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ES2126573T3 - Derivado de pirazol (1,5-a)pirimidina y agente antiinflamatorio que contiene este derivado. - Google Patents

Derivado de pirazol (1,5-a)pirimidina y agente antiinflamatorio que contiene este derivado.

Info

Publication number
ES2126573T3
ES2126573T3 ES91913666T ES91913666T ES2126573T3 ES 2126573 T3 ES2126573 T3 ES 2126573T3 ES 91913666 T ES91913666 T ES 91913666T ES 91913666 T ES91913666 T ES 91913666T ES 2126573 T3 ES2126573 T3 ES 2126573T3
Authority
ES
Spain
Prior art keywords
lower alkyl
substituted
hydroxy
phenyl
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91913666T
Other languages
English (en)
Inventor
Makoto Inoue
Kinji Hashimoto
Toshiko Kuwahara
Yukio Sugimoto
Takuji Uesako
Toshiaki Funato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Otsuka Pharmaceutical Factory Inc
Original Assignee
Otsuka Pharmaceutical Co Ltd
Otsuka Pharmaceutical Factory Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd, Otsuka Pharmaceutical Factory Inc filed Critical Otsuka Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2126573T3 publication Critical patent/ES2126573T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

DERIVADOS DE PIRAZOLO [1''5 POR LA FORMULA GENERAL (I), EN LA QUE R1, R2, R3 Y R4 REPRESENTAN CADA UNO HIDROGENO, CARBOXILO, ALCOXICARBONILO INFERIOR, FENILO, O ALQUILO INFERIOR O CICLOALQUILO, QUE PUEDEN SUSTITUIRSE CADA UNO POR HIDROXI, CARBOXILO O ALCOXICARBONILO INFERIOR O, ALTERNATIVAMENTE, R1 Y R2 PUEDEN COMBINARSE JUNTAMENTE PARA FORMAR ALQUILENO INFERIOR; R5 REPRESENTA -SR6 O -NR7R8; R4 REPRESENTA PIRIDILO O FENILO, QUE PUEDEN SUSTITUIRSE POR UNO O DOS GRUPOS SELECCIONADOS ENTRE HIDROXI Y ALQUILO INFERIOR, Y R7 Y R8 REPESENTAN CADA UNO HIDROGENO O FENILO, QUE PUEDEN SUSTITUIRSE POR DE UNO A TRES GRUPOS SELECCIONADOS ENTRE HIDROXI, ALQUILO INFERIOR, ALCOXI CARBONILO INFERIOR Y CARBOXILO O, ALTERNATIVAMENTE, R7 Y R8 PUEDEN COMBINARSE PARA FORMAR, JUNTAMENTE CON EL ATOMO DE NITROGENO AL CUAL ESTAN UNIDOS, 1 LO, 2 USTITUIRSE POR ALQUILO INFERIOR-HIDROXI O ALQUILO INFERIOR-DIFENIL, SALES DE LOS MISMOS Y UN ANTIINFLAMATORIO QUE CONTENGA COMO INGREDIENTE ACTIVO EL COMPUESTO CON LA FORMULA ANTERIOR, EN LA QUE R1, R3 Y R4 REPRESENTAN CADA UNO HIDROGENO, R2 REPRESENTA ALQUILO INFERIOR O CICLOALQUILO, Y R5 REPRESENTA -NR7R8, DONDE R7 REPRESENTA HIDROGENO Y R8 REPRESENTA FENIL SUSTITUIDO CON HIDROXI Y DOS GRUPOS DE ALQUILO INFERIOR.
ES91913666T 1991-04-22 1991-08-06 Derivado de pirazol (1,5-a)pirimidina y agente antiinflamatorio que contiene este derivado. Expired - Lifetime ES2126573T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9070791 1991-04-22

Publications (1)

Publication Number Publication Date
ES2126573T3 true ES2126573T3 (es) 1999-04-01

Family

ID=14006001

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91913666T Expired - Lifetime ES2126573T3 (es) 1991-04-22 1991-08-06 Derivado de pirazol (1,5-a)pirimidina y agente antiinflamatorio que contiene este derivado.

