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ES2190305A1 - Set of intermediate compounds for production of mirtazapine consists of reaction products yielding piperazine derivatives by cyclization in presence of reducing agent - Google Patents

Set of intermediate compounds for production of mirtazapine consists of reaction products yielding piperazine derivatives by cyclization in presence of reducing agent

Info

Publication number
ES2190305A1
ES2190305A1 ES200001306A ES200001306A ES2190305A1 ES 2190305 A1 ES2190305 A1 ES 2190305A1 ES 200001306 A ES200001306 A ES 200001306A ES 200001306 A ES200001306 A ES 200001306A ES 2190305 A1 ES2190305 A1 ES 2190305A1
Authority
ES
Spain
Prior art keywords
mirtazapine
production
reducing agent
cyclization
intermediate compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200001306A
Other languages
Spanish (es)
Other versions
ES2190305B1 (en
Inventor
I Llado Jordi Bosch
Garcia Pelayo Camps
Lascorz Juan Contreras
Miguel M Del Carmen Onrubia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medichem SA
Original Assignee
Medichem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem SA filed Critical Medichem SA
Priority to ES200001306A priority Critical patent/ES2190305B1/en
Publication of ES2190305A1 publication Critical patent/ES2190305A1/en
Application granted granted Critical
Publication of ES2190305B1 publication Critical patent/ES2190305B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The set of intermediate compounds for production of mirtazapine comprises the products of reactions yielding (+-)-3-phenyl-1-methyl piperazine. Also claimed is a process for making the compounds. Preferred Process: The process promotes cyclization in the presence of a reducing agent.
ES200001306A 2000-05-24 2000-05-24 INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF MIRTAZAPINE AND ITS OBTAINING PROCEDURES. Expired - Fee Related ES2190305B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES200001306A ES2190305B1 (en) 2000-05-24 2000-05-24 INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF MIRTAZAPINE AND ITS OBTAINING PROCEDURES.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200001306A ES2190305B1 (en) 2000-05-24 2000-05-24 INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF MIRTAZAPINE AND ITS OBTAINING PROCEDURES.

Publications (2)

Publication Number Publication Date
ES2190305A1 true ES2190305A1 (en) 2003-07-16
ES2190305B1 ES2190305B1 (en) 2004-07-01

Family

ID=27589259

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200001306A Expired - Fee Related ES2190305B1 (en) 2000-05-24 2000-05-24 INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF MIRTAZAPINE AND ITS OBTAINING PROCEDURES.

Country Status (1)

Country Link
ES (1) ES2190305B1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194464A1 (en) * 1985-02-15 1986-09-17 Research Corporation Technologies, Inc. (a Delaware corp.) Amino acid derivatives and use thereof for the preparation of an anticonvulsant
US4912110A (en) * 1985-07-31 1990-03-27 Laboratoire L. Lafton Antidepressive substituted phenylpiperazine compounds
US5378729A (en) * 1985-02-15 1995-01-03 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194464A1 (en) * 1985-02-15 1986-09-17 Research Corporation Technologies, Inc. (a Delaware corp.) Amino acid derivatives and use thereof for the preparation of an anticonvulsant
US5378729A (en) * 1985-02-15 1995-01-03 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant
US4912110A (en) * 1985-07-31 1990-03-27 Laboratoire L. Lafton Antidepressive substituted phenylpiperazine compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
W.R. RODERICK et al. "Derivatives of Piperazine. XXXV. Synthesis of 2-Phenylpiperazine and Some Derivatives", J. Med. Chem., 1966, Vol. 9, Nö 2, páginas 181-185. *

Also Published As

Publication number Publication date
ES2190305B1 (en) 2004-07-01

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