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ES2122456T3 - Aminoacidos excitadores sinteticos. - Google Patents

Aminoacidos excitadores sinteticos.

Info

Publication number
ES2122456T3
ES2122456T3 ES95305632T ES95305632T ES2122456T3 ES 2122456 T3 ES2122456 T3 ES 2122456T3 ES 95305632 T ES95305632 T ES 95305632T ES 95305632 T ES95305632 T ES 95305632T ES 2122456 T3 ES2122456 T3 ES 2122456T3
Authority
ES
Spain
Prior art keywords
sup
sub
amino acids
excitator
synthetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95305632T
Other languages
English (en)
Inventor
David R Helton
James Allen Monn
Darryle D Schoepp
Joseph P Tizzano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/496,643 external-priority patent/US5750566A/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2122456T3 publication Critical patent/ES2122456T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/38—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA NUEVOS COMPUESTOS QUE AFECTAN A CIERTOS RECEPTORES DE AMINOACIDOS EXCITADORES, Y SON UTILES EN EL TRATAMIENTO DE DESORDENES NEUROLOGICOS Y DESORDENES PSIQUIATRICOS. LOS COMPUESTOS TIENEN LA FORMULA EN DONDE: X ES (CH{SUB, 2}){SUB, N}; R{SUP,2} ES CO{SUB, 2}R{SUP,4} Y R{SUP,3} ES HIDROGENO, O R{SUP, 2} ES HIDROGENO Y R{SUP,3} ES CO{SUB, 2}R{SUP,4}; R{SUP,1} Y R{SUP,4} SON INDEPENDIENTEMENTE HIDROGENO, ALKILO C{SUB, 1}-C{SUB, 10}, ALQUENILO C{SUB, 2}-C{SUB, 10}, ARILO O ARIALKILO; Y N ES 1; O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS.
ES95305632T 1994-08-12 1995-08-11 Aminoacidos excitadores sinteticos. Expired - Lifetime ES2122456T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28995794A 1994-08-12 1994-08-12
US33734994A 1994-11-10 1994-11-10
US08/496,643 US5750566A (en) 1994-08-12 1995-06-29 Synthetic excitatory amino acids

Publications (1)

Publication Number Publication Date
ES2122456T3 true ES2122456T3 (es) 1998-12-16

Family

ID=27403949

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95305632T Expired - Lifetime ES2122456T3 (es) 1994-08-12 1995-08-11 Aminoacidos excitadores sinteticos.

Country Status (24)

