ES8500923A1 - Procedimiento para la preparacion de derivados de acido fenilacetico - Google Patents
Procedimiento para la preparacion de derivados de acido fenilaceticoInfo
- Publication number
- ES8500923A1 ES8500923A1 ES529806A ES529806A ES8500923A1 ES 8500923 A1 ES8500923 A1 ES 8500923A1 ES 529806 A ES529806 A ES 529806A ES 529806 A ES529806 A ES 529806A ES 8500923 A1 ES8500923 A1 ES 8500923A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- procedure
- acid derivatives
- phenylacetic acid
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical class OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- -1 polymethyleneimino Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Fertilizers (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ACIDO FENILACETICO, DE SUS ANTIPODAS OPTICAMENTE ACTIVOS Y DE SUS SALES DE ADICION CON ACIDOS FISIOLOGICAMENTE COMPATIBLES Y CON BASES, DE FORMULA (I), EN LA QUE A, W, R1, R2 Y R3 PUEDEN SER VARIOS RADICALES.CONSISTE EN LA TRANSFORMACION DE UN COMPUESTO DE FORMULA (II), EN LA QUE B ES UN GRUPO TRANSFORMABLE Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), EN EL CORRESPONDIENTE COMPUESTO CARBOXILICO, POR REACCION DE HIDROLISIS, TERMOLISIS O HIDROGENOLISIS, EN UN DISOLVENTE, EN PRESENCIA DE UN ACIDO O UNA BASE, A UNA TEMPERATURA ENTRE C10JC Y 120JC.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU EFECTO HIPOGLUCEMICO.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823225155 DE3225155A1 (de) | 1982-07-06 | 1982-07-06 | Neue n-benzylamide und deren salze, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| DE19823225188 DE3225188A1 (de) | 1982-07-06 | 1982-07-06 | Neue phenylessigsaeurederivate, ihre herstellung und diese verbindungen enthaltende arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES529806A0 ES529806A0 (es) | 1984-11-01 |
| ES8500923A1 true ES8500923A1 (es) | 1984-11-01 |
Family
ID=25802849
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES523869A Expired ES8501382A1 (es) | 1982-07-06 | 1983-07-05 | Procedimiento para la preparacion de derivados de acido fenilacetico. |
| ES529807A Expired ES8500924A1 (es) | 1982-07-06 | 1984-02-17 | Procedimiento para la preparacion de derivados de acido fenilacetico |
| ES529808A Granted ES529808A0 (es) | 1982-07-06 | 1984-02-17 | Procedimiento para la preparacion de derivados de acido fenilacetico |
| ES529806A Expired ES8500923A1 (es) | 1982-07-06 | 1984-02-17 | Procedimiento para la preparacion de derivados de acido fenilacetico |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES523869A Expired ES8501382A1 (es) | 1982-07-06 | 1983-07-05 | Procedimiento para la preparacion de derivados de acido fenilacetico. |
| ES529807A Expired ES8500924A1 (es) | 1982-07-06 | 1984-02-17 | Procedimiento para la preparacion de derivados de acido fenilacetico |
| ES529808A Granted ES529808A0 (es) | 1982-07-06 | 1984-02-17 | Procedimiento para la preparacion de derivados de acido fenilacetico |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0099017B1 (es) |
| KR (1) | KR900004925B1 (es) |
| AU (1) | AU561274B2 (es) |
| CA (1) | CA1214773A (es) |
| CS (1) | CS240970B2 (es) |
| DD (1) | DD210907A5 (es) |
| DE (1) | DE3375783D1 (es) |
| DK (1) | DK159850C (es) |
| ES (4) | ES8501382A1 (es) |
| FI (1) | FI78477C (es) |
| GB (1) | GB2124220B (es) |
| GR (1) | GR78661B (es) |
| HU (1) | HU195651B (es) |
| IE (1) | IE56171B1 (es) |
| IL (1) | IL69172A (es) |
| NO (1) | NO159590C (es) |
| NZ (1) | NZ204814A (es) |
| PL (1) | PL143992B1 (es) |
| PT (1) | PT76986B (es) |
| SU (1) | SU1170969A3 (es) |
| YU (1) | YU146883A (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5312924A (en) | 1983-12-30 | 1994-05-17 | Dr. Karl Thomae Gmbh | Phenylacetic acid benzylamides |
| DE3347565A1 (de) * | 1983-12-30 | 1985-07-11 | Thomae Gmbh Dr K | Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| GB8903592D0 (en) * | 1989-02-16 | 1989-04-05 | Boots Co Plc | Therapeutic agents |
| FR2763590B1 (fr) * | 1997-05-22 | 2000-03-24 | Synthelabo | Derives d'acides[[[(arylmethyl)amino]carbonyl] alkyl]- aromatiques, leur preparation et leur application en therapeutique |
| CA2526506A1 (en) * | 2003-06-09 | 2004-12-16 | Boehringer Ingelheim International Gmbh | Inhibitors of papilloma virus |
| EP2364977A1 (en) | 2010-01-26 | 2011-09-14 | Reuter Chemische Apparatebau KG | Process for the enantiomeric enrichment of 3-methyl-1-(2-piperidinophenyl)-1-butylamine |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE764238A (fr) * | 1971-03-17 | 1971-09-13 | Lilly Industries Ltd | Derives de phenylalkylamine |
