[go: up one dir, main page]

ES2123287T3 - Derivados 3-benzoil benzofuranicos como antagonistas de la hormona tiroidea. - Google Patents

Derivados 3-benzoil benzofuranicos como antagonistas de la hormona tiroidea.

Info

Publication number
ES2123287T3
ES2123287T3 ES95929866T ES95929866T ES2123287T3 ES 2123287 T3 ES2123287 T3 ES 2123287T3 ES 95929866 T ES95929866 T ES 95929866T ES 95929866 T ES95929866 T ES 95929866T ES 2123287 T3 ES2123287 T3 ES 2123287T3
Authority
ES
Spain
Prior art keywords
sub
sup
benzofuranicos
benzoil
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95929866T
Other languages
English (en)
Inventor
Charlotta Mellin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Karo Healthcare AB
Original Assignee
Karo Bio AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karo Bio AB filed Critical Karo Bio AB
Application granted granted Critical
Publication of ES2123287T3 publication Critical patent/ES2123287T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION PROPORCIONA COMPUESTOS REPRESENTADOS POR LA FORMULA (I), EN LA QUE: HA=I O BR, X=CH{SUB,2} O C=O, R{SUP,1}=ALQUILO C{SUB,1-4}, R{SUP,2}=-NHSO{SUB,2}R{SUP,3}; NHCONHR{SUP,3}, DONDE R{SUP,3}=-CF{SUB,3}, ALQUILO C{SUB,1-3}, 4-R{SUP,4}C{SUB,6}H{SUB,4}-; DONDE R{SUP,4}=ALCOXI- C{SUB,1-4}; HIDROXI-; FLUOR-; O NITRO-; O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS. DICHOS COMPUESTOS PUEDEN SER UTILIZADOS ESPECIALMENTE EN EL TRATAMIENTO DE ALTERACIONES Y ENFERMEDADES GENETICAS REGULADAS POR T3.
ES95929866T 1994-08-11 1995-08-11 Derivados 3-benzoil benzofuranicos como antagonistas de la hormona tiroidea. Expired - Lifetime ES2123287T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9416219A GB9416219D0 (en) 1994-08-11 1994-08-11 Receptor ligands

Publications (1)

Publication Number Publication Date
ES2123287T3 true ES2123287T3 (es) 1999-01-01

Family

ID=10759723

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95929866T Expired - Lifetime ES2123287T3 (es) 1994-08-11 1995-08-11 Derivados 3-benzoil benzofuranicos como antagonistas de la hormona tiroidea.

Country Status (12)

Country Link
US (1) US5854282A (es)
EP (1) EP0775129B1 (es)
JP (1) JPH10504297A (es)
KR (1) KR970704725A (es)
AT (1) ATE172460T1 (es)
AU (1) AU694551B2 (es)
CA (1) CA2197185A1 (es)
DE (1) DE69505542T2 (es)
DK (1) DK0775129T3 (es)
ES (1) ES2123287T3 (es)
GB (1) GB9416219D0 (es)
WO (1) WO1996005190A1 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999058519A1 (en) * 1998-05-12 1999-11-18 American Home Products Corporation Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6166069A (en) * 1998-05-12 2000-12-26 American Home Products Corporation Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6317722B1 (en) * 1998-09-18 2001-11-13 Amazon.Com, Inc. Use of electronic shopping carts to generate personal recommendations
FR2803846B1 (fr) 2000-01-17 2002-04-05 Clariant France Sa 3-(1-hydroxy-pentylidene)-5-nitro-3h-benzofuran-2-one, son procede de preparation et son utilisation
GB0015205D0 (en) 2000-06-21 2000-08-09 Karobio Ab Bioisosteric thyroid receptor ligands and method
FR2817864B1 (fr) 2000-12-11 2003-02-21 Sanofi Synthelabo Derive de methanesulfonamido-benzofurane, son procede de preparation et son utilisation comme intermediaire de synthese
KR20040030818A (ko) * 2001-07-20 2004-04-09 카로 바이오 아베 심방 세동의 치료에 있어서의 벤조 퓨란 및 이들의 용도
DE10237819A1 (de) * 2002-08-19 2004-03-04 Bayer Ag 5-Nitrobenzofurane
CA2546601A1 (en) * 2003-11-19 2005-06-09 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
FR2864536B1 (fr) * 2003-12-24 2006-03-17 Clariant France Sa Procede de preparation de n-alkyl-2 (hydroxy-4-benzoyl)-3 benzofurannes et intermediaires pour sa mise en oeuvre
RU2007148927A (ru) * 2005-05-26 2009-07-10 Метабэйзис Терапьютикс, Инк. (Us) Новые тиреомиметики, содержащие фосфиновую кислоту
US20090232879A1 (en) 2005-05-26 2009-09-17 Metabasis Therapeutics, Inc. Thyromimetics for the Treatment of Fatty Liver Diseases
GB0611210D0 (en) * 2006-06-07 2006-07-19 Cambrex Karlskoga Ab Process
EP2036887A1 (en) * 2006-06-28 2009-03-18 Sanwa Kagaku Kenkyusho Co., Ltd Novel 6-5 bicycic heterocyclic derivative and medical use thereof
KR100858357B1 (ko) * 2006-10-02 2008-09-11 (주) 디지탈바이오텍 벤조퓨란계 유도체 화합물을 유효성분으로 함유하는인지기능 장애의 예방 및 치료용 조성물
FR2914644B1 (fr) * 2007-04-06 2009-06-05 Finorga Soc Par Actions Simpli Procede de preparation de 2-(n-butyl)-3-(4-hydroxybenzoyl) -5-nitrobenzofurane
FR2914643B1 (fr) * 2007-04-06 2009-06-05 Finorga Soc Par Actions Simpli Procede de preparation du 2-(n-butyl)-5-nitrobenzofurane
FR2915482B1 (fr) * 2007-04-27 2009-11-27 Finorga Procede de preparation du 2-(n-butyl)-5-nitrobenzofurane.
GB0719180D0 (en) 2007-10-02 2007-11-14 Cambrex Karlskoga Ab New process
HUP1000010A2 (en) 2010-01-08 2011-11-28 Sanofi Sa Process for producing dronedarone
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
CN101948455B (zh) * 2010-10-18 2012-11-14 山东邹平大展新材料有限公司 一种2-正丁基-3-(4-羟基苯甲酰基)-5-硝基苯并呋喃的制备方法
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (en) 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
WO2013121235A2 (en) 2012-02-13 2013-08-22 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
US9249119B2 (en) 2012-02-14 2016-02-02 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
WO2013124745A1 (en) 2012-02-22 2013-08-29 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
WO2013178337A1 (en) 2012-05-31 2013-12-05 Sanofi Process for preparation of dronedarone by grignard reaction
JP2020500199A (ja) 2016-11-21 2020-01-09 バイキング・セラピューティクス・インコーポレイテッド グリコーゲン蓄積症の治療方法
AU2018280118B2 (en) 2017-06-05 2021-07-15 Viking Therapeutics, Inc. Compositions for the treatment of fibrosis
EA202091979A1 (ru) 2018-03-22 2021-06-22 Вайкинг Терапьютикс, Инк. Кристаллические формы и способы получения кристаллических форм соединения
US12102646B2 (en) 2018-12-05 2024-10-01 Viking Therapeutics, Inc. Compositions for the treatment of fibrosis and inflammation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4255585A (en) * 1975-10-22 1981-03-10 Centre European De Recherches Pharmacologique Benzoheterocyclic derivatives of phenoxyacetic acid
DE3342624A1 (de) * 1983-11-25 1984-03-29 Heinfried Dr. 4019 Monheim Grote Benzaronderivate, verfahren zu ihrer herstellung und diese derivate enthaltende arzneimittel
US4851554A (en) * 1987-04-06 1989-07-25 University Of Tennessee Research Corporation Certain 3-substituted 2-alkyl benzofuran derivatives
JP2873599B2 (ja) * 1990-03-09 1999-03-24 寿製薬株式会社 新規ベンゾフラン誘導体、尿酸排泄剤及びその製法
FR2665444B1 (fr) * 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
SE9101509D0 (sv) * 1991-05-17 1991-05-17 Karobio Ab Receptor ligands

