AR094122A1 - Compuestos triciclicos moduladores de la actividad de cftr - Google Patents
Compuestos triciclicos moduladores de la actividad de cftrInfo
- Publication number
- AR094122A1 AR094122A1 ARP130104861A ARP130104861A AR094122A1 AR 094122 A1 AR094122 A1 AR 094122A1 AR P130104861 A ARP130104861 A AR P130104861A AR P130104861 A ARP130104861 A AR P130104861A AR 094122 A1 AR094122 A1 AR 094122A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- amino
- alkoxy
- halo
- r6oc
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 27
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000006526 (C1-C2) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 1
- 125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 1
- 206010012735 Diarrhoea Diseases 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- -1 amino- Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000030761 polycystic kidney disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Además se proporciona una combinación de agentes farmacológicamente activos y una composición farmacéutica para uso en el tratamiento de diarrea y enfermedades renales poliquísticas. Reivindicación 1: Un compuesto de la fórmula (1) o una sal farmacéuticamente aceptable del mismo, en donde R¹ representa fenilo, cicloalquenilo C₄₋₇ o Het¹, tal grupo R¹ puede ser no sustituido o sustituido en uno o dos átomos de carbono por sustituyentes Rᵃ, y puede sustituirse adicionalmente en un átomo de nitrógeno por un sustituyente Rᵃ¹; cada Rᵃ independientemente representa alquilo C₁₋₄, halo, halo-alquilo C₁₋₄, ciano, hidroxi-alquilo C₁₋₄, alcoxilo C₁₋₄, halo-alcoxilo C₁₋₄, alcoxi C₁₋₄alquilo C₁₋₄, R⁶OC(O)-, o R⁶OC(O)alquilo C₁₋₄-; Rᵃ¹ representa alquilo C₁₋₄, hidroxi-alquilo C₁₋₄, alcoxi C₁₋₄alquilo C₁₋₄, alquil C₁₋₄amino-alquil C₁₋₄-, di[alquil C₁₋₄]amino-alquil C₁₋₄-, aril-alquil C₁₋₄ o R⁶OC(O)alquilo C₁₋₄-; R² representa alquilo C₁₋₆, cicloalquilo C₃₋₇, cicloalquenilo C₄₋₇, fenilo, furanilo, tiazolilo o tienilo, tal R² puede ser no sustituido o sustituido en de uno a tres átomos de carbono con sustituyentes Rᵇ; cada Rᵇ independientemente representa alquilo C₁₋₄, halo, halo-alquilo C₁₋₄, ciano, alquil C₁₋₄amino-alquilo C₁₋₄-, di[alquil C₁₋₄]amino-alquilo C₁₋₄-, (R⁶)₂NC(O)alquilo C₁₋₄- o R⁶OC(O)alquilo C₁₋₄-; X representa S, Z representa CHR⁴ᵃ y n representa 1; o X representa CHR⁴ᵇ, Z representa NR⁵ y n representa 1 ó 2; o X representa CHR⁴ᵇ, Z representa CHR⁴ᵃ y n representa 0, 1 ó 2; o X representa C(=CH₂), CF₂ o C(CH₃)₂, Z representa CHR⁴ᵃ y n representa 0 ó 1; cada R³ independientemente representa metilo o etilo; cuando X representa S, R⁴ representa hidrógeno, alquilo C₁₋₄, halo-alquilo C₁₋₄, hidroxi-alquilo C₁₋₄, alcoxi C₁₋₄alquilo C₁₋₄-, amino-alquilo C₁₋₄-, alquil C₁₋₄amino-alquilo C₁₋₄-, di[alquil C₁₋₄]amino-alquilo C₁₋₄-, fenilo, Het¹-alquilo C₁₋₄-, Het²-alquilo C₁₋₄-, alquil C₁₋₄-S(O)₂NH-alquilo C₁₋₄-, o R⁷C(O)NH-alquilo C₁₋₄-; cuando X representa CHR⁴ᵇ, cada R⁴ independientemente representa hidrógeno, hidroxilo, alquilo C₁₋₄, alcoxilo C₁₋₄, halo-alquilo C₁₋₄, hidroxi-alquilo C₁₋₄, alcoxi C₁₋₄alquilo C₁₋₄-, amino-alquilo C₁₋₄-, alquil C₁₋₄amino-alquilo C₁₋₄-, di[alquil C₁₋₄]amino-alquilo C₁₋₄-, amino, alquil C₁₋₄amino-, di[alquil C₁₋₄]amino- ,fenilo, Het¹-alquilo C₁₋₄-, Het²-alquilo C₁₋₄-, alquil C₁₋₄-S(O)₂NH-alquilo C₁₋₄-, o R⁷C(O)NH-alquilo C₁₋₄-; R⁴ᵃ representa hidrógeno, alquilo C₁₋₄, hidroxi-alquilo C₁₋₄, halo-alquilo C₁₋₄, amino-alquilo C₁₋₄-, alquil C₁₋₄amino-alquilo C₁₋₄-, di[alquil C₁₋₄]amino-alquilo C₁₋₄-, Het¹-alquilo C₁₋₄-, Het²-alquilo C₁₋₄-, o