| NL7305171A (es) * | 1973-04-13 | 1974-10-15 | ||
| DE3100575A1 (de) * | 1981-01-10 | 1982-09-02 | Dr. Karl Thomae Gmbh, 7950 Biberach | "neue benzoesaeuren, ihre herstellung und ihre verwendung als arzneimittel" |
-
1983
- 1983-06-27 DE DE8383106233T patent/DE3375783D1/de not_active Expired
- 1983-06-27 SU SU833608901A patent/SU1170969A3/ru active
- 1983-06-27 EP EP83106233A patent/EP0099017B1/de not_active Expired
- 1983-06-29 FI FI832374A patent/FI78477C/fi not_active IP Right Cessation
- 1983-07-04 NO NO832430A patent/NO159590C/no unknown
- 1983-07-04 GR GR71859A patent/GR78661B/el unknown
- 1983-07-04 DD DD83252755A patent/DD210907A5/de unknown
- 1983-07-04 KR KR1019830003043A patent/KR900004925B1/ko not_active Expired
- 1983-07-05 DK DK310883A patent/DK159850C/da not_active IP Right Cessation
- 1983-07-05 ES ES523869A patent/ES8501382A1/es not_active Expired
- 1983-07-05 YU YU01468/83A patent/YU146883A/xx unknown
- 1983-07-05 AU AU16576/83A patent/AU561274B2/en not_active Ceased
- 1983-07-05 IE IE1573/83A patent/IE56171B1/en not_active IP Right Cessation
- 1983-07-05 NZ NZ204814A patent/NZ204814A/en unknown
- 1983-07-05 PT PT76986A patent/PT76986B/pt not_active IP Right Cessation
- 1983-07-05 HU HU832420A patent/HU195651B/hu unknown
- 1983-07-05 PL PL1983242873A patent/PL143992B1/pl unknown
- 1983-07-05 CA CA000431796A patent/CA1214773A/en not_active Expired
- 1983-07-05 CS CS835089A patent/CS240970B2/cs unknown
- 1983-07-06 GB GB08318250A patent/GB2124220B/en not_active Expired
- 1983-07-06 IL IL69172A patent/IL69172A/xx unknown
-
1984
- 1984-02-17 ES ES529807A patent/ES8500924A1/es not_active Expired
- 1984-02-17 ES ES529808A patent/ES529808A0/es active Granted
- 1984-02-17 ES ES529806A patent/ES8500923A1/es not_active Expired
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT81542B (pt) | Processo para a preparacao de derivados de imidazole substituidos e de composicoes farmaceuticas que os contem | |
| IT1171880B (it) | Derivati di 2-ammino-3-acilammino-6-benzilammino-piridina aventi azione antiepilettica e procedimento per la loro produzione | |
| AT384424B (de) | Verfahren zur herstellung von neuen 3-hydroxy-2-oxo-pyrrolidinderivaten und ihren salzen | |
| AU6747687A (en) | New derivatives of decahydroquinoline,their preparation process, the preparation intermediates, their use as medicaments and the compositions containing them | |
| ES2000456A6 (es) | Procedimiento para preparar deirvados de acido eicosatriinoico-5,8,11 y utilizacion de estos en composiciones farmaceuticas y cosmeticas. | |
| DK400781A (da) | Fremgangsmaade til fremstilling af 2-(1,4-benzodioxan-2-ylalkyl) imidazoler | |
| ES8500924A1 (es) | Procedimiento para la preparacion de derivados de acido fenilacetico | |
| ES2016017A6 (es) | Procedimiento para preparar derivados de acido 1,1-dioxocefem-4-carbotiolico. | |
| ES515872A0 (es) | "procedimiento para la preparacion de nuevos derivados de acidos 4-fenoxialcarboxilicos sustituidos con radicales haterociclicos". | |
| PT84680B (pt) | Processo para a preparacao de derivados de 1,5-benzotiazepina e de composicoes farmaceuticas que os contem | |
| DE3769451D1 (de) | Indan-derivate, verfahren zu ihrer herstellung und die erhaltenen zwischenprodukte, ihre verwendung als arzneimittel und diese enthaltende zusammensetzungen. | |
| ES515895A0 (es) | "un procedimiento para la preparacion de un compuesto de imidazol". | |
| PT82175B (pt) | Processo para preparacao de novos derivados de 3-piridilmetilnaftalina e de composicoes farmceuticas que os contem | |
| ES8106517A1 (es) | Procedimiento para la preparacion de nuevos derivados de 10-halogen-e-homo-eburnanos. | |
| PT78717A (de) | Neue 1-acetonyl-2-(phenylimino)-imidazolidine deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung | |
| AU589671B2 (en) | New textraoxo compounds | |
| ES8403130A1 (es) | Procedimiento para la preparacion de tienobenzodiazepinonas sustituidas. | |
| ES527308A0 (es) | Procedimiento para la preparacion de derivados de benzazepina | |
| ATE33837T1 (de) | Azolylmethylcycloacetale, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. | |
| ES8401062A1 (es) | Procedimiento para la preparacion de nuevas 1-furil-3,4-dihidroisoquinoleinas. | |
| ATE32719T1 (de) | Neues nortropinderivat, verfahren zu seiner herstellung und seine verwendung. | |
| AU564739B2 (en) | Acridanone derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970303 |