ES2760523T3 - Composición oftálmica remanente, especialmente para el tratamiento de la sequedad ocular - Google Patents

Composición oftálmica remanente, especialmente para el tratamiento de la sequedad ocular Download PDF

Info

Publication number: ES2760523T3
Authority: ES; Spain
Prior art keywords: composition; composition according; advantageously; oligosaccharide; hyaluronic acid
Prior art date: 2014-02-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

ES15713215T

Other languages

English (en)

Spanish (es)

Inventor

Fabrice Mercier

Léopold Schmetterer

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Medical Univ Of Vienna

Medizinische Universitaet Wien

Laboratoires Thea SAS

Original Assignee

Medical Univ Of Vienna

Medizinische Universitaet Wien

Laboratoires Thea SAS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-02-28

Filing date

2015-03-02

Publication date

2020-05-14

2015-03-02 Application filed by Medical Univ Of Vienna, Medizinische Universitaet Wien, Laboratoires Thea SAS filed Critical Medical Univ Of Vienna

2020-05-14 Application granted granted Critical

2020-05-14 Publication of ES2760523T3 publication Critical patent/ES2760523T3/es

Status Active legal-status Critical Current

2035-03-02 Anticipated expiration legal-status Critical

Links

239000000203 mixture Substances 0.000 title claims abstract description 105
238000011282 treatment Methods 0.000 title claims description 12
208000003556 Dry Eye Syndromes Diseases 0.000 title description 20
206010013774 Dry eye Diseases 0.000 title description 19
229920001542 oligosaccharide Polymers 0.000 claims abstract description 34
150000002482 oligosaccharides Chemical class 0.000 claims abstract description 34
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 31
229920002674 hyaluronan Polymers 0.000 claims abstract description 31
229960003160 hyaluronic acid Drugs 0.000 claims abstract description 31
150000003839 salts Chemical class 0.000 claims abstract description 10
-1 azapentacene Chemical compound 0.000 claims description 14
239000003755 preservative agent Substances 0.000 claims description 10
230000000845 anti-microbial effect Effects 0.000 claims description 5
HUCJFAOMUPXHDK-UHFFFAOYSA-N Xylometazoline Chemical compound CC1=CC(C(C)(C)C)=CC(C)=C1CC1=NCCN1 HUCJFAOMUPXHDK-UHFFFAOYSA-N 0.000 claims description 4
239000004599 antimicrobial Substances 0.000 claims description 4
MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims description 4
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims description 4
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WYWIFABBXFUGLM-UHFFFAOYSA-N oxymetazoline Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C)=C1CC1=NCCN1 WYWIFABBXFUGLM-UHFFFAOYSA-N 0.000 claims description 4
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PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims description 3
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QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 claims description 2
XUBOMFCQGDBHNK-JTQLQIEISA-N (S)-gatifloxacin Chemical compound FC1=CC(C(C(C(O)=O)=CN2C3CC3)=O)=C2C(OC)=C1N1CCN[C@@H](C)C1 XUBOMFCQGDBHNK-JTQLQIEISA-N 0.000 claims description 2
GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 claims description 2
XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical compound C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 claims description 2
229930003347 Atropine Natural products 0.000 claims description 2
MBUVEWMHONZEQD-UHFFFAOYSA-N Azeptin Chemical compound C1CN(C)CCCC1N1C(=O)C2=CC=CC=C2C(CC=2C=CC(Cl)=CC=2)=N1 MBUVEWMHONZEQD-UHFFFAOYSA-N 0.000 claims description 2
108010001478 Bacitracin Proteins 0.000 claims description 2
239000004099 Chlortetracycline Substances 0.000 claims description 2
CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims description 2
229930182566 Gentamicin Natural products 0.000 claims description 2
ZTVIKZXZYLEVOL-MCOXGKPRSA-N Homatropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(O)C1=CC=CC=C1 ZTVIKZXZYLEVOL-MCOXGKPRSA-N 0.000 claims description 2
RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 claims description 2
XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims description 2
ZCVMWBYGMWKGHF-UHFFFAOYSA-N Ketotifene Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2CC(=O)C2=C1C=CS2 ZCVMWBYGMWKGHF-UHFFFAOYSA-N 0.000 claims description 2
QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 claims description 2
BGDKAVGWHJFAGW-UHFFFAOYSA-N Tropicamide Chemical compound C=1C=CC=CC=1C(CO)C(=O)N(CC)CC1=CC=NC=C1 BGDKAVGWHJFAGW-UHFFFAOYSA-N 0.000 claims description 2
229960003216 aceclidine Drugs 0.000 claims description 2
229960000571 acetazolamide Drugs 0.000 claims description 2
BZKPWHYZMXOIDC-UHFFFAOYSA-N acetazolamide Chemical compound CC(=O)NC1=NN=C(S(N)(=O)=O)S1 BZKPWHYZMXOIDC-UHFFFAOYSA-N 0.000 claims description 2
WRJPSSPFHGNBMG-UHFFFAOYSA-N acetic acid 1-azabicyclo[2.2.2]octan-3-yl ester Chemical compound C1CC2C(OC(=O)C)CN1CC2 WRJPSSPFHGNBMG-UHFFFAOYSA-N 0.000 claims description 2
229960004150 aciclovir Drugs 0.000 claims description 2
MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims description 2
