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ES2327381T1 - Analizador de diagnostico automatizado y procedimiento. - Google Patents

Analizador de diagnostico automatizado y procedimiento. Download PDF

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Publication number
ES2327381T1
ES2327381T1 ES09004018T ES09004018T ES2327381T1 ES 2327381 T1 ES2327381 T1 ES 2327381T1 ES 09004018 T ES09004018 T ES 09004018T ES 09004018 T ES09004018 T ES 09004018T ES 2327381 T1 ES2327381 T1 ES 2327381T1
Authority
ES
Spain
Prior art keywords
sample
automated analyzer
automated
solid support
target nucleic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES09004018T
Other languages
English (en)
Inventor
Kelly Ammann
Ralph E. Burns
Ernest V. Hansberry
Glenn A. Horner
Cheryl A. Jakub
John E. Kling
Donald J. Nieglos
Robert E. Schneider
Robert J. Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gen Probe Inc
Original Assignee
Gen Probe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22181564&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2327381(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gen Probe Inc filed Critical Gen Probe Inc
Publication of ES2327381T1 publication Critical patent/ES2327381T1/es
Pending legal-status Critical Current

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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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Abstract

Analizador automatizado (50) para su utilización en la realización de un ensayo basado en ácidos nucleicos, comprendiendo el analizador (50) en el interior de una carcasa (60): una estructura móvil de imán (810) para someter una muestra a un campo magnético, en el que la estructura móvil de imán (810) soporta una pluralidad de imanes (814); un tubo aspirador (860) para aspirar un componente fluido de la muestra mientras la muestra es sometida al campo magnético de la estructura móvil de imán (810); una incubadora de amplificación (604) que comprende una carcasa (610) que comprende una abertura de acceso de recipiente (614) que está dimensionada para desplazar un recipiente de reacción (162) en o fuera de la incubadora de amplificación (604), en el que el recipiente de reacción (162) se cree contiene un ácido nucleico diana separado del componente fluido de la muestra; y un dispositivo de detección (950) para detectar una señal luminosa asociada con un producto de amplificación formado en la incubadora de amplificación (604), indicando el producto de amplificación la presencia de un ácido nucleico diana en la muestra.

Claims (14)

