в качестве ингибиторов sos1
MX2021013075A (es) Oxisteroles y metodos de uso de los mismos.
MX390625B (es) Inhibidores selectivos de jak1.
EA201590023A1 (ru) Новые 4-замещенные производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные бензимидазолами, в качестве противовирусных средств против респираторного синцитиального вируса
EA201890888A1 (ru) Новые спиро[3h-индол-3,2&#39;-пирролидин]-2(1h)-оновые соединения и производные в качестве ингибиторов mdm2-p53
HRP20160852T1 (hr) Biciklični heterociklični spojevi kao inhibitori protein tirozin kinaze
RU2014141579A (ru) Гетероциклические соединения в качестве ингибиторов бета-лактамаз
JP2019504050A5 (fi)
EA201590020A1 (ru) Новые производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные бензимидазолами, в качестве противовирусных средств против респираторного синцитиального вируса
JP2017528524A5 (fi)
BR112014019478A2 (pt) composto ou um sal farmacologicamente aceitável do mesmo, composição farmacêutica, uso de um composto ou de um sal farmacologicamente aceitável do mesmo, formulação inibidor do canal de sódio, métodos para tratamento e/ou prevenção de dor e de uma doença.
GEP20247627B (en) Macrocyclic compounds as sting agonists and methods and uses thereof
AR081058A1 (es) Derivados de arilmetoxi isoindolina, composiciones que los comprenden y su uso en el tratamiento del cancer.
EA201790713A1 (ru) N-АЛКИЛАРИЛ-5-ОКСОАРИЛОКТАГИДРОЦИКЛОПЕНТА[c]ПИРРОЛЬНЫЕ НЕГАТИВНЫЕ АЛОСТЕРИЧЕСКИЕ МОДУЛЯТОРЫ NR2B
EA201300617A1 (ru) β-ЛАКТАМОВЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ β-ЛАКТАМАЗЫ И ИХ ПРИМЕНЕНИЕ
EA201590022A1 (ru) Новые производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные гетероциклами, в качестве противовирусных средств против респираторного синцитиального вируса
EA201590021A1 (ru) Новые замещенные производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные гетероциклами, в качестве противовирусных средств против респираторного синцитиального вируса
JOP20190113A1 (ar) مثبطات بروتون تيروزين كيناز
MX2021006544A (es) Inhibidores de cinasa dependiente de ciclina 9 (cdk9) y polimorfos de los mismos para uso como agentes para el tratamiento de cancer.
EP4316504A3 (en) Compounds