229960001232 anecortave Drugs 0.000 claims description 2
229960002610 apraclonidine Drugs 0.000 claims description 2
IEJXVRYNEISIKR-UHFFFAOYSA-N apraclonidine Chemical compound ClC1=CC(N)=CC(Cl)=C1NC1=NCCN1 IEJXVRYNEISIKR-UHFFFAOYSA-N 0.000 claims description 2
229960000396 atropine Drugs 0.000 claims description 2
RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 claims description 2
229960004574 azelastine Drugs 0.000 claims description 2
229960003071 bacitracin Drugs 0.000 claims description 2
229930184125 bacitracin Natural products 0.000 claims description 2
CLKOFPXJLQSYAH-ABRJDSQDSA-N bacitracin A Chemical compound C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 CLKOFPXJLQSYAH-ABRJDSQDSA-N 0.000 claims description 2
229960004374 befunolol Drugs 0.000 claims description 2
ZPQPDBIHYCBNIG-UHFFFAOYSA-N befunolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=C1OC(C(C)=O)=C2 ZPQPDBIHYCBNIG-UHFFFAOYSA-N 0.000 claims description 2
229960002537 betamethasone Drugs 0.000 claims description 2
UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 claims description 2
229960004324 betaxolol Drugs 0.000 claims description 2
229960002470 bimatoprost Drugs 0.000 claims description 2
AQOKCDNYWBIDND-FTOWTWDKSA-N bimatoprost Chemical compound CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCC1=CC=CC=C1 AQOKCDNYWBIDND-FTOWTWDKSA-N 0.000 claims description 2
229960003679 brimonidine Drugs 0.000 claims description 2
229960000722 brinzolamide Drugs 0.000 claims description 2
HCRKCZRJWPKOAR-JTQLQIEISA-N brinzolamide Chemical compound CCN[C@H]1CN(CCCOC)S(=O)(=O)C2=C1C=C(S(N)(=O)=O)S2 HCRKCZRJWPKOAR-JTQLQIEISA-N 0.000 claims description 2
AIXAANGOTKPUOY-UHFFFAOYSA-N carbachol Chemical compound [Cl-].C[N+](C)(C)CCOC(N)=O AIXAANGOTKPUOY-UHFFFAOYSA-N 0.000 claims description 2
CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 claims description 2
229960004475 chlortetracycline Drugs 0.000 claims description 2
CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 claims description 2
235000019365 chlortetracycline Nutrition 0.000 claims description 2
229960003405 ciprofloxacin Drugs 0.000 claims description 2
IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 claims description 2
229960001815 cyclopentolate Drugs 0.000 claims description 2
SKYSRIRYMSLOIN-UHFFFAOYSA-N cyclopentolate Chemical compound C1CCCC1(O)C(C(=O)OCCN(C)C)C1=CC=CC=C1 SKYSRIRYMSLOIN-UHFFFAOYSA-N 0.000 claims description 2
RFWZESUMWJKKRN-UHFFFAOYSA-N dapiprazole Chemical compound CC1=CC=CC=C1N1CCN(CCC=2N3CCCCC3=NN=2)CC1 RFWZESUMWJKKRN-UHFFFAOYSA-N 0.000 claims description 2
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OZWKMVRBQXNZKK-UHFFFAOYSA-N ketorolac Chemical compound OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 OZWKMVRBQXNZKK-UHFFFAOYSA-N 0.000 claims description 2
229960004958 ketotifen Drugs 0.000 claims description 2
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GGXICVAJURFBLW-CEYXHVGTSA-N latanoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1 GGXICVAJURFBLW-CEYXHVGTSA-N 0.000 claims description 2
229960001699 ofloxacin Drugs 0.000 claims description 2
229960004114 olopatadine Drugs 0.000 claims description 2
JBIMVDZLSHOPLA-LSCVHKIXSA-N olopatadine Chemical compound C1OC2=CC=C(CC(O)=O)C=C2C(=C/CCN(C)C)\C2=CC=CC=C21 JBIMVDZLSHOPLA-LSCVHKIXSA-N 0.000 claims description 2
229960001528 oxymetazoline Drugs 0.000 claims description 2
HIANJWSAHKJQTH-UHFFFAOYSA-N pemirolast Chemical compound CC1=CC=CN(C2=O)C1=NC=C2C=1N=NNN=1 HIANJWSAHKJQTH-UHFFFAOYSA-N 0.000 claims description 2
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SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 claims description 2
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229960002673 sulfacetamide Drugs 0.000 claims description 2
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229960000707 tobramycin Drugs 0.000 claims description 2
NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 claims description 2
229960002368 travoprost Drugs 0.000 claims description 2
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VSQQQLOSPVPRAZ-RRKCRQDMSA-N trifluridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(C(F)(F)F)=C1 VSQQQLOSPVPRAZ-RRKCRQDMSA-N 0.000 claims description 2
229960001082 trimethoprim Drugs 0.000 claims description 2
IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 claims description 2
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MDKGKXOCJGEUJW-VIFPVBQESA-N (2s)-2-[4-(thiophene-2-carbonyl)phenyl]propanoic acid Chemical compound C1=CC([C@@H](C(O)=O)C)=CC=C1C(=O)C1=CC=CS1 MDKGKXOCJGEUJW-VIFPVBQESA-N 0.000 claims 1
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CNIIGCLFLJGOGP-UHFFFAOYSA-N 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole Chemical compound C=1C=CC2=CC=CC=C2C=1CC1=NCCN1 CNIIGCLFLJGOGP-UHFFFAOYSA-N 0.000 claims 1
QSAVEGSLJISCDF-UHFFFAOYSA-N 2-hydroxy-2-phenylacetic acid (1,2,2,6-tetramethyl-4-piperidinyl) ester Chemical compound C1C(C)(C)N(C)C(C)CC1OC(=O)C(O)C1=CC=CC=C1 QSAVEGSLJISCDF-UHFFFAOYSA-N 0.000 claims 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Ophthalmology & Optometry (AREA)
Inorganic Chemistry (AREA)
Biochemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