Country Status (12)

Country Link
US (1) US5688949A (es)
EP (1) EP0591528B1 (es)
JP (1) JPH0570353A (es)
KR (1) KR100191774B1 (es)
AT (1) ATE174917T1 (es)
AU (1) AU651986B2 (es)
CA (1) CA2107479C (es)
DE (1) DE69130683T2 (es)
DK (1) DK0591528T3 (es)
ES (1) ES2126573T3 (es)
TW (1) TW221434B (es)
WO (1) WO1992018504A1 (es)

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DE69717453T2 (de) * 1996-06-06 2003-07-10 Otsuka Pharmaceutical Factory, Inc. Amid derivate
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US6124289A (en) * 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
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US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
US7094782B1 (en) 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
HUP9603001A3 (en) * 1996-10-30 1999-07-28 Richter Gedeon Vegyeszet Heterocycle compounds comprising nitrogen, process for producing them and pharmaceutical compositions containing the same
AU4331500A (en) 1999-04-06 2000-10-23 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
AU4203500A (en) 1999-04-06 2000-10-23 Du Pont Pharmaceuticals Company Pyrazolopyrimidines as crf antagonists
US20020061897A1 (en) * 2000-03-30 2002-05-23 Elliott Richard L. Neuropeptide Y antagonists
US6630476B2 (en) 2000-07-07 2003-10-07 Bristol-Myers Squibb Pharma Company Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists
ATE345344T1 (de) * 2001-03-27 2006-12-15 Neurogen Corp (oxopyrazolo 1,5aöpyrimidin-2-yl) alkylcarbonsäureamide
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
JP4602076B2 (ja) * 2002-06-04 2010-12-22 ネオジェネシス ファーマシューティカルズ インコーポレイテッド 抗ウイルス剤としてのピラゾロ［１，５ａ］ピリミジン化合物
US7205308B2 (en) 2002-09-04 2007-04-17 Schering Corporation Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
US7196078B2 (en) * 2002-09-04 2007-03-27 Schering Corpoartion Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7119200B2 (en) 2002-09-04 2006-10-10 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
AR041136A1 (es) * 2002-09-04 2005-05-04 Pharmacopeia Drug Discovery Pirazolopirimidinas como inhibidores de cinasas dependientes de clclinas
US8673924B2 (en) 2002-09-04 2014-03-18 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
AR041133A1 (es) * 2002-09-04 2005-05-04 Pharmacopeia Drug Discovery Pirazolopirimidinas como inhibidores de la quinasa dependientes de la ciclina
US7161003B1 (en) * 2002-09-04 2007-01-09 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
WO2004022062A1 (en) * 2002-09-04 2004-03-18 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
EP2194058B1 (en) 2002-09-04 2013-11-27 Merck Sharp & Dohme Corp. Pyrazolopyrimidines suitable for the treatment of cancer diseases
NZ539162A (en) * 2002-09-04 2006-07-28 Schering Corp Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US8580782B2 (en) 2002-09-04 2013-11-12 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
EP1599482A4 (en) 2003-02-28 2008-10-01 Teijin Pharma Ltd PYRAZOLO1,5-A PYRIMIDINE DERIVATIVES
WO2004087707A1 (en) * 2003-03-31 2004-10-14 Vernalis (Cambridge) Limited Pyrazolopyrimidine compounds and their use in medicine
US6949895B2 (en) * 2003-09-03 2005-09-27 Axcelis Technologies, Inc. Unipolar electrostatic quadrupole lens and switching methods for charged beam transport
