SE9101509D0 - Receptor ligands - Google Patents
Receptor ligandsInfo
- Publication number
- SE9101509D0 SE9101509D0 SE9101509A SE9101509A SE9101509D0 SE 9101509 D0 SE9101509 D0 SE 9101509D0 SE 9101509 A SE9101509 A SE 9101509A SE 9101509 A SE9101509 A SE 9101509A SE 9101509 D0 SE9101509 D0 SE 9101509D0
- Authority
- SE
- Sweden
- Prior art keywords
- diiodo
- benzofuran
- pct
- diethylaminoethoxy
- benzoyl
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 230000001105 regulatory effect Effects 0.000 abstract 2
- SPJWRQCARFHMEB-UHFFFAOYSA-N (2-butyl-1-benzofuran-3-yl)-(4-hydroxy-3-iodophenyl)methanone Chemical compound CCCCC=1OC2=CC=CC=C2C=1C(=O)C1=CC=C(O)C(I)=C1 SPJWRQCARFHMEB-UHFFFAOYSA-N 0.000 abstract 1
- QLUUKNMPBTWGBB-UHFFFAOYSA-N (4-hydroxy-3,5-diiodophenyl)-(2-methyl-1-benzofuran-3-yl)methanone Chemical compound CC=1OC2=CC=CC=C2C=1C(=O)C1=CC(I)=C(O)C(I)=C1 QLUUKNMPBTWGBB-UHFFFAOYSA-N 0.000 abstract 1
- QAPAAMJNJUBIMZ-UHFFFAOYSA-N 1-benzofuran;hydrochloride Chemical compound Cl.C1=CC=C2OC=CC2=C1 QAPAAMJNJUBIMZ-UHFFFAOYSA-N 0.000 abstract 1
- OLIKCJUMYWSDIV-UHFFFAOYSA-N 2-[2,6-diiodo-4-[(2-methyl-1-benzofuran-3-yl)methyl]phenoxy]acetic acid Chemical compound CC=1OC2=CC=CC=C2C=1CC1=CC(I)=C(OCC(O)=O)C(I)=C1 OLIKCJUMYWSDIV-UHFFFAOYSA-N 0.000 abstract 1
- BBJNWOVHBXFYFH-UHFFFAOYSA-N 2-[4-(2-butyl-1-benzofuran-3-carbonyl)-2,6-diiodophenoxy]acetic acid Chemical compound CCCCC=1OC2=CC=CC=C2C=1C(=O)C1=CC(I)=C(OCC(O)=O)C(I)=C1 BBJNWOVHBXFYFH-UHFFFAOYSA-N 0.000 abstract 1
- AUYYCJSJGJYCDS-UHFFFAOYSA-N 2/3/6893 Natural products IC1=CC(CC(N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- FUKUFMFMCZIRNT-UHFFFAOYSA-N hydron;methanol;chloride Chemical compound Cl.OC FUKUFMFMCZIRNT-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/22—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/24—Halogenated derivatives
- C07C39/367—Halogenated derivatives polycyclic non-condensed, containing only six-membered aromatic rings as cyclic parts, e.g. halogenated poly-hydroxyphenylalkanes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9101509A SE9101509D0 (sv) | 1991-05-17 | 1991-05-17 | Receptor ligands |
| US08/142,350 US5567728A (en) | 1991-05-17 | 1992-05-12 | Receptor ligands |
| KR1019930703488A KR100235778B1 (ko) | 1991-05-17 | 1992-05-12 | T-3 조절 유전자 발현의존 질환의 치료 또는 예방약제와 약학적 조성물 및 화합물 |
| DK92910804.1T DK0584186T3 (da) | 1991-05-17 | 1992-05-12 | Receptorligander |
| AT92910804T ATE141504T1 (de) | 1991-05-17 | 1992-05-12 | Rezeptorliganden |
| EP92910804A EP0584186B1 (en) | 1991-05-17 | 1992-05-12 | Receptor ligands |
| CA002109625A CA2109625C (en) | 1991-05-17 | 1992-05-12 | 3,5,3'-triiodothyronine receptor ligands |
| JP4509908A JPH06507619A (ja) | 1991-05-17 | 1992-05-12 | レセプターリガンド |
| ES92910804T ES2090642T3 (es) | 1991-05-17 | 1992-05-12 | Ligandos de receptores. |
| DE69213003T DE69213003T2 (de) | 1991-05-17 | 1992-05-12 | Rezeptorliganden |
| PCT/SE1992/000307 WO1992020331A1 (en) | 1991-05-17 | 1992-05-12 | Receptor ligands |
| AU17743/92A AU660681B2 (en) | 1991-05-17 | 1992-05-12 | Receptor ligands |
| US08/480,643 US5585404A (en) | 1991-05-17 | 1995-06-07 | 3,5,3'-triiodothyronine receptor ligands |
| GR960403147T GR3021744T3 (en) | 1991-05-17 | 1996-11-20 | Receptor ligands |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9101509A SE9101509D0 (sv) | 1991-05-17 | 1991-05-17 | Receptor ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE9101509D0 true SE9101509D0 (sv) | 1991-05-17 |
Family
ID=20382770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE9101509A SE9101509D0 (sv) | 1991-05-17 | 1991-05-17 | Receptor ligands |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US5567728A (sv) |
| EP (1) | EP0584186B1 (sv) |
| JP (1) | JPH06507619A (sv) |
| KR (1) | KR100235778B1 (sv) |
| AT (1) | ATE141504T1 (sv) |
| AU (1) | AU660681B2 (sv) |
| CA (1) | CA2109625C (sv) |
| DE (1) | DE69213003T2 (sv) |
