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AR059622A1 - Quinolonas utiles como inhibidores de la sintetasa del oxido nitrico inducibles - Google Patents

Quinolonas utiles como inhibidores de la sintetasa del oxido nitrico inducibles

Info

Publication number
AR059622A1
AR059622A1 ARP070100770A ARP070100770A AR059622A1 AR 059622 A1 AR059622 A1 AR 059622A1 AR P070100770 A ARP070100770 A AR P070100770A AR P070100770 A ARP070100770 A AR P070100770A AR 059622 A1 AR059622 A1 AR 059622A1
Authority
AR
Argentina
Prior art keywords
heteroaryl
heterocycloalkyl
optionally substituted
cycloalkyl
aryl
Prior art date
Application number
ARP070100770A
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English (en)
Original Assignee
Kalypsys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kalypsys Inc filed Critical Kalypsys Inc
Publication of AR059622A1 publication Critical patent/AR059622A1/es

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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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Abstract

Quinolonas de la formula 1 que inhiben la sintasa NOS inducible conjuntamente con los métodos de sintetizacion y uso de los compuestos, incluyendo métodos de inhibicion o modulacion de síntesis del oxido nítrico y/o disminucion de los niveles de oxido nítrico en un paciente mediante la administracion de los compuestos para el tratamiento de enfermedades. Reivindicacion 1: Un método para lograr un efecto en un paciente caracterizado porque comprende la administracion a un paciente de una cantidad terapéuticamente efectiva de un compuesto de la formula 1, o una sal, éster, o prodroga del mismo, en donde: R1 se selecciona desde el grupo que consta de acil, alquiIo, alquileno, aminoalquilo, amidoalquilo, alquinilo, amido, amino, aminoalquilo, arilo, ariloalquilo, ariloalcoxi, ariloamino, ariltio, carboxilo, cicloalquilo, éster, éter, halo, haloalcoxi, haloalquilo, heteroarilo, heteroariloalquilo, heteroariloamino, heterocicloalquilo, heterocicloalquilalquilo, hidrazinil, hidrogeno, imino, tio, sulfonato, sulfonilamino y sulfonilaminoalquilo, cualquiera de los cuales puede sustituirse opcionalmente; R2 se selecciona del grupo que consta de acil, alcoxi, alcoxialquilo, alquilo, alquileno, alquiloamino, alquinilo, alquilimino, amido, amino, arilo, carboxi, ciano, cicloalquilo, éster, halo, haloalquilo, heteroarilo, heterocicloalquilo e hidrogeno, cualquiera de los cuales pueden sustituirse opcionalmente; o, alternativamente, R2 puede combinar con R1 para formar heterocicloalquilo, el cual puede sustituirse opcionalmente; R3 se selecciona desde el grupo que consta de alquilo, amino, ariloalquilo, arilo, cicloalquilo, haloalquilo, heteroariloalquilo, heterocicloalquilo e hidrogeno, cualquiera de los cuales pueden sustituirse opcionalmente; y A, B, C y D se seleccionan independientemente cada uno desde el grupo que consta de acil, alcoxi, alquilo, alquileno, alquiloamino, alquinil, amido, amino, aminosulfonil, arilo, ariloalcoxi, ariloamino, ariltio, carboxi, cicloalquilo, éster, éter, halo, haloalcoxi, haloalquilo, heteroarilo, heteroariloamino, heterocicloalquilo, hidrazinil, hidrogeno, imino, tio, sulfonato y sulfonilamino, cualquiera de los cuales pueden sustituirse opcionalmente; o, alternativamente, cualquiera de los dos o más A, B, C y D pueden combinarse para formar arilo, cicloalquilo, heteroarilo o heterocicloalquilo, cualquiera de los cuales pueden sustituirse opcionalmente; Y en donde el efecto se selecciona del grupo que consiste de la inhibicion de iNOS y el tratamiento de una enfermedad mediada por lnos en un paciente en necesidad del mismo.
ARP070100770A 2006-02-24 2007-02-23 Quinolonas utiles como inhibidores de la sintetasa del oxido nitrico inducibles AR059622A1 (es)

Applications Claiming Priority (2)

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US77656106P 2006-02-24 2006-02-24
US84869606P 2006-10-02 2006-10-02

Publications (1)

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AR059622A1 true AR059622A1 (es) 2008-04-16

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US (1) US20080139558A1 (es)
EP (1) EP1986747A2 (es)
JP (1) JP2009529496A (es)
KR (1) KR20080108478A (es)
AR (1) AR059622A1 (es)
AU (1) AU2007235132A1 (es)
BR (1) BRPI0707028A2 (es)
CA (1) CA2643011A1 (es)
IL (1) IL193526A0 (es)
MX (1) MX2008010931A (es)
TW (1) TW200803855A (es)
WO (1) WO2007117778A2 (es)

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EP2365749A4 (en) * 2008-11-13 2012-05-30 Merck Sharp & Dohme Quinolone NEURO PEPTIDE-S-Receptor Antagonists
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