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ES2190305B1 - INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF MIRTAZAPINE AND ITS OBTAINING PROCEDURES. - Google Patents

INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF MIRTAZAPINE AND ITS OBTAINING PROCEDURES.

Info

Publication number
ES2190305B1
ES2190305B1 ES200001306A ES200001306A ES2190305B1 ES 2190305 B1 ES2190305 B1 ES 2190305B1 ES 200001306 A ES200001306 A ES 200001306A ES 200001306 A ES200001306 A ES 200001306A ES 2190305 B1 ES2190305 B1 ES 2190305B1
Authority
ES
Spain
Prior art keywords
obtaining
mirtazapine
preparation
intermediate compounds
procedures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200001306A
Other languages
Spanish (es)
Other versions
ES2190305A1 (en
Inventor
Jordi Bosch I Llado
Pelayo Camps Garcia
Juan Contreras Lascorz
M. Del Carmen Onrubia Miguel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medichem SA
Original Assignee
Medichem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem SA filed Critical Medichem SA
Priority to ES200001306A priority Critical patent/ES2190305B1/en
Publication of ES2190305A1 publication Critical patent/ES2190305A1/en
Application granted granted Critical
Publication of ES2190305B1 publication Critical patent/ES2190305B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Compuestos intermedios para la preparación de mirtazapina y sus procedimientos de obtención. Se describe un procedimiento para la obtención de(+-)-3-fenil-1-metilpiperazina, importante intermedio para la obtención de mirtazapina, que se basa en someter a una reacción de ciclación, en presencia de un agente reductor, unos nuevos compuestos de fórmula general (I) **FIGURA** en la que Z es un grupo saliente capaz de sufrir un desplazamiento nucleofílico. Se describe también un procedimiento para la obtención de los nuevos compuestos de fórmula (I).Intermediate compounds for the preparation of mirtazapine and its procedures for obtaining. A process for obtaining (+ -) - 3-phenyl-1-methylpiperazine, an important intermediate for obtaining mirtazapine, which is based on subjecting a cyclization reaction, in the presence of a reducing agent, new compounds is described of general formula (I) ** FIGURE ** in which Z is a leaving group capable of undergoing a nucleophilic displacement. A process for obtaining the new compounds of formula (I) is also described.

ES200001306A 2000-05-24 2000-05-24 INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF MIRTAZAPINE AND ITS OBTAINING PROCEDURES. Expired - Fee Related ES2190305B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES200001306A ES2190305B1 (en) 2000-05-24 2000-05-24 INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF MIRTAZAPINE AND ITS OBTAINING PROCEDURES.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200001306A ES2190305B1 (en) 2000-05-24 2000-05-24 INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF MIRTAZAPINE AND ITS OBTAINING PROCEDURES.

Publications (2)

Publication Number Publication Date
ES2190305A1 ES2190305A1 (en) 2003-07-16
ES2190305B1 true ES2190305B1 (en) 2004-07-01

Family

ID=27589259

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200001306A Expired - Fee Related ES2190305B1 (en) 2000-05-24 2000-05-24 INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF MIRTAZAPINE AND ITS OBTAINING PROCEDURES.

Country Status (1)

Country Link
ES (1) ES2190305B1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4912110A (en) * 1985-07-31 1990-03-27 Laboratoire L. Lafton Antidepressive substituted phenylpiperazine compounds
US5378729A (en) * 1985-02-15 1995-01-03 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK173553B1 (en) * 1985-02-15 2001-03-12 Res Corp Technologies Inc Amino acid derivatives, anticonvulsant preparation containing amino acid derivatives, and use of amino acid derivatives for promotion

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378729A (en) * 1985-02-15 1995-01-03 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant
US4912110A (en) * 1985-07-31 1990-03-27 Laboratoire L. Lafton Antidepressive substituted phenylpiperazine compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
W.R. RODERICK et al. "Derivatives of Piperazine. XXXV. Synthesis of 2-Phenylpiperazine and Some Derivatives", J. Med. Chem., 1966, Vol. 9, Nº 2, páginas 181-185. *

Also Published As

Publication number Publication date
ES2190305A1 (en) 2003-07-16

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