PE20051089A1 (es) * 2004-01-22 2006-01-25 Novartis Ag Derivados de pirazolo [1,5-a] pirimidin-7-il-amina como inhibidores de quinasa de proteina
JP2008539047A (ja) 2005-04-28 2008-11-13 プロテウス バイオメディカル インコーポレイテッド ファーマインフォーマティックスシステム
DE602006016455D1 (de) * 2005-09-09 2010-10-07 Schering Corp Neue 4-cyano-, 4-amino-, und 4-aminomethylderivative von pyrazoloä1,5-aüpyridinen, pyrazoloä1,5-cüpyrimidinen und 2h-indazolverbindungen und 5-cyano-, 5-amino- und 5-aminomethylderivative von imidazoä1,2-aüpyridinen, und imidazoä1,5-aüpyrazinverbindungen als inhibitoren der cyclinabhänggen kinase
AU2006299338A1 (en) 2005-10-06 2007-04-12 Merck Sharp & Dohme Corp. Pyrazolopyrimidines as protein kinase inhibitors
EP1940847A2 (en) * 2005-10-06 2008-07-09 Schering Corporation Pyrazolopyrimidines as protein kinase inhibitors
GB0526419D0 (en) * 2005-12-23 2006-02-08 Cyclacel Ltd Formulation
CN101594878A (zh) 2006-09-18 2009-12-02 雷普特药品公司 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗
JP2010511058A (ja) * 2006-11-29 2010-04-08 アボット・ラボラトリーズ ジアシルグリセロールｏ−アシルトランスフェラーゼ１型酵素の阻害薬
EP2222675B1 (en) 2007-12-19 2013-09-11 Genentech, Inc. 5-anilinoimidazopyridines and methods of use
EP3395372B1 (en) 2009-02-20 2022-04-06 EnhanX Biopharm Inc. Glutathione-based drug delivery system
SG10201402069PA (en) 2009-05-06 2014-07-30 Lab Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
ES2475970T3 (es) * 2009-12-23 2014-07-11 Katholieke Universiteit Leuven Novedosos compuestos antivirales
US8927562B2 (en) * 2010-09-28 2015-01-06 Merck Sharp & Dohme Corp. Fused tricyclic inhibitors of mammalian target of rapamycin
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US9132129B2 (en) 2010-11-15 2015-09-15 Katholieke Universiteit Leuven Antiviral compounds
US8633198B1 (en) 2011-09-20 2014-01-21 Nant Holdings Ip, Llc Small molecule inhibitors of influenza A RNA-dependent RNA polymerase
CN106232119B (zh) * 2013-12-11 2021-02-19 河谷控股Ip有限责任公司 A型流感rna-依赖性rna聚合酶的小分子抑制剂
BR112016016798B1 (pt) * 2014-01-22 2022-06-28 Curovir Ab Composto, composição farmacêutica, e, uso de um composto
GB201410817D0 (en) 2014-06-17 2014-07-30 Ucb Biopharma Sprl And Katholieke Universiteit Leuven K U Leuven R & D Therapeutic agents
BR112020003676A2 (pt) * 2017-09-15 2020-09-01 Aduro Biotech, Inc. compostos de pirazolopirimidinona e usos dos mesmos
DE102018201598A1 (de) * 2018-02-02 2019-08-08 Beiersdorf Ag Stabile Wundheilsalbe
AU2021363703A1 (en) 2020-10-23 2023-06-22 Ildong Pharmaceutical Co., Ltd. Cftr modulator compounds, compositions, and uses thereof

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US3925385A (en) * 1972-04-20 1975-12-09 Icn Pharmaceuticals 6-Carbethoxy-3,7-disubstitutedpyrazolo{8 1,5a{9 pyrimidines
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Also Published As

Publication number Publication date
DE69130683D1 (de) 1999-02-04
KR100191774B1 (ko) 1999-06-15
EP0591528B1 (en) 1998-12-23
EP0591528A4 (en) 1995-02-15
WO1992018504A1 (en) 1992-10-29
DK0591528T3 (da) 1999-08-23
EP0591528A1 (en) 1994-04-13
DE69130683T2 (de) 1999-05-06
TW221434B (es) 1994-03-01
JPH0570353A (ja) 1993-03-23
AU651986B2 (en) 1994-08-11
US5688949A (en) 1997-11-18
ATE174917T1 (de) 1999-01-15
AU8295891A (en) 1992-11-17
CA2107479C (en) 1997-12-16
CA2107479A1 (en) 1992-10-23

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