| DK (1) | DK0584186T3 (sv) |
| ES (1) | ES2090642T3 (sv) |
| GR (1) | GR3021744T3 (sv) |
| SE (1) | SE9101509D0 (sv) |
| WO (1) | WO1992020331A1 (sv) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6316487B1 (en) | 1993-06-16 | 2001-11-13 | Aryx Therapeutics | Compounds for treatment of cardiac arrhythmia synthesis, and methods of use |
| US5364880A (en) * | 1993-06-16 | 1994-11-15 | Advanced Therapies, Inc. | Compound for treatment of cardiac arrhythmia, synthesis, and methods of use |
| GB9416219D0 (en) * | 1994-08-11 | 1994-10-05 | Karobio Ab | Receptor ligands |
| WO1999058519A1 (en) * | 1998-05-12 | 1999-11-18 | American Home Products Corporation | Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia |
| US6166069A (en) * | 1998-05-12 | 2000-12-26 | American Home Products Corporation | Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia |
| WO2001036351A2 (en) * | 1999-11-19 | 2001-05-25 | Corvas International, Inc. | Plasminogen activator inhibitor antagonists related applications |
| US6638977B1 (en) | 1999-11-19 | 2003-10-28 | Corvas International, Inc. | Plasminogen activator inhibitor antagonists |
| KR20040030818A (ko) * | 2001-07-20 | 2004-04-09 | 카로 바이오 아베 | 심방 세동의 치료에 있어서의 벤조 퓨란 및 이들의 용도 |
| ES2334712T3 (es) | 2005-07-15 | 2010-03-15 | Aryx Therapeutics, Inc. | Compuestos precursores antiritmicos, procedimientos de sintesis y uso de los mismos. |
| US8454682B2 (en) | 2010-04-13 | 2013-06-04 | Medtronic Vascular, Inc. | Anchor pin stent-graft delivery system |
| KR20230050232A (ko) * | 2021-10-07 | 2023-04-14 | 주식회사 이노보테라퓨틱스 | 벤조퓨라닐 히드록시페닐 메타논 유도체를 포함하는 hsp47 억제용 약학 조성물 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3248401A (en) * | 1966-04-26 | Diethylaminoe hoxybenzoyl benzofurans | ||
| FR1224490A (fr) * | 1959-05-14 | 1960-06-24 | Du Pont | Nouvelles matières thermoplastiques et leur procédé de fabrication |
| US3880891A (en) * | 1973-09-21 | 1975-04-29 | Smithkline Corp | Substituted benzofurans |
| GB1495680A (en) * | 1975-06-20 | 1977-12-21 | May & Baker Ltd | 1-(2-benzoylphenoxy)-2-hydroxy-3-aminopropanes |
| JPH02304022A (ja) * | 1989-05-18 | 1990-12-17 | Mitsubishi Kasei Corp | セロトニン拮抗剤 |
-
1991
- 1991-05-17 SE SE9101509A patent/SE9101509D0/sv unknown
-
1992
- 1992-05-12 DK DK92910804.1T patent/DK0584186T3/da active
- 1992-05-12 EP EP92910804A patent/EP0584186B1/en not_active Expired - Lifetime
- 1992-05-12 CA CA002109625A patent/CA2109625C/en not_active Expired - Fee Related
- 1992-05-12 AT AT92910804T patent/ATE141504T1/de not_active IP Right Cessation
- 1992-05-12 DE DE69213003T patent/DE69213003T2/de not_active Expired - Fee Related
- 1992-05-12 US US08/142,350 patent/US5567728A/en not_active Expired - Fee Related
- 1992-05-12 ES ES92910804T patent/ES2090642T3/es not_active Expired - Lifetime
- 1992-05-12 JP JP4509908A patent/JPH06507619A/ja active Pending
- 1992-05-12 WO PCT/SE1992/000307 patent/WO1992020331A1/en not_active Ceased
- 1992-05-12 AU AU17743/92A patent/AU660681B2/en not_active Ceased
- 1992-05-12 KR KR1019930703488A patent/KR100235778B1/ko not_active Expired - Fee Related
-
1995
- 1995-06-07 US US08/480,643 patent/US5585404A/en not_active Expired - Fee Related
-
1996
- 1996-11-20 GR GR960403147T patent/GR3021744T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU1774392A (en) | 1992-12-30 |
| GR3021744T3 (en) | 1997-02-28 |
| KR100235778B1 (ko) | 1999-12-15 |
| DE69213003D1 (de) | 1996-09-26 |
| WO1992020331A1 (en) | 1992-11-26 |
| ATE141504T1 (de) | 1996-09-15 |
| DE69213003T2 (de) | 1997-02-06 |
| EP0584186B1 (en) | 1996-08-21 |
| EP0584186A1 (en) | 1994-03-02 |
| AU660681B2 (en) | 1995-07-06 |
| DK0584186T3 (da) | 1996-09-09 |
| ES2090642T3 (es) | 1996-10-16 |
| US5567728A (en) | 1996-10-22 |
| CA2109625C (en) | 2000-03-28 |
| JPH06507619A (ja) | 1994-09-01 |
| US5585404A (en) | 1996-12-17 |
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