ES15713215T 2014-02-28 2015-03-02 Composición oftálmica remanente, especialmente para el tratamiento de la sequedad ocular Active ES2760523T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR1451662A FR3018045B1 (fr)	2014-02-28	2014-02-28	Composition ophtalmique remanente, notamment pour le traitement de la secheresse oculaire
PCT/FR2015/050499 WO2015136186A1 (fr)	2014-02-28	2015-03-02	Composition ophtalmique rémanente, notamment pour le traitement de la sécheresse oculaire

Publications (1)

Publication Number	Publication Date
ES2760523T3 true ES2760523T3 (es)	2020-05-14

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ES15713215T Active ES2760523T3 (es)	2014-02-28	2015-03-02	Composición oftálmica remanente, especialmente para el tratamiento de la sequedad ocular

Country Status (14)

Country	Link
EP (1)	EP3110425B1 (fr)
CY (1)	CY1122457T1 (fr)
DK (1)	DK3110425T3 (fr)
ES (1)	ES2760523T3 (fr)
FR (1)	FR3018045B1 (fr)
HR (1)	HRP20192142T1 (fr)
HU (1)	HUE047396T2 (fr)
LT (1)	LT3110425T (fr)
PL (1)	PL3110425T3 (fr)
PT (1)	PT3110425T (fr)
RS (1)	RS59721B1 (fr)
SI (1)	SI3110425T1 (fr)
SM (1)	SMT201900746T1 (fr)
WO (1)	WO2015136186A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT202000008299A1 (it) *	2020-04-17	2021-10-17	Glycores 2000 Srl	Composizione liquida oftalmica comprendente acido ialuronico lineare a basso peso molecolare
EP4039248A1 (fr) *	2021-02-04	2022-08-10	Warszawskie Zaklady Farmaceutyczne Polfa S.A.	Composition ophtalmique
EP4218717A1 (fr)	2022-02-01	2023-08-02	Laboratoires THEA	Composition ophtalmique comprenant du resvératrol pour traiter le syndrome de l' il sec
WO2024246753A1 (fr)	2023-05-29	2024-12-05	Technophage, Investigação E Desenvolvimento Em Biotecnologia, S.A.	Compositions ophtalmiques