R⁶OC(O)-; R⁴ᵇ representa hidrógeno o metilo; R⁵ representa hidrógeno o alquilo C₁₋₄; R⁶ representa hidrógeno o alquilo C₁₋₄; R⁷ representa alquilo C₁₋₂, alcoxilo C₁₋₂, alcoxi C₁₋₂-alquilo C₁₋₂ o fenilo; Het¹ representa un anillo de heteroarilo de 5 ó 6 miembros que comprende a) un átomo de oxígeno o azufre y opcionalmente uno o dos átomos de nitrógeno; o b) de uno a cuatro átomos de nitrógeno; y Het² representa un anillo heterocíclico de 4 a 7 miembros que comprende a) 1 ó 2 heteroátomos seleccionados a partir de N, O y S; o b) -C(O)- y 1 ó 2 heteroátomos seleccionados a partir de N y O.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261739335P | 2012-12-19 | 2012-12-19 | |
| US201361906141P | 2013-11-19 | 2013-11-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR094122A1 true AR094122A1 (es) | 2015-07-08 |
Family
ID=50030372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130104861A AR094122A1 (es) | 2012-12-19 | 2013-12-19 | Compuestos triciclicos moduladores de la actividad de cftr |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US9359381B2 (es) |
| EP (1) | EP2935278B1 (es) |
| JP (1) | JP6284546B2 (es) |
| KR (1) | KR20150097660A (es) |
| CN (1) | CN105143230B (es) |
| AP (1) | AP2015008539A0 (es) |
| AR (1) | AR094122A1 (es) |
| AU (1) | AU2013365739A1 (es) |
| BR (1) | BR112015014292A2 (es) |
| CA (1) | CA2895660A1 (es) |
| CL (1) | CL2015001730A1 (es) |
| CR (1) | CR20150325A (es) |
| CU (1) | CU20150066A7 (es) |
| EA (1) | EA201591177A1 (es) |
| ES (1) | ES2628369T3 (es) |
| HK (1) | HK1209741A1 (es) |
| IL (1) | IL239389A0 (es) |
| MX (1) | MX2015007939A (es) |
| PE (1) | PE20151055A1 (es) |
| PH (1) | PH12015501386A1 (es) |
| SG (1) | SG11201504594QA (es) |
| TN (1) | TN2015000279A1 (es) |
| TW (1) | TW201429974A (es) |
| UY (1) | UY35211A (es) |
| WO (1) | WO2014097148A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9056867B2 (en) | 2011-09-16 | 2015-06-16 | Novartis Ag | N-substituted heterocyclyl carboxamides |
| EP2935278B1 (en) | 2012-12-19 | 2017-03-15 | Novartis AG | Tricyclic compounds for inhibiting the cftr channel |
| KR20150095925A (ko) | 2012-12-19 | 2015-08-21 | 노파르티스 아게 | Cftr 억제제로서의 트리시클릭 화합물 |
| CN106715536B (zh) * | 2014-09-19 | 2021-06-01 | 莫门蒂夫性能材料股份有限公司 | 用于受控的硅氧烷交联的铂(ii)二烯配合物 |
| US9624233B2 (en) * | 2015-04-23 | 2017-04-18 | Trevi Therapeutics, Inc. | Compounds for treating pruritic conditions |
| CN106478558B (zh) * | 2016-10-17 | 2019-03-29 | 天津雅奥科技发展有限公司 | 一种4-羟甲基-二氢-呋喃-2(3h)-酮的合成方法 |
| US12319686B2 (en) | 2019-01-17 | 2025-06-03 | Hoffmann-La Roche Inc. | Process for the preparation of tetrahydropyridopyrimidines |
| CN114007623A (zh) * | 2019-06-12 | 2022-02-01 | 加利福尼亚大学董事会 | 治疗胆汁酸性腹泻的方法 |
| AU2022265718A1 (en) | 2021-04-29 | 2023-11-02 | Novartis Ag | Deubiquitinase-targeting chimeras and related methods |
| CN117654560B (zh) * | 2023-12-01 | 2024-06-04 | 安徽泽升科技股份有限公司 | 一种通过氧化氨基连续化制备硝基化合物的方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2382528A1 (en) | 1999-08-25 | 2001-03-01 | Banyu Pharmaceutical Co., Ltd. | Novel isoindole derivatives |
| JP2002255967A (ja) | 2001-02-27 | 2002-09-11 | Banyu Pharmaceut Co Ltd | イソインドール誘導体を有効成分とする糖尿病の治療剤、糖尿病の慢性合併症の予防剤又は肥満の治療剤。 |
| JP2007524596A (ja) | 2003-02-28 | 2007-08-30 | トランスフォーム・ファーマシューティカルズ・インコーポレイテッド | 共結晶医薬組成物 |
| MX2009006228A (es) | 2006-12-12 | 2009-06-22 | Schering Corp | Inhibidores de aspartil proteasa. |
| US20110015137A1 (en) * | 2007-07-05 | 2011-01-20 | Trustees Of Boston University | Reca inhibitors and their uses as microbial inhibitors or potentiators of antibiotic activity |
