ES2570748T3 - Nuevo análogo de cortistatina A y uso del mismo - Google Patents
Nuevo análogo de cortistatina A y uso del mismoInfo
- Publication number
- ES2570748T3 ES2570748T3 ES11825285T ES11825285T ES2570748T3 ES 2570748 T3 ES2570748 T3 ES 2570748T3 ES 11825285 T ES11825285 T ES 11825285T ES 11825285 T ES11825285 T ES 11825285T ES 2570748 T3 ES2570748 T3 ES 2570748T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- carbon atoms
- alkyl
- hydrogen atom
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un compuesto representado por la fórmula general (M):**Fórmula** en la que R1 representa un grupo heterocíclico aromático sustituido o sin sustituir seleccionado entre el grupo que consiste en un grupo piridilo, un grupo furilo, un grupo tienilo, un grupo indolilo, un grupo quinolilo, un grupo isoquinolilo, un grupo benzofuranilo, un grupo benzotienilo, un grupo imidazolilo, un grupo bencimidazolilo, un grupo tiazolilo, un grupo oxazolilo, un grupo pirazolilo, un grupo pirimidilo, un grupo pirazinilo, un grupo isoxazolilo, un grupo isoindolilo y un grupo pirrolilo, R2 representa un átomo de hidrógeno, un grupo alquilo sustituido o sin sustituir que tiene de 1 a 3 átomos de carbono, OR3, N(R3)2, C(>=O)OR3 o C(>=O)N(R3)2, R3 representa un átomo de hidrógeno, un grupo alquilo que tiene de 1 a 4 átomos de carbono o un grupo acilo que tiene de 1 a 4 átomos de carbono, R4 representa un átomo de hidrógeno, un átomo de oxígeno u OR5, R5 representa un átomo de hidrógeno, un grupo alquilo que tiene de 1 a 3 átomos de carbono o un grupo acilo que tiene de 1 a 3 átomos de carbono, y un sustituyente del grupo heterocíclico aromático sustituido o del grupo alquilo sustituido se selecciona independientemente entre el grupo que consiste en un átomo de flúor, un átomo de cloro, un grupo ciano, un grupo hidroxilo, un grupo nitro, un grupo alquilo, un grupo cicloalquilo, un grupo alcoxi, un grupo amino, un grupo fenilo, un grupo naftilo, un grupo antrilo, un grupo estirilo, un grupo piridilo, un grupo piridoindolilo, un grupo quinolilo y un grupo benzotiazolilo; o una sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010209131 | 2010-09-17 | ||
| PCT/JP2011/071264 WO2012036287A1 (ja) | 2010-09-17 | 2011-09-16 | 新規コルチスタチンａ類似体およびその用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2570748T3 true ES2570748T3 (es) | 2016-05-20 |
Family
ID=45831740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES11825285T Active ES2570748T3 (es) | 2010-09-17 | 2011-09-16 | Nuevo análogo de cortistatina A y uso del mismo |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8791263B2 (es) |
| EP (1) | EP2617720B1 (es) |
| JP (1) | JP5614858B2 (es) |
| ES (1) | ES2570748T3 (es) |
| WO (1) | WO2012036287A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103102305B (zh) * | 2013-02-05 | 2015-01-21 | 中国科学院新疆理化技术研究所 | 瘤果黑种草籽中具有骨架类型2的生物碱及其制备方法 |
| ES2709480T3 (es) | 2013-12-24 | 2019-04-16 | Harvard College | Análogos de cortistatina y síntesis y usos de los mismos |
| HUE055262T2 (hu) | 2014-08-11 | 2021-11-29 | Angion Biomedica Corp | Citokróm P450 inhibitorok és ezek alkalmazásai |
| AU2015374231B2 (en) | 2014-12-31 | 2020-07-23 | Angion Biomedica Corp. | Methods and agents for treating disease |
| EP3294298A4 (en) | 2015-05-08 | 2018-10-17 | President and Fellows of Harvard College | Cortistatin analogues, syntheses, and uses thereof |
| WO2017004411A1 (en) | 2015-07-01 | 2017-01-05 | President And Fellows Of Harvard College | Cortistatin analogues and syntheses and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2283159B1 (en) | 2008-05-05 | 2013-10-09 | The Scripps Research Institute | Synthesis of (+) cortistatin a and related compounds |
| WO2010024930A2 (en) * | 2008-08-28 | 2010-03-04 | President And Fellows Of Harvard College | Cortistatin analogues and syntheses therof |
-
2011
- 2011-09-16 ES ES11825285T patent/ES2570748T3/es active Active
- 2011-09-16 EP EP11825285.7A patent/EP2617720B1/en not_active Not-in-force
- 2011-09-16 WO PCT/JP2011/071264 patent/WO2012036287A1/ja not_active Ceased
- 2011-09-16 JP JP2012534073A patent/JP5614858B2/ja not_active Expired - Fee Related
- 2011-09-16 US US13/823,265 patent/US8791263B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2617720B1 (en) | 2016-03-30 |
| EP2617720A1 (en) | 2013-07-24 |
| WO2012036287A1 (ja) | 2012-03-22 |
| US8791263B2 (en) | 2014-07-29 |
| EP2617720A4 (en) | 2014-02-19 |
| JPWO2012036287A1 (ja) | 2014-02-03 |
| US20130210859A1 (en) | 2013-08-15 |
| JP5614858B2 (ja) | 2014-10-29 |
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