Country Link
US (2) US5925782A (es)
EP (1) EP0696577B1 (es)
JP (1) JP2883297B2 (es)
CN (1) CN1066135C (es)
AP (1) AP758A (es)
AT (1) ATE172186T1 (es)
AU (2) AU692276B2 (es)
BG (1) BG62728B1 (es)
CA (1) CA2156024C (es)
CZ (1) CZ291270B6 (es)
DE (1) DE69505318T2 (es)
DK (1) DK0696577T3 (es)
ES (1) ES2122456T3 (es)
FI (1) FI114861B (es)
HU (1) HU223845B1 (es)
IL (2) IL114910A (es)
MY (1) MY115977A (es)
NO (1) NO306342B1 (es)
NZ (1) NZ272772A (es)
PL (1) PL182285B1 (es)
RO (1) RO119147B1 (es)
SK (1) SK281288B6 (es)
TW (1) TW438741B (es)
WO (1) WO1996005175A1 (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL118727A (en) * 1995-06-29 2003-01-12 Lilly Co Eli (-)-2-spiro-5-hydantoinbicyclo [3.1.0] hexane-6-carboxylic acid, salts thereof and use thereof for the preparation of (+)-(2) aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid
AU703409B2 (en) * 1995-11-16 1999-03-25 Eli Lilly And Company Excitatory amino acid derivatives
US5912248A (en) * 1995-11-16 1999-06-15 Eli Lilly And Company Excitatory amino acid receptor antagonists
JP2000500752A (ja) 1995-11-16 2000-01-25 イーライ・リリー・アンド・カンパニー 興奮性アミノ酸受容体アンタゴニスト
US5688826A (en) * 1995-11-16 1997-11-18 Eli Lilly And Company Excitatory amino acid derivatives
ZA969485B (en) * 1995-11-16 1998-05-12 Lilly Co Eli Excitatory amino acid receptor antagonists.
GB9605429D0 (en) * 1995-11-16 1996-05-15 Lilly Co Eli Excitatory amino acid receptor antagonists
US5824662A (en) * 1996-09-27 1998-10-20 Guilford Pharmaceuticals Inc. Treatment of global and focal ischemia using naaladase inhibitors
US6017903A (en) 1996-09-27 2000-01-25 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors
PL332413A1 (en) 1996-09-27 1999-09-13 Guilford Pharm Inc Compositions containing inhibitors of naaladase as well as methods of treating glutamatic anomaly and influencing neuronic functions among animals
CA2275777A1 (en) * 1997-01-29 1998-07-30 Louise Richman Levine Treatment for premenstrual dysphoric disorder
ZA983930B (en) * 1997-05-14 1999-11-08 Lilly Co Eli Excitatory amino acid receptor modulators.
US6825211B1 (en) 1997-07-18 2004-11-30 Georgetown University Bicyclic metabotropic glutamate receptor ligands
ATE214704T1 (de) * 1997-07-18 2002-04-15 Hoffmann La Roche 5h-thiazolo(3,2-a)pyrimidinderivate
US6204292B1 (en) * 1997-07-18 2001-03-20 Georgetown University Bicyclic metabotropic glutamate receptor ligands
JP3727791B2 (ja) * 1998-01-08 2005-12-14 ファイザー・プロダクツ・インク 二環式［３．１．０］ヘキサン及び関連化合物
DK1052246T3 (da) * 1998-01-28 2003-06-16 Taisho Pharmaceutical Co Ltd Fluorholdige aminosyrederivater
US5933378A (en) * 1998-02-26 1999-08-03 Micron Technology, Inc. Integrated circuit having forced substrate test mode with improved substrate isolation
NZ506227A (en) * 1998-03-17 2003-06-30 Pfizer Prod Inc Bicyclo[2.2.1]heptanes and their use in treating neurological and psychiatric disorders
EP1396273A1 (en) * 1998-03-17 2004-03-10 Pfizer Products Inc. Bicyclo(2.2.1.)heptanes and related compounds
GB9815542D0 (en) * 1998-07-17 1998-09-16 Lilly Co Eli Bicyclohexane derivatives
CN1247527C (zh) 1998-08-31 2006-03-29 大正制药株式会社 6－氟双环[3.1.0]己烷衍生物
CH694053A5 (de) * 1998-09-03 2004-06-30 Hoffmann La Roche Verfahren zur Herstellung von 2-Amino-bicyclo[3.1.0]hexan-2,6-dicarbonsäure-Derivaten.
JP4192331B2 (ja) 1999-04-16 2008-12-10 住友化学株式会社 光学活性２−オキソビシクロ［３．１．０］ヘキサン−６−カルボン酸誘導体の製造方法
JP4783967B2 (ja) * 1999-07-21 2011-09-28 大正製薬株式会社 含フッ素アミノ酸誘導体を有効成分とする医薬
GB2355982A (en) * 1999-11-03 2001-05-09 Lilly Co Eli Heterocyclic amino acids
IL156364A0 (en) 2001-01-11 2004-01-04 Lilly Co Eli Prodrugs of excitatory amino acids
EP1310480A1 (en) * 2001-11-07 2003-05-14 Eli Lilly & Company Prodrugs of excitatory amino acids
US7038077B2 (en) 2001-01-11 2006-05-02 Eli Lilly And Company Prodrugs of excitatory amino acids
EP1463713A1 (en) * 2001-11-23 2004-10-06 Eli Lilly And Company Prodrugs of excitatory amino acids
WO2003057661A1 (en) * 2001-12-21 2003-07-17 Eli Lilly And Company Prodrugs of excitatory amino acids
US7456221B2 (en) 2001-12-21 2008-11-25 Eli Lilly And Company Prodrugs of excitatory amino acids
US20040116489A1 (en) * 2002-02-12 2004-06-17 Massey Steven Marc Synthetic excitatory amino acids
EP1715921B1 (en) * 2003-09-25 2013-04-24 Abraxis BioScience, Inc. Tetrahydroindolone derivatives for treatment of neurological conditions
US20050107439A1 (en) * 2003-11-10 2005-05-19 Helton David R. Composition and method for treating emesis
WO2009062134A1 (en) * 2007-11-09 2009-05-14 Cenomed Biosciences, Llc Treatment of post-traumatic stress disorder with tetrahydroindolone arylpiperazine compounds
US20090264443A1 (en) * 2008-04-18 2009-10-22 David Helton Treatment of organophosphate exposure with tetrahydroindolone arylpiperazine compounds
WO2010111080A2 (en) 2009-03-27 2010-09-30 Eli Lilly And Company Optimized treatment of schizophrenia