Also Published As

Publication number Publication date
ATE172460T1 (de) 1998-11-15
EP0775129B1 (en) 1998-10-21
AU3345595A (en) 1996-03-07
DE69505542D1 (de) 1998-11-26
GB9416219D0 (en) 1994-10-05
KR970704725A (ko) 1997-09-06
US5854282A (en) 1998-12-29
CA2197185A1 (en) 1996-02-22
AU694551B2 (en) 1998-07-23
DK0775129T3 (da) 1999-06-28
WO1996005190A1 (en) 1996-02-22
DE69505542T2 (de) 1999-06-02
JPH10504297A (ja) 1998-04-28
EP0775129A1 (en) 1997-05-28

Similar Documents

Publication Publication Date Title
ES2123287T3 (es) Derivados 3-benzoil benzofuranicos como antagonistas de la hormona tiroidea.
EA200000391A1 (ru) Производные тиенопиримидина и тиенопиридина, полезные в качестве противораковых агентов
ES2145922T3 (es) Compuestos espiro-azabiciclicos utiles en terapia.
ES2058892T3 (es) Uso de omeprazol como agente antimicrobiano.
ES2145275T3 (es) Derivados de piperazina como antagonistas 5-ht1a.
PE1591A1 (es) Procedimiento para la preparacion de agentes tiazoles antifungicos
FR2662162B1 (fr) Nouveaux derives de l'amino piperidine, de l'amino pyrrolidine et de l'amino perhydroazepine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
ES2150577T3 (es) Aminoeteres aromaticos como agentes para aliviar el dolor.
ES2094721T3 (es) Analogos de la camptotecina solubles en agua.
DK0565549T3 (da) Anvendelse af 1,3-oxathiolannucleosidanaloger til fremstilling af et præparat til behandling af hepatitis B
DE69231661D1 (de) Antifungizide trisubstituierte tetrahydrofurane
NO932607D0 (no) Piperidinderivater og anvendelse av disse
GT199700037A (es) Composiciones farmaceuticas para el tratamiento de la rinitis
ES2118708T3 (es) Composiciones de piperidina y su preparacion y utilizacion.
ES2092646T3 (es) Metanoantracenos como antagonistas de dopamina.
FI895447A7 (fi) Substituoidut terapeuttisina aineina käytettävät adeniinijohdannaiset
ES2043863T3 (es) Procedimiento para preparar derivados de la 1,2,5,6-tetrahidropiridina.
AR003137A1 (es) Una composicion farmaceutica para tratar la leucemia
CO4960654A1 (es) Metodo para el tratamiento de enfermedades fisiologicas relacionadas con el uso o con las secuelas provocadas por el uso de la cocaina u otros estimulantes psicomotores
MX11866A (es) Nuevas cicloalquilamidas y procedimiento para su preparacion.
ES2086528T3 (es) Nuevos compuestos biciclicos sustituidos con amino.
CO4410336A1 (es) Derivados de quinoxalina utiles en terapia
ES2119874T3 (es) Nuevos derivados de elipticina, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
PE296A1 (es) Derivados de 2-imidazolina-5-onas fungicidas
NZ332687A (en) use of 1-methyl-carbapenem derivatives as anti-helicobacter pylori agents

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 775129

Country of ref document: ES