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JP2004262777A (ja) *	2003-02-27	2004-09-24	Shiseido Co Ltd	アセチル化ヒアルロン酸含有眼用医薬組成物
CN1302812C (zh) *	2004-11-30	2007-03-07	中国海洋大学	含海藻糖和玻璃酸的眼部用药传递系统及其制备方法
TWI393567B (zh) *	2005-03-31	2013-04-21	Bausch & Lomb	治療乾眼之組合物及相關之製造方法及使用方法
US20080095754A1 (en) *	2006-10-18	2008-04-24	Burke Susan E	Ophthalmic compositions comprising diglycine
JP5315252B2 (ja) *	2006-12-22	2013-10-16	シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ	眼科用薬物の輸送に有用なゲル
CN101691479B (zh) *	2009-09-25	2013-01-16	海昌隐形眼镜有限公司	一种角膜接触镜保存液组合物及其制备方法
CN101691478A (zh) *	2009-09-25	2010-04-07	海昌隐形眼镜有限公司	含海藻糖的角膜接触镜护理组合物及其制备方法
US20110319502A1 (en) *	2010-06-25	2011-12-29	Coffey Martin J	Compositions and Methods for Enhancing Reduction of Spore-Forming Microorganisms
GB201017048D0 (en) *	2010-10-08	2010-11-24	Ucl Business Plc	Composition

2014
- 2014-02-28 FR FR1451662A patent/FR3018045B1/fr active Active
2015
- 2015-03-02 LT LT15713215T patent/LT3110425T/lt unknown
- 2015-03-02 RS RS20191561A patent/RS59721B1/sr unknown
- 2015-03-02 WO PCT/FR2015/050499 patent/WO2015136186A1/fr not_active Ceased
- 2015-03-02 HU HUE15713215A patent/HUE047396T2/hu unknown
- 2015-03-02 PL PL15713215T patent/PL3110425T3/pl unknown
- 2015-03-02 DK DK15713215T patent/DK3110425T3/da active
- 2015-03-02 PT PT157132150T patent/PT3110425T/pt unknown
- 2015-03-02 SI SI201531017T patent/SI3110425T1/sl unknown
- 2015-03-02 ES ES15713215T patent/ES2760523T3/es active Active
- 2015-03-02 EP EP15713215.0A patent/EP3110425B1/fr active Active
- 2015-03-02 HR HRP20192142TT patent/HRP20192142T1/hr unknown
- 2015-03-02 SM SM20190746T patent/SMT201900746T1/it unknown
2020
- 2020-01-07 CY CY20201100004T patent/CY1122457T1/el unknown

Also Published As

Publication number	Publication date
EP3110425B1 (fr)	2019-11-13
LT3110425T (lt)	2019-12-10
FR3018045A1 (fr)	2015-09-04
DK3110425T3 (da)	2019-12-09
EP3110425A1 (fr)	2017-01-04
SMT201900746T1 (it)	2020-01-14
SI3110425T1 (sl)	2020-01-31
HRP20192142T1 (hr)	2020-02-21
CY1122457T1 (el)	2021-01-27
WO2015136186A1 (fr)	2015-09-17
PL3110425T3 (pl)	2020-03-31
RS59721B1 (sr)	2020-01-31
PT3110425T (pt)	2019-12-11
FR3018045B1 (fr)	2017-06-16
HUE047396T2 (hu)	2020-04-28

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ES2761373T3 (es)	2020-05-19	Composiciones oftálmicas con protección contra la desecación y retención mejoradas
US20190008832A1 (en)	2019-01-10	Compositions for the treatment of presbyopia
ES2760523T3 (es)	2020-05-14	Composición oftálmica remanente, especialmente para el tratamiento de la sequedad ocular
JP2024061871A (ja)	2024-05-08	眼科組成物
JP2025023354A (ja)	2025-02-14	異物感改善用眼科組成物
EP2057983A1 (fr)	2009-05-13	Compositions pour la protection topique des tissus oculaires à partir des effets nuisibles des rayonnements à ultraviolets
JP2024166367A (ja)	2024-11-28	眼科組成物
JP5147156B2 (ja)	2013-02-20	角膜障害抑制剤
ES2496919T3 (es)	2014-09-22	Formulaciones tópicas con un óxido de amina terciaria
KR102268002B1 (ko)	2021-06-23	효과 지속성 점안제 조성물
JP2019189607A (ja)	2019-10-31	眼科組成物
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