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3532744A (en) * 1967-07-28 1970-10-06 American Home Prod 1- and 2-amino substituted indane and tetralene carboxylic acids
US3704312A (en) * 1970-10-30 1972-11-28 American Home Prod Bialicyclic amino acids
US3746495A (en) * 1971-06-01 1973-07-17 American Home Prod Anti-ulcer therapy
JP2757960B2 (ja) 1988-10-17 1998-05-25 サントリー株式会社 （２Ｒ，３Ｓ，４Ｓ）−α−（カルボキシシクロプロピル）グリシン
ATE137215T1 (de) 1991-10-18 1996-05-15 Suntory Ltd 2-(2,3-dicarboxycyclopropyl)-glycin und ein verfahren zu ihrer herstellung
GB9325368D0 (en) * 1993-12-10 1994-02-16 Univ Bristol Organic compounds
US5661184A (en) * 1994-08-12 1997-08-26 Eli Lilly And Company Psychiatric agents
IL118727A (en) 1995-06-29 2003-01-12 Lilly Co Eli (-)-2-spiro-5-hydantoinbicyclo [3.1.0] hexane-6-carboxylic acid, salts thereof and use thereof for the preparation of (+)-(2) aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid
US5688826A (en) 1995-11-16 1997-11-18 Eli Lilly And Company Excitatory amino acid derivatives

Also Published As

Publication number Publication date
CZ207495A3 (en) 1996-05-15
DE69505318D1 (de) 1998-11-19
WO1996005175A1 (en) 1996-02-22
AP758A (en) 1999-09-10
CN1066135C (zh) 2001-05-23
RO119147B1 (ro) 2004-04-30
BG101213A (en) 1998-03-31
EP0696577B1 (en) 1998-10-14
FI114861B (fi) 2005-01-14
MY115977A (en) 2003-10-31
PL182285B1 (pl) 2001-12-31
AU3325195A (en) 1996-03-07
EP0696577A1 (en) 1996-02-14
SK13397A3 (en) 1997-07-09
HK1013983A1 (en) 1999-09-17
JPH08188561A (ja) 1996-07-23
NO953191L (no) 1996-02-13
US5925680A (en) 1999-07-20
CZ291270B6 (cs) 2003-01-15
SK281288B6 (sk) 2001-02-12
DK0696577T3 (da) 1999-06-23
US5925782A (en) 1999-07-20
NO306342B1 (no) 1999-10-25
CN1123272A (zh) 1996-05-29
JP2883297B2 (ja) 1999-04-19
HU223845B1 (hu) 2005-02-28
FI953837L (fi) 1996-02-13
BG62728B1 (bg) 2000-06-30
IL114910A0 (en) 1995-12-08
PL309972A1 (en) 1996-02-19
AU692276B2 (en) 1998-06-04
DE69505318T2 (de) 1999-03-25
NZ272772A (en) 1997-10-24
FI953837A0 (fi) 1995-08-14
IL133493A0 (en) 2001-04-30
ATE172186T1 (de) 1998-10-15
AP9700922A0 (en) 1997-01-31
CA2156024A1 (en) 1996-02-13
AU2853095A (en) 1996-02-22
CA2156024C (en) 2004-10-05
HU9502380D0 (en) 1996-05-28
HUT75524A (en) 1997-05-28
NO953191D0 (no) 1995-08-14
TW438741B (en) 2001-06-07
IL114910A (en) 2000-06-29

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