| AU2008345225A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| IN2012DN00719A (es) * | 2009-08-10 | 2015-06-19 | Univ California | |
| USRE48842E1 (en) * | 2011-05-27 | 2021-12-07 | The Regents Of The University Of California | Pyrimido-pyrrolo-oxazine-dione compound inhibitors of the cystic fibrosis transmembrane conductance regulator protein and uses therefor |
| EP2935278B1 (en) | 2012-12-19 | 2017-03-15 | Novartis AG | Tricyclic compounds for inhibiting the cftr channel |
| KR20150095925A (ko) | 2012-12-19 | 2015-08-21 | 노파르티스 아게 | Cftr 억제제로서의 트리시클릭 화합물 |
-
2013
- 2013-12-17 EP EP13826625.9A patent/EP2935278B1/en active Active
- 2013-12-17 CA CA2895660A patent/CA2895660A1/en not_active Abandoned
- 2013-12-17 BR BR112015014292A patent/BR112015014292A2/pt not_active IP Right Cessation
- 2013-12-17 WO PCT/IB2013/061043 patent/WO2014097148A1/en not_active Ceased
- 2013-12-17 JP JP2015548837A patent/JP6284546B2/ja not_active Expired - Fee Related
- 2013-12-17 KR KR1020157019061A patent/KR20150097660A/ko not_active Withdrawn
- 2013-12-17 AU AU2013365739A patent/AU2013365739A1/en not_active Abandoned
- 2013-12-17 MX MX2015007939A patent/MX2015007939A/es unknown
- 2013-12-17 US US14/653,084 patent/US9359381B2/en active Active
- 2013-12-17 HK HK15110599.7A patent/HK1209741A1/xx unknown
- 2013-12-17 US US14/109,922 patent/US20140171417A1/en not_active Abandoned
- 2013-12-17 PE PE2015001056A patent/PE20151055A1/es not_active Application Discontinuation
- 2013-12-17 EA EA201591177A patent/EA201591177A1/ru unknown
- 2013-12-17 CN CN201380073218.3A patent/CN105143230B/zh not_active Expired - Fee Related
- 2013-12-17 ES ES13826625.9T patent/ES2628369T3/es active Active
- 2013-12-17 AP AP2015008539A patent/AP2015008539A0/xx unknown
- 2013-12-17 SG SG11201504594QA patent/SG11201504594QA/en unknown
- 2013-12-18 TW TW102147023A patent/TW201429974A/zh unknown
- 2013-12-19 AR ARP130104861A patent/AR094122A1/es unknown
- 2013-12-19 UY UY0001035211A patent/UY35211A/es not_active Application Discontinuation
-
2015
- 2015-06-11 IL IL239389A patent/IL239389A0/en unknown
- 2015-06-16 TN TNP2015000279A patent/TN2015000279A1/fr unknown
- 2015-06-17 PH PH12015501386A patent/PH12015501386A1/en unknown
- 2015-06-18 CL CL2015001730A patent/CL2015001730A1/es unknown
- 2015-06-19 CR CR20150325A patent/CR20150325A/es unknown
- 2015-06-19 CU CUP2015000066A patent/CU20150066A7/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1209741A1 (en) | 2016-04-08 |
| US9359381B2 (en) | 2016-06-07 |
| KR20150097660A (ko) | 2015-08-26 |
| IL239389A0 (en) | 2015-07-30 |
| ES2628369T3 (es) | 2017-08-02 |
| WO2014097148A9 (en) | 2015-02-19 |
| TW201429974A (zh) | 2014-08-01 |
| EP2935278B1 (en) | 2017-03-15 |
| CN105143230A (zh) | 2015-12-09 |
| CL2015001730A1 (es) | 2015-08-28 |
| AU2013365739A1 (en) | 2015-07-09 |
| EP2935278A1 (en) | 2015-10-28 |
| TN2015000279A1 (en) | 2016-10-03 |
| CN105143230B (zh) | 2017-06-09 |
| CA2895660A1 (en) | 2014-06-26 |
| EA201591177A1 (ru) | 2015-11-30 |
| UY35211A (es) | 2014-07-31 |
| CR20150325A (es) | 2015-08-10 |
| JP2016509579A (ja) | 2016-03-31 |
| PH12015501386A1 (en) | 2015-09-02 |
| BR112015014292A2 (pt) | 2017-07-11 |
| US20140171417A1 (en) | 2014-06-19 |
| PE20151055A1 (es) | 2015-08-05 |
| SG11201504594QA (en) | 2015-07-30 |
| AP2015008539A0 (en) | 2015-06-30 |
| MX2015007939A (es) | 2016-03-11 |
| JP6284546B2 (ja) | 2018-02-28 |
| CU20150066A7 (es) | 2015-11-27 |
| US20150336986A1 (en) | 2015-11-26 |
| WO2014097148A1 (en) | 2014-06-26 |
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