1. Analizador automatizado (50) para su utilización en la realización de un ensayo basado en ácidos nucleicos, comprendiendo el analizador (50) en el interior de una carcasa (60):
una estructura móvil de imán (810) para someter una muestra a un campo magnético, en el que la estructura móvil de imán (810) soporta una pluralidad de imanes (814);
un tubo aspirador (860) para aspirar un componente fluido de la muestra mientras la muestra es sometida al campo magnético de la estructura móvil de imán (810);
una incubadora de amplificación (604) que comprende una carcasa (610) que comprende una abertura de acceso de recipiente (614) que está dimensionada para desplazar un recipiente de reacción (162) en o fuera de la incubadora de amplificación (604), en el que el recipiente de reacción (162) se cree contiene un ácido nucleico diana separado del componente fluido de la muestra; y
un dispositivo de detección (950) para detectar una señal luminosa asociada con un producto de amplificación formado en la incubadora de amplificación (604), indicando el producto de amplificación la presencia de un ácido nucleico diana en la muestra.
2. Analizador automatizado (50) según la reivindicación 1, en el que la estructura móvil de imán (810) resulta móvil entre las primera y segunda posiciones, en el que los imanes (814) no presentan un efecto sustancial sobre las partículas sensibles magnéticamente presentes en la muestra cuando la estructura móvil de imán (810) está en la primera posición, y en el que los imanes (814) presentan un efecto sustancial sobre las partículas sensibles magnéticamente presentes en la muestra cuando la estructura móvil de imán (810) está en la segunda posición.
3. Analizador automatizado (50) según la reivindicación 1 ó 2, en el que el dispositivo de detección (950) comprende un tubo fotomultiplicador (956) para la detección de la señal luminosa.
4. Analizador automatizado (50) según la reivindicación 1 ó 2, en el que el dispositivo de detección (950) comprende un sensor óptico para detectar la señal luminosa.
5. Analizador automatizado (50) según la reivindicación 4, en el que el sensor óptico es un diodo.
6. Analizador automatizado (50) según cualquiera de las reivindicaciones 1 a 5, que comprende además una estación de rampa de temperatura (700) dispuesta entre la estructura móvil de imán (810) y la incubadora de amplificación (604), en el que la estación de rampa de temperatura (700) comprende un calentador o refrigerador para elevar o disminuir la temperatura de un fluido que se cree contiene el ácido nucleico diana.
7. Analizador automatizado (50) según cualquiera de las reivindicaciones 1 a 6, que comprende además un mecanismo de transporte (502) para desplazar el recipiente de reacción (160) en y fuera de la incubadora de amplificación (604).
8. Analizador automatizado (50) según la reivindicación 7, en el que el mecanismo de transporte (502) presenta un gancho de manipulación retráctil y extensible (506) para acoplar y desplazar el recipiente de reacción (160) en y fuera de la incubadora de amplificación (604).
9. Analizador automatizado (50) según la reivindicación 7 u 8, en el que el mecanismo de transporte (502) es giratorio.
10. Analizador automatizado (50) según cualquiera de las reivindicaciones 1 a 9, que comprende además los reactivos almacenados para realizar una reacción de amplificación basada en ácidos nucleicos.
11. Procedimiento para determinar la presencia de un ácido nucleico diana en una muestra, comprendiendo el procedimiento realizar dentro de una carcasa las etapas automatizadas que consisten en:
a) combinar una muestra con un material de soporte sólido en condiciones que permitan la inmovilización del ácido nucleico diana sobre el material de soporte sólido;
b) aislar el material de soporte sólido de los componentes no inmovilizados de la muestra y aspirar los componentes no inmovilizados de la muestra;
d) lavar el material de soporte sólido una o más veces con un tampón de lavado;
e) amplificar una secuencia diana contenida en el ácido nucleico diana; y
\newpage
f) detectar un producto de amplificación formado en la etapa (e) como una indicación de la presencia del ácido nucleico diana en la muestra.
12. Procedimiento según la reivindicación 11, en el que el material de soporte sólido es una partícula sensible magnéticamente, y en el que la etapa (b) comprende someter el material de soporte sólido a un campo magnético.
13. Procedimiento según la reivindicación 11 ó 12, en el que el ácido nucleico diana está inmovilizado sobre el material de soporte sólido con una sonda de captura.
14. Procedimiento según cualquiera de las reivindicaciones 11 a 13, en el que la etapa de detección comprende hibridar una sonda marcada de manera detectable al producto de amplificación.
ES09004018T 1998-05-01 1999-04-30 Analizador de diagnostico automatizado y procedimiento. Pending ES2327381T1 (es)

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US8392798P 1998-05-01 1998-05-01
US83927P 1998-05-01

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ES05077602T Expired - Lifetime ES2322958T3 (es) 1998-05-01 1999-04-30 Proceso automatizado para aislar y amplificar una secuencia de acido nucleico diana.
ES09004018T Pending ES2327381T1 (es) 1998-05-01 1999-04-30 Analizador de diagnostico automatizado y procedimiento.
ES05015156T Expired - Lifetime ES2322859T3 (es) 1998-05-01 1999-04-30 Analizador de diagnostico automatizado.
ES99920156T Expired - Lifetime ES2253889T3 (es) 1998-05-01 1999-04-30 Metodo y analizador de diagnostico automatizado.
ES05019229T Expired - Lifetime ES2286750T3 (es) 1998-05-01 1999-04-30 Dispositivo para agitar el contenido liquido de un contenedor.

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ES99920156T Expired - Lifetime ES2253889T3 (es) 1998-05-01 1999-04-30 Metodo y analizador de diagnostico automatizado.
ES05019229T Expired - Lifetime ES2286750T3 (es) 1998-05-01 1999-04-30 Dispositivo para agitar el contenido liquido de un contenedor.

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